{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:56:42Z","timestamp":1791158202496,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":391,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.devcel.2014.04.022","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T11:58:12Z","timestamp":1401191892000},"page":"377-391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction"],"prefix":"10.1016","volume":"29","author":[{"given":"Lixin","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Inuzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangpeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavali","family":"Shaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Malumbres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Letai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc W.","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2014.04.022_bib1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.molcel.2007.06.013","article-title":"APC\/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase","volume":"27","author":"Amador","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc3007","article-title":"Strategies to improve radiotherapy with targeted drugs","volume":"11","author":"Begg","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2014.04.022_bib3","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","article-title":"Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity","volume":"286","author":"Bouillet","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.devcel.2014.04.022_bib4","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.febslet.2011.05.022","article-title":"p53 regulation by ubiquitin","volume":"585","author":"Brooks","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.devcel.2014.04.022_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ccr.2006.03.027","article-title":"Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members","volume":"9","author":"Certo","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molcel.2010.01.025","article-title":"The BCL-2 family reunion","volume":"37","author":"Chipuk","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc2615","article-title":"Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics","volume":"9","author":"Cragg","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2014.04.022_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molcel.2008.12.020","article-title":"betaTrCP- and Rsk1\/2-mediated degradation of BimEL inhibits apoptosis","volume":"33","author":"Dehan","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ccr.2007.07.001","article-title":"BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents","volume":"12","author":"Deng","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib10","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1101\/gad.12.12.1871","article-title":"The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation","volume":"12","author":"Fang","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2014.04.022_bib11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ncb1847","article-title":"Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction","volume":"11","author":"Gao","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2014.04.022_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ccr.2008.07.002","article-title":"Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs","volume":"14","author":"Gascoigne","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nature07396","article-title":"BAX activation is initiated at a novel interaction site","volume":"455","author":"Gavathiotis","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2014.04.022_bib14","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2014.04.022_bib15","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1083\/jcb.200111001","article-title":"Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC\/C switches from activation by Cdc20 to Cdh1","volume":"157","author":"Hagting","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2014.04.022_bib16","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1182\/blood-2010-04-280818","article-title":"Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim","volume":"116","author":"Happo","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.devcel.2014.04.022_bib17","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.94.5.2007","article-title":"Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage","volume":"94","author":"Hara","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2014.04.022_bib18","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.1013102","article-title":"The anaphase-promoting complex: it\u2019s not just for mitosis any more","volume":"16","author":"Harper","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2014.04.022_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ccr.2009.08.020","article-title":"Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly","volume":"16","author":"Huang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature09732","article-title":"SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction","volume":"471","author":"Inuzuka","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2014.04.022_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbrc.2011.10.055","article-title":"Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA","volume":"415","author":"Jiang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.devcel.2014.04.022_bib22","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1101\/gad.1157503","article-title":"SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase","volume":"17","author":"Jin","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2014.04.022_bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jso.23109","article-title":"Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients","volume":"106","author":"Kato","year":"2012","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.devcel.2014.04.022_bib24","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/sj.onc.1210799","article-title":"CDC20, a potential cancer therapeutic target, is negatively regulated by p53","volume":"27","author":"Kidokoro","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.devcel.2014.04.022_bib25","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1126\/science.274.5293.1652","article-title":"How proteolysis drives the cell cycle","volume":"274","author":"King","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.devcel.2014.04.022_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2005.02.003","article-title":"BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly","volume":"17","author":"Kuwana","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1535-6108(02)00127-7","article-title":"Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics","volume":"2","author":"Letai","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1073\/pnas.0406424101","article-title":"HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule","volume":"102","author":"Liu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2014.04.022_bib29","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2005.08.013","article-title":"CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC\/C-dependent proteolysis","volume":"122","author":"Mailand","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ccr.2010.10.028","article-title":"Targeting mitotic exit leads to tumor regression in\u00a0vivo: Modulation by Cdk1, Mastl, and the PP2A\/B55\u03b1,\u03b4 phosphatase","volume":"18","author":"Manchado","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2014.04.022_bib32","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1158\/0008-5472.CAN-04-4391","article-title":"Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants","volume":"65","author":"McDaid","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2014.04.022_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/embor.2010.190","article-title":"Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim","volume":"12","author":"Moujalled","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.devcel.2014.04.022_bib34","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/ncb1799","article-title":"The APC\/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction","volume":"10","author":"Nilsson","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2014.04.022_bib35","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nature05734","article-title":"Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation","volume":"446","author":"Reddy","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2014.04.022_bib36","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1101\/gad.945701","article-title":"Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins","volume":"15","author":"Reimann","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2014.04.022_bib37","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1190217","article-title":"BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program","volume":"330","author":"Ren","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.devcel.2014.04.022_bib38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbrc.2011.09.110","article-title":"Cell death pathology: the war against cancer","volume":"414","author":"Rufini","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.devcel.2014.04.022_bib39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ncb1092","article-title":"The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression","volume":"6","author":"Searle","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2014.04.022_bib40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ccr.2005.02.008","article-title":"Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy","volume":"7","author":"Tan","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib41","doi-asserted-by":"crossref","first-page":"10969","DOI":"10.1074\/jbc.M109.094920","article-title":"c-Cbl promotes T\u00a0cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase\/Akt pathway","volume":"285","author":"Thien","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2014.04.022_bib42","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.molcel.2011.09.024","article-title":"Cdh1 regulates osteoblast function through an APC\/C-independent modulation of Smurf1","volume":"44","author":"Wan","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib43","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI57080","article-title":"Good COP1 or bad COP1? In\u00a0vivo veritas","volume":"121","author":"Wei","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2014.04.022_bib44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature09779","article-title":"Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7","volume":"471","author":"Wertz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2014.04.022_bib45","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1073\/pnas.0912802107","article-title":"UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex","volume":"107","author":"Wu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2014.04.022_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2014.04.022_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molcel.2007.06.009","article-title":"Cdc20: a WD40 activator for a cell cycle degradation machine","volume":"27","author":"Yu","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib48","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ccr.2010.08.010","article-title":"Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage","volume":"18","author":"Zeng","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2014.04.022_bib49","doi-asserted-by":"crossref","first-page":"16416","DOI":"10.1074\/jbc.M802360200","article-title":"RACK1 and CIS mediate the degradation of BimEL in cancer cells","volume":"283","author":"Zhang","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2014.04.022_bib50","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1158\/0008-5472.CAN-08-0632","article-title":"Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2","volume":"68","author":"Zheng","year":"2008","journal-title":"Cancer Res."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580714002421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580714002421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T17:50:55Z","timestamp":1538589055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580714002421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1534580714002421"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2014.04.022","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718424021.793496050","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718424021.793495779","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718424021.793495828","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2014.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}