{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:58:56Z","timestamp":1792785536201,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R01HD080224"],"award-info":[{"award-number":["R01HD080224"]}]},{"name":"NIH","award":["DP1ES025458"],"award-info":[{"award-number":["DP1ES025458"]}]},{"name":"the Austrian Academy of Sciences","id":[{"id":"https:\/\/ror.org\/03anc3s24","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Research Council","award":["ERC-StG-338252"],"award-info":[{"award-number":["ERC-StG-338252"]}],"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005237","name":"Helen Hay Whitney Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005237","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.devcel.2018.06.023","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T11:32:59Z","timestamp":1532604779000},"page":"481-494.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":413,"title":["Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm"],"prefix":"10.1016","volume":"46","author":[{"given":"Upasna","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Conine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Reichholf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Kukreja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika A.","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan L.","family":"Ameres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"Rando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2018.06.023_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nmeth.4610","article-title":"Cell-type specific sequencing of microRNAs from complex animal tissues","volume":"15","author":"Alberti","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2018.06.023_bib2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1091\/mbc.e11-08-0689","article-title":"Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena","volume":"23","author":"Andersen","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib3","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1016\/j.febslet.2014.09.001","article-title":"tRNA fragments in human health and disease","volume":"588","author":"Anderson","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.devcel.2018.06.023_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nature04916","article-title":"A novel class of small RNAs bind to MILI protein in mouse testes","volume":"442","author":"Aravin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2018.06.023_bib5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.1142612","article-title":"Developmentally regulated piRNA clusters implicate MILI in transposon control","volume":"316","author":"Aravin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gde.2010.01.008","article-title":"Paramutation in maize: RNA mediated trans-generational gene silencing","volume":"20","author":"Arteaga-Vazquez","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.devcel.2018.06.023_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molcel.2008.06.002","article-title":"PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans","volume":"31","author":"Batista","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1095\/biolreprod.113.110486","article-title":"Epididymosomes convey different repertoires of microRNAs throughout the bovine epididymis","volume":"89","author":"Belleann\u00e9e","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.devcel.2018.06.023_bib9","doi-asserted-by":"crossref","first-page":"e38457","DOI":"10.1371\/journal.pone.0038457","article-title":"Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling","volume":"7","author":"Bj\u00f6rkgren","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.devcel.2018.06.023_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.1194776","article-title":"A small-RNA perspective on gametogenesis, fertilization, and early zygotic development","volume":"330","author":"Bourc'his","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib11","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.cell.2007.01.043","article-title":"Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila","volume":"128","author":"Brennecke","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib12","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1165171","article-title":"An epigenetic role for maternally inherited piRNAs in transposon silencing","volume":"322","author":"Brennecke","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib13","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1095\/biolreprod.104.031666","article-title":"Train A, an RNase A-like protein without RNase activity, is secreted and reabsorbed by the same epididymal cells under testicular control","volume":"71","author":"Castella","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.devcel.2018.06.023_bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.aad7977","article-title":"Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder","volume":"351","author":"Chen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrg.2016.106","article-title":"Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2018.06.023_bib16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.devcel.2018.06.024","article-title":"Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice","volume":"46","author":"Conine","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib17","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1101\/gad.1996210","article-title":"A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo","volume":"24","author":"Couvillion","year":"2010","journal-title":"Genes. Dev."},{"key":"10.1016\/j.devcel.2018.06.023_bib18","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nmeth.3508","article-title":"ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments","volume":"12","author":"Cozen","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2018.06.023_bib19","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.molmet.2015.12.002","article-title":"High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring","volume":"5","author":"de Castro Barbosa","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.devcel.2018.06.023_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.semcdb.2014.04.021","article-title":"Regulation of spermatogenesis by small non-coding RNAs: role of the germ granule","volume":"29","author":"de Mateo","year":"2014","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.devcel.2018.06.023_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature11416","article-title":"Paramutation in Drosophila linked to emergence of a piRNA-producing locus","volume":"490","author":"de Vanssay","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2018.06.023_bib22","doi-asserted-by":"crossref","first-page":"10959","DOI":"10.1074\/jbc.M109.077560","article-title":"Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly","volume":"285","author":"Emara","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2018.06.023_bib23","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cell.2012.10.045","article-title":"Piwi-interacting RNAs protect DNA against loss during Oxytricha genome rearrangement","volume":"151","author":"Fang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib24","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1190614","article-title":"Epigenetic reprogramming in plant and animal development","volume":"330","author":"Feng","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2018.06.023_bib26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.febslet.2008.12.043","article-title":"Stress induces tRNA cleavage by angiogenin in mammalian cells","volume":"583","author":"Fu","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.devcel.2018.06.023_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nn.3695","article-title":"Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice","volume":"17","author":"Gapp","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2018.06.023_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbagrm.2014.04.006","article-title":"Global characterization and target identification of piRNAs and endo-siRNAs in mouse gametes and zygotes","volume":"1839","author":"Garc\u00eda-L\u00f3pez","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.devcel.2018.06.023_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1101\/gad.205278.112","article-title":"Mouse TU tagging: a chemical\/genetic intersectional method for purifying cell type-specific nascent RNA","volume":"27","author":"Gay","year":"2013","journal-title":"Genes. Dev."},{"key":"10.1016\/j.devcel.2018.06.023_bib30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrg2504","article-title":"Small silencing RNAs: an expanding universe","volume":"10","author":"Ghildiyal","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2018.06.023_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/imr.12013","article-title":"Transfer of extracellular vesicles during immune cell-cell interactions","volume":"251","author":"Guti\u00e9rrez-V\u00e1zquez","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.devcel.2018.06.023_bib32","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.286.5441.950","article-title":"A species of small antisense RNA in posttranscriptional gene silencing in plants","volume":"286","author":"Hamilton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib33","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/nmeth.4435","article-title":"Thiol-linked alkylation of RNA to assess expression dynamics","volume":"14","author":"Herzog","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2018.06.023_bib34","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1093\/nar\/gkr693","article-title":"Identification and remediation of biases in the activity of RNA ligases in small-RNA deep sequencing","volume":"39","author":"Jayaprakash","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2018.06.023_bib35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1095\/biolreprod.105.039719","article-title":"The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis","volume":"73","author":"Johnston","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.devcel.2018.06.023_bib36","doi-asserted-by":"crossref","first-page":"e44542","DOI":"10.1371\/journal.pone.0044542","article-title":"Novel small noncoding RNAs in mouse spermatozoa, zygotes and early embryos","volume":"7","author":"Kawano","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.devcel.2018.06.023_bib37","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.celrep.2014.08.027","article-title":"Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes","volume":"8","author":"Koppers-Lalic","year":"2014","journal-title":"Cell. Rep."},{"key":"10.1016\/j.devcel.2018.06.023_bib38","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2018.06.023_bib39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ydbio.2012.06.017","article-title":"cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit","volume":"369","author":"Krapf","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2018.06.023_bib40","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1242\/dev.00973","article-title":"Mili, a mammalian member of piwi family gene, is essential for spermatogenesis","volume":"131","author":"Kuramochi-Miyagawa","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.devcel.2018.06.023_bib41","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.1254400","article-title":"Parenting from before conception","volume":"345","author":"Lane","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib42","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2018.06.023_bib43","doi-asserted-by":"crossref","first-page":"42744","DOI":"10.1074\/jbc.M510356200","article-title":"Starvation-induced cleavage of the tRNA anticodon loop in Tetrahymena thermophila","volume":"280","author":"Lee","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2018.06.023_bib44","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1101\/gad.1837609","article-title":"A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)","volume":"23","author":"Lee","year":"2009","journal-title":"Genes. Dev."},{"key":"10.1016\/j.devcel.2018.06.023_bib45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molcel.2013.02.016","article-title":"An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes","volume":"50","author":"Li","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib46","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/dbio.1994.1257","article-title":"Intercellular cytoplasm transport during Drosophila oogenesis","volume":"165","author":"Mahajan-Miklos","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2018.06.023_bib47","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.cell.2009.03.040","article-title":"Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary","volume":"137","author":"Malone","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib48","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1093\/nar\/gkx103","article-title":"tRNA-derived small RNAs target transposable element transcripts","volume":"45","author":"Martinez","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2018.06.023_bib49","doi-asserted-by":"crossref","first-page":"16030","DOI":"10.1038\/nplants.2016.30","article-title":"Silencing in sperm cells is directed by RNA movement from the surrounding nurse cell","volume":"2","author":"Mart\u00ednez","year":"2016","journal-title":"Nat. Plants"},{"key":"10.1016\/j.devcel.2018.06.023_bib50","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1093\/jxb\/err032","article-title":"Cytoplasmic connection of sperm cells to the pollen vegetative cell nucleus: potential roles of the male germ unit revisited","volume":"62","author":"McCue","year":"2011","journal-title":"J.\u00a0Exp. Bot."},{"key":"10.1016\/j.devcel.2018.06.023_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/REP-11-0057","article-title":"Chromatoid body and small RNAs in male germ cells","volume":"142","author":"Meikar","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.devcel.2018.06.023_bib52","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(02)00909-1","article-title":"Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena","volume":"110","author":"Mochizuki","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1095\/biolreprod.115.132209","article-title":"The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation","volume":"93","author":"Nixon","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.devcel.2018.06.023_bib54","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/cr.2012.141","article-title":"A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm","volume":"22","author":"Peng","year":"2012","journal-title":"Cell. Res."},{"key":"10.1016\/j.devcel.2018.06.023_bib55","first-page":"e50195","article-title":"Metabolic labeling of newly transcribed RNA for high resolution gene expression profiling of RNA synthesis, processing and decay in cell culture","volume":"78","author":"R\u00e4dle","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.devcel.2018.06.023_bib56","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cell.2012.10.020","article-title":"Daddy issues: paternal effects on phenotype","volume":"151","author":"Rando","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib57","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature04674","article-title":"RNA-mediated non-Mendelian inheritance of an epigenetic change in the mouse","volume":"441","author":"Rassoulzadegan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2018.06.023_bib58","doi-asserted-by":"crossref","first-page":"31794","DOI":"10.1038\/srep31794","article-title":"Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome","volume":"6","author":"Reilly","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2018.06.023_bib59","doi-asserted-by":"crossref","first-page":"13699","DOI":"10.1073\/pnas.1508347112","article-title":"Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress","volume":"112","author":"Rodgers","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2018.06.023_bib60","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fgene.2018.00032","article-title":"Heavy chronic intermittent ethanol exposure alters small noncoding RNAs in mouse sperm and epididymosomes","volume":"9","author":"Rompala","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.devcel.2018.06.023_bib61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2017.06.013","article-title":"LTR-retrotransposon control by tRNA-derived small RNAs","volume":"170","author":"Schorn","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1095\/biolreprod.116.142190","article-title":"SpermBase: a database for sperm-borne RNA contents","volume":"95","author":"Schuster","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.devcel.2018.06.023_bib63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aad6780","article-title":"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals","volume":"351","author":"Sharma","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib64","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.cmet.2017.02.003","article-title":"Metabolic inputs into the epigenome","volume":"25","author":"Sharma","year":"2017","journal-title":"Cell. Metab."},{"key":"10.1016\/j.devcel.2018.06.023_bib65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cell.2012.06.015","article-title":"piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline","volume":"150","author":"Shirayama","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib66","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cell.2008.12.038","article-title":"Epigenetic reprogramming and small RNA silencing of transposable elements in pollen","volume":"136","author":"Slotkin","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib67","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/wrna.96","article-title":"Transfer RNA-derived fragments: origins, processing, and functions","volume":"2","author":"Sobala","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.devcel.2018.06.023_bib68","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/aja.1001780109","article-title":"Comparative study of cytoplasmic elimination in spermatids of selected mammalian species","volume":"178","author":"Sprando","year":"1987","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.devcel.2018.06.023_bib69","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1745-7262.2007.00281.x","article-title":"Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit","volume":"9","author":"Sullivan","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.devcel.2018.06.023_bib70","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1530\/REP-13-0058","article-title":"Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology","volume":"146","author":"Sullivan","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.devcel.2018.06.023_bib71","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1261\/rna.1232808","article-title":"tRNA cleavage is a conserved response to oxidative stress in eukaryotes","volume":"14","author":"Thompson","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.devcel.2018.06.023_bib72","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2018.06.023_bib73","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1126\/science.1129333","article-title":"A distinct small RNA pathway silences selfish genetic elements in the germline","volume":"313","author":"Vagin","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib74","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1126\/science.1074973","article-title":"Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi","volume":"297","author":"Volpe","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib75","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200811106","article-title":"Angiogenin cleaves tRNA and promotes stress-induced translational repression","volume":"185","author":"Yamasaki","year":"2009","journal-title":"J.\u00a0Cell. Biol."},{"key":"10.1016\/j.devcel.2018.06.023_bib76","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.aah4428","article-title":"A chemical biology route to site-specific authentic protein modifications","volume":"354","author":"Yang","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.devcel.2018.06.023_bib77","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nmeth.3478","article-title":"Efficient and quantitative high-throughput tRNA sequencing","volume":"12","author":"Zheng","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2018.06.023_bib78","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1126\/science.1079695","article-title":"ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation","volume":"299","author":"Zilberman","year":"2003","journal-title":"Science"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580718305409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580718305409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:29:22Z","timestamp":1761521362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580718305409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1534580718305409"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2018.06.023","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/194522","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.733715231.793549261","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2018.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2018.06.024","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}