{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:52:37Z","timestamp":1791978757800,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL155815"],"award-info":[{"award-number":["R01HL155815"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014221","name":"Heritage Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2444815"],"award-info":[{"award-number":["2444815"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2145802"],"award-info":[{"award-number":["2145802"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023015","name":"Advanced Research Projects Agency for Health","doi-asserted-by":"publisher","award":["ARPA-H-ICHUB-24-101-504"],"award-info":[{"award-number":["ARPA-H-ICHUB-24-101-504"]}],"id":[{"id":"10.13039\/100023015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Device"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.device.2026.101299","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:30:40Z","timestamp":1789140640000},"page":"101299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiplex ovarian hormone monitoring in sweat using a dual-aptamer wearable sensor"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6774-1125","authenticated-orcid":false,"given":"Yerim","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-6825","authenticated-orcid":false,"given":"Cui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-034X","authenticated-orcid":false,"given":"Jeonghee","family":"Yeom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-1473","authenticated-orcid":false,"given":"Jihong","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-4562","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.device.2026.101299_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13390","article-title":"Estradiol action in the female hypothalamo\u2013pituitary\u2013gonadal axis","volume":"36","author":"Moenter","year":"2024","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.device.2026.101299_bib2","first-page":"149","article-title":"Neuroendocrine Control of the Menstrual Cycle. Yen and Jaffe\u2019s Reproductive","author":"Hall","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.device.2026.101299_bib3","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.rbmo.2014.02.003","article-title":"Novel aspects of the endocrinology of the menstrual cycle","volume":"28","author":"Messinis","year":"2014","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.device.2026.101299_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","article-title":"What exactly is endometrial receptivity?","volume":"111","author":"Lessey","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.device.2026.101299_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2020.595183","article-title":"Luteal Phase in Assisted Reproductive Technology","volume":"2","author":"Tesarik","year":"2020","journal-title":"Front. Reprod. Health"},{"key":"10.1016\/j.device.2026.101299_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/259345","article-title":"Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder","volume":"2010","author":"Shechter","year":"2010","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.device.2026.101299_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/20533691241237110","article-title":"Hormone replacement therapy (HRT) in perimenopausal women with migraine","volume":"30","author":"MacGregor","year":"2024","journal-title":"Post Reprod. Health"},{"key":"10.1016\/j.device.2026.101299_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/2053369117731172","article-title":"Migraine, menopause and hormone replacement therapy","volume":"24","author":"MacGregor","year":"2018","journal-title":"Post Reprod. Health"},{"key":"10.1016\/j.device.2026.101299_bib9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0015-0282(01)02909-0","article-title":"Executive summary: stages of reproductive aging workshop (STRAW)","volume":"76","author":"Soules","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.device.2026.101299_bib10","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/jc.2011-3362","article-title":"Executive Summary of the Stages of Reproductive Aging Workshop + 10: Addressing the Unfinished Agenda of Staging Reproductive Aging","volume":"97","author":"Harlow","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.device.2026.101299_bib11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1515\/CCLM.2006.160","article-title":"Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT\u00ae analyzer","volume":"44","author":"Stricker","year":"2006","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.device.2026.101299_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/humupd\/dml020","article-title":"Ovarian feedback, mechanism of action and possible clinical implications","volume":"12","author":"Messinis","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.device.2026.101299_bib13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/jwh.2015.5556","article-title":"Perimenopause: From Research to Practice","volume":"25","author":"Santoro","year":"2016","journal-title":"J. Womens Health"},{"key":"10.1016\/j.device.2026.101299_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/gme.0b013e31817ee0c2","article-title":"Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition","volume":"16","author":"Hale","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.device.2026.101299_bib15","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1158\/1055-9965.EPI-08-0996","article-title":"Total and Unopposed Estrogen Exposure across Stages of the Transition to Menopause","volume":"18","author":"O\u2019Connor","year":"2009","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.device.2026.101299_bib16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ogc.2011.05.006","article-title":"Vasomotor Symptoms and Menopause: Findings from the Study of Women\u2019s Health across the Nation","volume":"38","author":"Thurston","year":"2011","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.device.2026.101299_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/NSS.S125807","article-title":"Sleep problems during the menopausal transition: prevalence, impact, and management challenges","volume":"10","author":"Baker","year":"2018","journal-title":"Nat. Sci. Sleep"},{"key":"10.1016\/j.device.2026.101299_bib18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jbmr.259","article-title":"Association of menopausal vasomotor symptoms with increased bone turnover during the menopausal transition","volume":"26","author":"Crandall","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.device.2026.101299_bib19","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1111\/jsm.12686","article-title":"Genitourinary Syndrome of Menopause: New Terminology for Vulvovaginal Atrophy from the International Society for the Study of Women\u2019s Sexual Health and The North American Menopause Society","volume":"11","author":"Portman","year":"2014","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.device.2026.101299_bib20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/13697137.2018.1467400","article-title":"Progesterone for the prevention and treatment of osteoporosis in women","volume":"21","author":"Prior","year":"2018","journal-title":"Climacteric"},{"key":"10.1016\/j.device.2026.101299_bib21","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1210\/jc.2015-2236","article-title":"Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline","volume":"100","author":"Stuenkel","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.device.2026.101299_bib22","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1212\/01.wnl.0000233888.18228.19","article-title":"Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen","volume":"67","author":"MacGregor","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.device.2026.101299_bib23","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1210\/jc.2012-3780","article-title":"Challenges to the Measurement of Estradiol: An Endocrine Society Position Statement","volume":"98","author":"Rosner","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.device.2026.101299_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1210\/jc.2013-2905","article-title":"Measurement of Estradiol\u2014Challenges Ahead","volume":"99","author":"Stanczyk","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.device.2026.101299_bib25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1196\/annals.1384.022","article-title":"Patterns of Salivary Estradiol and Progesterone across the Menstrual Cycle","volume":"1098","author":"Gandara","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.device.2026.101299_bib26","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1007\/s43032-021-00754-5","article-title":"Self-Monitoring of Urinary Hormones in Combination with Telemedicine \u2014 a Timely Review and Opinion Piece in Medically Assisted Reproduction","volume":"29","author":"Hart","year":"2022","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.device.2026.101299_bib27","doi-asserted-by":"crossref","DOI":"10.2196\/45139","article-title":"Innovative Approaches to Menstruation and Fertility Tracking Using Wearable Reproductive Health Technology: Systematic Review","volume":"26","author":"Lyzwinski","year":"2024","journal-title":"J. Med. Internet Res."},{"key":"10.1016\/j.device.2026.101299_bib28","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1021\/acs.chemrev.2c00823","article-title":"Skin-Interfaced Wearable Sweat Sensors for Precision Medicine","volume":"123","author":"Min","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.device.2026.101299_bib29","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1039\/C7CS00730B","article-title":"Wearable and flexible electronics for continuous molecular monitoring","volume":"48","author":"Yang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.device.2026.101299_bib30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41565-023-01513-0","article-title":"A wearable aptamer nanobiosensor for non-invasive female hormone monitoring","volume":"19","author":"Ye","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.device.2026.101299_bib31","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1152\/japplphysiol.00867.2017","article-title":"Body map of regional vs. whole body sweating rate and sweat electrolyte concentrations in men and women during moderate exercise-heat stress","volume":"124","author":"Baker","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.device.2026.101299_bib32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00421-020-04323-7","article-title":"Physiological mechanisms determining eccrine sweat composition","volume":"120","author":"Baker","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.device.2026.101299_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdermsci.2017.10.013","article-title":"Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol","volume":"89","author":"Simmers","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.device.2026.101299_bib34","doi-asserted-by":"crossref","first-page":"17990","DOI":"10.1021\/ja056555h","article-title":"A Reagentless Signal-On Architecture for Electronic, Aptamer-Based Sensors via Target-Induced Strand Displacement","volume":"127","author":"Xiao","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.device.2026.101299_bib35","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.bios.2006.10.004","article-title":"Electrochemical detection of 17\u03b2-estradiol using DNA aptamer immobilized gold electrode chip","volume":"22","author":"Kim","year":"2007","journal-title":"Biosens. Bioelectron. X."},{"key":"10.1016\/j.device.2026.101299_bib36","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1021\/ac503639s","article-title":"Aptamer-Based Label-Free Impedimetric Biosensor for Detection of Progesterone","volume":"87","author":"Contreras Jim\u00e9nez","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.device.2026.101299_bib37","article-title":"A non-invasive wearable stress patch for real-time cortisol monitoring using a pseudoknot-assisted aptamer","volume":"227","author":"Singh","year":"2023","journal-title":"Biosens. Bioelectron. X."},{"key":"10.1016\/j.device.2026.101299_bib38","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/adfm.201503316","article-title":"Inkjet-Printed Flexible Gold Electrode Arrays for Bioelectronic Interfaces","volume":"26","author":"Khan","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.device.2026.101299_bib39","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.1021\/ja9719586","article-title":"Characterization of DNA Probes Immobilized on Gold Surfaces","volume":"119","author":"Herne","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.device.2026.101299_bib40","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1038\/nprot.2007.413","article-title":"Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing","volume":"2","author":"Xiao","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.device.2026.101299_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601355","article-title":"Thin, Soft, Skin-Mounted Microfluidic Networks with Capillary Bursting Valves for Chrono-Sampling of Sweat","volume":"6","author":"Choi","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.device.2026.101299_bib42","article-title":"Confounding effects on the response of electrochemical aptamer-based biosensors","volume":"41","author":"Fontaine","year":"2023","journal-title":"Curr. Opin. Electrochem."},{"key":"10.1016\/j.device.2026.101299_bib43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bioelechem.2006.03.012","article-title":"Influence of ionic strength, pH and aptamer configuration for binding affinity to thrombin","volume":"70","author":"Hianik","year":"2007","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.device.2026.101299_bib44","article-title":"Analysis of aptamer-target binding and molecular mechanisms by thermofluorimetric analysis and molecular dynamics simulation","volume":"11","author":"Zhang","year":"2023","journal-title":"Front. Chem."},{"key":"10.1016\/j.device.2026.101299_bib45","doi-asserted-by":"crossref","first-page":"12573","DOI":"10.1039\/C9NR02797A","article-title":"Measurements of aptamer\u2013protein binding kinetics using graphene field-effect transistors","volume":"11","author":"Wang","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.device.2026.101299_bib46","doi-asserted-by":"crossref","DOI":"10.1063\/1.4921039","article-title":"The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications","volume":"9","author":"Sonner","year":"2015","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.device.2026.101299_bib47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/acssensors.4c02877","article-title":"Toward At-Home and Wearable Monitoring of Female Hormones: Emerging Nanotechnologies and Clinical Prospects","volume":"10","author":"Meng","year":"2025","journal-title":"ACS Sens."},{"key":"10.1016\/j.device.2026.101299_bib48","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1126\/science.abj9912","article-title":"Cuticular pad\u2013inspired selective frequency damper for nearly dynamic noise\u2013free bioelectronics","volume":"376","author":"Park","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.device.2026.101299_bib49","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1016\/j.cell.2023.08.016","article-title":"Menopause\u2014Biology, consequences, supportive care, and therapeutic options","volume":"186","author":"Davis","year":"2023","journal-title":"Cell"}],"container-title":["Device"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666998626002516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666998626002516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:34:39Z","timestamp":1791977679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666998626002516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"alternative-id":["S2666998626002516"],"URL":"https:\/\/doi.org\/10.1016\/j.device.2026.101299","relation":{},"ISSN":["2666-9986"],"issn-type":[{"value":"2666-9986","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiplex ovarian hormone monitoring in sweat using a dual-aptamer wearable sensor","name":"articletitle","label":"Article Title"},{"value":"Device","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.device.2026.101299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101299"}}