{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:01:38Z","timestamp":1792123298382,"version":"4.4.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 GM114140"],"award-info":[{"award-number":["R01 GM114140"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000863","name":"Ellison Medical Foundation","doi-asserted-by":"publisher","award":["AG-SS-2951-12"],"award-info":[{"award-number":["AG-SS-2951-12"]}],"id":[{"id":"10.13039\/100000863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.devcel.2017.07.014","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T12:15:45Z","timestamp":1502972145000},"page":"542-553.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C.\u00a0elegans Cell Fate Specification"],"prefix":"10.1016","volume":"42","author":[{"given":"Claire","family":"de la Cova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Townley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Regot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Greenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2017.07.014_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1534\/genetics.113.160846","article-title":"Simultaneous expression of multiple proteins under a single promoter in Caenorhabditis elegans via a versatile 2A-based toolkit","volume":"196","author":"Ahier","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2017.07.014_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.molcel.2012.11.002","article-title":"Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals","volume":"49","author":"Albeck","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib3","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1242\/dev.126.9.1947","article-title":"Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells","volume":"126","author":"Ambros","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.devcel.2017.07.014_bib4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molcel.2013.09.015","article-title":"Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation","volume":"52","author":"Aoki","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.devcel.2011.04.009","article-title":"MPK-1 ERK controls membrane organization in C.\u00a0elegans oogenesis via a sex-determination module","volume":"20","author":"Arur","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib6","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1073\/pnas.0812285106","article-title":"Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development","volume":"106","author":"Arur","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2017.07.014_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrm3048","article-title":"Feedback regulation of EGFR signalling: decision making by early and delayed loops","volume":"12","author":"Avraham","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib8","series-title":"WormBook","article-title":"Chemosensation in C.\u00a0elegans","author":"Bargmann","year":"2006"},{"key":"10.1016\/j.devcel.2017.07.014_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.devcel.2012.12.001","article-title":"Robustness and epistasis in the C.\u00a0elegans vulval signaling network revealed by pathway dosage modulation","volume":"24","author":"Barkoulas","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.1055642","article-title":"Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C.\u00a0elegans vulval development","volume":"291","author":"Berset","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.devcel.2017.07.014_bib11","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1101\/gad.333505","article-title":"The C.\u00a0elegans homolog of the mammalian tumor suppressor Dep-1\/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions","volume":"19","author":"Berset","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.devcel.2008.09.011","article-title":"Plasticity and errors of a robust developmental system in different environments","volume":"15","author":"Braendle","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1242\/dev.125.6.1083","article-title":"EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C.\u00a0elegans","volume":"125","author":"Burdine","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.devcel.2017.07.014_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuron.2011.02.039","article-title":"A RasGRP, C.\u00a0elegans RGEF-1b, couples external stimuli to behavior by activating LET-60 (Ras) in sensory neurons","volume":"70","author":"Chen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2017.07.014_bib15","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/dev.121.8.2525","article-title":"Three genes of the MAP kinase cascade, mek-2, mpk-1\/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans","volume":"121","author":"Church","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.devcel.2017.07.014_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0092-8674(00)81419-1","article-title":"Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha","volume":"94","author":"Conti","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0012-1606(03)00033-2","article-title":"Cis regulatory requirements for vulval cell-specific expression of the Caenorhabditis elegans fibroblast growth factor gene egl-17","volume":"257","author":"Cui","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib18","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1101\/gad.203703.112","article-title":"SEL-10\/Fbw7-dependent negative feedback regulation of LIN-45\/Braf signaling in C.\u00a0elegans via a conserved phosphodegron","volume":"26","author":"de la Cova","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(95)90101-9","article-title":"An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C.\u00a0elegans hermaphrodites","volume":"83","author":"DeVore","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1534\/genetics.115.182162","article-title":"CRISPR-based methods for Caenorhabditis elegans genome engineering","volume":"202","author":"Dickinson","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2017.07.014_bib21","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1534\/genetics.115.178335","article-title":"Streamlined genome engineering with a self-excising drug selection cassette","volume":"200","author":"Dickinson","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2017.07.014_bib22","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.devcel.2014.11.004","article-title":"A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C.\u00a0elegans","volume":"31","author":"Drake","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib23","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1101\/gad.1560107","article-title":"The molecular signature and cis-regulatory architecture of a C.\u00a0elegans gustatory neuron","volume":"21","author":"Etchberger","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib24","doi-asserted-by":"crossref","first-page":"e25047","DOI":"10.1371\/journal.pone.0025047","article-title":"A functional nuclear localization sequence in the C.\u00a0elegans TRPV channel OCR-2","volume":"6","author":"Ezak","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2017.07.014_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/326259a0","article-title":"A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans","volume":"326","author":"Ferguson","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2017.07.014_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cub.2006.12.024","article-title":"Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis","volume":"17","author":"F\u00e9lix","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib27","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1006\/jmbi.2000.3642","article-title":"Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha","volume":"297","author":"Fontes","year":"2000","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nmeth.1865","article-title":"Improved mos1-mediated transgenesis in C.\u00a0elegans","volume":"9","author":"Fr\u00f8kj\u00e6r-Jensen","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2017.07.014_bib29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nmeth.2889","article-title":"Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon","volume":"11","author":"Fr\u00f8kj\u00e6r-Jensen","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2017.07.014_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","article-title":"The lin-12 locus specifies cell fates in Caenorhabditis elegans","volume":"34","author":"Greenwald","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib31","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1101\/gad.11.20.2715","article-title":"Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase","volume":"11","author":"Hajnal","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib32","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1101\/gad.12.16.2623","article-title":"Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning","volume":"12","author":"Harfe","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib33","doi-asserted-by":"crossref","first-page":"19264","DOI":"10.1073\/pnas.0804598105","article-title":"A genetically encoded fluorescent sensor of ERK activity","volume":"105","author":"Harvey","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2017.07.014_bib34","doi-asserted-by":"crossref","first-page":"e05178","DOI":"10.7554\/eLife.05178","article-title":"Intercellular propagation of extracellular signal-regulated kinase activation revealed by in\u00a0vivo imaging of mouse skin","volume":"4","author":"Hiratsuka","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.devcel.2017.07.014_bib35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2443.2005.00856.x","article-title":"Neural circuit-dependent odor adaptation in C.\u00a0elegans is regulated by the Ras-MAPK pathway","volume":"10","author":"Hirotsu","year":"2005","journal-title":"Genes Cells"},{"key":"10.1016\/j.devcel.2017.07.014_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/dev.00924","article-title":"A cell-specific enhancer that specifies lin-3 expression in the C.\u00a0elegans anchor cell for vulval development","volume":"131","author":"Hwang","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.devcel.2017.07.014_bib37","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/genetics\/149.4.1809","article-title":"Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase","volume":"149","author":"Jacobs","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2017.07.014_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/gad.13.2.163","article-title":"Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase","volume":"13","author":"Jacobs","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/bioinformatics\/btr095","article-title":"Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software","volume":"27","author":"Kamentsky","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2017.07.014_bib40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-4614-4015-4_10","article-title":"Control of oocyte growth and meiotic maturation in Caenorhabditis elegans","volume":"757","author":"Kim","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib41","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.cub.2007.10.061","article-title":"Trends, stasis, and drift in the evolution of nematode vulva development","volume":"17","author":"Kiontke","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrc3983","article-title":"The dynamic control of signal transduction networks in cancer cells","volume":"15","author":"Kolch","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2017.07.014_bib43","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1534\/genetics.107.081356","article-title":"Multiple functions and dynamic activation of MPK-1 extracellular signal-regulated kinase signaling in Caenorhabditis elegans germline development","volume":"177","author":"Lee","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2017.07.014_bib44","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.cub.2015.05.039","article-title":"Dynamics of inductive ERK signaling in the Drosophila embryo","volume":"25","author":"Lim","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib45","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2144\/000112615","article-title":"Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans","volume":"43","author":"Lyssenko","year":"2007","journal-title":"Biotechniques"},{"key":"10.1016\/j.devcel.2017.07.014_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib47","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/j.bpj.2015.10.021","article-title":"A transport model for estimating the time course of ERK activation in the C.\u00a0elegans germline","volume":"109","author":"Mattingly","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.devcel.2017.07.014_bib48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/dbio.1998.9109","article-title":"On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans","volume":"205","author":"McCarter","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib49","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.cub.2008.08.013","article-title":"3\u2032 UTRs are the primary regulators of gene expression in the C.\u00a0elegans germline","volume":"18","author":"Merritt","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib50","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1126\/science.1057586","article-title":"A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation","volume":"291","author":"Miller","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.devcel.2017.07.014_bib51","doi-asserted-by":"crossref","first-page":"20368","DOI":"10.1073\/pnas.0709989104","article-title":"Wnt signal from multiple tissues and lin-3\/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans","volume":"104","author":"Myers","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2017.07.014_bib52","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.cell.2014.04.039","article-title":"High-sensitivity measurements of multiple kinase activities in live single cells","volume":"157","author":"Regot","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib53","doi-asserted-by":"crossref","first-page":"838","DOI":"10.15252\/msb.20156458","article-title":"Frequency modulation of ERK activation dynamics rewires cell fate","volume":"11","author":"Ryu","year":"2015","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib54","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1101\/gad.261917.115","article-title":"Dimerization-driven degradation of C.\u00a0elegans and human E proteins","volume":"29","author":"Sallee","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2017.07.014_bib55","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ncb1543","article-title":"Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate","volume":"9","author":"Santos","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.devcel.2017.07.014_bib56","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0092-8674(89)90060-3","article-title":"Cell autonomy of lin-12 function in a cell fate decision in C.\u00a0elegans","volume":"57","author":"Seydoux","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib57","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/msb.2009.90","article-title":"Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor","volume":"5","author":"Shankaran","year":"2009","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib58","doi-asserted-by":"crossref","first-page":"24784","DOI":"10.1074\/jbc.M115.662247","article-title":"Receptor level mechanisms are required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) activity pulses","volume":"290","author":"Sparta","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2017.07.014_bib59","series-title":"The C. elegans Research Community","article-title":"Vulval development","author":"Sternberg","year":"2005"},{"key":"10.1016\/j.devcel.2017.07.014_bib60","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","article-title":"Pattern formation during vulval development in C.\u00a0elegans","volume":"44","author":"Sternberg","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0012-1606(80)90353-X","article-title":"Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans","volume":"78","author":"Sulston","year":"1980","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib62","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1242\/dev.122.9.2823","article-title":"A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans","volume":"122","author":"Sundaram","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.devcel.2017.07.014_bib63","series-title":"The C. elegans Research Community","article-title":"Canonical RTK-Ras-ERK signaling and related alternative pathways","author":"Sundaram","year":"2013"},{"key":"10.1016\/j.devcel.2017.07.014_bib64","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)81186-1","article-title":"MAP kinase signaling specificity mediated by the LIN-1 Ets\/LIN-31 WH transcription factor complex during C.\u00a0elegans vulval induction","volume":"93","author":"Tan","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2017.07.014_bib65","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ydbio.2005.08.007","article-title":"lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras\/MAP kinase signaling in C.\u00a0elegans","volume":"286","author":"Tiensuu","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2017.07.014_bib66","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1073\/pnas.211564598","article-title":"Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells","volume":"98","author":"Ting","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2017.07.014_bib67","doi-asserted-by":"crossref","first-page":"ra76","DOI":"10.1126\/scisignal.2002983","article-title":"The temporal pattern of stimulation determines the extent and duration of MAPK activation in a Caenorhabditis elegans sensory neuron","volume":"5","author":"Tomida","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2017.07.014_bib68","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.1091639","article-title":"Crosstalk between the EGFR and LIN-12\/Notch pathways in C.\u00a0elegans vulval development","volume":"303","author":"Yoo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.devcel.2017.07.014_bib69","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1534\/genetics.111.128389","article-title":"Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans","volume":"188","author":"Zhang","year":"2011","journal-title":"Genetics"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580717305877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580717305877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T05:59:45Z","timestamp":1659333585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580717305877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1534580717305877"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2017.07.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.729075652.793537764","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C.\u00a0elegans Cell Fate Specification","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2017.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2017.08.023","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}