{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:34:16Z","timestamp":1782819256670,"version":"3.54.5"},"reference-count":83,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001448","name":"Alpha-1 Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001448","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.devcel.2021.02.011","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T09:11:39Z","timestamp":1615108299000},"page":"747-760.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Conversion of the death inhibitor ARC to a killer activates pancreatic \u03b2 cell death in diabetes"],"prefix":"10.1016","volume":"56","author":[{"given":"Wendy M.","family":"McKimpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Irving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson Lek Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenia","family":"Tiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair M.","family":"Jagger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Streamson C.","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Pessin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.-Y.","family":"Foo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Lomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Kitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2021.02.011_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/FJC.0000000000000583","article-title":"Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived alpha-1 antitrypsin: a post hoc analysis of the VCU-\u03b11RT study","volume":"71","author":"Abouzaki","year":"2018","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.devcel.2021.02.011_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/dom.12723","article-title":"When \u03b2-cells fail: lessons from dedifferentiation","volume":"18","author":"Accili","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.devcel.2021.02.011_bib3","doi-asserted-by":"crossref","first-page":"15589","DOI":"10.1074\/jbc.M701762200","article-title":"Glucose mediates the translocation of neuroD1 by O-linked glycosylation","volume":"282","author":"Andrali","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mce.2012.01.020","article-title":"Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms","volume":"355","author":"Banerjee","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.devcel.2021.02.011_bib5","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1172\/JCI117518","article-title":"Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus","volume":"94","author":"Beck-Nielsen","year":"1994","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2021.02.011_bib6","doi-asserted-by":"crossref","first-page":"a009191","DOI":"10.1101\/cshperspect.a009191","article-title":"Insulin receptor signaling in normal and insulin-resistant states","volume":"6","author":"Boucher","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.devcel.2021.02.011_bib7","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1126\/science.278.5345.1966","article-title":"Conversion of Bcl-2 to a Bax-like death effector by caspases","volume":"278","author":"Cheng","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.devcel.2021.02.011_bib8","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.271.5251.994","article-title":"Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor","volume":"271","author":"Chua","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.devcel.2021.02.011_bib9","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1073\/pnas.95.2.554","article-title":"Modulation of cell death by Bcl-XL through caspase interaction","volume":"95","author":"Clem","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.02.011_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00429772","article-title":"Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice","volume":"14","author":"Coleman","year":"1978","journal-title":"Diabetologia"},{"key":"10.1016\/j.devcel.2021.02.011_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF01221856","article-title":"The influence of genetic background on the expression of the obese (Ob) gene in the mouse","volume":"9","author":"Coleman","year":"1973","journal-title":"Diabetologia"},{"key":"10.1016\/j.devcel.2021.02.011_bib12","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114578","article-title":"Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy","volume":"85","author":"Crystal","year":"1990","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2021.02.011_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2021.02.011_bib14","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2021.02.011_bib15","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/sj.cdd.4400855","article-title":"Endogenous and exogenous ARC in serum withdrawal mediated PC12 cell apoptosis: a new pro-apoptotic role for ARC","volume":"8","author":"Dowds","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.devcel.2021.02.011_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2021.02.011_bib17","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/s41588-019-0470-3","article-title":"CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation","volume":"51","author":"Esteghamat","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2021.02.011_bib18","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1074\/jbc.M609046200","article-title":"Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2","volume":"282","author":"Foo","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib19","doi-asserted-by":"crossref","first-page":"20826","DOI":"10.1073\/pnas.0710017104","article-title":"Regulation of p53 tetramerization and nuclear export by ARC","volume":"104","author":"Foo","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.02.011_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.124.4.619","article-title":"Disruption of epithelial cell-matrix interactions induces apoptosis","volume":"124","author":"Frisch","year":"1994","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2021.02.011_bib21","doi-asserted-by":"crossref","first-page":"32642","DOI":"10.1074\/jbc.272.51.32642","article-title":"A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase","volume":"272","author":"Fukuda","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib22","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI110360","article-title":"Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects","volume":"68","author":"Gadek","year":"1981","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2021.02.011_bib23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.devcel.2021.02.011_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0167-4781(96)00036-X","article-title":"Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats","volume":"1306","author":"Geertman","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.devcel.2021.02.011_bib25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00441-004-0989-0","article-title":"Extracellular matrix distribution and islet morphology in the early postnatal pancreas: anomalies in the non-obese diabetic mouse","volume":"318","author":"Geutskens","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.devcel.2021.02.011_bib26","doi-asserted-by":"crossref","first-page":"21233","DOI":"10.1074\/jbc.M400695200","article-title":"Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation","volume":"279","author":"Gustafsson","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrendo.2012.236","article-title":"Coming full circle in diabetes mellitus: from complications to initiation","volume":"9","author":"Harcourt","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.devcel.2021.02.011_bib28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.diabres.2006.06.020","article-title":"Impaired activity of serum alpha-1-antitrypsin in diabetes mellitus","volume":"75","author":"Hashemi","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.devcel.2021.02.011_bib29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0014-5793(03)00444-7","article-title":"Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia\/hypoxia","volume":"543","author":"Hong","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.devcel.2021.02.011_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2021.02.011_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/BJ20131650","article-title":"Altered native stability is the dominant basis for susceptibility of \u03b11-antitrypsin mutants to polymerization","volume":"460","author":"Irving","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.devcel.2021.02.011_bib32","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.rmed.2011.02.002","article-title":"The discovery of \u03b11-antitrypsin and its role in health and disease","volume":"105","author":"Janciauskiene","year":"2011","journal-title":"Respir. Med."},{"key":"10.1016\/j.devcel.2021.02.011_bib33","doi-asserted-by":"crossref","first-page":"9847","DOI":"10.1038\/srep09847","article-title":"Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis","volume":"5","author":"Jang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2021.02.011_bib34","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diab.43.8.1066","article-title":"Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes","volume":"43","author":"Kahn","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4161\/isl.2.3.11654","article-title":"\u03b11-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic \u03b2-cells","volume":"2","author":"Kalis","year":"2010","journal-title":"Islets"},{"key":"10.1016\/j.devcel.2021.02.011_bib36","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.devcel.2021.02.011_bib37","doi-asserted-by":"crossref","first-page":"12631","DOI":"10.1038\/ncomms12631","article-title":"Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic \u03b2 cells in diabetic mice","volume":"7","author":"Kim-Muller","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2021.02.011_bib38","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1073\/pnas.95.9.5156","article-title":"ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases","volume":"95","author":"Koseki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.02.011_bib39","doi-asserted-by":"crossref","first-page":"15443","DOI":"10.1073\/pnas.1018366109","article-title":"Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival","volume":"109","author":"Koulmanda","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.02.011_bib40","doi-asserted-by":"crossref","first-page":"13560","DOI":"10.1038\/ncomms13560","article-title":"The biomechanical properties of an epithelial tissue determine the location of its vasculature","volume":"7","author":"Kragl","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2021.02.011_bib41","first-page":"400","article-title":"NOL3 (nucleolar protein 3 (apoptosis repressor with CARD domain))","volume":"14","author":"Kung","year":"2010","journal-title":"Atlas Genet. Cytogenet. Oncol. Haematol."},{"key":"10.1016\/j.devcel.2021.02.011_bib42","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/379632a0","article-title":"Abnormal splicing of the leptin receptor in diabetic mice","volume":"379","author":"Lee","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2021.02.011_bib43","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.2337\/db06-1771","article-title":"Distinct in\u00a0vivo roles of caspase-8 in beta-cells in physiological and diabetes models","volume":"56","author":"Liadis","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib44","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1074\/jbc.270.10.5282","article-title":"Preparation and characterization of latent alpha 1-antitrypsin","volume":"270","author":"Lomas","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-8645-3_1","article-title":"Overview of serpins and their roles in biological systems","volume":"1826","author":"Lucas","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2021.02.011_bib46","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1007\/s00125-010-1829-2","article-title":"Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease","volume":"53","author":"Ma","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.devcel.2021.02.011_bib47","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1182\/blood-2017-11-815746","article-title":"\u03b11-antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease","volume":"131","author":"Magenau","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.devcel.2021.02.011_bib48","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmet.2013.03.005","article-title":"Imbalance between neutrophil elastase and its inhibitor \u03b11-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure","volume":"17","author":"Mansuy-Aubert","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.devcel.2021.02.011_bib49","doi-asserted-by":"crossref","first-page":"C143","DOI":"10.1152\/ajpcell.00504.2018","article-title":"A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes","volume":"317","author":"McKimpson","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.devcel.2021.02.011_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2337\/db12-0504","article-title":"The apoptosis inhibitor ARC alleviates the ER stress response to promote \u03b2-cell survival","volume":"62","author":"McKimpson","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib51","doi-asserted-by":"crossref","first-page":"e0145792","DOI":"10.1371\/journal.pone.0145792","article-title":"The cell death inhibitor ARC is induced in a tissue-specific manner by deletion of the tumor suppressor gene Men1, but not required for tumor development and growth","volume":"10","author":"McKimpson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2021.02.011_bib52","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1038\/s41598-017-07107-w","article-title":"ARC is essential for maintaining pancreatic islet structure and beta-cell viability during type 2 diabetes","volume":"7","author":"McKimpson","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2021.02.011_bib53","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1158\/0008-5472.CAN-11-2192","article-title":"Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance","volume":"71","author":"Medina-Ramirez","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2021.02.011_bib54","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.4161\/cc.7.11.5979","article-title":"ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer","volume":"7","author":"Mercier","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.devcel.2021.02.011_bib55","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/sj.cdd.4401631","article-title":"ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance","volume":"12","author":"Mercier","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.devcel.2021.02.011_bib56","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.molcel.2004.08.020","article-title":"Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions","volume":"15","author":"Nam","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2021.02.011_bib57","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1074\/jbc.M609186200","article-title":"The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant","volume":"282","author":"Nam","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib58","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.devcel.2006.01.015","article-title":"The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation","volume":"10","author":"Nikolova","year":"2006","journal-title":"Dev. Cell"},{"issue":"Suppl 4","key":"10.1016\/j.devcel.2021.02.011_bib59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1463-1326.2008.00955.x","article-title":"Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation","volume":"10","author":"Otonkoski","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.devcel.2021.02.011_bib60","doi-asserted-by":"crossref","first-page":"a007666","DOI":"10.1101\/cshperspect.a007666","article-title":"Endoplasmic reticulum stress, pancreatic beta-cell degeneration, and diabetes","volume":"2","author":"Papa","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.devcel.2021.02.011_bib61","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2337\/diabetes.47.3.358","article-title":"Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat","volume":"47","author":"Pick","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib62","doi-asserted-by":"crossref","first-page":"21777","DOI":"10.1074\/jbc.R800084200","article-title":"Human caspases: activation, specificity, and regulation","volume":"284","author":"Pop","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib63","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.1104345","article-title":"Type 2 diabetes-a matter of beta-cell life and death?","volume":"307","author":"Rhodes","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.devcel.2021.02.011_bib64","doi-asserted-by":"crossref","first-page":"100984","DOI":"10.1016\/j.molmet.2020.100984","article-title":"Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and \u03b2-cell dysfunction","volume":"37","author":"Rodr\u00edguez-Comas","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.devcel.2021.02.011_bib65","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1464-5491.2008.02584.x","article-title":"An association between type 2 diabetes and alpha-antitrypsin deficiency","volume":"25","author":"Sandstr\u00f6m","year":"2008","journal-title":"Diabet. Med."},{"key":"10.1016\/j.devcel.2021.02.011_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3727\/096368909788237195","article-title":"Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation","volume":"18","author":"Stendahl","year":"2009","journal-title":"Cell Transplant."},{"key":"10.1016\/j.devcel.2021.02.011_bib67","doi-asserted-by":"crossref","first-page":"10951","DOI":"10.1074\/jbc.274.16.10951","article-title":"Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c","volume":"274","author":"Stoss","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.devcel.2021.02.011_bib68","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2021.02.011_bib69","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2021.02.011_bib70","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.07.029","article-title":"Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure","volume":"150","author":"Talchai","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2021.02.011_bib71","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.2337\/db16-1352","article-title":"Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced \u03b2-cell apoptosis and JNK pathway activation","volume":"66","author":"Templin","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib72","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2021.02.011_bib73","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1172\/JCI4431","article-title":"A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse","volume":"103","author":"Wang","year":"1999","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2021.02.011_bib74","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.febslet.2005.03.040","article-title":"Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei","volume":"579","author":"Wang","year":"2005","journal-title":"FEBS Lett."},{"issue":"Suppl 3","key":"10.1016\/j.devcel.2021.02.011_bib75","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.2337\/diabetes.53.suppl_3.S16","article-title":"Five stages of evolving beta-cell dysfunction during progression to diabetes","volume":"53","author":"Weir","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib76","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1056\/NEJM198704233161704","article-title":"Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema","volume":"316","author":"Wewers","year":"1987","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.devcel.2021.02.011_bib77","doi-asserted-by":"crossref","first-page":"17345","DOI":"10.1073\/pnas.0806198105","article-title":"NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions","volume":"105","author":"Yang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2021.02.011_bib78","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2337\/diab.46.5.887","article-title":"A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL\/6 (Akita) mutant mice","volume":"46","author":"Yoshioka","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib79","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1161\/CIRCULATIONAHA.111.034512","article-title":"A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension","volume":"124","author":"Zaiman","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2021.02.011_bib80","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.2337\/db06-1273","article-title":"Alpha1-antitrypsin protects beta-cells from apoptosis","volume":"56","author":"Zhang","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2021.02.011_bib81","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0076-6879(08)01420-1","article-title":"Identification and characterization of endoplasmic reticulum stress-induced apoptosis in\u00a0vivo","volume":"442","author":"Zhang","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.devcel.2021.02.011_bib82","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2021.02.011_bib83","doi-asserted-by":"crossref","first-page":"E340","DOI":"10.1152\/ajpendo.2000.278.2.E340","article-title":"Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion","volume":"278","author":"Zhou","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580721001222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580721001222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:38:26Z","timestamp":1761521906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580721001222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":83,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1534580721001222"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2021.02.011","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conversion of the death inhibitor ARC to a killer activates pancreatic \u03b2 cell death in diabetes","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2021.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}