{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:28:07Z","timestamp":1792718887609,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":371,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.devcel.2015.03.001","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T11:46:51Z","timestamp":1428320811000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":249,"title":["Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting"],"prefix":"10.1016","volume":"33","author":[{"given":"Alejandra","family":"Figueroa-Clarevega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2015.03.001_bib1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1242\/dev.02411","article-title":"JAK\/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions","volume":"133","author":"Arbouzova","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.03.001_bib2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/ijc.24784","article-title":"Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice","volume":"126","author":"Asp","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.devcel.2015.03.001_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrc3720","article-title":"IGF binding proteins in cancer: mechanistic and clinical insights","volume":"14","author":"Baxter","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2015.03.001_bib4","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00520-010-0972-0","article-title":"Animal models of the cancer anorexia-cachexia syndrome","volume":"19","author":"Bennani-Baiti","year":"2011","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.devcel.2015.03.001_bib5","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1101\/gad.1211604","article-title":"Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors","volume":"18","author":"Bilder","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2015.03.001_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/dmm.010389","article-title":"Cellular and molecular mechanisms of muscle atrophy","volume":"6","author":"Bonaldo","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.devcel.2015.03.001_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1534-5807(02)00117-X","article-title":"Drosophila\u2019s insulin\/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions","volume":"2","author":"Britton","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib8","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1093\/emboj\/cdg548","article-title":"scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila","volume":"22","author":"Brumby","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2015.03.001_bib9","doi-asserted-by":"crossref","first-page":"03189","DOI":"10.7554\/eLife.03189","article-title":"The transcriptional response to tumorigenic polarity loss in Drosophila","volume":"4","author":"Bunker","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2015.03.001_bib10","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1073\/pnas.0903971106","article-title":"Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response","volume":"106","author":"Charroux","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2015.03.001_bib11","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1126\/science.1216689","article-title":"Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing","volume":"336","author":"Colombani","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.03.001_bib13","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.devcel.2010.05.014","article-title":"Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter","volume":"18","author":"Cordero","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature11127","article-title":"Chemical genetic discovery of targets and anti-targets for cancer polypharmacology","volume":"486","author":"Dar","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/260252a0","article-title":"Demonstration of sensory neurones in the ectopic cuticle of spineless-aristapedia, a homoeotic mutant of Drosophila","volume":"260","author":"Deak","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2010.10.007","article-title":"FOXO\/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging","volume":"143","author":"Demontis","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib17","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1242\/dmm.012559","article-title":"Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models","volume":"6","author":"Demontis","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.devcel.2015.03.001_bib18","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1073\/pnas.0803998105","article-title":"The Parkinson\u2019s disease genes pink1 and parkin promote mitochondrial fission and\/or inhibit fusion in Drosophila","volume":"105","author":"Deng","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2015.03.001_bib19","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.cub.2006.08.052","article-title":"Akt\u00a0and FOXO dysregulation contribute to infection-induced wasting in Drosophila","volume":"16","author":"Dionne","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib20","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/dbio.2000.0135","article-title":"Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis","volume":"231","author":"Drummond-Barbosa","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1242\/jeb.197.1.215","article-title":"Regulation of feeding behavior in adult Drosophila melanogaster varies with feeding regime and nutritional state","volume":"197","author":"Edgecomb","year":"1994","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/bse0530141","article-title":"The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man","volume":"53","author":"Elsum","year":"2012","journal-title":"Essays Biochem."},{"key":"10.1016\/j.devcel.2015.03.001_bib24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/35006074","article-title":"A Drosophila model of Parkinson\u2019s disease","volume":"404","author":"Feany","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.devcel.2015.03.001_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.devcel.2015.03.001_bib27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1126\/science.1216735","article-title":"Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation","volume":"336","author":"Garelli","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.03.001_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrc3461","article-title":"Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics","volume":"13","author":"Gonzalez","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2015.03.001_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nature05382","article-title":"Specialized hepatocyte-like cells regulate Drosophila lipid metabolism","volume":"445","author":"Gutierrez","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0012-1606(63)90146-5","volume":"7","author":"Hadorn","year":"1963","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib31","doi-asserted-by":"crossref","first-page":"a011288","DOI":"10.1101\/cshperspect.a011288","article-title":"The hippo pathway","volume":"4","author":"Harvey","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib32","first-page":"10","article-title":"Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance","volume":"7","author":"Honegger","year":"2008","journal-title":"J.\u00a0Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13539-011-0051-5","article-title":"The role of insulin resistance in the development of muscle wasting during cancer cachexia","volume":"3","author":"Honors","year":"2012","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.devcel.2015.03.001_bib34","doi-asserted-by":"crossref","first-page":"8253","DOI":"10.1073\/pnas.0702726104","article-title":"Prandiology of Drosophila and the CAFE assay","volume":"104","author":"Ja","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2015.03.001_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.125.1.1","article-title":"Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues","volume":"125","author":"Karim","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devcel.2015.03.001_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.devcel.2015.02.012","article-title":"Systemic organ wasting induced by localized expression of the\u00a0secreted insulin\/IGF antagonist ImpL2","volume":"33","author":"Kwon","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature06286","article-title":"Drosophila and the genetics of the internal milieu","volume":"450","author":"Leopold","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1101\/gad.204479.112","article-title":"A secreted decoy of InR antagonizes insulin\/IGF signaling to restrict body growth in Drosophila","volume":"27","author":"Okamoto","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2015.03.001_bib39","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.1088474","article-title":"A genetic screen in Drosophila for metastatic behavior","volume":"302","author":"Pagliarini","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.devcel.2015.03.001_bib40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"Pan","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib41","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04788","article-title":"Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin","volume":"441","author":"Park","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2015.03.001_bib42","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1242\/dmm.000950","article-title":"An innate immune response of blood cells to tumors and tissue damage in Drosophila","volume":"1","author":"Pastor-Pareja","year":"2008","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.devcel.2015.03.001_bib43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcdb.2014.03.012","article-title":"Tissue design: how Drosophila tumors remodel their neighborhood","volume":"28","author":"Patel","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2015.03.001_bib44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2012.08.019","article-title":"Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion","volume":"151","author":"Rajan","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2004.07.009","article-title":"Role and regulation of starvation-induced autophagy in the Drosophila fat body","volume":"7","author":"Scott","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2015.03.001_bib46","series-title":"The Development of Drosophila melanogaster","first-page":"1","article-title":"Developmental genetics of oogenesis","author":"Spradling","year":"1993"},{"key":"10.1016\/j.devcel.2015.03.001_bib47","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","article-title":"Cachexia in cancer patients","volume":"2","author":"Tisdale","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2015.03.001_bib48","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2015.03.001_bib49","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1038\/onc.2011.125","article-title":"Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model","volume":"30","author":"Willecke","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.devcel.2015.03.001_bib50","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s004270050145","article-title":"Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes","volume":"207","author":"Woodhouse","year":"1998","journal-title":"Dev. Genes Evol."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580715001434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580715001434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T08:29:49Z","timestamp":1651652989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580715001434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1534580715001434"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2015.03.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725426903.793506383","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725426903.793510416","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2015.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2015.02.012","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}