{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:51:13Z","timestamp":1787741473042,"version":"build-2784847793"},"reference-count":81,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,8]],"date-time":"2027-04-08T00:00:00Z","timestamp":1807142400000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002920","name":"University Grants Committee Research Grants Council","doi-asserted-by":"publisher","award":["17210520"],"award-info":[{"award-number":["17210520"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-000653"],"award-info":[{"award-number":["MOH-000653"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12272332"],"award-info":[{"award-number":["12272332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1163462"],"award-info":[{"award-number":["1163462"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1136592"],"award-info":[{"award-number":["1136592"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-MSG-2023-0001"],"award-info":[{"award-number":["NRF-MSG-2023-0001"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP220103951"],"award-info":[{"award-number":["DP220103951"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007672","name":"Mechanobiology Institute, Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Cell"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.devcel.2026.01.016","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:46:34Z","timestamp":1772639194000},"page":"787-803.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiscale mechanisms driving tissue rupture by invading cells"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-8467","authenticated-orcid":false,"given":"Selwin K.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine Z.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Bao-Xian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mui Hoon","family":"Nai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Shagirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine Fei Li","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzie","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.P.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marcq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpha S.","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chwee Teck","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Hiraiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Chuan","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.devcel.2026.01.016_bib1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.cell.2011.11.016","article-title":"Cancer invasion and the microenvironment: plasticity and reciprocity","volume":"147","author":"Friedl","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2026.01.016_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","article-title":"Ovarian cancer metastasis: integrating insights from disparate model organisms","volume":"5","author":"Naora","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.devcel.2026.01.016_bib3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ydbio.2010.05.005","article-title":"Neural crest migration: patterns, phases and signals","volume":"344","author":"Kulesa","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1126\/science.abj0425","article-title":"Cell division in tissues enables macrophage infiltration","volume":"376","author":"Akhmanova","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.devcel.2026.01.016_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fcell.2019.00250","article-title":"Developmental Stage-Specific Distribution of Macrophages in Mouse Mammary Gland","volume":"7","author":"Stewart","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib6","doi-asserted-by":"crossref","first-page":"E854","DOI":"10.1073\/pnas.1508541113","article-title":"Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters","volume":"113","author":"Cheung","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2026.01.016_bib7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.aaz4741","article-title":"Tissue topography steers migrating Drosophila border cells","volume":"370","author":"Dai","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.devcel.2026.01.016_bib8","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2014.03.045","article-title":"Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration","volume":"157","author":"Cai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2026.01.016_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1082857","article-title":"Editorial: Forces in biology - Cell and developmental mechanobiology and its implications in disease - Volume II","volume":"10","author":"Wu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.598179","article-title":"Editorial: Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Iwanicki","year":"2011","journal-title":"Cancer Discov."},{"key":"10.1016\/j.devcel.2026.01.016_bib12","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1172\/JCI74778","article-title":"Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion","volume":"124","author":"Kenny","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.devcel.2026.01.016_bib13","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1172\/JCI69815","article-title":"Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance","volume":"124","author":"Davidowitz","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.devcel.2026.01.016_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19584-1","article-title":"Transient commensal clonal interactions can drive tumor metastasis","volume":"11","author":"Naffar-Abu Amara","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.devcel.2026.01.016_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1440-1843.2002.00404.x","article-title":"Mesothelial cells: their structure, function and role in serosal repair","volume":"7","author":"Mutsaers","year":"2002","journal-title":"Respirology"},{"key":"10.1016\/j.devcel.2026.01.016_bib16","first-page":"490","article-title":"AN ELECTRON MICROSCOPIC STUDY OF THE INVASION OF ASCITES TUMOR CELLS INTO THE ABDOMINAL WALL","volume":"25","author":"Birbeck","year":"1965","journal-title":"Cancer Res."},{"key":"10.1016\/j.devcel.2026.01.016_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molonc.2007.02.004","article-title":"The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression","volume":"1","author":"Kenny","year":"2007","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.devcel.2026.01.016_bib18","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.89.148304","article-title":"Cracks and crazes: on calculating the macroscopic fracture energy of glassy polymers from molecular simulations","volume":"89","author":"Rottler","year":"2002","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.devcel.2026.01.016_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022458","article-title":"Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens","volume":"6","author":"Smutny","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.devcel.2026.01.016_bib20","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1091\/mbc.e05-04-0330","article-title":"Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts","volume":"16","author":"Shewan","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2026.01.016_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fcell.2019.00090","article-title":"Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II","volume":"7","author":"Wu","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib22","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1016\/j.celrep.2017.02.078","article-title":"Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility","volume":"18","author":"Acharya","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.devcel.2026.01.016_bib23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41567-020-01134-7","article-title":"Motility-induced fracture reveals a ductile-to-brittle crossover in a simple animal\u2019s epithelia","volume":"17","author":"Prakash","year":"2021","journal-title":"Nat. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib24","series-title":"Failure Analysis and Fractography of Polymer Composites","author":"Greenhalgh","year":"2009"},{"key":"10.1016\/j.devcel.2026.01.016_bib25","series-title":"Fracture Mechanics: Fundamentals and Applications","author":"Anderson","year":"2017"},{"key":"10.1016\/j.devcel.2026.01.016_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41567-022-01826-2","article-title":"Mechanical stress driven by rigidity sensing governs epithelial stability","volume":"19","author":"Sonam","year":"2023","journal-title":"Nat. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/s41567-024-02504-1","article-title":"Active hole formation in epithelioid tissues","volume":"20","author":"Lv","year":"2024","journal-title":"Nat. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10452-005-6567-z","article-title":"Basics and principles of particle image velocimetry (PIV) for mapping biogenic and biologically relevant flows","volume":"40","author":"Stamhuis","year":"2006","journal-title":"Aquat. Ecol."},{"key":"10.1016\/j.devcel.2026.01.016_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ydbio.2009.09.009","article-title":"Apical constriction: a cell shape change that can drive morphogenesis","volume":"341","author":"Sawyer","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib30","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1242\/dev.102228","article-title":"Apical constriction: themes and variations on a cellular mechanism driving morphogenesis","volume":"141","author":"Martin","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.devcel.2026.01.016_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature07522","article-title":"Pulsed contractions of an actin-myosin network drive apical constriction","volume":"457","author":"Martin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2026.01.016_bib32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1083\/jcb.200910099","article-title":"Integration of contractile forces during tissue invagination","volume":"188","author":"Martin","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/15419061.2013.856889","article-title":"Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions","volume":"20","author":"Wu","year":"2013","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.devcel.2026.01.016_bib34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.201603077","article-title":"RhoA GTPase inhibition organizes contraction during epithelial morphogenesis","volume":"214","author":"Mason","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ejcb.2014.09.001","article-title":"Pulsatile contractility of actomyosin networks organizes the cellular cortex at lateral cadherin junctions","volume":"93","author":"Wu","year":"2014","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib36","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.bpj.2016.03.002","article-title":"Inference of Internal Stress in a Cell Monolayer","volume":"110","author":"Nier","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.devcel.2026.01.016_bib37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrm2957","article-title":"Cell adhesion: integrating cytoskeletal dynamics and cellular tension","volume":"11","author":"Parsons","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ncb2900","article-title":"Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia","volume":"16","author":"Wu","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib39","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrm.2017.98","article-title":"Mechanobiology of collective cell behaviours","volume":"18","author":"Ladoux","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4161\/15384101.2014.989127","article-title":"Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer","volume":"14","author":"Wu","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.devcel.2026.01.016_bib41","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1091\/mbc.E14-07-1223","article-title":"An RPTPalpha\/Src family kinase\/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions","volume":"26","author":"Gomez","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.devcel.2026.01.016_bib42","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1074\/jbc.M113.544478","article-title":"Cortactin scaffolds Arp2\/3 and WAVE2 at the epithelial zonula adherens","volume":"289","author":"Han","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.devcel.2026.01.016_bib43","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.cub.2014.06.028","article-title":"Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens","volume":"24","author":"Leerberg","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib44","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.121.2.469","article-title":"Inhibition of fibronectin binding and fibronectin-mediated cell adhesion to collagen by a peptide from the second type I repeat of thrombospondin","volume":"121","author":"Sipes","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib45","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/430973a","article-title":"Anoikis: cancer and the homeless cell","volume":"430","author":"Liotta","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2026.01.016_bib46","first-page":"3666","article-title":"Star-convex polyhedra for 3D object detection and segmentation in microscopy","author":"Weigert","year":"2020","journal-title":"arXiv"},{"key":"10.1016\/j.devcel.2026.01.016_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.104140","article-title":"Protocol for AI-assisted quantitative analysis and setup of tumor spheroid invasion into tissue","volume":"6","author":"Ho","year":"2025","journal-title":"Star Protoc."},{"key":"10.1016\/j.devcel.2026.01.016_bib48","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41556-020-0552-6","article-title":"Cell-cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion","volume":"22","author":"Ilina","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib49","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-018-0479-2","article-title":"A fluid-to-solid jamming transition underlies vertebrate body axis elongation","volume":"561","author":"Mongera","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2026.01.016_bib50","article-title":"RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics","volume":"12","author":"Lemahieu","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.devcel.2026.01.016_bib51","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41580-023-00688-7","article-title":"Adherens junctions as molecular regulators of emergent tissue mechanics","volume":"25","author":"Camp\u00e0s","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib52","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/s41567-021-01215-1","article-title":"Embryonic Tissues as Active Foams","volume":"17","author":"Kim","year":"2021","journal-title":"Nat. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib53","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1083\/jcb.201802144","article-title":"Myoepithelial cells are a dynamic barrier to epithelial dissemination","volume":"217","author":"Sirka","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib54","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41586-019-1044-3","article-title":"Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects","volume":"568","author":"M\u00fcnster","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2026.01.016_bib55","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41586-019-1492-9","article-title":"Genetic induction and mechanochemical propagation of a morphogenetic wave","volume":"572","author":"Bailles","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2026.01.016_bib56","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1103\/RevModPhys.57.827","article-title":"Wetting: statics and dynamics","volume":"57","author":"de Gennes","year":"1985","journal-title":"Rev. Mod. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib57","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.devcel.2026.01.016_bib58","doi-asserted-by":"crossref","DOI":"10.5334\/jors.bl","article-title":"PIVlab \u2013 Towards User-friendly, Affordable and Accurate Digital Particle Image Velocimetry in MATLAB","volume":"2","author":"Thielicke","year":"2014","journal-title":"J. Open Res. Softw."},{"key":"10.1016\/j.devcel.2026.01.016_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100098","article-title":"A Biologist's Guide to Traction Force Microscopy Using Polydimethylsiloxane Substrate for Two-Dimensional Cell Cultures","volume":"1","author":"Teo","year":"2020","journal-title":"Star Protoc."},{"key":"10.1016\/j.devcel.2026.01.016_bib60","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5334\/jors.334","article-title":"Particle Image Velocimetry for MATLAB: Accuracy and enhanced algorithms in PIVlab","volume":"9","author":"Thielicke","year":"2021","journal-title":"J. Open Res. Softw."},{"key":"10.1016\/j.devcel.2026.01.016_bib61","series-title":"Study of Multicellular Architecture with Controlled Microenvironment Etude d'Architecture Multicellulaire avec le Microenvironnement Contr\u00f4l\u00e9","author":"Tseng","year":"2011"},{"key":"10.1016\/j.devcel.2026.01.016_bib62","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.devcel.2023.01.005","article-title":"Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation","volume":"58","author":"Kawaue","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2026.01.016_bib63","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/febs.17304","article-title":"A ZO-2 scaffolding mechanism regulates the Hippo signalling pathway","volume":"292","author":"Liu","year":"2025","journal-title":"FEBS J."},{"key":"10.1016\/j.devcel.2026.01.016_bib64","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1093\/hmg\/ddv298","article-title":"Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization","volume":"24","author":"Greenlees","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.devcel.2026.01.016_bib65","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cub.2011.02.018","article-title":"Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens","volume":"21","author":"Mangold","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib66","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.bpj.2014.10.045","article-title":"Self-organizing actomyosin patterns on the cell cortex at epithelial cell-cell junctions","volume":"107","author":"Moore","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.devcel.2026.01.016_bib67","article-title":"The Senescence-Associated-Secretory Phenotype constituting HIF-1\u03b1 activation is independent of micronuclei induction and associated cGAS-mediated interferon response","author":"Ho","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.devcel.2026.01.016_bib68","doi-asserted-by":"crossref","first-page":"ra16","DOI":"10.1126\/scisignal.2000098","article-title":"Mechanical signals trigger myosin II redistribution and mesoderm invagination in Drosophila embryos","volume":"2","author":"Pouille","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.devcel.2026.01.016_bib69","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1073\/pnas.1813255116","article-title":"Theory of mechanochemical patterning in biphasic biological tissues","volume":"116","author":"Recho","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2026.01.016_bib70","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2305375120","article-title":"A mechanism-based theory of cellular and tissue plasticity","volume":"120","author":"Sun","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2026.01.016_bib71","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41567-018-0279-5","article-title":"Active wetting of epithelial tissues","volume":"15","author":"P\u00e9rez-Gonz\u00e1lez","year":"2019","journal-title":"Nat. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib72","doi-asserted-by":"crossref","first-page":"R626","DOI":"10.1016\/j.cub.2013.06.019","article-title":"Three functions of cadherins in cell adhesion","volume":"23","author":"Ma\u00eetre","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib73","doi-asserted-by":"crossref","first-page":"E8618","DOI":"10.1073\/pnas.1705179114","article-title":"Cell volume change through water efflux impacts cell stiffness and stem cell fate","volume":"114","author":"Guo","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2026.01.016_bib74","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.cub.2020.02.078","article-title":"Traction Forces Control Cell-Edge Dynamics and Mediate Distance Sensitivity during Cell Polarization","volume":"30","author":"Messi","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib75","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1073\/pnas.1705492114","article-title":"Activation and synchronization of the oscillatory morphodynamics in multicellular monolayer","volume":"114","author":"Lin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.devcel.2026.01.016_bib76","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1016\/j.cell.2024.05.008","article-title":"DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells","volume":"187","author":"Hu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.devcel.2026.01.016_bib77","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41567-020-01037-7","article-title":"Theory of mechanochemical patterning and optimal migration in cell monolayers","volume":"17","author":"Boocock","year":"2020","journal-title":"Nat. Phys."},{"key":"10.1016\/j.devcel.2026.01.016_bib78","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcdb.2017.08.030","article-title":"Membrane tension: A challenging but universal physical parameter in cell biology","volume":"71","author":"Pontes","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.devcel.2026.01.016_bib79","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1140\/epje\/s10189-022-00166-6","article-title":"Compression of a pressurized spherical shell by a spherical or flat probe","volume":"45","author":"Couturier","year":"2022","journal-title":"Eur. Phys. J. E Soft Matter"},{"key":"10.1016\/j.devcel.2026.01.016_bib80","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1098\/rsif.2011.0352","article-title":"The indentation of pressurized elastic shells: from polymeric capsules to yeast cells","volume":"9","author":"Vella","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.devcel.2026.01.016_bib81","article-title":"Theca cell mechanics and tissue pressure regulate mammalian ovarian folliculogenesis","author":"Biswas","year":"2024","journal-title":"bioRxiv"}],"container-title":["Developmental Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580726000390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1534580726000390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:15:36Z","timestamp":1783541736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580726000390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1534580726000390"],"URL":"https:\/\/doi.org\/10.1016\/j.devcel.2026.01.016","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.25.559247","asserted-by":"object"}]},"ISSN":["1534-5807"],"issn-type":[{"value":"1534-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiscale mechanisms driving tissue rupture by invading cells","name":"articletitle","label":"Article Title"},{"value":"Developmental Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.devcel.2026.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}