{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:41:30Z","timestamp":1780774890096,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":388,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.devcel.2015.01.023","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T12:14:55Z","timestamp":1427112895000},"page":"667-677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Submandibular Parasympathetic Gangliogenesis Requires Sprouty-Dependent Wnt Signals from Epithelial Progenitors"],"prefix":"10.1016","volume":"32","author":[{"given":"Wendy\u00a0M.","family":"Knosp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah\u00a0M.","family":"Knox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle\u00a0M.A.","family":"Lombaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace\u00a0L.","family":"Haddox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali\u00a0N.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0P.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2015.01.023_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/cge.12032","article-title":"The developmental genetics of Hirschsprung\u2019s disease","volume":"83","author":"Bergeron","year":"2013","journal-title":"Clin. Genet."},{"key":"10.1016\/j.devcel.2015.01.023_bib2","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0012-1606(75)90136-0","article-title":"Early development of parasympathetic nerves in the mouse submandibular gland","volume":"43","author":"Coughlin","year":"1975","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib4","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis","volume":"127","author":"De Moerlooze","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.1253281","article-title":"Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors","volume":"345","author":"Dyachuk","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.01.023_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1242\/dev.099507","article-title":"A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain","volume":"141","author":"Dyer","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib8","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1242\/dev.127.22.4877","article-title":"Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin","volume":"127","author":"Enomoto","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ng1507","article-title":"Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands","volume":"37","author":"Entesarian","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2015.01.023_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.1253286","article-title":"Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors","volume":"345","author":"Espinosa-Medina","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.01.023_bib11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.200408051","article-title":"L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers","volume":"168","author":"Gavert","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1101\/gad.10.2.165","article-title":"Keratinocyte growth factor is required for hair development but not for wound healing","volume":"10","author":"Guo","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2015.01.023_bib13","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.diff.2008.10.006","article-title":"EGF-receptor regulates salivary gland branching morphogenesis by supporting proliferation and maturation of epithelial cells and survival of mesenchymal cells","volume":"77","author":"H\u00e4\u00e4r\u00e4","year":"2009","journal-title":"Differentiation"},{"key":"10.1016\/j.devcel.2015.01.023_bib14","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1242\/dev.057711","article-title":"Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis","volume":"138","author":"H\u00e4\u00e4r\u00e4","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/dvdy.24097","article-title":"FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium","volume":"243","author":"Kera","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2015.01.023_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/wdev.4","article-title":"Salivary gland organogenesis","volume":"1","author":"Knosp","year":"2012","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib17","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.1192046","article-title":"Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis","volume":"329","author":"Knox","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.01.023_bib18","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ncomms2493","article-title":"Parasympathetic stimulation improves epithelial organ regeneration","volume":"4","author":"Knox","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2015.01.023_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ng1097-223","article-title":"Cre-mediated chromosome loss in mice","volume":"17","author":"Lewandoski","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2015.01.023_bib20","doi-asserted-by":"crossref","first-page":"11402","DOI":"10.1073\/pnas.1205015109","article-title":"Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2015.01.023_bib21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.stemcr.2013.10.013","article-title":"Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis","volume":"1","author":"Lombaert","year":"2013","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.devcel.2015.01.023_bib22","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/MCB.22.4.1184-1193.2002","article-title":"Negative feedback loop of Wnt signaling through upregulation of conductin\/axin2 in colorectal and liver tumors","volume":"22","author":"Lustig","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib23","doi-asserted-by":"crossref","first-page":"ra55","DOI":"10.1126\/scisignal.2000304","article-title":"Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis","volume":"2","author":"Makarenkova","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2015.01.023_bib24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200409182","article-title":"Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation","volume":"168","author":"Mansukhani","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1507\/endocrj.EJ12-0361","article-title":"Involvement of the parasympathetic nervous system in the initiation of regeneration of pancreatic \u03b2-cells","volume":"60","author":"Medina","year":"2013","journal-title":"Endocr. J."},{"key":"10.1016\/j.devcel.2015.01.023_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1399-0004.2006.00597.x","article-title":"LADD syndrome is caused by FGF10 mutations","volume":"69","author":"Milunsky","year":"2006","journal-title":"Clin. Genet."},{"key":"10.1016\/j.devcel.2015.01.023_bib27","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1101\/gad.12.20.3156","article-title":"Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless","volume":"12","author":"Min","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2015.01.023_bib28","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1242\/dev.095687","article-title":"FGF signaling regulates Wnt ligand expression to control vulval cell lineage polarity in C.\u00a0elegans","volume":"140","author":"Minor","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib29","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1242\/dev.126.20.4465","article-title":"Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed","volume":"126","author":"Minowada","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/dvdy.20078","article-title":"Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland","volume":"230","author":"Miyazaki","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2015.01.023_bib31","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s11481-012-9404-x","article-title":"Wnt signaling in vertebrate neural development and function","volume":"7","author":"Mulligan","year":"2012","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.devcel.2015.01.023_bib32","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1242\/dev.091256","article-title":"GDNF is required for neural colonization of the pancreas","volume":"140","author":"Mu\u00f1oz-Bravo","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.devcel.2014.06.012","article-title":"Parasympathetic innervation regulates tubulogenesis in the developing salivary gland","volume":"30","author":"Nedvetsky","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.01.023_bib34","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1006\/bbrc.2000.3721","article-title":"FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development","volume":"277","author":"Ohuchi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.devcel.2015.01.023_bib35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ydbio.2011.07.023","article-title":"Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals","volume":"358","author":"Patel","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib36","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1242\/dev.048439","article-title":"Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration","volume":"137","author":"Piloto","year":"2010","journal-title":"Development"},{"issue":"Pt A","key":"10.1016\/j.devcel.2015.01.023_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4615-0717-8_2","article-title":"GDNF family signalling in exocrine tissues: distinct roles for GDNF and neurturin in parasympathetic neuron development","volume":"506","author":"Rossi","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrm2428","article-title":"A gene regulatory network orchestrates neural crest formation","volume":"9","author":"Sauka-Spengler","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib39","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1242\/dev.034355","article-title":"N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons","volume":"136","author":"Shiau","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nn2051","article-title":"Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion","volume":"11","author":"Shiau","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2015.01.023_bib41","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.devcel.2005.02.009","article-title":"Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling","volume":"8","author":"Shim","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.01.023_bib42","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1101\/gr.157586.113","article-title":"Insights into neural crest development and evolution from genomic analysis","volume":"23","author":"Sim\u00f5es-Costa","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2015.01.023_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ydbio.2011.07.024","article-title":"Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo","volume":"358","author":"Simrick","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib44","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.01690","article-title":"FGFR2b signaling regulates ex\u00a0vivo submandibular gland epithelial cell proliferation and branching morphogenesis","volume":"132","author":"Steinberg","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.01.023_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ydbio.2014.01.021","article-title":"Neural crest and placode interaction during the development of the cranial sensory system","volume":"389","author":"Steventon","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib46","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1126\/science.1204831","article-title":"Control of mitotic spindle angle by the RAS-regulated ERK1\/2 pathway determines lung tube shape","volume":"333","author":"Tang","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.01.023_bib47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/dbio.2001.0351","article-title":"Involvement of heparin-binding EGF-like growth factor and its processing by metalloproteinases in early epithelial morphogenesis of the submandibular gland","volume":"237","author":"Umeda","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.01.023_bib48","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/stem.36","article-title":"Endogenous Wnt signaling maintains neural progenitor cell potency","volume":"27","author":"Wexler","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.devcel.2015.01.023_bib49","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1242\/dev.063784","article-title":"Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum","volume":"138","author":"Yu","year":"2011","journal-title":"Development"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580715000660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580715000660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:27:29Z","timestamp":1761521249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580715000660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1534580715000660"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2015.01.023","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Submandibular Parasympathetic Gangliogenesis Requires Sprouty-Dependent Wnt Signals from Epithelial Progenitors","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2015.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}