{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:57:17Z","timestamp":1790963837929,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016784","name":"Equipex","doi-asserted-by":"publisher","award":["ANR-10-INBS-09-08"],"award-info":[{"award-number":["ANR-10-INBS-09-08"]}],"id":[{"id":"10.13039\/100016784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"ARC Foundation for Cancer Research","doi-asserted-by":"publisher","award":["ARCPGA12019120000973_1574"],"award-info":[{"award-number":["ARCPGA12019120000973_1574"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010463","name":"Institut Curie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"French National Cancer Institute","doi-asserted-by":"publisher","award":["BIO-07-ICR-1"],"award-info":[{"award-number":["BIO-07-ICR-1"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.devcel.2024.12.005","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T10:38:43Z","timestamp":1735209523000},"page":"1018-1035.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression"],"prefix":"10.1016","volume":"60","author":[{"given":"David","family":"Remy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Antoine-Bally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"de Tocqueville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Jolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Mac\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Champenois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Nemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Raynal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amulya","family":"Priya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le","family":"Berlioz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Dahmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Meseure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-733X","authenticated-orcid":false,"given":"Philippe","family":"Chavrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2024.12.005_bib1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10549-018-4697-y","article-title":"Targeting the PI3K\/AKT\/mTOR pathway in triple-negative breast cancer: a review","volume":"169","author":"Costa","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.devcel.2024.12.005_bib2","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41568-018-0074-8","article-title":"mTOR signalling and cellular metabolism are mutual determinants in cancer","volume":"18","author":"Mossmann","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2024.12.005_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib4","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.cell.2022.04.013","article-title":"mTOR substrate phosphorylation in growth control","volume":"185","author":"Battaglioni","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41586-020-2444-0","article-title":"A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome","volume":"585","author":"Napolitano","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.12.005_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.707372","article-title":"The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging","volume":"2","author":"Fernandes","year":"2021","journal-title":"Front. Aging"},{"key":"10.1016\/j.devcel.2024.12.005_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.12.005_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-cancerbio-030518-055835","article-title":"MiT\/TFE Family of Transcription Factors, Lysosomes, and Cancer","volume":"3","author":"Perera","year":"2019","journal-title":"Annu. Rev. Cancer Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.aax0364","article-title":"Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex","volume":"366","author":"Lawrence","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.12.005_bib10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41586-022-05652-7","article-title":"Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex","volume":"614","author":"Cui","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.12.005_bib11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/0008-5472.CAN-14-2211","article-title":"Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein","volume":"75","author":"Kamphorst","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2024.12.005_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms16031","article-title":"Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions","volume":"8","author":"Olivares","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.12.005_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.12703\/r\/10-39","article-title":"Tissue remodeling by invadosomes","volume":"10","author":"Cambi","year":"2021","journal-title":"Fac Rev"},{"key":"10.1016\/j.devcel.2024.12.005_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41580-022-00530-6","article-title":"Mechanisms and roles of podosomes and invadopodia","volume":"24","author":"Linder","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrm3141","article-title":"The \u2018ins\u2019 and \u2018outs\u2019 of podosomes and invadopodia: characteristics, formation and function","volume":"12","author":"Murphy","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev-cellbio-111315-125227","article-title":"Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion","volume":"32","author":"Castro-Castro","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12930-y","article-title":"MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion","volume":"10","author":"Ferrari","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2024.12.005_bib18","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201910132","article-title":"Intersection of TKS5 and FGD1\/CDC42 signaling cascades directs the formation of invadopodia","volume":"219","author":"Zagryazhskaya-Masson","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib19","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1158\/0008-5472.CAN-10-4376","article-title":"Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors","volume":"71","author":"Perentes","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2024.12.005_bib20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/onc.2015.87","article-title":"p63\/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer","volume":"35","author":"Lodillinsky","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.devcel.2024.12.005_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.devcel.2018.08.025","article-title":"Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs","volume":"47","author":"Feinberg","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib22","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1101\/gad.1451806","article-title":"A cancer cell metalloprotease triad regulates the basement membrane transmigration program","volume":"20","author":"Hotary","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2024.12.005_bib23","article-title":"mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1-MMP Endocytosis Arrest","volume":"8","author":"Colombero","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.devcel.2024.12.005_bib24","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1080\/15548627.2023.2239633","article-title":"Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A\/TKS5-MMP14 pathway in ovarian carcinoma","volume":"19","author":"Lin","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.devcel.2024.12.005_bib25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1083\/jcb.200709076","article-title":"The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA","volume":"181","author":"Sakurai-Yageta","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add9084","article-title":"Codependencies of mTORC1 signaling and endolysosomal actin structures","volume":"9","author":"Priya","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.devcel.2024.12.005_bib27","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.12.005_bib28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2017.09.046","article-title":"mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient","volume":"171","author":"Wyant","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.devcel.2024.12.005_bib30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/emboj.2012.32","article-title":"A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB","volume":"31","author":"Settembre","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.devcel.2024.12.005_bib31","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.devcel.2024.12.005_bib32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib33","first-page":"E1373","article-title":"Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.12.005_bib34","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.213587","article-title":"Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence","volume":"131","author":"Choy","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.devcel.2024.12.005_bib35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature07782","article-title":"Tumours with PI3K activation are resistant to dietary restriction","volume":"458","author":"Kalaany","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2024.12.005_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-0716-2887-4_14","article-title":"Invadopodia Methods: Detection of Invadopodia Formation and Activity in Cancer Cells Using Reconstituted 2D and 3D Collagen-Based Matrices","volume":"2608","author":"Remy","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib37","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1083\/jcb.201306162","article-title":"Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia","volume":"203","author":"Monteiro","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib38","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1016\/j.cell.2021.08.035","article-title":"Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion","volume":"184","author":"Nader","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2010.09.026","article-title":"Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress","volume":"40","author":"SenGupta","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib40","article-title":"The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage","volume":"7","author":"Brady","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2024.12.005_bib41","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1158\/0008-5472.CAN-08-3709","article-title":"Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells","volume":"69","author":"Liz\u00e1rraga","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2024.12.005_bib42","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1083\/jcb.201903006","article-title":"TFEB controls retromer expression in response to nutrient availability","volume":"218","author":"Curnock","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib43","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201812098","article-title":"SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis","volume":"219","author":"Sharma","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib44","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1101\/gad.213827.113","article-title":"A RANKL-PKCbeta-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts","volume":"27","author":"Ferron","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.devcel.2024.12.005_bib45","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.cmet.2023.02.006","article-title":"Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity","volume":"35","author":"Ozcan","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.devcel.2024.12.005_bib46","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jalz.2017.07.754","article-title":"Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs","volume":"14","author":"Parcon","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.devcel.2024.12.005_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215918","article-title":"Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming","volume":"550","author":"Zhang","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.devcel.2024.12.005_bib48","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1096\/fj.09-149518","article-title":"NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space","volume":"24","author":"Busco","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.devcel.2024.12.005_bib49","article-title":"A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB","volume":"120","author":"Lin","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2024.12.005_bib50","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cell.2016.08.041","article-title":"A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds","volume":"167","author":"Bruna","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib51","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1002\/ijc.32266","article-title":"A large collection of integrated genomically characterized patient-derived xenografts highlighting the heterogeneity of triple-negative breast cancer","volume":"145","author":"Coussy","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.devcel.2024.12.005_bib52","doi-asserted-by":"crossref","first-page":"48206","DOI":"10.18632\/oncotarget.10195","article-title":"Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers","volume":"7","author":"Hatem","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.devcel.2024.12.005_bib53","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ccr.2008.03.007","article-title":"Regulation of in situ to invasive breast carcinoma transition","volume":"13","author":"Hu","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-63310-2","article-title":"Co-targeting EGFR and mTOR with gefitinib and everolimus in triple-negative breast cancer cells","volume":"10","author":"El Guerrab","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2024.12.005_bib55","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/jamaoncol.2016.5281","article-title":"Targeting the PI3K\/AKT\/mTOR Pathway for the Treatment of Mesenchymal Triple-Negative Breast Cancer: Evidence From a Phase 1 Trial of mTOR Inhibition in Combination With Liposomal Doxorubicin and Bevacizumab","volume":"3","author":"Basho","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.devcel.2024.12.005_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002406","article-title":"The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism","volume":"22","author":"Nazemi","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib57","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/ijc.22572","article-title":"Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts","volume":"120","author":"Tait","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.devcel.2024.12.005_bib58","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ncb1420","article-title":"p63 regulates an adhesion programme and cell survival in epithelial cells","volume":"8","author":"Carroll","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.devcel.2013.11.019","article-title":"Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1","volume":"28","author":"Forster","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10911-005-9586-4","article-title":"Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia","volume":"10","author":"Gudjonsson","year":"2005","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.devcel.2024.12.005_bib61","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tcb.2022.08.003","article-title":"\u0394Np63alpha in cancer: importance and therapeutic opportunities","volume":"33","author":"Fisher","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib62","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.cell.2013.11.029","article-title":"Collective invasion in breast cancer requires a conserved basal epithelial program","volume":"155","author":"Cheung","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2024.12.005_bib63","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1172\/JCI45014","article-title":"Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies","volume":"121","author":"Lehmann","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2024.12.005_bib64","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.febslet.2011.03.010","article-title":"The role of LKB1 and AMPK in cellular responses to stress and damage","volume":"585","author":"Alexander","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.devcel.2024.12.005_bib65","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-021-08844-y","article-title":"TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study","volume":"21","author":"Bertozzi","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.devcel.2024.12.005_bib66","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.clbc.2016.11.006","article-title":"Transcription Factor EB Expression in Early Breast Cancer Relates to Lysosomal\/Autophagosomal Markers and Prognosis","volume":"17","author":"Giatromanolaki","year":"2017","journal-title":"Clin. Breast Cancer"},{"key":"10.1016\/j.devcel.2024.12.005_bib67","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144871","article-title":"Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis","volume":"131","author":"El-Houjeiri","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.devcel.2024.12.005_bib68","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1016\/j.csbj.2021.07.014","article-title":"Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer","volume":"19","author":"Gy\u0151rffy","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.devcel.2024.12.005_bib69","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/jnci\/92.14.1185a","article-title":"MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ","volume":"92","author":"Miller","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.devcel.2024.12.005_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002790","article-title":"The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis","volume":"5","author":"Roczniak-Ferguson","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2024.12.005_bib71","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nn.3787","article-title":"Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA","volume":"17","author":"Cortes","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.devcel.2024.12.005_bib72","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.M111023200","article-title":"Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter","volume":"277","author":"Korchynskyi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2024.12.005_bib73","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.devcel.2024.12.005_bib75","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2024.12.005_bib78","doi-asserted-by":"crossref","DOI":"10.5334\/jors.bl","article-title":"PIVlab \u2013 Towards User-friendly, Affordable and Accurate Digital Particle Image Velocimetry in MATLAB","volume":"2","author":"Thielicke","year":"2014","journal-title":"J. Open Res. Softw."},{"key":"10.1016\/j.devcel.2024.12.005_bib74","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41556-022-00976-y","article-title":"A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids","volume":"24","author":"Gollwitzer","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib76","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/bit.10655","article-title":"Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types","volume":"83","author":"Kelm","year":"2003","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.devcel.2024.12.005_bib77","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejcb.2010.09.004","article-title":"HDAC6 is required for invadopodia activity and invasion by breast tumor cells","volume":"90","author":"Rey","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.devcel.2024.12.005_bib79","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.devcel.2024.12.005_bib80","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2024.12.005_bib81","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12859-017-1674-0","article-title":"Ranking metrics in gene set enrichment analysis: do they matter?","volume":"18","author":"Zyla","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.devcel.2024.12.005_bib82","first-page":"4244s","article-title":"Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors","volume":"46","author":"McCarty","year":"1986","journal-title":"Cancer Res."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580724007275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580724007275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:03:59Z","timestamp":1762549439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580724007275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":82,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1534580724007275"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2024.12.005","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2024.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}