{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:21:50Z","timestamp":1790677310138,"version":"4.1.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":387,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001033","name":"Jane Coffin Childs Memorial Fund for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"School of Medicine, Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.devcel.2019.05.015","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T10:34:24Z","timestamp":1559817264000},"page":"212-228.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes"],"prefix":"10.1016","volume":"50","author":[{"given":"Margot E.","family":"Bowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"McClendon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah K.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryo","family":"Sorayya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine L.","family":"Van Nostrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wysocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Attardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2019.05.015_bib3","doi-asserted-by":"crossref","first-page":"baw093","DOI":"10.1093\/database\/baw093","article-title":"The Ensembl gene annotation system","author":"Aken","year":"2016","journal-title":"Database"},{"key":"10.1016\/j.devcel.2019.05.015_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2019.05.015_bib5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1101\/gad.14.6.704","article-title":"PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22\/gas3 family","volume":"14","author":"Attardi","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.05.015_bib6","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nature08733","article-title":"CHD7 cooperates with PBAF to control multipotent neural crest formation","volume":"463","author":"Bajpai","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.05.015_bib7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ng1879","article-title":"iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53","volume":"38","author":"Bergamaschi","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/jmg.2010.087106","article-title":"CHD7 mutations and CHARGE syndrome: the clinical implications of an expanding phenotype","volume":"48","author":"Bergman","year":"2011","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1539","article-title":"A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size","volume":"37","author":"Bond","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib10","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1093\/hmg\/ddi375","article-title":"Multiple mutations in mouse Chd7 provide models for CHARGE syndrome","volume":"14","author":"Bosman","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib11","first-page":"68","article-title":"The role of p53 in developmental syndromes","volume":"9","author":"Bowen","year":"2019","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib12","doi-asserted-by":"crossref","first-page":"a013847","DOI":"10.1101\/cshperspect.a013847","article-title":"Embryonic heart progenitors and cardiogenesis","volume":"3","author":"Brade","year":"2013","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"10.1016\/j.devcel.2019.05.015_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.cell.2011.03.035","article-title":"Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression","volume":"145","author":"Brady","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/bs.ctdb.2015.12.003","article-title":"The neural crest migrating into the twenty-first century","volume":"116","author":"Bronner","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature25449","article-title":"Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders","volume":"554","author":"Cal\u00f3","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.05.015_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1172-7-13","article-title":"Nijmegen breakage syndrome (NBS)","volume":"7","author":"Chrzanowska","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.devcel.2019.05.015_bib17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1161\/CIRCGENETICS.113.000054","article-title":"The cardiac phenotype in patients with a CHD7 mutation","volume":"6","author":"Corsten-Janssen","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib18","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/378203a0","article-title":"Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53","volume":"378","author":"de Oca Luna","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.05.015_bib20","doi-asserted-by":"crossref","first-page":"13403","DOI":"10.1073\/pnas.0603730103","article-title":"Tcof1\/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities","volume":"103","author":"Dixon","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2019.05.015_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pedneo.2014.10.002","article-title":"Birth defects in the newborn population: race and ethnicity","volume":"56","author":"Egbe","year":"2015","journal-title":"Pediatr. Neonatol."},{"key":"10.1016\/j.devcel.2019.05.015_bib22","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1242\/dev.127.9.1869","article-title":"Migration of cardiac neural crest cells in Splotch embryos","volume":"127","author":"Epstein","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.05.015_bib23","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1038\/onc.2016.502","article-title":"Census and evaluation of p53 target genes","volume":"36","author":"Fischer","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.devcel.2019.05.015_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1101\/pdb.prot073452","article-title":"Whole-mount X-Gal staining of mouse tissues","volume":"2014","author":"Gierut","year":"2014","journal-title":"Cold Spring Harbor Protoc."},{"key":"10.1016\/j.devcel.2019.05.015_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/wdev.89","article-title":"Genetic causes of microcephaly and lessons for neuronal development","volume":"2","author":"Gilmore","year":"2013","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/gene.10066","article-title":"Conditional allele of mdm2 which encodes a p53 inhibitor","volume":"32","author":"Grier","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2019.05.015_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrc992","article-title":"The role of p53 in determining sensitivity to radiotherapy","volume":"3","author":"Gudkov","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2019.05.015_bib28","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1242\/dev.073064","article-title":"Temporal control of neural crest lineage generation by Wnt\/\u03b2-catenin signaling","volume":"139","author":"Hari","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.05.015_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ajmg.a.32179","article-title":"Cranial nerve manifestations in CHARGE syndrome","volume":"146A","author":"Blake","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.devcel.2019.05.015_bib30","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S0925-4773(03)00099-6","article-title":"Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain","volume":"119","author":"Hayashi","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2019.05.015_bib31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/dbio.2000.9732","article-title":"Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures","volume":"222","author":"H\u00e9bert","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","article-title":"Tumor spectrum analysis in p53-mutant mice","volume":"4","author":"Jacks","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib33","doi-asserted-by":"crossref","first-page":"17123","DOI":"10.1073\/pnas.1111245108","article-title":"Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages","volume":"108","author":"Jiang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2019.05.015_bib34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng1498","article-title":"The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality","volume":"37","author":"Johnson","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nm1725","article-title":"Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function","volume":"14","author":"Jones","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2019.05.015_bib36","article-title":"Immunohistochemistry of whole-mount mouse embryos","author":"Joyner","year":"2008","journal-title":"CHS Protoc."},{"key":"10.1016\/j.devcel.2019.05.015_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/cdd.2017.171","article-title":"Deconstructing networks of p53-mediated tumor suppression in\u00a0vivo","volume":"25","author":"Kaiser","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.devcel.2019.05.015_bib38","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","article-title":"Putting p53 in context","volume":"170","author":"Kastenhuber","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib39","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1101\/gad.212282.112","article-title":"Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses","volume":"27","author":"Kenzelmann Broz","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.05.015_bib40","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/bdra.23590","article-title":"White paper on the study of birth defects","volume":"109","author":"Khokha","year":"2017","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.devcel.2019.05.015_bib41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2019.05.015_bib42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2\u2013Cre transgenic mice: a new model for endothelial cell-lineage analysis in\u00a0vivo","volume":"230","author":"Kisanuki","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/febs.13554","article-title":"Inhibitor of apoptosis proteins as intracellular signaling intermediates","volume":"283","author":"Kocab","year":"2016","journal-title":"FEBS Journal"},{"key":"10.1016\/j.devcel.2019.05.015_bib44","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2019.05.015_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1073\/pnas.0909734107","article-title":"A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2019.05.015_bib47","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1172\/JCI92171","article-title":"Dysfunction of the MDM2\/p53 axis is linked to premature aging","volume":"127","author":"Lessel","year":"2017","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.devcel.2019.05.015_bib48","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAM tools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2019.05.015_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2012.01.020","article-title":"Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells","volume":"46","author":"Li","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib95","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.stem.2013.07.018","article-title":"High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis","volume":"13","author":"Liu","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib50","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2019.05.015_bib52","doi-asserted-by":"crossref","first-page":"e1006282","DOI":"10.1371\/journal.pgen.1006282","article-title":"Haploinsufficiency for core exon junction complex components disrupts embryonic neurogenesis and causes p53-mediated microcephaly","volume":"12","author":"Mao","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib53","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1158\/0008-5472.CAN-05-0366","article-title":"Mice lacking the p53\/p63 target gene perp are resistant to papilloma development","volume":"65","author":"Marques","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2019.05.015_bib54","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature03837","article-title":"Neural crest origins of the neck and shoulder","volume":"436","author":"Matsuoka","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.05.015_bib55","doi-asserted-by":"crossref","first-page":"15071","DOI":"10.1038\/nrdp.2015.71","article-title":"22q11.2 deletion syndrome","volume":"1","author":"McDonald-McGinn","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.devcel.2019.05.015_bib56","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20150517","article-title":"Regulation of the p53 response and its relationship to cancer","volume":"469","author":"Meek","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.devcel.2019.05.015_bib57","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ccell.2017.09.007","article-title":"A p53 super-tumor suppressor reveals a tumor suppressive p53-Ptpn14-Yap axis in pancreatic cancer","volume":"32","author":"Mello","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.mod.2008.07.003","article-title":"Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest","volume":"125","author":"Morgan","year":"2008","journal-title":"Mech. Dev."},{"key":"10.1016\/j.devcel.2019.05.015_bib59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/jmcb\/mjx004","article-title":"Mdm proteins: critical regulators of embry ogenesis and homeostasis","volume":"9","author":"Moyer","year":"2017","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib60","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2019.05.015_bib61","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot5169","article-title":"Alcian blue staining of the mouse fetal cartilaginous skeleton","volume":"2009","author":"Nagy","year":"2009","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.devcel.2019.05.015_bib62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng714","article-title":"Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53","volume":"29","author":"Parant","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib63","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/tera.90002","article-title":"Contribution of birth defects to infant mortality in the United States","volume":"66","author":"Petrini","year":"2002","journal-title":"Teratology"},{"key":"10.1016\/j.devcel.2019.05.015_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1101\/sqb.2016.81.030841","article-title":"To prime, or not to prime: that is the question","volume":"81","author":"Potter","year":"2016","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib64","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2015.08.036","article-title":"Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest","volume":"163","author":"Prescott","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib65","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1242\/bio.20149969","article-title":"Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development","volume":"4","author":"Quintens","year":"2015","journal-title":"Biol. Open"},{"key":"10.1016\/j.devcel.2019.05.015_bib1","series-title":"R: a language and environment for statistical computing","year":"2016"},{"key":"10.1016\/j.devcel.2019.05.015_bib66","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12861-016-0138-5","article-title":"Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis","volume":"16","author":"Robson","year":"2016","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib67","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ymeth.2013.04.006","article-title":"BH3 profiling in whole cells by fluorimeter or FACS","volume":"61","author":"Ryan","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.devcel.2019.05.015_bib69","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1242\/dev.126.15.3437","article-title":"MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube","volume":"126","author":"Saga","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.05.015_bib70","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ng0695-175","article-title":"A subset of p53-deficient embryos exhibit exencephaly","volume":"10","author":"Sah","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib71","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1038\/ncomms10328","article-title":"Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation","volume":"7","author":"Sakai","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2019.05.015_bib72","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ccell.2016.11.011","article-title":"Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics","volume":"31","author":"Sarosiek","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib96","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molcel.2013.09.003","article-title":"HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress","volume":"52","author":"Sen","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2019.05.015_bib73","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/ng.971","article-title":"A primary microcephaly protein complex forms a ring around parental centrioles","volume":"43","author":"Sir","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib74","doi-asserted-by":"crossref","first-page":"16652","DOI":"10.1038\/s41598-017-16952-8","article-title":"Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus","volume":"7","author":"Slomnicki","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2019.05.015_bib75","doi-asserted-by":"crossref","first-page":"W589","DOI":"10.1093\/nar\/gkv350","article-title":"The BioMart community portal: an innovative alternative to large, centralized data repositories","volume":"43","author":"Smedley","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2019.05.015_bib76","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/jhg.2015.135","article-title":"Cerebellar vermis hypoplasia in CHARGE syndrome: clinical and molecular characterization of 18 unrelated Korean patients","volume":"61","author":"Sohn","year":"2016","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib77","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib78","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ydbio.2014.01.021","article-title":"Neural crest and placode interaction during the development of the cranial sensory system","volume":"389","author":"Steventon","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib79","doi-asserted-by":"crossref","first-page":"506","DOI":"10.14336\/AD.2016.1120","article-title":"P53 dysfunction in neurodegenerative diseases - the cause or effect of pathological changes?","volume":"8","author":"Szybi\u0144ska","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.devcel.2019.05.015_bib80","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1128\/MCB.00555-06","article-title":"Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development","volume":"27","author":"Terzian","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib81","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ajhg.2018.07.020","article-title":"De novo mutations activating germline TP53 in an inherited bone-marrow-failure syndrome","volume":"103","author":"Toki","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib82","doi-asserted-by":"crossref","first-page":"24611","DOI":"10.18632\/oncotarget.5232","article-title":"Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in\u00a0vivo","volume":"6","author":"Tonelli","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.devcel.2019.05.015_bib83","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2144\/00291bm09","article-title":"Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)","volume":"29","author":"Truett","year":"2000","journal-title":"BioTechniques"},{"key":"10.1016\/j.devcel.2019.05.015_bib84","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ophtha.2009.08.023","article-title":"Ocular and orbital manifestations of the inherited bone marrow failure syndromes: fanconi anemia and dyskeratosis congenita","volume":"117","author":"Tsilou","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.devcel.2019.05.015_bib85","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.4161\/15384101.2014.987627","article-title":"Guilty as CHARGED: p53\u2019s expanding role in disease","volume":"13","author":"Van Nostrand","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.devcel.2019.05.015_bib86","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature13585","article-title":"Inappropriate p53 activation during development induces features of CHARGE syndrome","volume":"514","author":"Van Nostrand","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2019.05.015_bib87","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2005.08.041","article-title":"The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary\/anterior heart field","volume":"287","author":"Verzi","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.05.015_bib88","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/gim.2015.29","article-title":"Treacher Collins syndrome: a clinical and molecular study based on a large series of patients","volume":"18","author":"Vincent","year":"2016","journal-title":"Genet. Med."},{"key":"10.1016\/j.devcel.2019.05.015_bib89","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/hmg\/11.8.915","article-title":"Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways","volume":"11","author":"Vitelli","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.devcel.2019.05.015_bib90","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrc2584","article-title":"p53 polymorphisms: cancer implications","volume":"9","author":"Whibley","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2019.05.015_bib91","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/jvi.59.2.444-452.1986","article-title":"Monoclonal antibody analysis of p53 expression in normal and transformed cells","volume":"59","author":"Yewdell","year":"1986","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.devcel.2019.05.015_bib92","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/coa.12312","article-title":"Waardenburg syndrome: more common than you think!","volume":"40","author":"Zaman","year":"2015","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.devcel.2019.05.015_bib93","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1073\/pnas.1617414114","article-title":"p53 pathway is involved in cell competition during mouse embryogenesis","volume":"114","author":"Zhang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2019.05.015_bib94","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/path.4077","article-title":"Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development","volume":"228","author":"Zhang","year":"2012","journal-title":"J.\u00a0Pathol."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580719303879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580719303879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:32:10Z","timestamp":1761521530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580719303879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1534580719303879"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2019.05.015","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2019.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}