{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:49:56Z","timestamp":1792439396905,"version":"4.5.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["CAS- WX2022SDC-XK14"],"award-info":[{"award-number":["CAS- WX2022SDC-XK14"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-076"],"award-info":[{"award-number":["YSBR-076"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-036"],"award-info":[{"award-number":["YSBR-036"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-012"],"award-info":[{"award-number":["YSBR-012"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z230011"],"award-info":[{"award-number":["Z230011"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011186","name":"Institute of Zoology, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018123","name":"Society for Research on Adolescence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021ZD0202400"],"award-info":[{"award-number":["2021ZD0202400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0804000"],"award-info":[{"award-number":["2020YFA0804000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103700"],"award-info":[{"award-number":["2022YFA1103700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF1201005"],"award-info":[{"award-number":["2021YFF1201005"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0802202"],"award-info":[{"award-number":["2019YFA0802202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82071588"],"award-info":[{"award-number":["82071588"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["92049116"],"award-info":[{"award-number":["92049116"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["91949209"],"award-info":[{"award-number":["91949209"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["32100937"],"award-info":[{"award-number":["32100937"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["31970597"],"award-info":[{"award-number":["31970597"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0112200"],"award-info":[{"award-number":["2020YFA0112200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103800"],"award-info":[{"award-number":["2022YFA1103800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82192863"],"award-info":[{"award-number":["82192863"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0113400"],"award-info":[{"award-number":["2020YFA0113400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0803401"],"award-info":[{"award-number":["2020YFA0803401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014974","name":"Institute of Biophysics, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014974","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","award":["2023QNRC001"],"award-info":[{"award-number":["2023QNRC001"]}],"id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["E1CAZW0401"],"award-info":[{"award-number":["E1CAZW0401"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2020085"],"award-info":[{"award-number":["2020085"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32121001"],"award-info":[{"award-number":["32121001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92168201"],"award-info":[{"award-number":["92168201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81921006"],"award-info":[{"award-number":["81921006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92049304"],"award-info":[{"award-number":["92049304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92149301"],"award-info":[{"award-number":["92149301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122024"],"award-info":[{"award-number":["82122024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82125011"],"award-info":[{"award-number":["82125011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.devcel.2024.02.008","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:40:02Z","timestamp":1710326402000},"page":"991-1009.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA"],"prefix":"10.1016","volume":"59","author":[{"given":"Shijia","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianzhao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Izpisua Belmonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-8177","authenticated-orcid":false,"given":"Guang-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2024.02.008_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/genetics\/116.1.9","article-title":"Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae","volume":"116","author":"Rine","year":"1987","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2024.02.008_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.11.2.241","article-title":"An unusual form of transcriptional silencing in yeast ribosomal DNA","volume":"11","author":"Smith","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2024.02.008_bib3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/bbrc.2000.3000","article-title":"Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins","volume":"273","author":"Frye","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib4","doi-asserted-by":"crossref","first-page":"E952","DOI":"10.1073\/pnas.1104969108","article-title":"Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3\/atypical protein kinase C (aPKC) signaling","volume":"108","author":"Beirowski","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.02.008_bib5","doi-asserted-by":"crossref","first-page":"14608","DOI":"10.1073\/pnas.1111308108","article-title":"Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production","volume":"108","author":"Jing","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.02.008_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molcel.2011.07.019","article-title":"SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome","volume":"44","author":"Hirschey","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib8","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1073\/pnas.0802917105","article-title":"Sirt1 protects against high-fat diet-induced metabolic damage","volume":"105","author":"Pfluger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.02.008_bib9","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cmet.2019.02.014","article-title":"LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation","volume":"29","author":"Simon","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.devcel.2024.02.008_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/cr.2016.4","article-title":"SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2","volume":"26","author":"Pan","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s13238-020-00728-4","article-title":"SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer","volume":"11","author":"Bi","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib12","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1093\/nar\/gkab161","article-title":"SIRT3 consolidates heterochromatin and counteracts senescence","volume":"49","author":"Diao","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111254","article-title":"The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation","volume":"188","author":"Mu","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.devcel.2024.02.008_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.stemcr.2014.04.015","article-title":"Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells","volume":"3","author":"Rimmel\u00e9","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.devcel.2024.02.008_bib15","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.aaa2361","article-title":"A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging","volume":"347","author":"Mohrin","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.02.008_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.celrep.2018.12.101","article-title":"Mitochondrial stress-initiated aberrant activation of the NLRP3 inflammasome regulates the functional deterioration of hematopoietic stem cell aging","volume":"26","author":"Luo","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2024.02.008_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molcel.2023.10.006","article-title":"Stress, epigenetics, and aging: unraveling the intricate crosstalk","volume":"84","author":"Wu","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnad001","article-title":"Endogenous retroviruses make aging go viral","volume":"2","author":"Zhou","year":"2023","journal-title":"Life Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/lifemedi\/lnac030","article-title":"Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging","volume":"1","author":"Sun","year":"2022","journal-title":"Life Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11082","article-title":"Topological domains in mammalian genomes identified by analysis of chromatin interactions","volume":"485","author":"Dixon","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.1181369","article-title":"Comprehensive mapping of long-range interactions reveals folding principles of the human genome","volume":"326","author":"Lieberman-Aiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.02.008_bib22","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2013.04.053","article-title":"Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment","volume":"153","author":"Phillips-Cremins","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.molcel.2016.05.018","article-title":"Chromatin domains: the unit of chromosome organization","volume":"62","author":"Dixon","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib24","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.molcel.2021.12.004","article-title":"Now open: evolving insights to the roles of lysine acetylation in chromatin organization and function","volume":"82","author":"Chen","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib25","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/s43587-023-00486-y","article-title":"SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B","volume":"3","author":"Ye","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.devcel.2024.02.008_bib26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-biochem-082520-125411","article-title":"Understanding the function of mammalian sirtuins and protein lysine acylation","volume":"90","author":"Wang","year":"2021","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.devcel.2024.02.008_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3327","article-title":"An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms","volume":"4","author":"Rauh","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2017.11.003","article-title":"Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair","volume":"61","author":"SenGupta","year":"2018","journal-title":"DNA Repair"},{"key":"10.1016\/j.devcel.2024.02.008_bib29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature11043","article-title":"SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation","volume":"487","author":"Barber","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molcel.2004.08.031","article-title":"Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin","volume":"16","author":"Vaquero","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib31","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature06736","article-title":"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin","volume":"452","author":"Michishita","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib32","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.4161\/cc.8.16.9367","article-title":"Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6","volume":"8","author":"Michishita","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.devcel.2024.02.008_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.1238858","article-title":"A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection","volume":"341","author":"Eskandarian","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.02.008_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Kundaje","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nmeth.1906","article-title":"ChromHMM: automating chromatin-state discovery and characterization","volume":"9","author":"Ernst","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.02.008_bib36","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.devcel.2022.05.004","article-title":"Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging","volume":"57","author":"Liu","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.molcel.2017.04.010","article-title":"Dynamic rewiring of promoter-anchored chromatin loops during adipocyte differentiation","volume":"66","author":"Siersb\u00e6k","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41576-022-00530-4","article-title":"New insights into genome folding by loop extrusion from inducible degron technologies","volume":"24","author":"de Wit","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2024.02.008_bib39","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/ncb3573","article-title":"Tissue-specific CTCF\u2013cohesin-mediated chromatin architecture delimits enhancer interactions and function in\u00a0vivo","volume":"19","author":"Hanssen","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","article-title":"Characterization of four human pregnancy-associated plasma proteins","volume":"118","author":"Lin","year":"1974","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.devcel.2024.02.008_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1054\/ghir.1998.0083","article-title":"Characterization and partial purification of the insulin-like growth factor (IGF)-dependent IGF binding protein-4-specific protease from human fibroblast conditioned media","volume":"9","author":"Lawrence","year":"1999","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib42","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1474-9726.2007.00328.x","article-title":"Loss of pregnancy-associated plasma protein A extends lifespan in mice","volume":"6","author":"Conover","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib43","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0002-9378(81)90957-1","article-title":"Pregnancy-associated plasma protein A: circulating levels during normal pregnancy","volume":"139","author":"Folkersen","year":"1981","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.devcel.2024.02.008_bib44","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.cell.2017.05.004","article-title":"Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization","volume":"169","author":"Nora","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/19491034.2020.1782024","article-title":"CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism","volume":"11","author":"Hansen","year":"2020","journal-title":"Nucleus"},{"key":"10.1016\/j.devcel.2024.02.008_bib46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41580-019-0132-4","article-title":"The role of 3D genome organization in development and cell differentiation","volume":"20","author":"Zheng","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib47","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrg.2016.112","article-title":"Organization and function of the 3D genome","volume":"17","author":"Bonev","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2024.02.008_bib48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41586-018-0437-z","article-title":"SIRT6 deficiency results in developmental retardation in cynomolgus monkeys","volume":"560","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cell.2022.12.017","article-title":"Resurrection of endogenous retroviruses during aging reinforces senescence","volume":"186","author":"Liu","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba3200","article-title":"Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons","volume":"6","author":"Turelli","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.devcel.2024.02.008_bib51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1095\/biolreprod61.4.1083","article-title":"Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive Tissues","volume":"61","author":"Overgaard","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.devcel.2024.02.008_bib52","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","article-title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib53","doi-asserted-by":"crossref","first-page":"S907","DOI":"10.1016\/j.ajog.2020.09.047","article-title":"Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways","volume":"226","author":"Redman","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.devcel.2024.02.008_bib54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.placenta.2019.06.377","article-title":"Trophoblast type-specific expression of senescence markers in the human placenta","volume":"85","author":"Higuchi","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.devcel.2024.02.008_bib55","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1101\/gad.227512.113","article-title":"Cell fusion induced by ERVWE1 or measles virus causes cellular senescence","volume":"27","author":"Chuprin","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2024.02.008_bib56","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1210\/en.2019-00144","article-title":"Human trophoblast differentiation is associated with profound gene regulatory and epigenetic changes","volume":"160","author":"Kwak","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.devcel.2024.02.008_bib57","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.aaa1356","article-title":"A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging","volume":"348","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.02.008_bib58","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s13238-018-0517-8","article-title":"Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome","volume":"9","author":"Wu","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib59","doi-asserted-by":"crossref","first-page":"D825","DOI":"10.1093\/nar\/gkaa894","article-title":"Aging Atlas: a multi-omics database for aging biology","volume":"49","author":"Liu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib60","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab274","article-title":"ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues","volume":"22","author":"Liu","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.devcel.2024.02.008_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-018-1599-6","article-title":"Predicting age from the transcriptome of human dermal fibroblasts","volume":"19","author":"Fleischer","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib62","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.devcel.2020.11.002","article-title":"A single-cell transcriptomic atlas of human skin aging","volume":"56","author":"Zou","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib63","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib64","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/s42255-021-00478-5","article-title":"Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases","volume":"3","author":"Ritchie","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.devcel.2024.02.008_bib65","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61073","article-title":"Plasma proteomic biomarker signature of age predicts health and life span","volume":"9","author":"Tanaka","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2024.02.008_bib66","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.164558","article-title":"Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice","volume":"102","author":"Vakhrusheva","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib67","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000441603","article-title":"Age-related changes in sirtuin 7 expression in calorie-restricted and refed rats","volume":"62","author":"Wronska","year":"2016","journal-title":"Gerontology"},{"key":"10.1016\/j.devcel.2024.02.008_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218134","article-title":"Melatonin and sirtuins in buccal epithelium: potential biomarkers of aging and age-related pathologies","volume":"21","author":"Carbone","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.devcel.2024.02.008_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35424-w","article-title":"Sirt6 attenuates chondrocyte senescence and osteoarthritis progression","volume":"13","author":"Ji","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib70","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.devcel.2024.02.008_bib71","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1007\/s11427-022-2161-3","article-title":"The landscape of aging","volume":"65","author":"Cai","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.devcel.2024.02.008_bib72","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11427-023-2305-0","article-title":"Biomarkers of aging","volume":"66","author":"Bao","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.devcel.2024.02.008_bib73","doi-asserted-by":"crossref","first-page":"10909","DOI":"10.1093\/nar\/gkaa858","article-title":"Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts","volume":"48","author":"Guan","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib74","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13315","article-title":"ATF3 drives senescence by reconstructing accessible chromatin profiles","volume":"20","author":"Zhang","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cell.2022.12.027","article-title":"Loss of epigenetic information as a cause of mammalian aging","volume":"186","author":"Yang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24402-3","article-title":"Reactivation of a developmentally silenced embryonic globin gene","volume":"12","author":"King","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib77","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203452119","article-title":"3D chromatin remodeling potentiates transcriptional programs driving cell invasion","volume":"119","author":"Lebeau","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.02.008_bib78","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1101\/gad.267583.115","article-title":"The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains","volume":"29","author":"Alekseyenko","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2024.02.008_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnad010","article-title":"Chromatin 3D structure, phase separation and disease","volume":"2","author":"Fan","year":"2023","journal-title":"Life Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib80","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/lifemedi\/lnac046","article-title":"NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1","volume":"1","author":"Wu","year":"2022","journal-title":"Life Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6011","article-title":"SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age","volume":"5","author":"Van Meter","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib82","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3109\/00016349.2010.505639","article-title":"Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview","volume":"89","author":"Kirkegaard","year":"2010","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.devcel.2024.02.008_bib83","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ghir.2006.11.003","article-title":"Pregnancy-associated plasma protein-A (PAPP-A): A local regulator of IGF bioavailability through cleavage of IGFBPs","volume":"17","author":"Boldt","year":"2007","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib84","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrendo.2013.67","article-title":"The GH\/IGF-1 axis in ageing and longevity","volume":"9","author":"Junnila","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.devcel.2024.02.008_bib85","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/gerona\/glq032","article-title":"Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A","volume":"65a","author":"Conover","year":"2010","journal-title":"J.\u00a0Gerontol.: S. A"},{"key":"10.1016\/j.devcel.2024.02.008_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.112070","article-title":"Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes","volume":"172","author":"Conover","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.devcel.2024.02.008_bib87","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/lifemedi\/lnac016","article-title":"Failures at every level: breakdown of the epigenetic machinery of aging","volume":"1","author":"Zhao","year":"2022","journal-title":"Life Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10831-8","article-title":"Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis","volume":"10","author":"Deng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib89","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41422-020-0385-7","article-title":"Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration","volume":"31","author":"Liang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib90","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1093\/nar\/gkaa425","article-title":"ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin","volume":"48","author":"Hu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib91","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.02.008_bib92","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib93","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib94","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib95","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib96","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib97","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib98","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.02.008_bib99","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib100","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/bioinformatics\/btp340","article-title":"A clustering approach for identification of enriched domains from histone modification ChIP-Seq data","volume":"25","author":"Zang","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib101","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib102","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib103","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib104","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/bioinformatics\/btaa692","article-title":"pyGenomeTracks: reproducible plots for multivariate genomic datasets","volume":"37","author":"Lopez-Delisle","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.devcel.2024.02.008_bib106","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib107","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib108","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-232","article-title":"BSMAP: whole genome bisulfite sequence MAPping program","volume":"10","author":"Xi","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib109","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-015-0831-x","article-title":"HiC-Pro: an optimized and flexible pipeline for Hi-C data processing","volume":"16","author":"Servant","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/bioinformatics\/btz540","article-title":"Cooler: scalable storage for Hi-C data and other genomically labeled arrays","volume":"36","author":"Abdennur","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib111","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cels.2016.07.002","article-title":"Juicer provides a one-click system for analyzing loop-resolution Hi-C experiments","volume":"3","author":"Durand","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.devcel.2024.02.008_bib112","article-title":"Hi-C analyses with GENOVA: a case study with cohesin variants","volume":"3","author":"van der Weide","year":"2021","journal-title":"NAR Genom. Bioinform."},{"key":"10.1016\/j.devcel.2024.02.008_bib113","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1505","article-title":"TopDom: an efficient and deterministic method for identifying topological domains in genomes","volume":"44","author":"Shin","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib114","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1093\/bioinformatics\/btaa073","article-title":"Coolpup.py: versatile pile-up analysis of Hi-C data","volume":"36","author":"Flyamer","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib116","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-017-1621-0","article-title":"Pgltools: a genomic arithmetic tool suite for manipulation of Hi-C peak and other chromatin interaction data","volume":"18","author":"Greenwald","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib117","article-title":"Cooltools: Enabling High-Resolution Hi-C Analysis in Python","author":"Abdennur","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.devcel.2024.02.008_bib118","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.gpb.2021.08.001","article-title":"The genome sequence archive family: toward explosive data growth and diverse data types","volume":"19","author":"Chen","year":"2021","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.devcel.2024.02.008_bib119","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/procel\/pwad012","article-title":"CRISPR-based screening identifies XPO7 as a positive regulator of senescence","volume":"14","author":"Li","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib120","doi-asserted-by":"crossref","DOI":"10.34133\/research.0192","article-title":"MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer","volume":"6","author":"Wang","year":"2023","journal-title":"Research"},{"key":"10.1016\/j.devcel.2024.02.008_bib121","first-page":"202","article-title":"4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis","volume":"14","author":"He","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib122","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/procel\/pwad017","article-title":"APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation","volume":"14","author":"Zhao","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib123","first-page":"3323","article-title":"BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates","volume":"50","author":"Liang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.02.008_bib124","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s13238-021-00872-5","article-title":"Large-scale chemical screen identifies gallic acid as a geroprotector for human stem cells","volume":"13","author":"Shan","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib125","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s43587-022-00186-z","article-title":"Destabilizing heterochromatin by APOE mediates senescence","volume":"2","author":"Zhao","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.devcel.2024.02.008_bib126","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000201","article-title":"Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis","volume":"17","author":"Fu","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.devcel.2024.02.008_bib127","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.02.008_bib128","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nprot.2017.016","article-title":"Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening","volume":"12","author":"Joung","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2024.02.008_bib129","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.cell.2017.11.008","article-title":"YY1 is a structural regulator of enhancer-promoter loops","volume":"171","author":"Weintraub","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.02.008_bib130","article-title":"Dissecting super-enhancer hierarchy based on chromatin interactions","volume":"9","author":"Huang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib131","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nmeth.3630","article-title":"Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements","volume":"12","author":"Thakore","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.02.008_bib132","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/ard-2022-222653","article-title":"3D genome alterations in T\u00a0cells associated with disease activity of systemic lupus erythematosus","volume":"82","author":"Zhao","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.devcel.2024.02.008_bib133","article-title":"Comprehensive 3D epigenomic maps define limbal stem\/progenitor cell function and identity","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.02.008_bib134","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd2655","article-title":"A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence","volume":"13","author":"Wang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.devcel.2024.02.008_bib135","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1038\/s41596-020-0373-x","article-title":"Efficient low-cost chromatin profiling with CUT&Tag","volume":"15","author":"Kaya-Okur","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2024.02.008_bib136","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-08940-5","article-title":"Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression","volume":"10","author":"Greenwald","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580724001072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580724001072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:53:49Z","timestamp":1778522029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580724001072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":136,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1534580724001072"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2024.02.008","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2024.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}