{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:18:58Z","timestamp":1793423938578,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.devcel.2020.02.019","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T10:30:32Z","timestamp":1585218632000},"page":"102-116.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":163,"title":["Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing"],"prefix":"10.1016","volume":"53","author":[{"given":"Miao","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrain","family":"Sanchez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Bassel-Duby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2020.02.019_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2014.10.003","article-title":"In\u00a0vivo activation of a conserved microRNA program induces mammalian heart regeneration","volume":"15","author":"Aguirre","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.cell.2015.10.035","article-title":"No evidence for cardiomyocyte number expansion in preadolescent mice","volume":"163","author":"Alkass","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.yjmcc.2013.05.004","article-title":"Sequencing of mRNA identifies re-expression of fetal splice variants in cardiac hypertrophy","volume":"62","author":"Ames","year":"2013","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.devcel.2020.02.019_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan8081","article-title":"Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy","volume":"9","author":"Amoasii","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.devcel.2020.02.019_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nm.4481","article-title":"Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity","volume":"24","author":"Bartelt","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2020.02.019_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.devcel.2020.02.019_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2009.07.034","article-title":"Role of Nrf1 in antioxidant response element-mediated gene expression and beyond","volume":"244","author":"Biswas","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.devcel.2020.02.019_bib8","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.18632\/oncotarget.14196","article-title":"Targeting cancer stem cell propagation with palbociclib, a CDK4\/6 inhibitor: telomerase drives tumor cell heterogeneity","volume":"8","author":"Bonuccelli","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.devcel.2020.02.019_bib9","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1182\/blood-2011-06-359406","article-title":"NF-Y is necessary for hematopoietic stem cell proliferation and survival","volume":"119","author":"Bungartz","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.devcel.2020.02.019_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.devcel.2020.02.019_bib11","first-page":"484","article-title":"Regulation of creatine kinase induction in differentiating mouse myoblasts","volume":"5","author":"Chamberlain","year":"1985","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib12","doi-asserted-by":"crossref","first-page":"e92903","DOI":"10.1371\/journal.pone.0092903","article-title":"A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes","volume":"9","author":"Cox","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2020.02.019_bib13","doi-asserted-by":"crossref","DOI":"10.1242\/dev.171983","article-title":"Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease","volume":"145","author":"Cui","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.devcel.2020.02.019_bib14","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1126\/science.aab1601","article-title":"Multiplex single cell profiling of chromatin accessibility by combinatorial cellular indexing","volume":"348","author":"Cusanovich","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.devcel.2020.02.019_bib15","first-page":"H399","article-title":"Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep","volume":"238","author":"Fisher","year":"1980","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.devcel.2020.02.019_bib16","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1101\/gr.148080.112","article-title":"NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors","volume":"23","author":"Fleming","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41586-019-1191-6","article-title":"MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs","volume":"569","author":"Gabisonia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2020.02.019_bib18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.7554\/eLife.05871","article-title":"Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish","volume":"4","author":"Gemberling","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2020.02.019_bib19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nmeth.4407","article-title":"Massively parallel single-nucleus RNA-seq with DroNc-seq","volume":"14","author":"Habib","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2020.02.019_bib20","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0026-0495(03)00094-5","article-title":"Inhibition of proteasome activity by selected amino acids","volume":"52","author":"Hamel","year":"2003","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.devcel.2020.02.019_bib21","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1101\/gad.316802.118","article-title":"Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts","volume":"32","author":"Hu","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2020.02.019_bib22","doi-asserted-by":"crossref","first-page":"e1006109","DOI":"10.1371\/journal.pgen.1006109","article-title":"NF-YB regulates spermatogonial stem cell self-renewal and proliferation in the planarian Schmidtea mediterranea","volume":"12","author":"Iyer","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.devcel.2020.02.019_bib23","doi-asserted-by":"crossref","first-page":"e1003731","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib24","first-page":"2855","article-title":"Transcriptional regulation of the muscle creatine kinase gene and regulated expression in transfected mouse myoblasts","volume":"6","author":"Jaynes","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib25","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1093\/nar\/24.21.4289","article-title":"Small Maf proteins interact with the human transcription factor TCF11\/Nrf1\/LCR-F1","volume":"24","author":"Johnsen","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2020.02.019_bib27","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1089\/ars.2009.2743","article-title":"Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation","volume":"12","author":"Koopman","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.devcel.2020.02.019_bib28","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1101\/gr.192237.115","article-title":"Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells","volume":"25","author":"Kowalczyk","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib29","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1038\/s41598-017-04426-w","article-title":"A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA","volume":"7","author":"Lake","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2020.02.019_bib30","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2020.02.019_bib31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/CIRCULATIONAHA.118.034250","article-title":"Genetic lineage tracing of nonmyocyte population by dual recombinases","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2020.02.019_bib32","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2020.02.019_bib33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.devcel.2020.02.019_bib34","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/cvr\/26.12.1172","article-title":"Developmental changes in energy substrate use by the heart","volume":"26","author":"Lopaschuk","year":"1992","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib35","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1093\/nar\/gki681","article-title":"Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in\u00a0vivo DNA double-strand breaks","volume":"33","author":"Lundin","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2014.021","article-title":"Surgical models for cardiac regeneration in neonatal mice","volume":"9","author":"Mahmoud","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2020.02.019_bib37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0968-0004(98)01201-8","article-title":"Role of the CCAAT-binding protein CBF\/NF-Y in transcription","volume":"23","author":"Maity","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.devcel.2020.02.019_bib38","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.118.035186","article-title":"Undeniable evidence that the adult mammalian heart lacks an endogenous regenerative stem cell","volume":"138","author":"Maliken","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2020.02.019_bib39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/hum.2008.197","article-title":"Partial rescue of growth failure in growth hormone (GH)-deficient mice by a single injection of a double-stranded adeno-associated viral vector expressing the GH gene driven by a muscle-specific regulatory cassette","volume":"20","author":"Martari","year":"2009","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.devcel.2020.02.019_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrclinonc.2016.60","article-title":"Cancer metabolism: a therapeutic perspective","volume":"14","author":"Martinez-Outschoorn","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.devcel.2020.02.019_bib41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/MCB.00862-07","article-title":"Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10","volume":"28","author":"Menheniott","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","article-title":"Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration","volume":"173","author":"Mohamed","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.devcel.2019.01.017","article-title":"YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in\u00a0vivo","volume":"48","author":"Monroe","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib44","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2005781","article-title":"Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice","volume":"8","author":"Morikawa","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2020.02.019_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2020.02.019_bib46","doi-asserted-by":"crossref","first-page":"33554","DOI":"10.1074\/jbc.M804597200","article-title":"Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes","volume":"283","author":"Ohtsuji","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.02.019_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2020.02.019_bib48","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/medicina44110107","article-title":"Cardiomyocyte remodeling in ischemic heart disease","volume":"44","author":"Pangonyte","year":"2008","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.devcel.2020.02.019_bib49","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fphys.2013.00102","article-title":"Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?","volume":"4","author":"Piquereau","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.devcel.2020.02.019_bib50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2164-14-99","article-title":"Nuclear factor I genomic binding associates with chromatin boundaries","volume":"14","author":"Pjanic","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.devcel.2020.02.019_bib51","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.devcel.2020.02.019_bib52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.02.019_bib53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib54","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2020.02.019_bib55","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/CIRCULATIONAHA.117.028252","article-title":"Multicellular transcriptional analysis of mammalian heart regeneration","volume":"136","author":"Quaife-Ryan","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2020.02.019_bib56","doi-asserted-by":"crossref","DOI":"10.3791\/59120","article-title":"ATAC-seq assay with low mitochondrial DNA contamination from primary human CD4+ T lymphocytes","author":"Rickner","year":"2019","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.devcel.2020.02.019_bib57","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2020.02.019_bib58","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/bjc.2016.152","article-title":"Hallmarks of cancer stem cell metabolism","volume":"114","author":"Sancho","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.devcel.2020.02.019_bib59","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41587-019-0068-4","article-title":"Characterization of cell fate probabilities in single-cell data with Palantir","volume":"37","author":"Setty","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.devcel.2020.02.019_bib60","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib61","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1038\/s41467-018-06617-z","article-title":"A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human","volume":"9","author":"Singh","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2020.02.019_bib62","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib63","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.02.019_bib64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fcell.2017.00019","article-title":"Bioengineering approaches to mature human pluripotent stem cell-derived cardiomyocytes","volume":"5","author":"Sun","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib65","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molcel.2012.08.003","article-title":"Failure of amino acid homeostasis causes cell death following proteasome inhibition","volume":"48","author":"Suraweera","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","article-title":"Return to the fetal gene program: a suggested metabolic link to gene expression in the heart","volume":"1188","author":"Taegtmeyer","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.devcel.2020.02.019_bib67","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature17959","article-title":"Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury","volume":"534","author":"Tao","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2020.02.019_bib68","doi-asserted-by":"crossref","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","article-title":"A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice","volume":"7","author":"Tian","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.devcel.2020.02.019_bib69","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.devcel.2020.02.019_bib70","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.cell.2018.05.061","article-title":"Recovering gene interactions from single-cell data using data diffusion","volume":"174","author":"van Dijk","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib71","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1073\/pnas.1116136109","article-title":"YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy","volume":"109","author":"von Gise","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.02.019_bib72","doi-asserted-by":"crossref","first-page":"18455","DOI":"10.1073\/pnas.1905824116","article-title":"Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling","volume":"116","author":"Wang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.02.019_bib73","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.cell.2017.10.003","article-title":"NRF1 is an ER membrane sensor that is central to cholesterol homeostasis","volume":"171","author":"Widenmaier","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.02.019_bib74","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1172\/JCI112174","article-title":"Metabolic fate of extracted glucose in normal human myocardium","volume":"76","author":"Wisneski","year":"1985","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2020.02.019_bib75","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: computational identification of cell doublets in single-cell transcriptomic data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst"},{"key":"10.1016\/j.devcel.2020.02.019_bib76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1681\/ASN.2018090912","article-title":"Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis","volume":"30","author":"Wu","year":"2019","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.devcel.2020.02.019_bib77","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.02.019_bib78","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrm3619","article-title":"Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair","volume":"14","author":"Xin","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib79","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0008-6363(96)00254-4","article-title":"Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts","volume":"33","author":"Yasmin","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.devcel.2020.02.019_bib80","doi-asserted-by":"crossref","first-page":"D144","DOI":"10.1093\/nar\/gkr965","article-title":"AnimalTFDB: a comprehensive animal transcription factor database","volume":"40","author":"Zhang","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.devcel.2020.02.019_bib81","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2020.02.019_bib82","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"updated-by":[{"DOI":"10.1016\/j.devcel.2020.11.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000}}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580720301465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580720301465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:34:42Z","timestamp":1761521682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580720301465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1534580720301465"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2020.02.019","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737624046.793573042","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2020.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}