{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:53:59Z","timestamp":1792223639275,"version":"4.4.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["1U54 HD083092"],"award-info":[{"award-number":["1U54 HD083092"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["HL 089898"],"award-info":[{"award-number":["HL 089898"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["HL 091947"],"award-info":[{"award-number":["HL 091947"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["HL 117641"],"award-info":[{"award-number":["HL 117641"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["HL 129570"],"award-info":[{"award-number":["HL 129570"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["AR 061370"],"award-info":[{"award-number":["AR 061370"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disability Research Center","doi-asserted-by":"publisher","award":["F31HL136065"],"award-info":[{"award-number":["F31HL136065"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"NICHD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007856","name":"Baylor College of Medicine","doi-asserted-by":"publisher","award":["U54 HG006348"],"award-info":[{"award-number":["U54 HG006348"]}],"id":[{"id":"10.13039\/100007856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DE 023177"],"award-info":[{"award-number":["DE 023177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL 127717"],"award-info":[{"award-number":["HL 127717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL 130804"],"award-info":[{"award-number":["HL 130804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL 118761"],"award-info":[{"award-number":["HL 118761"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Vivian L. Smith Foundation"},{"name":"MacDonald Research Fund","award":["16RDM001"],"award-info":[{"award-number":["16RDM001"]}]},{"DOI":"10.13039\/501100001674","name":"LeDucq Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.devcel.2019.01.017","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T10:37:42Z","timestamp":1550140662000},"page":"765-779.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":291,"title":["YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In\u00a0Vivo"],"prefix":"10.1016","volume":"48","author":[{"given":"Tanner O.","family":"Monroe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Heallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.L.","family":"Krijger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"de Laat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xander H.T.","family":"Wehrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G.","family":"Rodney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2019.01.017_bib1","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1242\/jcs.01159","article-title":"Sequential myofibrillar breakdown accompanies mitotic division of mammalian cardiomyocytes","volume":"117","author":"Ahuja","year":"2004","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.devcel.2019.01.017_bib2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.cell.2015.10.035","article-title":"No evidence for cardiomyocyte number expansion in preadolescent mice","volume":"163","author":"Alkass","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","article-title":"Dynamics of cell generation and turnover in the human heart","volume":"161","author":"Bergmann","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","article-title":"Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury","volume":"138","author":"Bersell","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib5","first-page":"1459","article-title":"Moderate and high amounts of tamoxifen in \u03b1MHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death","volume":"6","author":"Bersell","year":"2013","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.devcel.2019.01.017_bib6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00395-005-0524-9","article-title":"Design-based stereological estimation of the total number of cardiac myocytes in histological sections","volume":"100","author":"Br\u00fcel","year":"2005","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib7","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2019.01.017_bib8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cell.2006.04.018","article-title":"A dedicated Wnt secretion factor","volume":"125","author":"Ching","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib9","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1101\/gad.301184.117","article-title":"Transcriptional integration of mitogenic and mechanical signals by Myc and YAP","volume":"31","author":"Croci","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.01.017_bib10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/cr.2015.101","article-title":"YAP activates the Hippo pathway in a negative feedback loop","volume":"25","author":"Dai","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/cvr\/cvu054","article-title":"Cell-cell interaction in the heart via Wnt\/\u03b2-catenin pathway after cardiac injury","volume":"102","author":"Deb","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cell.2016.05.052","article-title":"Nfib promotes metastasis through a widespread increase in chromatin accessibility","volume":"166","author":"Denny","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2019.01.017_bib14","first-page":"3692","article-title":"Pak3 regulates apical-basal polarity in migrating border cells during Drosophila oogenesis","volume":"142","author":"Felix","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.01.017_bib95","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1471-2105-8-252","article-title":"Compression-based classification of biological sequences and structures via the Universal Similarity Metric: experimental assessment","volume":"8","author":"Ferragina","year":"2007","journal-title":"BMC bioinformatics"},{"key":"10.1016\/j.devcel.2019.01.017_bib15","first-page":"24","article-title":"Splice variant insertions in the C-terminus impairs YAP's transactivation domain","volume":"6","author":"Finch-Edmondson","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.devcel.2019.01.017_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-cellbio-111315-124953","article-title":"Neurogenesis and gliogenesis in nervous system plasticity and repair","volume":"32","author":"Fris\u00e9n","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib17","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.molcel.2015.09.001","article-title":"YAP drives growth by controlling transcriptional pause release from dynamic enhancers","volume":"60","author":"Galli","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2014.06.029","article-title":"Cytokinesis failure triggers hippo tumor suppressor pathway activation","volume":"158","author":"Ganem","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib19","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/ncomms6288","article-title":"Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease","volume":"5","author":"Gilsbach","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2019.01.017_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.devcel.2018.01.021","article-title":"Myocardial polyploidization creates a barrier to heart regeneration in zebrafish","volume":"44","author":"Gonz\u00e1lez-Rosa","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib21","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/jcp.25512","article-title":"Dedicator of cytokinesis 2 in cell signaling regulation and disease development","volume":"232","author":"Guo","year":"2017","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib22","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/nprot.2007.243","article-title":"Quantitative analysis of chromosome conformation capture assays (3C-qPCR)","volume":"2","author":"Hag\u00e8ge","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2019.01.017_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dev.045500","article-title":"Hippo signaling: growth control and beyond","volume":"138","author":"Halder","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.01.017_bib24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/biostatistics\/kxr054","article-title":"Removing technical variability in RNA-seq data using conditional quantile normalization","volume":"13","author":"Hansen","year":"2012","journal-title":"Biostatistics"},{"key":"10.1016\/j.devcel.2019.01.017_bib25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrm2141","article-title":"Helping Wingless take flight: how WNT proteins are secreted","volume":"8","author":"Hausmann","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib26","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1242\/dev.102798","article-title":"Hippo signaling impedes adult heart regeneration","volume":"140","author":"Heallen","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.01.017_bib27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.201005141","article-title":"Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism","volume":"190","author":"Hiramoto-Yamaki","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib29","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1073\/pnas.1523930113","article-title":"Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT\/beta-catenin signaling","volume":"113","author":"Hofsteen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.devcel.2019.01.017_bib30","doi-asserted-by":"crossref","first-page":"e1002233","DOI":"10.1371\/journal.pbio.1002233","article-title":"The actin nucleator Cobl is controlled by calcium and calmodulin","volume":"13","author":"Hou","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.01.017_bib32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.devcel.2018.02.004","article-title":"A role for ploidy in heart regeneration","volume":"44","author":"Kadow","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cvr\/cvw228","article-title":"ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance","volume":"113","author":"Kalfon","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121739","article-title":"Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease","volume":"3","author":"Kokkonen-Simon","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.devcel.2019.01.017_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/383050a0","article-title":"Role of inscuteable in orienting asymmetric cell divisions in Drosophila","volume":"383","author":"Kraut","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.01.017_bib36","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib37","doi-asserted-by":"crossref","first-page":"H753","DOI":"10.1152\/ajpheart.00404.2012","article-title":"Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes","volume":"303","author":"Laughner","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","article-title":"Hippo pathway deficiency reverses systolic heart failure after infarction","volume":"550","author":"Leach","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.01.017_bib39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/CIRCRESAHA.116.304472","article-title":"Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity","volume":"116","author":"Li","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib40","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1210\/en.2015-1161","article-title":"Formin 1 regulates ectoplasmic specialization in the rat testis through its actin nucleation and bundling activity","volume":"156","author":"Li","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.devcel.2019.01.017_bib41","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib43","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.cub.2018.04.018","article-title":"Dynamic fluctuations in subcellular localization of the hippo pathway effector Yorkie in\u00a0vivo","volume":"28","author":"Manning","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib44","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.neuro.28.051804.101459","article-title":"Adult neurogenesis in the mammalian central nervous system","volume":"28","author":"Ming","year":"2005","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.devcel.2019.01.017_bib45","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.cub.2012.05.016","article-title":"Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration","volume":"22","author":"Miyaoka","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib46","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.neuron.2015.05.018","article-title":"Epigenomic signatures of neuronal diversity in the mammalian brain","volume":"86","author":"Mo","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2019.01.017_bib47","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","article-title":"Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration","volume":"173","author":"Mohamed","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.01.017_bib49","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature22979","article-title":"Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation","volume":"547","author":"Morikawa","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.01.017_bib50","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2005781","article-title":"Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice","volume":"8","author":"Morikawa","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2019.01.017_bib51","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gad.262816.115","article-title":"A YAP\/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis","volume":"29","author":"Moroishi","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.01.017_bib52","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/nm789","article-title":"Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor","volume":"8","author":"Naya","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2019.01.017_bib53","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1038\/s41467-018-06639-7","article-title":"Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure","volume":"9","author":"Nomura","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2019.01.017_bib54","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.cell.2013.11.033","article-title":"Rapid and pervasive changes in genome-wide enhancer usage during mammalian development","volume":"155","author":"Nord","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib55","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.yjmcc.2010.01.010","article-title":"Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway","volume":"48","author":"Pachori","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib56","doi-asserted-by":"crossref","first-page":"24063","DOI":"10.18632\/oncotarget.8211","article-title":"An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.devcel.2019.01.017_bib57","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.celrep.2016.01.030","article-title":"Atypical protein kinase C-dependent polarized cell division is required for myocardial trabeculation","volume":"14","author":"Passer","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2019.01.017_bib58","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/ng.3929","article-title":"Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration","volume":"49","author":"Patterson","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.01.017_bib59","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The biology of YAP\/TAZ: hippo signaling and beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2019.01.017_bib60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/CIRCRESAHA.115.306337","article-title":"Deciphering the epigenetic code of cardiac myocyte transcription","volume":"117","author":"Preissl","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib61","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib62","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yjmcc.2015.06.019","article-title":"Prolonged Cre expression driven by the alpha-myosin heavy chain promoter can be cardiotoxic","volume":"86","author":"Pugach","year":"2015","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib63","doi-asserted-by":"crossref","first-page":"11.12.1","DOI":"10.1002\/0471250953.bi1112s47","article-title":"BEDTools: the Swiss-army tool for genome feature analysis","volume":"47","author":"Quinlan","year":"2014","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.devcel.2019.01.017_bib64","doi-asserted-by":"crossref","first-page":"14582","DOI":"10.1038\/ncomms14582","article-title":"Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth","volume":"8","author":"Ragni","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2019.01.017_bib65","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijcard.2016.10.021","article-title":"Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release","volume":"225","author":"Reynolds","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib67","first-page":"e53979","article-title":"Simultaneous assessment of cardiomyocyte DNA synthesis and ploidy: a method to assist quantification of cardiomyocyte regeneration and turnover","volume":"111","author":"Richardson","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.devcel.2019.01.017_bib68","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1242\/jcs.082610","article-title":"Missing-in-metastasis MIM\/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia","volume":"124","author":"Saarikangas","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.devcel.2019.01.017_bib69","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.biochi.2012.04.018","article-title":"Histone H3 phosphorylation - a versatile chromatin modification for different occasions","volume":"94","author":"Sawicka","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.devcel.2019.01.017_bib70","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1101\/gr.192294.115","article-title":"Structured nucleosome fingerprints enable high-resolution mapping of chromatin architecture within regulatory regions","volume":"25","author":"Schep","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib71","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib72","doi-asserted-by":"crossref","first-page":"H220","DOI":"10.1152\/ajpheart.1997.272.1.H220","article-title":"Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts","volume":"272","author":"Soonpaa","year":"1997","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib73","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nature25975","article-title":"Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults","volume":"555","author":"Sorrells","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.01.017_bib74","doi-asserted-by":"crossref","first-page":"e1005465","DOI":"10.1371\/journal.pgen.1005465","article-title":"YAP1 exerts its transcriptional control via TEAD-mediated activation of enhancers","volume":"11","author":"Stein","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.devcel.2019.01.017_bib75","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.cell.2013.07.020","article-title":"Developmental fate and cellular maturity encoded in human regulatory DNA landscapes","volume":"154","author":"Stergachis","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib76","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.devcel.2019.01.017_bib77","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.chom.2015.11.002","article-title":"Meta- and orthogonal integration of influenza \u201cOMICs\u201d data defines a role for UBR4 in virus budding","volume":"18","author":"Tripathi","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.devcel.2019.01.017_bib78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.devcel.2007.06.006","article-title":"Wnt\/beta-catenin signaling and cardiogenesis: timing does matter","volume":"13","author":"Tzahor","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2019.01.017_bib79","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1126\/science.aam5894","article-title":"Cardiac regeneration strategies: staying young at heart","volume":"356","author":"Tzahor","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.devcel.2019.01.017_bib80","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.celrep.2015.10.032","article-title":"Transcriptional landscape of cardiomyocyte maturation","volume":"13","author":"Uosaki","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2019.01.017_bib81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/B978-0-12-391938-0.00004-5","article-title":"4C technology: protocols and data analysis","volume":"513","author":"van de Werken","year":"2012","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.devcel.2019.01.017_bib82","doi-asserted-by":"crossref","first-page":"H1742","DOI":"10.1152\/ajpheart.00478.2003","article-title":"Myocardial density and composition: a basis for calculating intracellular metabolite concentrations","volume":"286","author":"Vinnakota","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib83","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/s41467-018-04083-1","article-title":"Exercise induces new cardiomyocyte generation in the adult mammalian heart","volume":"9","author":"Vujic","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2019.01.017_bib84","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","article-title":"GOplot: an R package for visually combining expression data with functional analysis","volume":"31","author":"Walter","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2019.01.017_bib85","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1073\/pnas.1405411111","article-title":"Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.devcel.2019.01.017_bib86","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/bdra.20785","article-title":"BMP signaling in congenital heart disease: new developments and future directions","volume":"91","author":"Wang","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.devcel.2019.01.017_bib87","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/HCO.0000000000000050","article-title":"Macro advances in microRNAs and myocardial regeneration","volume":"29","author":"Wang","year":"2014","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.devcel.2019.01.017_bib88","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cvr\/cvn289","article-title":"Build it up-Tear it down: protein quality control in the cardiac sarcomere","volume":"81","author":"Willis","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.devcel.2019.01.017_bib89","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrm3619","article-title":"Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair","volume":"14","author":"Xin","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib90","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/ncb3216","article-title":"Genome-wide association between YAP\/TAZ\/TEAD and AP-1 at enhancers drives oncogenic growth","volume":"17","author":"Zanconato","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2019.01.017_bib96","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol"},{"key":"10.1016\/j.devcel.2019.01.017_bib91","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.01.017_bib92","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.01.017_bib93","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1242\/dev.093690","article-title":"Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation","volume":"141","author":"Zhao","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.01.017_bib94","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2012.12.033","article-title":"Genome-wide chromatin state transitions associated with developmental and environmental cues","volume":"152","author":"Zhu","year":"2013","journal-title":"Cell"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580719300450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580719300450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:30:15Z","timestamp":1761521415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580719300450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":96,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1534580719300450"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2019.01.017","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In\u00a0Vivo","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2019.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2019.03.007","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}