{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:18:53Z","timestamp":1790090333737,"version":"4.0.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["F30 DK134109"],"award-info":[{"award-number":["F30 DK134109"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA013696"],"award-info":[{"award-number":["P30 CA013696"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK060694"],"award-info":[{"award-number":["R01 DK060694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD026880"],"award-info":[{"award-number":["S10OD026880"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD020056"],"award-info":[{"award-number":["S10OD020056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH UL1TR001873"],"award-info":[{"award-number":["NIH UL1TR001873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30 DK134109"],"award-info":[{"award-number":["F30 DK134109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031313","name":"Herbert Irving Comprehensive Cancer Center, Columbia University","doi-asserted-by":"publisher","award":["R01 DK060694"],"award-info":[{"award-number":["R01 DK060694"]}],"id":[{"id":"10.13039\/100031313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031313","name":"Herbert Irving Comprehensive Cancer Center, Columbia University","doi-asserted-by":"publisher","award":["S10OD026880"],"award-info":[{"award-number":["S10OD026880"]}],"id":[{"id":"10.13039\/100031313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.devcel.2024.07.021","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T21:51:48Z","timestamp":1724363508000},"page":"3025-3042.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia"],"prefix":"10.1016","volume":"59","author":[{"given":"Alina L.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorsay","family":"Sadeghian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Falvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Chandwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Pitarresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Rustgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2024.07.021_bib1","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1172\/JCI57131","article-title":"Pancreatic ductal cells in development, regeneration, and neoplasia","volume":"121","author":"Reichert","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.07.021_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.stem.2014.11.001","article-title":"Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease","volume":"16","author":"Puri","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib3","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2007.09.009","article-title":"In\u00a0Vivo Lineage Tracing Defines the Role of Acinar-to-Ductal Transdifferentiation in Inflammatory Ductal Metaplasia","volume":"133","author":"Strobel","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.devcel.2024.07.021_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nrgastro.2017.12","article-title":"Acinar cell plasticity and development of pancreatic ductal adenocarcinoma","volume":"14","author":"Storz","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.devcel.2024.07.021_bib5","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ccr.2011.05.011","article-title":"Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence","volume":"19","author":"Guerra","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib7","doi-asserted-by":"crossref","first-page":"18907","DOI":"10.1073\/pnas.0810111105","article-title":"Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia","volume":"105","author":"De La O","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.07.021_bib8","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1053\/j.gastro.2018.12.042","article-title":"Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis","volume":"156","author":"Crawford","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.devcel.2024.07.021_bib9","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ccr.2012.10.025","article-title":"Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as\u00a0the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma","volume":"22","author":"Kopp","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/science.add5327","article-title":"Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis","volume":"380","author":"Burdziak","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.07.021_bib11","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41586-020-03147-x","article-title":"A gene\u2013environment-induced epigenetic program initiates tumorigenesis","volume":"590","author":"Alonso-Curbelo","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.07.021_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s43018-020-00134-z","article-title":"Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer","volume":"2","author":"Li","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.devcel.2024.07.021_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbcan.2019.04.003","article-title":"The AP-1 transcriptional complex: local switch or remote command?","volume":"1872","author":"Bejjani","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.devcel.2024.07.021_bib14","first-page":"129","article-title":"The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation","volume":"1072","author":"Angel","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.devcel.2024.07.021_bib15","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/sj.onc.1204383","article-title":"AP-1 in cell proliferation and survival","volume":"20","author":"Shaulian","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.devcel.2024.07.021_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1098\/rstb.1996.0008","article-title":"The regulation of AP-1 activity by mitogen-activated protein kinases","volume":"351","author":"Karin","year":"1996","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.devcel.2024.07.021_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ccell.2017.07.007","article-title":"Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma","volume":"32","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: A double-edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2024.07.021_bib19","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1128\/MCB.01776-06","article-title":"Ubiquitin-Independent Proteasomal Degradation of Fra-1 Is Antagonized by Erk1\/2 Pathway-Mediated Phosphorylation of a Unique C-Terminal Destabilizer","volume":"27","author":"Basbous","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib20","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1128\/MCB.23.12.4401-4415.2003","article-title":"Accumulation of Fra-1 in ras-Transformed Cells Depends on Both Transcriptional Autoregulation and MEK-Dependent Posttranslational Stabilization","volume":"23","author":"Casalino","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib21","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1038\/sj.emboj.7600282","article-title":"The Fos-related antigen Fra-1 is an activator of bone matrix formation","volume":"23","author":"Eferl","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2024.07.021_bib22","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1073\/pnas.87.9.3619","article-title":"Isolation and characterization of fra-2, an additional member of the fos gene family (fos-related gene\/cellular trandormation\/transcription factor AP-1\/immediate early gene\/cell cycle)","volume":"87","author":"Nishina","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.devcel.2024.07.021_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1172\/JCI40045","article-title":"\u03b2-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice","volume":"120","author":"Morris","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.07.021_bib24","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/PAS.0000000000000533","article-title":"A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas","volume":"39","author":"Basturk","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.devcel.2024.07.021_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.gastro.2022.04.013","article-title":"Estrogen-Related Receptor \u03b3 Maintains Pancreatic Acinar Cell Function and Identity by Regulating Cellular Metabolism","volume":"163","author":"Choi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.devcel.2024.07.021_bib27","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143414","article-title":"Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation","volume":"131","author":"Tamura","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.07.021_bib28","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.3390\/cancers13102462","article-title":"CUX1 Enhances Pancreatic Cancer Formation by Synergizing with KRAS and Inducing MEK\/ERK-Dependent Proliferation","volume":"13","author":"Griesmann","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.devcel.2024.07.021_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-physiol-021014-071727","article-title":"Regeneration and Repair of the Exocrine Pancreas","volume":"77","author":"Murtaugh","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.devcel.2024.07.021_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012311","article-title":"The Pancreatic and Duodenal Homeobox Protein PDX-1 Regulates the Ductal Specific Keratin 19 through the Degradation of MEIS1 and DNA Binding","volume":"5","author":"von Burstin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2024.07.021_bib31","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.devcel.2010.05.015","article-title":"Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors","volume":"18","author":"Schaffer","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib32","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/gutjnl-2012-304287","article-title":"Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation","volume":"63","author":"von Figura","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.devcel.2024.07.021_bib33","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/1878-0261.12699","article-title":"Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice","volume":"14","author":"Hedegger","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.devcel.2024.07.021_bib34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jcmgh.2019.05.006","article-title":"Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis","volume":"8","author":"Wen","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.devcel.2024.07.021_bib35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.gastro.2010.04.003","article-title":"Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells","volume":"139","author":"Masui","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.devcel.2024.07.021_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18207-z","article-title":"Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells\u2019 heterogeneity","volume":"11","author":"Schlesinger","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.07.021_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-cellbio-101512-122405","article-title":"Pancreas organogenesis: From lineage determination to morphogenesis","volume":"29","author":"Shih","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib38","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1172\/JCI86477","article-title":"RelA regulates CXCL1\/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis","volume":"126","author":"Lesina","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.07.021_bib39","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ccell.2016.04.014","article-title":"CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma","volume":"29","author":"Steele","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib40","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1182\/blood.V84.6.1760.1760","article-title":"Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor","volume":"84","author":"Tian","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.devcel.2024.07.021_bib41","doi-asserted-by":"crossref","first-page":"800","DOI":"10.2741\/2103","article-title":"Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders","volume":"12","author":"Touw","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.devcel.2024.07.021_bib42","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1158\/2159-8290.CD-14-0474","article-title":"Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions","volume":"5","author":"Liou","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.devcel.2024.07.021_bib43","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1172\/JCI94287","article-title":"The BRG1\/SOX9 axis is critical for acinar cell\u2013derived pancreatic tumorigenesis","volume":"128","author":"Tsuda","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.devcel.2024.07.021_bib44","article-title":"Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture","volume":"144","author":"Martinez","year":"2019","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.devcel.2024.07.021_bib45","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cytogfr.2014.07.011","article-title":"G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent","volume":"25","author":"Bendall","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.devcel.2024.07.021_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.932608","article-title":"A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer","volume":"12","author":"Park","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.devcel.2024.07.021_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116229","article-title":"Granulocyte Colony-Stimulating Factor Reduces Fibrosis in a Mouse Model of Chronic Pancreatitis","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2024.07.021_bib48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00018-022-04638-y","article-title":"AP1\/FRA1 confers resistance to MAPK cascade inhibition in pancreatic cancer","volume":"80","author":"Schneeweis","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.devcel.2024.07.021_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14294","article-title":"An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer","volume":"8","author":"Vallejo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.07.021_bib50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/modpathol.3880544","article-title":"Direct Correlation between Proliferative Activity and Dysplasia in Pancreatic Intraepithelial Neoplasia (PanIN): Additional Evidence for a Recently Proposed Model of Progression","volume":"15","author":"Klein","year":"2002","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.devcel.2024.07.021_bib51","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs5.50175","article-title":"Prognostic impact of Ki-67 proliferative index in resectable pancreatic ductal adenocarcinoma","volume":"3","author":"Pergolini","year":"2019","journal-title":"BJS Open"},{"key":"10.1016\/j.devcel.2024.07.021_bib52","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.dnarep.2007.12.004","article-title":"ATF3 and FRA1 have opposite functions in JNK- and ERK-dependent DNA damage responses","volume":"7","author":"Hamdi","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.devcel.2024.07.021_bib53","article-title":"The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis","volume":"8","author":"Wan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201301001","article-title":"Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-\u039aB and MMPs","volume":"202","author":"Liou","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-82800-5","article-title":"Assessment of common housekeeping genes as reference for gene expression studies using RT-qPCR in mouse choroid plexus","volume":"11","author":"Ho","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2024.07.021_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2024.07.021_bib57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.devcel.2024.07.021_bib58","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.07.021_bib59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.07.021_bib60","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/nprot.2012.101","article-title":"Identifying ChIP-seq enrichment using MACS","volume":"7","author":"Feng","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2024.07.021_bib61","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.07.021_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.07.021_bib63","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple Combinations of\u00a0Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib64","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib65","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.devcel.2024.07.021_bib66","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s41467-021-21583-9","article-title":"Comprehensive analysis of single cell ATAC-seq data with SnapATAC","volume":"12","author":"Fang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.07.021_bib67","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: Large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib68","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ng959","article-title":"The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors","volume":"32","author":"Kawaguchi","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.devcel.2024.07.021_bib69","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1101\/gad.943001","article-title":"Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev","volume":"15","author":"Jackson","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2024.07.021_bib70","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2004.11.004","article-title":"Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome","volume":"119","author":"Olive","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib71","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.devcel.2024.07.021_bib72","first-page":"259","article-title":"Primary explant cultures of adult and embryonic pancreas","volume":"103","author":"Esni","year":"2005","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.devcel.2024.07.021_bib73","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fphys.2018.00129","article-title":"DIE-RNA: A reproducible strategy for the digestion of normal and injured pancreas, isolation of pancreatic cells from genetically engineered mouse models and extraction of high quality RNA","volume":"9","author":"Assi","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.devcel.2024.07.021_bib74","unstructured":"EpiCypher. (2022). CUTANA Cross-linking Protocol v1.9 EpiCypher \u00ae CUTANA TM Cross-linking Protocol. https:\/\/www.epicypher.com\/content\/documents\/protocols\/cut-and-run-cross-linking-protocol.pdf."},{"key":"10.1016\/j.devcel.2024.07.021_bib75","author":"Janssens"},{"key":"10.1016\/j.devcel.2024.07.021_bib76","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46314","article-title":"Improved cut&run chromatin profiling tools","volume":"8","author":"Meers","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2024.07.021_bib77","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cell.2018.03.016","article-title":"Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.07.021_bib78","author":"Liu"},{"key":"10.1016\/j.devcel.2024.07.021_bib79","series-title":"FastQC: a quality control tool for high throughput sequence data","author":"Andrews","year":"2010"},{"key":"10.1016\/j.devcel.2024.07.021_bib80","series-title":"Broad Institute, GitHub Repository","year":"2019"},{"key":"10.1016\/j.devcel.2024.07.021_bib81","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"RSeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.devcel.2024.07.021_bib82","first-page":"275","article-title":"False discovery rates: a new deal","volume":"18","author":"Stephens","year":"2017","journal-title":"Biostatistics"},{"key":"10.1016\/j.devcel.2024.07.021_bib83","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1038\/s41467-019-10756-2","article-title":"Nuclei multiplexing with barcoded antibodies for single-nucleus genomics","volume":"10","author":"Gaublomme","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.07.021_bib84","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41591-020-0844-1","article-title":"A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors","volume":"26","author":"Slyper","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.devcel.2024.07.021_bib85","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41587-019-0206-z","article-title":"Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T\u00a0cell exhaustion","volume":"37","author":"Satpathy","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.devcel.2024.07.021_bib86","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/j.gastro.2020.09.010","article-title":"Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology","volume":"160","author":"Feldmann","year":"2021","journal-title":"Gastroenterology"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580724004830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580724004830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:21:38Z","timestamp":1778617298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580724004830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":86,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1534580724004830"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2024.07.021","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2024.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}