{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:53:23Z","timestamp":1791910403738,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20346"],"award-info":[{"award-number":["U21A20346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001573"],"award-info":[{"award-number":["82001573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871189"],"award-info":[{"award-number":["81871189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.devcel.2024.04.009","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:33:46Z","timestamp":1713954826000},"page":"1842-1859.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9565-1106","authenticated-orcid":false,"given":"Bin","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bo","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2024.04.009_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \"Great Obstetrical Syndromes\" are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.devcel.2024.04.009_bib2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.devcel.2024.04.009_bib3","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.devcel.2024.04.009_bib4","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/HYPERTENSIONAHA.110.157743","article-title":"Learning from the placenta: acute atherosis and vascular remodeling in preeclampsia-novel aspects for atherosclerosis and future cardiovascular health","volume":"56","author":"Staff","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.devcel.2024.04.009_bib5","doi-asserted-by":"crossref","first-page":"287.e1","DOI":"10.1016\/j.ajog.2016.12.029","article-title":"Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta","volume":"216","author":"Labarrere","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.devcel.2024.04.009_bib6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.04.009_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phrs.2019.04.017","article-title":"Endothelial progenitor cells: Potential novel therapeutics for ischaemic stroke","volume":"144","author":"Bayraktutan","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.devcel.2024.04.009_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1172\/JCI8071","article-title":"Origins of circulating endothelial cells and endothelial outgrowth from blood","volume":"105","author":"Lin","year":"2000","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.04.009_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-8794-3-18","article-title":"Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities","volume":"3","author":"Medina","year":"2010","journal-title":"BMC Med. Genomics"},{"issue":"Suppl 1","key":"10.1016\/j.devcel.2024.04.009_bib10","first-page":"S59","article-title":"Spatially oriented, temporally sequential smooth muscle cell-endothelial progenitor cell bi-level cell sheet neovascularizes ischemic myocardium","volume":"128","author":"Shudo","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2024.04.009_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12489","article-title":"Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice","volume":"65","author":"Lee","year":"2018","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.devcel.2024.04.009_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13699","article-title":"Chronological attenuation of NPRA\/PKG\/AMPK signaling promotes vascular aging and elevates blood pressure","volume":"21","author":"Long","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.devcel.2024.04.009_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00395-019-0717-2","article-title":"Endothelial \u03b11AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction","volume":"114","author":"Kr\u00f6ller-Sch\u00f6n","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.devcel.2024.04.009_bib14","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1038\/s41467-018-07132-x","article-title":"PRKAA1\/AMPK\u03b11-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis","volume":"9","author":"Yang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.04.009_bib15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tem.2020.05.009","article-title":"Metabolic Signatures of Distinct Endothelial Phenotypes","volume":"31","author":"Dumas","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.devcel.2024.04.009_bib16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2024.04.009_bib17","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1161\/ATVBAHA.111.226670","article-title":"Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation","volume":"31","author":"Davis-Dusenbery","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.devcel.2024.04.009_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0140-6736(03)15172-0","article-title":"CCN proteins: multifunctional signalling regulators","volume":"363","author":"Perbal","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.devcel.2024.04.009_bib19","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-Kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.devcel.2024.04.009_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.devcel.2024.04.009_bib21","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/eurheartj\/ehr065","article-title":"Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1","volume":"33","author":"Cudmore","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.devcel.2024.04.009_bib22","doi-asserted-by":"crossref","first-page":"2003694","DOI":"10.1183\/13993003.03694-2020","article-title":"AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1","volume":"58","author":"Ahmad","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.devcel.2024.04.009_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bcp.2016.12.009","article-title":"Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity","volume":"127","author":"Maamoun","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.devcel.2024.04.009_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10047-019-01114-6","article-title":"Circulating endothelial progenitor cells in small-diameter artificial blood vessel","volume":"23","author":"Munisso","year":"2020","journal-title":"J.\u00a0Artif. Organs"},{"key":"10.1016\/j.devcel.2024.04.009_bib25","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/nprot.2012.093","article-title":"Establishment of outgrowth endothelial cells from peripheral blood","volume":"7","author":"Martin-Ramirez","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2024.04.009_bib26","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1172\/JCI93649","article-title":"Blood endothelial cells: utility from ambiguity","volume":"127","author":"Hebbel","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.04.009_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1476-4598-13-177","article-title":"Circulating mouse Flk1+\/c-Kit+\/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts","volume":"13","author":"Russell","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.devcel.2024.04.009_bib28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1161\/CIRCULATIONAHA.112.108159","article-title":"Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice","volume":"126","author":"Li","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2024.04.009_bib29","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/cvr\/cvaa011","article-title":"Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1\/Cdc42\/Arpc1b","volume":"117","author":"Li","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.devcel.2024.04.009_bib30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/CIRCULATIONAHA.118.034615","article-title":"LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor \u03b2 Signaling and Fibrosis","volume":"139","author":"Xie","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2024.04.009_bib31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"Adamson","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2024.04.009_bib32","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/humrep\/dez124","article-title":"Uterine spiral artery muscle dedifferentiation","volume":"34","author":"Robson","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.devcel.2024.04.009_bib33","doi-asserted-by":"crossref","first-page":"S895","DOI":"10.1016\/j.ajog.2020.09.026","article-title":"Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia","volume":"226","author":"Staff","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"Suppl","key":"10.1016\/j.devcel.2024.04.009_bib34","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1016\/j.placenta.2013.10.020","article-title":"Review: the enigmatic role of endoglin in the placenta","volume":"35","author":"Gregory","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.devcel.2024.04.009_bib35","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000221429.94591.72","article-title":"Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells","volume":"47","author":"Hattori","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.devcel.2024.04.009_bib36","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1161\/CIRCULATIONAHA.112.101261","article-title":"Oxysterol-induced soluble endoglin release and its involvement in hypertension","volume":"126","author":"Valbuena-Diez","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.devcel.2024.04.009_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.04.009_bib38","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational Hypertension and Preeclampsia","volume":"135","year":"2020","journal-title":"Obstetrics\u00a0& Gynecology"},{"key":"10.1016\/j.devcel.2024.04.009_bib39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1161\/HYPERTENSIONAHA.117.10250","article-title":"Dysregulated Expression of RPS4Y1 (Ribosomal Protein S4, Y-Linked 1) Impairs STAT3 (Signal Transducer and Activator of Transcription 3) Signaling to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia","volume":"71","author":"Chen","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.devcel.2024.04.009_bib40","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.15252\/emmm.201607066","article-title":"Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis","volume":"9","author":"Xu","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.devcel.2024.04.009_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-1-4939-2929-0_8","article-title":"Isolation and Culture of Aortic Smooth Muscle Cells and In\u00a0Vitro Calcification Assay","volume":"1339","author":"Villa-Bellosta","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2024.04.009_bib42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1089\/ars.2019.7891","article-title":"The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy","volume":"34","author":"Yang","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.devcel.2024.04.009_bib43","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.2337\/db10-0582","article-title":"Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase\/p16INK4A signaling pathway","volume":"59","author":"Chang","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.devcel.2024.04.009_bib44","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1096\/fj.201802058RR","article-title":"Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia","volume":"33","author":"Peng","year":"2019","journal-title":"FASEB J."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153458072400234X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153458072400234X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:02:00Z","timestamp":1762549320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153458072400234X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":44,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S153458072400234X"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2024.04.009","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2024.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}