{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:51:59Z","timestamp":1790232719623,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P01HD093393"],"award-info":[{"award-number":["P01HD093393"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SCR_013731"],"award-info":[{"award-number":["SCR_013731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SCR_003280"],"award-info":[{"award-number":["SCR_003280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","award":["SCR_022630"],"award-info":[{"award-number":["SCR_022630"]}],"id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.devcel.2025.04.026","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:32:29Z","timestamp":1747996349000},"page":"2487-2502.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-2569","authenticated-orcid":false,"given":"Nicole A.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhish","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary N.","family":"Agricola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan P.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kofron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-3590","authenticated-orcid":false,"given":"Aaron M.","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2025.04.026_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ydbio.2021.05.015","article-title":"Developmental basis of trachea-esophageal birth defects","volume":"477","author":"Edwards","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1089\/scd.2020.0075","article-title":"Genetic Mouse Models and Induced Pluripotent Stem Cells for Studying Tracheal-Esophageal Separation and Esophageal Development","volume":"29","author":"Raad","year":"2020","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.devcel.2025.04.026_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-019-0077-0","article-title":"Oesophageal atresia","volume":"5","author":"van Lennep","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.devcel.2025.04.026_bib4","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/00005537-200308000-00010","article-title":"Complete laryngotracheoesophageal cleft: complicated management issues","volume":"113","author":"Chitkara","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.devcel.2025.04.026_bib5","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/MPG.0b013e3182a373dc","article-title":"Chromosome aberrations and gene mutations in patients with esophageal atresia","volume":"57","author":"Bednarczyk","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.devcel.2025.04.026_bib6","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/ajmg.a.38303","article-title":"Associated anomalies in cases with esophageal atresia","volume":"173","author":"Stoll","year":"2017","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.devcel.2025.04.026_bib7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ejmg.2014.05.009","article-title":"Clinical and etiological heterogeneity in patients with tracheo-esophageal malformations and associated anomalies","volume":"57","author":"Brosens","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.devcel.2025.04.026_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/dvdy.21075","article-title":"Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia","volume":"236","author":"Li","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.devcel.2025.04.026_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.devcel.2009.06.005","article-title":"Wnt2\/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut","volume":"17","author":"Goss","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib10","doi-asserted-by":"crossref","first-page":"16287","DOI":"10.1073\/pnas.0902274106","article-title":"beta-Catenin promotes respiratory progenitor identity in mouse foregut","volume":"106","author":"Harris-Johnson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2025.04.026_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.celrep.2016.05.060","article-title":"A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification","volume":"16","author":"Rankin","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2025.04.026_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.devcel.2019.11.002","article-title":"Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation","volume":"51","author":"Kim","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.devcel.2019.11.003","article-title":"Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation","volume":"51","author":"Nasr","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.887107","article-title":"Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity","volume":"10","author":"Cote","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-cellbio-100818-125134","article-title":"A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo","volume":"35","author":"Pickett","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/srep33420","article-title":"The PCP pathway regulates Baz planar distribution in epithelial cells","volume":"6","author":"Aigouy","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2025.04.026_bib17","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/hmg\/10.22.2593","article-title":"Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification","volume":"10","author":"Murdoch","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.devcel.2025.04.026_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36456","article-title":"Spatial and temporal analysis of PCP protein dynamics during neural tube closure","volume":"7","author":"Butler","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.devcel.2025.04.026_bib19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.modgep.2006.07.007","article-title":"Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation","volume":"7","author":"Torban","year":"2007","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.devcel.2025.04.026_bib20","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.043448","article-title":"Membrane trafficking in health and disease","volume":"13","author":"Yarwood","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.devcel.2025.04.026_bib21","article-title":"Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas","volume":"3","author":"Zhong","year":"2022","journal-title":"HGG Adv."},{"key":"10.1016\/j.devcel.2025.04.026_bib22","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2025.04.026_bib23","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/dvg.22720","article-title":"Simple and efficient CRISPR\/Cas9-mediated targeted mutagenesis in Xenopus tropicalis","volume":"51","author":"Nakayama","year":"2013","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2025.04.026_bib24","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1242\/dev.099853","article-title":"Efficient RNA\/Cas9-mediated genome editing in Xenopus tropicalis","volume":"141","author":"Guo","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.devcel.2025.04.026_bib25","doi-asserted-by":"crossref","first-page":"11540","DOI":"10.1074\/jbc.M608351200","article-title":"Increased Internalization of p120-uncoupled E-cadherin and a Requirement for a Dileucine Motif in the Cytoplasmic Domain for Endocytosis of the Protein","volume":"282","author":"Miyashita","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2025.04.026_bib26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrm.2017.11","article-title":"Planar cell polarity in development and disease","volume":"18","author":"Butler","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/joa.12676","article-title":"The core planar cell polarity gene, Vangl2, maintains apical-basal organisation of the corneal epithelium","volume":"234","author":"Panzica","year":"2019","journal-title":"J. Anat."},{"key":"10.1016\/j.devcel.2025.04.026_bib28","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1242\/dev.034066","article-title":"Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2","volume":"136","author":"vandenBerg","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.devcel.2025.04.026_bib29","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/ncb2284","article-title":"Mitotic internalization of planar cell polarity proteins preserves tissue polarity","volume":"13","author":"Devenport","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib30","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1091\/mbc.E20-10-0669","article-title":"Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins","volume":"32","author":"Ecker","year":"2021","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.devcel.2018.03.008","article-title":"The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A","volume":"45","author":"Puri","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib32","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1681\/ASN.2005121277","article-title":"Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells","volume":"17","author":"Yang","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.devcel.2025.04.026_bib33","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2004.12.023","article-title":"AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly","volume":"120","author":"Dong","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0896-6273(00)80519-X","article-title":"Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles","volume":"21","author":"Kantheti","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.devcel.2025.04.026_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ncb1244","article-title":"Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2\/3 complex and F-actin dynamics","volume":"7","author":"Dubois","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.gene.2018.06.078","article-title":"WIP\/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions","volume":"674","author":"Gryaznova","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.devcel.2025.04.026_bib37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41431-020-0680-2","article-title":"Novel candidate genes in esophageal atresia\/tracheoesophageal fistula identified by exome sequencing","volume":"29","author":"Wang","year":"2021","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.devcel.2025.04.026_bib38","article-title":"Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia","volume":"15","author":"Zhang","year":"2020","journal-title":"PLOS One"},{"key":"10.1016\/j.devcel.2025.04.026_bib39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cub.2009.12.021","article-title":"Endocytosis is required for efficient apical constriction during Xenopus gastrulation","volume":"20","author":"Lee","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4734","article-title":"Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure","volume":"5","author":"Ossipova","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2025.04.026_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1242\/dev.111161","article-title":"Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation","volume":"142","author":"Ossipova","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.devcel.2025.04.026_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ydbio.2008.03.017","article-title":"Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum","volume":"318","author":"Seifert","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib43","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1006\/dbio.1993.1263","article-title":"Descriptive and Experimental Analysis of the Epithelial Remodellings That Control Semicircular Canal Formation in the Developing Mouse Inner Ear","volume":"159","author":"Martin","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.semcdb.2016.09.015","article-title":"Sculpting the labyrinth: Morphogenesis of the developing inner ear","volume":"65","author":"Alsina","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107677","article-title":"Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity","volume":"31","author":"Flasse","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2025.04.026_bib46","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.devcel.2024.03.010","article-title":"Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation","volume":"59","author":"Paramore","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib47","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202692","article-title":"Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex","volume":"151","author":"Paramore","year":"2024","journal-title":"Development"},{"key":"10.1016\/j.devcel.2025.04.026_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ydbio.2023.05.002","article-title":"Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass","volume":"499","author":"Barlow","year":"2023","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ydbio.2018.01.012","article-title":"Getting direction(s): The Eph\/ephrin signaling system in cell positioning","volume":"447","author":"Niethamer","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110510","article-title":"Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting","volume":"38","author":"Lewis","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2025.04.026_bib51","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ydbio.2015.08.021","article-title":"Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature","volume":"406","author":"Lewis","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib52","doi-asserted-by":"crossref","first-page":"32030","DOI":"10.1074\/jbc.M113.538223","article-title":"Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion","volume":"289","author":"Yu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2025.04.026_bib53","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.devcel.2009.11.005","article-title":"Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits","volume":"17","author":"Ferguson","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2025.04.026_bib54","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1021\/bi500400g","article-title":"Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting","volume":"53","author":"Iliescu","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.devcel.2025.04.026_bib55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/bdra.23305","article-title":"Expanding the mutational spectrum associated to neural tube defects: literature revision and description of novel VANGL1 mutations","volume":"103","author":"Merello","year":"2015","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.devcel.2025.04.026_bib56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/path.5158","article-title":"Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury","volume":"246","author":"Papakrivopoulou","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.devcel.2025.04.026_bib57","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.yexcr.2014.11.003","article-title":"Planar cell polarity of the kidney","volume":"343","author":"Schnell","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.devcel.2025.04.026_bib58","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/bdra.23291","article-title":"Promoter methylation and expression of the VANGL2 gene in the myocardium of pediatric patients with tetralogy of fallot","volume":"100","author":"Yuan","year":"2014","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.devcel.2025.04.026_bib59","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s00246-018-1860-5","article-title":"Planar Cell Polarity Signaling in Mammalian Cardiac Morphogenesis","volume":"39","author":"Li","year":"2018","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.devcel.2025.04.026_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4161\/org.7.3.18462","article-title":"Planar polarity: A new player in both lung development and disease","volume":"7","author":"Yates","year":"2011","journal-title":"Organogenesis"},{"key":"10.1016\/j.devcel.2025.04.026_bib61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4939-8784-9_2","article-title":"Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos","volume":"1865","author":"Wlizla","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib62","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nmeth.3543","article-title":"CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo","volume":"12","author":"Moreno-Mateos","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.devcel.2025.04.026_bib63","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41586-018-0686-x","article-title":"Predictable and precise template-free CRISPR editing of pathogenic variants","volume":"563","author":"Shen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2025.04.026_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71412-0","article-title":"Maximizing CRISPR\/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos","volume":"10","author":"Naert","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.devcel.2025.04.026_bib65","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gky354","article-title":"CRISPOR: intuitive guide selection for CRISPR\/Cas9 genome editing experiments and screens","volume":"46","author":"Concordet","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2025.04.026_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1534\/genetics.117.300468","article-title":"Tissue-Specific Gene Inactivation in Xenopus laevis: Knockout of lhx1 in the Kidney with CRISPR\/Cas9","volume":"208","author":"DeLay","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.devcel.2025.04.026_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku936","article-title":"Easy quantitative assessment of genome editing by sequence trace decomposition","volume":"42","author":"Brinkman","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.devcel.2025.04.026_bib68","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.cub.2016.05.036","article-title":"Maintenance of the Epithelial Barrier and Remodeling of Cell-Cell Junctions during Cytokinesis","volume":"26","author":"Higashi","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2025.04.026_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23329","article-title":"Novel vectors for functional interrogation of Xenopus ORFeome coding sequences","volume":"57","author":"Sterner","year":"2019","journal-title":"Genesis"},{"key":"10.1016\/j.devcel.2025.04.026_bib70","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3432","article-title":"Measurement of Mitotic Spindle Angle and Mitotic Cell Distance in Fixed Tissue of Drosophila Larval Brains","volume":"9","author":"Franco","year":"2019","journal-title":"Bio Protoc."}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580725002862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580725002862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:16:08Z","timestamp":1773263768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580725002862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":70,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1534580725002862"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2025.04.026","relation":{},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2025.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}