{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:20:56Z","timestamp":1792110056172,"version":"4.4.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18CDA34070047"],"award-info":[{"award-number":["18CDA34070047"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI036929"],"award-info":[{"award-number":["R01AI036929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI104920"],"award-info":[{"award-number":["R01AI104920"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI109044"],"award-info":[{"award-number":["R01AI109044"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["1S10OD021514-01"],"award-info":[{"award-number":["1S10OD021514-01"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["RTI2018- 094494-B-C21"],"award-info":[{"award-number":["RTI2018- 094494-B-C21"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.devcel.2021.01.012","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T20:34:02Z","timestamp":1614026042000},"page":"443-460.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells"],"prefix":"10.1016","volume":"56","author":[{"given":"Effie E.","family":"Bastounis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Serrano-Alcalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathima","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"G\u00f3mez-Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzi S.","family":"Oswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Garc\u00eda-Aznar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Theriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2021.01.012_bib1","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1128\/JVI.01172-13","article-title":"Polarized cell migration during cell-to-cell transmission of herpes simplex virus in human skin keratinocytes","volume":"87","author":"Abaitua","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.devcel.2021.01.012_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-1-4939-6371-3_13","article-title":"Segmentation and quantitative analysis of epithelial tissues","volume":"1478","author":"Aigouy","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib3","article-title":"Collective MAPK signaling dynamics coordinates epithelial homeostasis","author":"Aikin","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.devcel.2021.01.012_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dmm.003970","article-title":"Drosophila melanogaster as a model for human intestinal infection and pathology","volume":"4","author":"Apidianakis","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.devcel.2021.01.012_bib5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1083\/jcb.201307106","article-title":"Both contractile axial and lateral traction force dynamics drive amoeboid cell motility","volume":"204","author":"Bastounis","year":"2014","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib6","first-page":"57361","article-title":"A multi-well format polyacrylamide-based assay for studying the effect of extracellular matrix stiffness on the bacterial infection of adherent cells","volume":"137","author":"Bastounis","year":"2018","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.devcel.2021.01.012_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41564-018-0288-2","article-title":"Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility","volume":"4","author":"Beerli","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib9","doi-asserted-by":"crossref","first-page":"066008","DOI":"10.1088\/1478-3975\/8\/6\/066008","article-title":"Mechano-sensing and cell migration: a 3D model approach","volume":"8","author":"Borau","year":"2011","journal-title":"Phys. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1741-7007-8-152","article-title":"DrosophilaEGFR pathway coordinates stem cell proliferation and gut remodeling following infection","volume":"8","author":"Buchon","year":"2010","journal-title":"BMC Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib11","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.celrep.2019.01.108","article-title":"Controlling epithelial polarity: a human enteroid model for host-pathogen interactions","volume":"26","author":"Co","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2021.01.012_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-432-6_4","article-title":"The use of bromodeoxyuridine incorporation assays to assess corneal stem cell proliferation","volume":"1014","author":"Crane","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-60327-409-8_8","article-title":"Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry","volume":"682","author":"Darzynkiewicz","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib14","doi-asserted-by":"crossref","first-page":"13343","DOI":"10.1073\/pnas.0705815104","article-title":"Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry","volume":"104","author":"del \u00c1lamo","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.01.012_bib15","first-page":"115","article-title":"NF-\u03baB and innate immunity","volume":"349","author":"Dev","year":"2011","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.devcel.2021.01.012_bib16","doi-asserted-by":"crossref","first-page":"e1001194","DOI":"10.1371\/journal.ppat.1001194","article-title":"Potentiation of epithelial innate host responses by intercellular communication","volume":"6","author":"Dolowschiak","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.devcel.2021.01.012_bib17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.chom.2018.03.004","article-title":"Listeria adhesion protein induces intestinal epithelial barrier dysfunction for bacterial translocation","volume":"23","author":"Drolia","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.devcel.2021.01.012_bib19","first-page":"e10","article-title":"Advanced methods of microscope control using \u03bcManager software","volume":"1","author":"Edelstein","year":"2014","journal-title":"J.\u00a0Biol. Methods"},{"key":"10.1016\/j.devcel.2021.01.012_bib20","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41564-019-0583-6","article-title":"Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence","volume":"4","author":"Engstr\u00f6m","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib21","doi-asserted-by":"crossref","first-page":"e1006395","DOI":"10.1371\/journal.pcbi.1006395","article-title":"Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation","volume":"15","author":"Escribano","year":"2019","journal-title":"PLoS Comp. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10237-018-1010-2","article-title":"A hybrid computational model for collective cell durotaxis","volume":"17","author":"Escribano","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib23","doi-asserted-by":"crossref","first-page":"e1007094","DOI":"10.1371\/journal.ppat.1007094","article-title":"Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing","volume":"14","author":"Faralla","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.devcel.2021.01.012_bib25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.devcel.2009.09.003","article-title":"Myosin II dynamics are regulated by tension in intercalating cells","volume":"17","author":"Fernandez-Gonzalez","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2021.01.012_bib26","doi-asserted-by":"crossref","first-page":"17333","DOI":"10.1073\/pnas.1007765107","article-title":"The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}","volume":"107","author":"Gouin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.01.012_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02778-19","article-title":"Ubiquitination of Listeria virulence factor InlC contributes to the host response to infection","volume":"10","author":"Gouin","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.devcel.2021.01.012_bib28","first-page":"3331","article-title":"Extracellular cleavage of E-cadherin promotes epithelial cell extrusion","volume":"127","author":"Grieve","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.devcel.2021.01.012_bib29","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcdb.2016.05.010","article-title":"Epithelial cell extrusion: pathways and pathologies","volume":"67","author":"Gudipaty","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib30","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/ncb3438","article-title":"Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells","volume":"18","author":"Hayer","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib31","doi-asserted-by":"crossref","first-page":"eaar5926","DOI":"10.1126\/scisignal.aar5926","article-title":"Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO","volume":"12","author":"Herb","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2021.01.012_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.devcel.2021.01.012_bib34","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ncb1853","article-title":"Characterization of the interface between normal and transformed epithelial cells","volume":"11","author":"Hogan","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00250-18","article-title":"Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells","volume":"92","author":"Holly","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.devcel.2021.01.012_bib37","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1158\/0008-5472.CAN-10-3626","article-title":"CARMA3 is crucial for EGFR-Induced activation of NF-\u03baB and tumor progression","volume":"71","author":"Jiang","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2021.01.012_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yexcr.2009.08.005","article-title":"Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction","volume":"316","author":"Joshi","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.devcel.2021.01.012_bib39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1089\/scd.2007.0014","article-title":"Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3","volume":"16","author":"Kang","year":"2007","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.devcel.2021.01.012_bib40","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.immuni.2010.10.015","article-title":"Cell-cell propagation of NF-\u03baB transcription factor and MAP kinase activation amplifies innate immunity against bacterial infection","volume":"33","author":"Kasper","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.devcel.2021.01.012_bib41","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1083\/jcb.149.2.471","article-title":"Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila","volume":"149","author":"Kiehart","year":"2000","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib42","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2021.01.012_bib43","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature07952","article-title":"Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment","volume":"459","author":"Kim","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2021.01.012_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","article-title":"Noncanonical inflammasome activation of caspase-4\/caspase-11 mediates epithelial defenses against enteric bacterial pathogens","volume":"16","author":"Knodler","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.devcel.2021.01.012_bib45","doi-asserted-by":"crossref","first-page":"17733","DOI":"10.1073\/pnas.1006098107","article-title":"Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia","volume":"107","author":"Knodler","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.01.012_bib46","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.cub.2016.08.057","article-title":"Epithelial cell packing induces distinct modes of cell extrusions","volume":"26","author":"Kocgozlu","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib47","doi-asserted-by":"crossref","first-page":"14647","DOI":"10.1038\/s41598-019-50690-3","article-title":"Experimental validation of force inference in epithelia from cell to tissue scale","volume":"9","author":"Kong","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2021.01.012_bib48","first-page":"1229","article-title":"Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours","volume":"127","author":"Kuipers","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.devcel.2021.01.012_bib49","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cell.2016.09.023","article-title":"Rickettsia Sca4 reduces vinculin-mediated intercellular tension to promote spread","volume":"167","author":"Lamason","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2021.01.012_bib50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mib.2016.11.007","article-title":"Actin-based motility and cell-to-cell spread of bacterial pathogens","volume":"35","author":"Lamason","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib51","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cmi.2015.106","article-title":"MCP-1-induced ERK\/GSK-3\u03b2\/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells","volume":"14","author":"Li","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.devcel.2021.01.012_bib52","doi-asserted-by":"crossref","first-page":"e202001064","DOI":"10.1083\/jcb.202001064","article-title":"SuperPlots: communicating reproducibility and variability in cell biology","volume":"219","author":"Lord","year":"2020","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.devcel.2021.01.012_bib54","doi-asserted-by":"crossref","first-page":"W501","DOI":"10.1093\/nar\/gkx372","article-title":"Pathview web: user friendly pathway visualization and data integration","volume":"45","author":"Luo","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2021.01.012_bib55","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1074\/jbc.M410994200","article-title":"Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway","volume":"280","author":"Manna","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.01.012_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1462-5822.2000.00038.x","article-title":"A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages","volume":"2","author":"Mansell","year":"2000","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.devcel.2021.01.012_bib58","doi-asserted-by":"crossref","first-page":"R762","DOI":"10.1016\/j.cub.2019.06.030","article-title":"Multiple influences of mechanical forces on cell competition","volume":"29","author":"Matamoro-Vidal","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib59","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1091\/mbc.e14-01-0690","article-title":"E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion","volume":"25","author":"McEwen","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2021.01.012_bib60","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00526-18","article-title":"RECON-dependent inflammation in hepatocytes enhances Listeria monocytogenes cell-to-cell spread","volume":"9","author":"McFarland","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.devcel.2021.01.012_bib61","article-title":"The unjamming transition is distinct from the epithelial-to-mesenchymal transition","author":"Mitchel","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.devcel.2021.01.012_bib62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.actbio.2007.10.014","article-title":"Modeling mechanosensing and its effect on the migration and proliferation of adherent cells","volume":"4","author":"Moreo","year":"2008","journal-title":"Acta Biomater"},{"key":"10.1016\/j.devcel.2021.01.012_bib63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.devcel.2021.01.012_bib64","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jbiomech.2013.12.004","article-title":"Changes in the stiffness of human mesenchymal stem cells with the progress of cell death as measured by atomic force microscopy","volume":"47","author":"Nikolaev","year":"2014","journal-title":"J.\u00a0Biomech."},{"key":"10.1016\/j.devcel.2021.01.012_bib65","doi-asserted-by":"crossref","first-page":"17063","DOI":"10.1038\/nmicrobiol.2017.63","article-title":"LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-\u03baB","volume":"2","author":"Noad","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib66","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00285-011-0427-3","article-title":"Continuum limits of pattern formation in hexagonal-cell monolayers","volume":"64","author":"O'Dea","year":"2012","journal-title":"J.\u00a0Math. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib67","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.devcel.2018.01.009","article-title":"Cell extrusion: a stress-responsive force for good or evil in epithelial homeostasis","volume":"44","author":"Ohsawa","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2021.01.012_bib68","doi-asserted-by":"crossref","first-page":"e40032","DOI":"10.7554\/eLife.40032","article-title":"Listeria monocytogenes cell-to-cell spread in epithelia is heterogeneous and dominated by rare pioneer bacteria","volume":"8","author":"Ortega","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2021.01.012_bib69","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1091\/mbc.e16-12-0851","article-title":"Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells","volume":"28","author":"Ortega","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2021.01.012_bib70","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1371\/journal.ppat.0020003","article-title":"Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion","volume":"2","author":"Pentecost","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.devcel.2021.01.012_bib71","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1074\/jbc.M705209200","article-title":"Immediate-early signaling induced by E-cadherin engagement and adhesion","volume":"283","author":"Perez","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.01.012_bib72","doi-asserted-by":"crossref","first-page":"e0169622","DOI":"10.1371\/journal.pone.0169622","article-title":"NF-kappaB is involved in the regulation of EMT genes in breast cancer cells","volume":"12","author":"Pires","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2021.01.012_bib73","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrmicro2539","article-title":"Modulation of NF-\u03baB signalling by microbial pathogens","volume":"9","author":"Rahman","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib74","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ncb1964","article-title":"The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria","volume":"11","author":"Rajabian","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib75","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molcel.2014.03.010","article-title":"Bacteria fighting back: how pathogens target and subvert the host innate immune system","volume":"54","author":"Reddick","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2021.01.012_bib76","doi-asserted-by":"crossref","first-page":"e1005603","DOI":"10.1371\/journal.ppat.1005603","article-title":"Endothelial cells use a formin-dependent phagocytosis-like process to internalize the bacterium Listeria monocytogenes","volume":"12","author":"Rengarajan","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.devcel.2021.01.012_bib77","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1186\/s12864-018-4957-6","article-title":"A map of gene expression in neutrophil-like cell lines","volume":"19","author":"Rinc\u00f3n","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.devcel.2021.01.012_bib78","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1083\/jcb.146.6.1333","article-title":"Listeria monocytogenes exploits normal host cell processes to spread from cell to cell","volume":"146","author":"Robbins","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib79","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0960-9822(01)00587-5","article-title":"An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism","volume":"11","author":"Rosenblatt","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib81","doi-asserted-by":"crossref","first-page":"e51427","DOI":"10.1371\/journal.pone.0051427","article-title":"Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers","volume":"7","author":"Schmedt","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2021.01.012_bib100","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nature Methods"},{"key":"10.1016\/j.devcel.2021.01.012_bib83","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.devcel.2021.01.012_bib85","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-1-4939-1164-6_15","article-title":"UV laser ablation to measure cell and tissue-generated forces in the zebrafish embryo in\u00a0vivo and ex\u00a0vivo","volume":"1189","author":"Smutny","year":"2015","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.devcel.2021.01.012_bib86","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrmicro1320","article-title":"Actin-dependent movement of bacterial pathogens","volume":"4","author":"Stevens","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.devcel.2021.01.012_bib87","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1242\/dmm.001321","article-title":"Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK\/NF-kappaB\/Snail1 pathway","volume":"1","author":"Strippoli","year":"2008","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.devcel.2021.01.012_bib88","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.aaf7119","article-title":"Collective cell durotaxis emerges from long-range intercellular force transmission","volume":"353","author":"Sunyer","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.devcel.2021.01.012_bib89","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200609116","article-title":"Two distinct modes of myosin assembly and dynamics during epithelial wound closure","volume":"176","author":"Tamada","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib90","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nmat3025","article-title":"Collective cell guidance by cooperative intercellular forces","volume":"10","author":"Tambe","year":"2011","journal-title":"Nat. Mater."},{"key":"10.1016\/j.devcel.2021.01.012_bib91","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.201307172","article-title":"TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO\u2013IKK supramolecular structures","volume":"204","author":"Tarantino","year":"2014","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib93","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1074\/jbc.RA118.003662","article-title":"The NFkappa B subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells","volume":"293","author":"Tian","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.01.012_bib94","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1083\/jcb.109.4.1597","article-title":"Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes","volume":"109","author":"Tilney","year":"1989","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib95","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1021\/es0629561","article-title":"Stiffness alterations of single cells induced by UV in the presence of nanoTiO2","volume":"41","author":"Vileno","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.devcel.2021.01.012_bib96","doi-asserted-by":"crossref","first-page":"11373","DOI":"10.1038\/ncomms11373","article-title":"Mechanical cell competition kills cells via induction of lethal p53 levels","volume":"7","author":"Wagstaff","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2021.01.012_bib97","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri3901","article-title":"Regulation of innate immune cell function by mTOR","volume":"15","author":"Weichhart","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.devcel.2021.01.012_bib98","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial\u2013mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2021.01.012_bib99","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1083\/jcb.201905047","article-title":"Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis","volume":"218","author":"Zhang","year":"2019","journal-title":"J.\u00a0Cell Biol."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580721000708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580721000708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:40:11Z","timestamp":1761522011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580721000708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1534580721000708"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2021.01.012","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.22.915140","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2021.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}