{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:51:58Z","timestamp":1790232718148,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":381,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.devcel.2019.11.003","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T11:16:15Z","timestamp":1575544575000},"page":"665-674.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation"],"prefix":"10.1016","volume":"51","author":[{"given":"Talia","family":"Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary N.","family":"Agricola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan P.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Kinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keziah","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Vardanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Trisno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Wook","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Kofron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2019.11.003_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/dvdy.24219","article-title":"One shall become two: separation of the esophagus and trachea from the common foregut tube","volume":"244","author":"Billmyre","year":"2015","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2019.11.003_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/dvg.22719","article-title":"Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR\/Cas system","volume":"51","author":"Blitz","year":"2013","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2019.11.003_bib3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2019.11.003_bib4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ejmg.2014.05.009","article-title":"Clinical and etiological heterogeneity in patients with tracheo-esophageal malformations and associated anomalies","volume":"57","author":"Brosens","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.devcel.2019.11.003_bib5","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jcb.24811","article-title":"Tissue crosstalk in lung development","volume":"115","author":"Hines","year":"2014","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.devcel.2019.11.003_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/jpsu.2003.50005","article-title":"Role of Sonic hedgehog in the development of the trachea and oesophagus","volume":"38","author":"Ioannides","year":"2003","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.devcel.2019.11.003_bib7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ydbio.2009.11.005","article-title":"Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death","volume":"337","author":"Ioannides","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.11.003_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1091\/mbc.e03-05-0319","article-title":"Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment","volume":"15","author":"Ivanov","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2019.11.003_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1086\/429346","article-title":"Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations","volume":"76","author":"Johnston","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2019.11.003_bib10","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/dvdy.23826","article-title":"Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis","volume":"241","author":"Kim","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2019.11.003_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2019.11.002","article-title":"Isl1 regulation of Nkx2.1 in the early foregut epithelium is required for trachea-esophageal separation and lung lobation","volume":"51","author":"Kim","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2019.11.003_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/1717","article-title":"Sonic hedgehog is essential to foregut development","volume":"20","author":"Litingtung","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.11.003_bib13","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.stem.2012.01.019","article-title":"Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells","volume":"10","author":"Longmire","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.devcel.2019.11.003_bib14","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a cell-permeable inhibitor of dynamin","volume":"10","author":"Macia","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2019.11.003_bib15","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.128.12.2397","article-title":"Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations","volume":"128","author":"Mahlapuu","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.11.003_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/dbio.1999.9234","article-title":"Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-\/-) mouse embryos","volume":"209","author":"Minoo","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.11.003_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/1711","article-title":"Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus","volume":"20","author":"Motoyama","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2019.11.003_bib18","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1242\/dev.01905","article-title":"Cooperative requirement of the Gli proteins in neurogenesis","volume":"132","author":"Nguyen","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.11.003_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1242\/dev.111161","article-title":"Vangl2 cooperates with Rab11 and myosin V to regulate apical constriction during vertebrate gastrulation","volume":"142","author":"Ossipova","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.11.003_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/wdev.179","article-title":"The initial establishment and epithelial morphogenesis of the esophagus: a new model of tracheal-esophageal separation and transition of simple columnar into stratified squamous epithelium in the developing esophagus","volume":"4","author":"Que","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.devcel.2019.11.003_bib21","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.003855","article-title":"Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm","volume":"134","author":"Que","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.devcel.2019.11.003_bib22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.celrep.2016.05.060","article-title":"A retinoic acid-hedgehog cascade coordinates mesoderm-inducing signals and endoderm competence during lung specification","volume":"16","author":"Rankin","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2019.11.003_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ydbio.2010.11.037","article-title":"A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer","volume":"351","author":"Rankin","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2019.11.003_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/dvdy.24180","article-title":"A Molecular atlas of Xenopus respiratory system development","volume":"244","author":"Rankin","year":"2015","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2019.11.003_bib25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/jmg.2005.038158","article-title":"Oesophageal atresia, tracheo-oesophageal fistula, and the VACTERL association: review of genetics and epidemiology","volume":"43","author":"Shaw-Smith","year":"2006","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.devcel.2019.11.003_bib26","doi-asserted-by":"crossref","first-page":"e23329","DOI":"10.1002\/dvg.23329","article-title":"Novel vectors for functional interrogation of Xenopus ORFeome coding sequences","volume":"57","author":"Sterner","year":"2019","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2019.11.003_bib27","doi-asserted-by":"crossref","first-page":"e19153","DOI":"10.7554\/eLife.19153","article-title":"Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx","volume":"6","author":"Tabler","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2019.11.003_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.stem.2018.08.008","article-title":"Esophageal organoids from human pluripotent stem cells delineate Sox2 functions during esophageal specification","volume":"23","author":"Trisno","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.devcel.2019.11.003_bib29","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1101\/gad.1693008","article-title":"A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb","volume":"22","author":"Vokes","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.11.003_bib30","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1101\/gad.815400","article-title":"Matrix metalloproteinases: effectors of development and normal physiology","volume":"14","author":"Vu","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2019.11.003_bib31","doi-asserted-by":"crossref","first-page":"15817","DOI":"10.1073\/pnas.1205669109","article-title":"Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi","volume":"109","author":"Walton","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2019.11.003_bib32","doi-asserted-by":"crossref","first-page":"158444","DOI":"10.1242\/dev.158444","article-title":"aPKC is a key polarity determinant in coordinating the function of three distinct cell polarities during collective migration","volume":"145","author":"Wang","year":"2018","journal-title":"Development"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580719309116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580719309116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:33:24Z","timestamp":1761521604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580719309116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1534580719309116"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2019.11.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737032157.793571491","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/777664","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2019.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2019.11.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}