{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:31:11Z","timestamp":1791275471176,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":391,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.devcel.2014.08.026","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T12:02:20Z","timestamp":1414411340000},"page":"159-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["A Mechanical Jack-like Mechanism Drives Spontaneous Fracture Healing in Neonatal Mice"],"prefix":"10.1016","volume":"31","author":[{"given":"Chagai","family":"Rot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Blecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Friesem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elazar","family":"Zelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2014.08.026_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/154405910808700215","article-title":"Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis","volume":"87","author":"Ai-Aql","year":"2008","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.devcel.2009.10.010","article-title":"Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction","volume":"17","author":"Blitz","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2014.08.026_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3181\/00379727-200-43410A","article-title":"Regulation of fracture repair by growth factors","volume":"200","author":"Bolander","year":"1992","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.devcel.2014.08.026_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajpa.1330260308","article-title":"Pathology in the Darajani baboon","volume":"26","author":"Bramblett","year":"1967","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.devcel.2014.08.026_bib5","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s11999-008-0612-x","article-title":"Management of fractures of the humerus in Ancient Egypt, Greece, and Rome: an historical review","volume":"467","author":"Brorson","year":"2009","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib6","first-page":"19","article-title":"What happens to wild animals with broken bones","volume":"10","author":"Bulstrode","year":"1990","journal-title":"Iowa Orthop. J."},{"key":"10.1016\/j.devcel.2014.08.026_bib7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/01241398-200111000-00023","article-title":"Growth plate forces in the adolescent human knee: a radiographic and mechanical study of epiphyseal staples","volume":"21","author":"Bylski-Austrow","year":"2001","journal-title":"J.\u00a0Pediatr. Orthop."},{"issue":"432","key":"10.1016\/j.devcel.2014.08.026_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.blo.0000156452.91271.fb","article-title":"Pediatric fractures of the humerus","author":"Caviglia","year":"2005","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1359\/jbmr.2002.17.3.513","article-title":"Differential temporal expression of members of the transforming growth factor \u03b2 superfamily during murine fracture healing","volume":"17","author":"Cho","year":"2002","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0021-9290(98)00153-5","article-title":"Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing","volume":"32","author":"Claes","year":"1999","journal-title":"J.\u00a0Biomech."},{"key":"10.1016\/j.devcel.2014.08.026_bib11","series-title":"Rockwood and Green\u2019s Fractures in Adults","article-title":"Principles of nonoperative fracture treatment","author":"Court-Brown","year":"2010"},{"key":"10.1016\/j.devcel.2014.08.026_bib12","series-title":"Bones: Structure and Mechanics","first-page":"310","article-title":"Safety factors and scaling effects in bones","author":"Currey","year":"2002"},{"key":"10.1016\/j.devcel.2014.08.026_bib13","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.injury.2005.07.019","article-title":"Current concepts of molecular aspects of bone healing","volume":"36","author":"Dimitriou","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.devcel.2014.08.026_bib14","first-page":"81","article-title":"On the natural repair of fractures, as seen in the skeletons of anthropoid apes","volume":"46","author":"Duckworth","year":"1911","journal-title":"J.\u00a0Anat. Physiol."},{"issue":"355, Suppl","key":"10.1016\/j.devcel.2014.08.026_bib15","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"Einhorn","year":"1998","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0925-4773(99)00142-2","article-title":"Does adult fracture repair recapitulate embryonic skeletal formation?","volume":"87","author":"Ferguson","year":"1999","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2014.08.026_bib17","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2106\/00004623-195133040-00014","article-title":"The influence of pressure and tension on growing bone in experiments with animals","volume":"33-A","author":"Gelbke","year":"1951","journal-title":"J.\u00a0Bone Joint Surg. Am."},{"key":"10.1016\/j.devcel.2014.08.026_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/jor.1100150308","article-title":"Structure and function of embryonic growth plate in the absence of functioning skeletal muscle","volume":"15","author":"Germiller","year":"1997","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jcb.10435","article-title":"Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation","volume":"88","author":"Gerstenfeld","year":"2003","journal-title":"J.\u00a0Cell. Biochem."},{"issue":"Suppl 4","key":"10.1016\/j.devcel.2014.08.026_bib20","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0020-1383(08)70003-2","article-title":"Fracture healing: the diamond concept","volume":"38","author":"Giannoudis","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.devcel.2014.08.026_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jmor.1052060105","article-title":"Paralysis and growth of the musculoskeletal system in the embryonic chick","volume":"206","author":"Hall","year":"1990","journal-title":"J.\u00a0Morphol."},{"key":"10.1016\/j.devcel.2014.08.026_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1067\/mjd.2000.105567","article-title":"Pharmacology of botulinum toxin","volume":"43","author":"Huang","year":"2000","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.devcel.2014.08.026_bib23","first-page":"498","article-title":"Of the diseases of bones and joints, of fractures, dislocations &c","volume":"Vol. 1","author":"Hunter","year":"1837"},{"key":"10.1016\/j.devcel.2014.08.026_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/BPO.0b013e3181558c67","article-title":"Remodeling of birth fractures of the humeral diaphysis","volume":"28","author":"Husain","year":"2008","journal-title":"J.\u00a0Pediatric Orthopaed."},{"key":"10.1016\/j.devcel.2014.08.026_bib25","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.devcel.2009.04.013","article-title":"Muscle contraction is necessary to maintain joint progenitor cell fate","volume":"16","author":"Kahn","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2014.08.026_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1302\/0301-620X.58B1.1270489","article-title":"Remodelling by asymmetrical epiphysial growth. An experimental study in dogs","volume":"58","author":"Karaharju","year":"1976","journal-title":"J.\u00a0Bone Joint Surg. Br."},{"key":"10.1016\/j.devcel.2014.08.026_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1534-5807(02)00157-0","article-title":"Reaching a genetic and molecular understanding of skeletal development","volume":"2","author":"Karsenty","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2014.08.026_bib28","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2014.08.026_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0736-0266(00)00006-1","article-title":"Molecular aspects of healing in stabilized and non-stabilized fractures","volume":"19","author":"Le","year":"2001","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1302\/0301-620X.78B1.0780042","article-title":"Bone growth and remodelling after fracture","volume":"78","author":"Murray","year":"1996","journal-title":"J.\u00a0Bone Joint Surg. Br."},{"key":"10.1016\/j.devcel.2014.08.026_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1101\/gad.13.2.225","article-title":"Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling","volume":"13","author":"Murtaugh","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2014.08.026_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jbiomech.2007.09.031","article-title":"A dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones","volume":"41","author":"Nowlan","year":"2008","journal-title":"J.\u00a0Biomech."},{"key":"10.1016\/j.devcel.2014.08.026_bib33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.cellbio.16.1.191","article-title":"Bone development","volume":"16","author":"Olsen","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2014.08.026_bib34","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2014.08.026_bib35","first-page":"307","article-title":"Growth of the cartilages of the mid-line cranial base: a radiographic and histological study","volume":"136","author":"Roberts","year":"1983","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.devcel.2014.08.026_bib36","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2106\/00004623-197759050-00004","article-title":"Functional bracing of fractures of the shaft of the humerus","volume":"59","author":"Sarmiento","year":"1977","journal-title":"J.\u00a0Bone Joint Surg. Am."},{"key":"10.1016\/j.devcel.2014.08.026_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: the cellular picture","volume":"19","author":"Schindeler","year":"2008","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.devcel.2014.08.026_bib38","series-title":"Notes on Diseases and Healed Fractures of Wild Apes: And Their Bearing on the Antiquity of Pathological Conditions in Man","author":"Schultz","year":"1939"},{"key":"10.1016\/j.devcel.2014.08.026_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajpa.1330020102","article-title":"Age changes and variability in gibbons. A Morphological study on a population sample of a man-like ape","volume":"2","author":"Schultz","year":"1944","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.devcel.2014.08.026_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.22203\/eCM.v015a05","article-title":"Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts","volume":"15","author":"Shapiro","year":"2008","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.devcel.2014.08.026_bib41","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1242\/dev.063768","article-title":"Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis","volume":"138","author":"Sharir","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.devcel.2014.08.026_bib42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ydbio.2012.07.026","article-title":"Muscle contraction controls skeletal morphogenesis through regulation of chondrocyte convergent extension","volume":"370","author":"Shwartz","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2014.08.026_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.diff.2013.07.003","article-title":"One load to rule them all: mechanical control of the musculoskeletal system in development and aging","volume":"86","author":"Shwartz","year":"2013","journal-title":"Differentiation"},{"key":"10.1016\/j.devcel.2014.08.026_bib44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000142474","article-title":"Inhibition of tibial growth by means of compression of its proximal epiphysial disc in the rabbit","volume":"55","author":"Sijbrandij","year":"1963","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.devcel.2014.08.026_bib45","first-page":"85","article-title":"The effect of compression on the growth of epiphyseal bone","volume":"103","author":"Strobino","year":"1956","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1016\/j.devcel.2014.08.026_bib46","series-title":"Rockwood and Green\u2019s fractures in adults","first-page":"3","article-title":"Biomechanics of fracture and fracture fixation","author":"Tencer","year":"2010"},{"key":"10.1016\/j.devcel.2014.08.026_bib47","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/jor.20418","article-title":"Decreased muscle loading delays maturation of the tendon enthesis during postnatal development","volume":"25","author":"Thomopoulos","year":"2007","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib48","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0736-0266(02)00017-7","article-title":"A model for intramembranous ossification during fracture healing","volume":"20","author":"Thompson","year":"2002","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.devcel.2014.08.026_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0925-4773(97)00203-7","article-title":"Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair","volume":"71","author":"Vortkamp","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2014.08.026_bib50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1302\/0301-620X.74B5.1527131","article-title":"Remodelling of angular deformity after femoral shaft fractures in children","volume":"74","author":"Wallace","year":"1992","journal-title":"J.\u00a0Bone Joint Surg. Br."},{"key":"10.1016\/j.devcel.2014.08.026_bib51","doi-asserted-by":"crossref","first-page":"A3","DOI":"10.1016\/j.injury.2004.12.007","article-title":"Principles of fracture remodeling in children","volume":"36","author":"Wilkins","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.devcel.2014.08.026_bib52","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1302\/0301-620X.72B2.2312573","article-title":"The relationship between periosteal division and compression or distraction of the growth plate. An experimental study in the rabbit","volume":"72","author":"Wilson-MacDonald","year":"1990","journal-title":"J.\u00a0Bone Joint Surg. Br."},{"key":"10.1016\/j.devcel.2014.08.026_bib53","series-title":"Das Gesetz der Transformation der Knochen","author":"Wolff","year":"1892"},{"key":"10.1016\/j.devcel.2014.08.026_bib54","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ydbio.2006.07.028","article-title":"Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function","volume":"299","author":"Young","year":"2006","journal-title":"Dev. Biol."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580714005577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580714005577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T13:54:59Z","timestamp":1565963699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580714005577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1534580714005577"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2014.08.026","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725227274.793501939","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Mechanical Jack-like Mechanism Drives Spontaneous Fracture Healing in Neonatal Mice","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2014.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2014.10.009","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}