{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:49:45Z","timestamp":1789732185355,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes &amp; Metabolism"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.diabet.2013.01.006","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T16:47:01Z","timestamp":1367254021000},"page":"497-504","source":"Crossref","is-referenced-by-count":39,"title":["The association of type 2 diabetes and insulin resistance\/secretion with persistent organic pollutants in two First Nations communities in northern Ontario"],"prefix":"10.1016","volume":"39","author":[{"given":"S.","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Blais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Robidoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Haman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kr\u00fcmmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Seabert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Imbeault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2013.01.006_bib0005","first-page":"561","article-title":"Type 2 diabetes mellitus in Canada's First Nations: status of an epidemic in progress","volume":"163","author":"Young","year":"2000","journal-title":"CMAJ"},{"issue":"Suppl. 2","key":"10.1016\/j.diabet.2013.01.006_bib0010","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1038\/ijo.2010.236","article-title":"Obesity and type 2 diabetes in Northern Canada's remote First Nations communities: the dietary dilemma","volume":"34","author":"Haman","year":"2010","journal-title":"Int J Obes"},{"key":"10.1016\/j.diabet.2013.01.006_bib0015","doi-asserted-by":"crossref","first-page":"267509","DOI":"10.1155\/2011\/267509","article-title":"Obesity and type 2 diabetes prevalence in adults from two remote first nations communities in northwestern Ontario, Canada","volume":"2011","author":"Imbeault","year":"2011","journal-title":"J Obes"},{"key":"10.1016\/j.diabet.2013.01.006_bib0020","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/oby.2007.51","article-title":"Obesity and physical activity among aboriginal canadians","volume":"16","author":"Katzmarzyk","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.diabet.2013.01.006_bib0025","first-page":"21","article-title":"Obesity and the eating habits of the Aboriginal population","volume":"19","author":"Garriguet","year":"2008","journal-title":"Health Rep"},{"key":"10.1016\/j.diabet.2013.01.006_bib0030","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.2337\/dc06-0543","article-title":"A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999\u20132002","volume":"29","author":"Lee","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2013.01.006_bib0035","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1289\/ehp.10315","article-title":"Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans","volume":"115","author":"Codru","year":"2007","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.diabet.2013.01.006_bib0040","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/EDE.0b013e318212fab9","article-title":"Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes","volume":"22","author":"Grandjean","year":"2011","journal-title":"Epidemiology"},{"key":"10.1016\/j.diabet.2013.01.006_bib0045","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.envint.2010.02.012","article-title":"Strong associations between low-dose organochlorine pesticides and type 2 diabetes in Korea","volume":"36","author":"Son","year":"2010","journal-title":"Environ Int"},{"key":"10.1016\/j.diabet.2013.01.006_bib0050","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.2337\/dc08-0850","article-title":"Association of brominated flame retardants with diabetes and metabolic syndrome in the U.S. population, 2003\u20132004","volume":"31","author":"Lim","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2013.01.006_bib0055","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jhazmat.2010.09.084","article-title":"Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance","volume":"185","author":"Chang","year":"2011","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.diabet.2013.01.006_bib0060","doi-asserted-by":"crossref","first-page":"15977","DOI":"10.1371\/journal.pone.0015977","article-title":"Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.diabet.2013.01.006_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1029\/2004GL022229","article-title":"The significance of the grasshopper effect on the atmospheric distribution of persistent organic substances","volume":"32","author":"Semeena","year":"2005","journal-title":"Geophys Res Lett"},{"key":"10.1016\/j.diabet.2013.01.006_bib0070","first-page":"618","article-title":"Inuit exposure to organochlorines through the aquatic food chain in Arctic Quebec","volume":"101","author":"Dewailly","year":"1993","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.diabet.2013.01.006_bib0075","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/physrev.1995.75.3.473","article-title":"Pathophysiology of insulin resistance in human disease","volume":"75","author":"Reaven","year":"1995","journal-title":"Physiol Rev"},{"key":"10.1016\/j.diabet.2013.01.006_bib0080","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.2337\/diabetes.52.7.1799","article-title":"Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study","volume":"52","author":"Duncan","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2013.01.006_bib0085","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.01.006_bib0090","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbrc.2005.01.140","article-title":"Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain","volume":"329","author":"Csehi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.diabet.2013.01.006_bib0095","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1210\/jc.87.5.2084","article-title":"Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro","volume":"87","author":"Bastard","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2013.01.006_bib0100","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1074\/jbc.M700098200","article-title":"Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1","volume":"282","author":"Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.diabet.2013.01.006_bib0105","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/taap.2002.9408","article-title":"Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence","volume":"181","author":"Hennig","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.diabet.2013.01.006_bib0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/10408449709021615","article-title":"Aryl hydrocarbon receptor-mediated signal transduction","volume":"27","author":"Rowlands","year":"1997","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.diabet.2013.01.006_bib0115","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.98106775","article-title":"Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife","volume":"106","author":"Van Den Berg","year":"1998","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.diabet.2013.01.006_bib0120","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1289\/ehp.10554","article-title":"Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis","volume":"116","author":"Arsenescu","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.diabet.2013.01.006_bib0125","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/ijo.2008.169","article-title":"Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime","volume":"32","author":"Mullerova","year":"2008","journal-title":"Int J Obes"},{"key":"10.1016\/j.diabet.2013.01.006_bib0130","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/0960327107076886","article-title":"Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus","volume":"26","author":"Rignell-Hydbom","year":"2007","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.diabet.2013.01.006_bib0135","article-title":"Traditional foodways in two contemporary Northern First Nations communities","volume":"3","author":"Robidoux","year":"2012","journal-title":"Can J Native Stud"},{"key":"10.1016\/j.diabet.2013.01.006_bib0140","first-page":"615","article-title":"Determination of plasma glucose by hexokinase-glucose-6-phosphate dehydrogenase method","volume":"101","author":"Richterich","year":"1971","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1016\/j.diabet.2013.01.006_bib0145","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabet.2013.01.006_bib0150","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2337\/dc06-2190","article-title":"Association between serum concentrations of persistent organic pollutants and insulin resistance among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999\u20132002","volume":"30","author":"Lee","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2013.01.006_bib0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF00212394","article-title":"Maternal transfer of organochlorine compounds in Lake Superior siscowet (Salvelinus namaycush siscowet) to their eggs","volume":"55","author":"Miller","year":"1995","journal-title":"Bull Environ Contam Toxicol"},{"key":"10.1016\/j.diabet.2013.01.006_bib0160","doi-asserted-by":"crossref","first-page":"E574","DOI":"10.1152\/ajpendo.00394.2001","article-title":"Weight loss-induced rise in plasma pollutant is associated with reduced skeletal muscle oxidative capacity","volume":"282","author":"Imbeault","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.diabet.2013.01.006_bib0165","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.chemosphere.2008.12.035","article-title":"Prevalence of diabetes and body burdens of polychlorinated biphenyls, polybrominated diphenyl ethers, and p,p\u2032-diphenyldichloroethene in Great Lakes sport fish consumers","volume":"75","author":"Turyk","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.diabet.2013.01.006_bib0170","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients","volume":"20","author":"Hotta","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.diabet.2013.01.006_bib0175","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1007\/s00125-007-0834-6","article-title":"Associations between insulin resistance and TNF-\u03b1 in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes","volume":"50","author":"Plomgaard","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabet.2013.01.006_bib0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.jhh.1001785","article-title":"Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-\u03b1) and essential hypertension","volume":"19","author":"Bautista","year":"2005","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.diabet.2013.01.006_bib0185","first-page":"711","article-title":"Influence of amlodipine and atenolol on lipopolysaccharide (LPS)-induced serum concentrations of TNF-\u03b1, IL-1\u03b2, IL-6 in spontaneously hypertensive rats (SHR)","volume":"58","author":"Andrzejczak","year":"2006","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.diabet.2013.01.006_bib0190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1440-1797.2007.00764.x","article-title":"Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome","volume":"12","author":"Yilmaz","year":"2007","journal-title":"Nephrology"},{"key":"10.1016\/j.diabet.2013.01.006_bib0195","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/aje\/kwg191","article-title":"Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population","volume":"158","author":"Kriska","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.diabet.2013.01.006_bib0200","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.0901321","article-title":"Persistent organic pollutant exposure leads to insulin resistance syndrome","volume":"118","author":"Ruzzin","year":"2010","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.diabet.2013.01.006_bib0205","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI115558","article-title":"Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus","volume":"89","author":"Nurjhan","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.diabet.2013.01.006_bib0210","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1038\/sj.ijo.0801817","article-title":"Increase in plasma pollutant levels in response to weight loss in humans is related to in vitro subcutaneous adipocyte basal lipolysis","volume":"25","author":"Imbeault","year":"2001","journal-title":"Int J Obes"},{"key":"10.1016\/j.diabet.2013.01.006_bib0215","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s00125-008-1066-0","article-title":"A cross-sectional study of the association between persistent organic pollutants and glucose intolerance among Greenland Inuit","volume":"51","author":"J\u00f8rgensen","year":"2008","journal-title":"Diabetologia"}],"container-title":["Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363613000335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363613000335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T02:47:09Z","timestamp":1562986029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363613000335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1262363613000335"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2013.01.006","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}