{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:51:04Z","timestamp":1792111864381,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.devcel.2020.04.015","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T11:16:03Z","timestamp":1589800563000},"page":"418-430.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis"],"prefix":"10.1016","volume":"53","author":[{"given":"J\u00e9r\u00f4me","family":"B\u00fcrgi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Abrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinka","family":"Castanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Andres","family":"Abriata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixu Emili","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Superti-Furga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Dal","family":"Peraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Gonzalez","family":"Gaitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise Gisou","family":"van der Goot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2020.04.015_bib1","doi-asserted-by":"crossref","first-page":"e1000792","DOI":"10.1371\/journal.ppat.1000792","article-title":"Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors","volume":"6","author":"Abrami","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.devcel.2020.04.015_bib2","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1073\/pnas.0910782107","article-title":"Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake","volume":"107","author":"Abrami","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.04.015_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1083\/jcb.200507067","article-title":"Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis","volume":"172","author":"Abrami","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2020.04.015_bib4","doi-asserted-by":"crossref","first-page":"36700","DOI":"10.1074\/jbc.M109.061275","article-title":"Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating Talin-induced integrin activation","volume":"284","author":"Anthis","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib5","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/emboj.2009.287","article-title":"The structure of an integrin\/talin complex reveals the basis of inside-out signal transduction","volume":"28","author":"Anthis","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2020.04.015_bib6","doi-asserted-by":"crossref","first-page":"29699","DOI":"10.1074\/jbc.M503508200","article-title":"Specification of the direction of adhesive signaling by the integrin \u03b2 cytoplasmic domain","volume":"280","author":"Arias-Salgado","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib7","doi-asserted-by":"crossref","first-page":"49342","DOI":"10.1074\/jbc.M307900200","article-title":"Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions","volume":"278","author":"Bradley","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib8","doi-asserted-by":"crossref","first-page":"15861","DOI":"10.1038\/ncomms15861","article-title":"CMG2\/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome","volume":"8","author":"B\u00fcrgi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2020.04.015_bib9","doi-asserted-by":"crossref","first-page":"21749","DOI":"10.1074\/jbc.M111996200","article-title":"The phosphotyrosine binding-like domain of Talin activates integrins","volume":"277","author":"Calderwood","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ncb2632","article-title":"Anthrax toxin receptor 2a controls mitotic spindle positioning","volume":"15","author":"Castanon","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2020.04.015_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.devcel.2011.01.008","article-title":"Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment","volume":"20","author":"Cheng","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2020.04.015_bib12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbamem.2013.07.017","article-title":"Mechanisms of talin-dependent integrin signaling and crosstalk","volume":"1838","author":"Das","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.devcel.2020.04.015_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/humu.20872","article-title":"Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum","volume":"30","author":"Deuquet","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.devcel.2020.04.015_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/emmm.201100124","article-title":"Hyaline fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors","volume":"3","author":"Deuquet","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.devcel.2020.04.015_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/emboj.2011.442","article-title":"The dark sides of capillary morphogenesis gene 2","volume":"31","author":"Deuquet","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2020.04.015_bib16","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jmb.2005.01.071","article-title":"The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins","volume":"347","author":"Doszt\u00e1nyi","year":"2005","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.devcel.2020.04.015_bib17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1086\/378781","article-title":"Mutations in capillary morphogenesis Gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis","volume":"73","author":"Dowling","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2020.04.015_bib18","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1074\/jbc.M311911200","article-title":"Structural insights into the interaction of ROCKI with the switch regions of RhoA","volume":"279","author":"Dvorsky","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib19","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2020.04.015_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/toxins8030069","article-title":"The ins and outs of anthrax toxin","volume":"8","author":"Friebe","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.devcel.2020.04.015_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1097-2765(02)00823-7","article-title":"Structural determinants of integrin recognition by talin","volume":"11","author":"Garc\u00eda-Alvarez","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2020.04.015_bib22","doi-asserted-by":"crossref","first-page":"10577","DOI":"10.1021\/bi9015296","article-title":"Direct interaction between anthrax toxin Receptor 1 and the actin cytoskeleton","volume":"48","author":"Garlick","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.devcel.2020.04.015_bib23","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/1873-3468.13081","article-title":"The tale of two talins - two isoforms to fine-tune integrin signalling","volume":"592","author":"Gough","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.devcel.2020.04.015_bib24","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1600-051X.2005.00760.x","article-title":"Periodontal treatment of two siblings with juvenile hyaline fibromatosis","volume":"32","author":"Hakki","year":"2005","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.devcel.2020.04.015_bib25","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1074\/jbc.271.2.695","article-title":"Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T\u00a0cell activation","volume":"271","author":"Hanke","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1086\/378418","article-title":"Mutations in the gene encoding capillary morphogenesis Protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis","volume":"73","author":"Hanks","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2020.04.015_bib27","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1365-2133.2007.08147.x","article-title":"A novel point mutation in the gene encoding capillary morphogenesis protein 2 in a Japanese patient with juvenile hyaline fibromatosis","volume":"157","author":"Hatamochi","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.devcel.2020.04.015_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J.\u00a0Mol. Graphics"},{"key":"10.1016\/j.devcel.2020.04.015_bib29","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1083\/jcb.200703036","article-title":"Vinculin controls focal adhesion formation by direct interactions with talin and actin","volume":"179","author":"Humphries","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2020.04.015_bib30","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.039446","article-title":"Adhesion signaling - crosstalk between integrins, Src and Rho","volume":"122","author":"Huveneers","year":"2009","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.devcel.2020.04.015_bib31","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/j.1460-2075.1996.tb00539.x","article-title":"The small GTP-binding protein Rho binds to and activates a 160\u00a0kDa Ser\/Thr protein kinase homologous to myotonic dystrophy kinase","volume":"15","author":"Ishizaki","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2020.04.015_bib32","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1038\/ncomms2888","article-title":"Formin mDia1 senses and generates mechanical forces on actin filaments","volume":"4","author":"J\u00e9gou","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2020.04.015_bib33","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.devcel.2020.04.015_bib34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2020.04.015_bib35","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.190991","article-title":"Talin \u2013 the master of integrin adhesions","volume":"130","author":"Klapholz","year":"2017","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.devcel.2020.04.015_bib36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cm.21268","article-title":"Characterization of myosin II regulatory light chain isoforms in HeLa cells","volume":"72","author":"Kondo","year":"2015","journal-title":"Cytoskeleton (Hoboken)"},{"key":"10.1016\/j.devcel.2020.04.015_bib37","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain torsion potentials for the Amber ff99SB protein force field","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins"},{"key":"10.1016\/j.devcel.2020.04.015_bib38","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.devcel.2020.04.015_bib39","doi-asserted-by":"crossref","first-page":"e39918","DOI":"10.1371\/journal.pone.0039918","article-title":"Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations","volume":"7","author":"Piana","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2020.04.015_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2005.03.012","article-title":"Src kinase regulation by phosphorylation and dephosphorylation","volume":"331","author":"Roskoski","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.devcel.2020.04.015_bib41","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","article-title":"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2020.04.015_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jdermsci.2009.06.005","article-title":"Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis","volume":"55","author":"Tanaka","year":"2009","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.devcel.2020.04.015_bib43","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2--a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2020.04.015_bib44","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.devcel.2020.04.015_bib45","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/humu.22324","article-title":"In-depth analysis of hyaline fibromatosis syndrome frameshift mutations at the same site reveal the necessity of personalized therapy","volume":"34","author":"Yan","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.devcel.2020.04.015_bib46","first-page":"866","article-title":"Identification of novel compound heterozygous mutations in the ANTXR2 gene in a Chinese patient with juvenile hyaline fibromatosis","volume":"34","author":"Zhang","year":"2017","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580720303178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580720303178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:35:49Z","timestamp":1761521749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580720303178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1534580720303178"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2020.04.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737982687.793576878","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2020.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}