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Med."},{"key":"10.1016\/j.devcel.2026.02.018_bib195","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature13772","article-title":"Synaptic, transcriptional and chromatin genes disrupted in autism","volume":"515","author":"De Rubeis","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.devcel.2026.02.018_bib196","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: Increased ratio of excitation\/inhibition in key neural systems","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.devcel.2026.02.018_bib197","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nn.4420","article-title":"Lessons learned from studying syndromic autism spectrum disorders","volume":"19","author":"Sztainberg","year":"2016","journal-title":"Nat. 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Evol."},{"key":"10.1016\/j.devcel.2026.02.018_bib201","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.devcel.2010.05.017","article-title":"CDK5RAP2 regulates centriole engagement and cohesion in mice","volume":"18","author":"Barrera","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.devcel.2026.02.018_bib202","doi-asserted-by":"crossref","first-page":"15520","DOI":"10.1523\/JNEUROSCI.4630-09.2009","article-title":"Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice","volume":"29","author":"Youn","year":"2009","journal-title":"J. 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