{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:56Z","timestamp":1790483216855,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.devcel.2020.06.020","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T10:30:23Z","timestamp":1595241023000},"page":"134-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma"],"prefix":"10.1016","volume":"54","author":[{"given":"Bernhard","family":"Englinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A.","family":"Hack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella G.","family":"Filbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2020.06.020_bib1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2016.10.018","article-title":"EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells","volume":"64","author":"Beringer","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2020.06.020_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41591-019-0383-9","article-title":"Developmental origins and emerging therapeutic opportunities for childhood cancer","volume":"25","author":"Filbin","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2020.06.020_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ccell.2020.06.004","article-title":"Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma","volume":"38","author":"Gojo","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2020.06.020_bib4","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/neuonc\/noz058","article-title":"EZHIP\/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma","volume":"21","author":"H\u00fcbner","year":"2019","journal-title":"Neuro-oncol."},{"key":"10.1016\/j.devcel.2020.06.020_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s41232-020-00117-8","article-title":"Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1","volume":"40","author":"Ishida","year":"2020","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.devcel.2020.06.020_bib6","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.cell.2020.04.047","article-title":"Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma","volume":"181","author":"Michealraj","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2020.06.020_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ccell.2015.04.002","article-title":"Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups","volume":"27","author":"Pajtler","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2020.06.020_bib8","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1038\/s41467-019-11800-x","article-title":"EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells","volume":"10","author":"Ragazzini","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2020.06.020_bib9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nchembio.1204","article-title":"NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink","volume":"9","author":"Ulanovskaya","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.devcel.2020.06.020_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41586-019-1158-7","article-title":"Childhood cerebellar tumours mirror conserved fetal transcriptional programs","volume":"572","author":"Vladoiu","year":"2019","journal-title":"Nature"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580720304998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580720304998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:38:04Z","timestamp":1761521884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580720304998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1534580720304998"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2020.06.020","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2020.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2020.06.004","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2020.04.047","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}