{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:51:22Z","timestamp":1790646682207,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolism"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.diabet.2013.11.002","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T22:01:07Z","timestamp":1386799267000},"page":"191-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Central orchestration of peripheral nutrient partitioning and substrate utilization: Implications for the metabolic syndrome"],"prefix":"10.1016","volume":"40","author":[{"given":"R.G.P.","family":"Denis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Joly-Amado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Castel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Delbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Luquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2013.11.002_bib0005","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/01.hco.0000240586.76344.f5","article-title":"The prevention and treatment of metabolic syndrome and high-risk obesity","volume":"21","author":"Molavi","year":"2006","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.diabet.2013.11.002_bib0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance","volume":"106","author":"Kahn","year":"2000","journal-title":"The J Clin Invest"},{"issue":"Suppl 4","key":"10.1016\/j.diabet.2013.11.002_bib0015","doi-asserted-by":"crossref","first-page":"SIV5","DOI":"10.1016\/S0140-6736(98)90267-7","article-title":"Diabetes. Exploding type II","volume":"352","author":"Kopelman","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.diabet.2013.11.002_bib0020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1365-2826.2006.01456.x","article-title":"The metabolic syndrome: a brain disease?","volume":"18","author":"Buijs","year":"2006","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.diabet.2013.11.002_bib0025","first-page":"123","article-title":"Hypothalamic control of food intake in rats and cats","volume":"24","author":"Anand","year":"1951","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.diabet.2013.11.002_bib0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ar.1090780203","article-title":"Hypothalamic lesions and adiposity in the rat","volume":"78","author":"Heatherington","year":"1940","journal-title":"Anat Rec"},{"key":"10.1016\/j.diabet.2013.11.002_bib0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","article-title":"From lesions to leptin: hypothalamic control of food intake and body weight","volume":"22","author":"Elmquist","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.diabet.2013.11.002_bib0040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0045","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1126\/science.281.5383.1683","article-title":"Biological action of leptin as an angiogenic factor","volume":"281","author":"Sierra-Honigmann","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.diabet.2013.11.002_bib0050","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1073\/pnas.96.5.2327","article-title":"Regulation of fatty acid homeostasis in cells: novel role of leptin","volume":"96","author":"Unger","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.diabet.2013.11.002_bib0055","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0060","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1074\/jbc.272.10.6093","article-title":"The leptin receptor","volume":"272","author":"Tartaglia","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.diabet.2013.11.002_bib0065","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(00)81294-5","article-title":"Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db\/db mice","volume":"84","author":"Chen","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.diabet.2013.11.002_bib0070","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.2337\/db08-0210","article-title":"Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions","volume":"57","author":"O\u2019Rahilly","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2013.11.002_bib0075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nature05026","article-title":"Central nervous system control of food intake and body weight","volume":"443","author":"Morton","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0080","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/296659a0","article-title":"Neuropeptide Y\u00a0\u2013\u00a0a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide","volume":"296","author":"Tatemoto","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0085","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1210\/endo-115-1-427","article-title":"and human pancreatic polypeptide stimulate feeding behavior in rats","volume":"115","author":"Clark","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.diabet.2013.11.002_bib0090","doi-asserted-by":"crossref","first-page":"1902S","DOI":"10.1093\/jn\/127.9.1902S","article-title":"The role of the agouti gene in the yellow obese syndrome","volume":"12","author":"Miltenberger","year":"1997","journal-title":"J Nutr"},{"key":"10.1016\/j.diabet.2013.11.002_bib0095","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1073\/pnas.91.7.2562","article-title":"A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation","volume":"91","author":"Michaud","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.diabet.2013.11.002_bib0100","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.278.5335.135","article-title":"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein","volume":"278","author":"Ollmann","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.diabet.2013.11.002_bib0105","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1101\/gad.11.5.593","article-title":"Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice","volume":"11","author":"Shutter","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.diabet.2013.11.002_bib0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-8993(97)00184-4","article-title":"Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations","volume":"756","author":"Horvath","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.diabet.2013.11.002_bib0120","doi-asserted-by":"crossref","first-page":"13684","DOI":"10.1523\/JNEUROSCI.3770-09.2009","article-title":"Proopiomelanocortin expression in both GABA and glutamate neurons","volume":"29","author":"Hentges","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0125","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1210\/endo.131.5.1425443","article-title":"Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis","volume":"131","author":"Horvath","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.diabet.2013.11.002_bib0130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0135","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0031-9384(01)00611-4","article-title":"Hypothalamic and vagal neuropeptide circuitries regulating food intake","volume":"74","author":"Broberger","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1016\/j.diabet.2013.11.002_bib0140","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9384(01)00612-6","article-title":"The hypothalamus and the control of energy homeostasis: different circuits, different purposes","volume":"74","author":"Williams","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1016\/j.diabet.2013.11.002_bib0145","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1089459","article-title":"Rapid rewiring of arcuate nucleus feeding circuits by leptin","volume":"304","author":"Pinto","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.diabet.2013.11.002_bib0150","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1073\/pnas.95.25.15043","article-title":"The neuropeptide Y\/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice","volume":"95","author":"Broberger","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.diabet.2013.11.002_bib0155","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cmet.2007.10.008","article-title":"Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways","volume":"6","author":"Zhou","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.diabet.2013.11.002_bib0160","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1523\/JNEUROSCI.23-18-07143.2003","article-title":"Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter","volume":"23","author":"Liu","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0303-7207(96)04017-8","article-title":"Obesity, diabetes and functions for proopiomelanocortin-derived peptides","volume":"128","author":"Mountjoy","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.diabet.2013.11.002_bib0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0175","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1523\/JNEUROSCI.20-04-01550.2000","volume":"20","author":"Fekete","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0079-6123(06)53012-2","article-title":"The TRH neuron: a hypothalamic integrator of energy metabolism","volume":"153","author":"Lechan","year":"2006","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.diabet.2013.11.002_bib0185","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice","volume":"88","author":"Huszar","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.diabet.2013.11.002_bib0190","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1210\/jcem.84.4.5728","article-title":"Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans","volume":"84","author":"Hinney","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2013.11.002_bib0195","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1749-6632.1999.tb08702.x","article-title":"Implications of the phenotype of POMC deficiency for the role of POMC-derived peptides in skin physiology","volume":"885","author":"Krude","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0200","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nn1548","article-title":"Agouti-related peptide-expressing neurons are mandatory for feeding","volume":"8","author":"Gropp","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0205","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1096\/fj.04-3434fje","article-title":"Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype","volume":"19","author":"Bewick","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.diabet.2013.11.002_bib0210","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1115524","article-title":"NPY\/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates","volume":"310","author":"Luquet","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.diabet.2013.11.002_bib0215","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0712062105","article-title":"Starvation after AgRP neuron ablation is independent of melanocortin signaling","volume":"10","author":"Wu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.diabet.2013.11.002_bib0220","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.cell.2009.04.022","article-title":"Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation","volume":"137","author":"Wu","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.diabet.2013.11.002_bib0335","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2010.10.110","article-title":"GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism","volume":"660","author":"Wu","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.diabet.2013.11.002_bib0230","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nature10899","article-title":"Deciphering a neuronal circuit that mediates appetite","volume":"483","author":"Wu","year":"2012","journal-title":"Nature"},{"issue":"7474","key":"10.1016\/j.diabet.2013.11.002_bib0340","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature12596","article-title":"Genetic identification of a neural circuit that suppresses appetite","volume":"503","author":"Carter","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0240","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nn.3147","article-title":"AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors","volume":"15","author":"Dietrich","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0245","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fendo.2012.00169","article-title":"Arcuate AgRP neurons and the regulation of energy balance","volume":"3","author":"Cansell","year":"2012","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.diabet.2013.11.002_bib0250","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1038\/emboj.2012.287","article-title":"AgRP neurons: a switch between peripheral carbohydrate and lipid utilization","volume":"31","author":"Varela","year":"2012","journal-title":"Embo J"},{"key":"10.1016\/j.diabet.2013.11.002_bib0255","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nmeth.f.327","article-title":"Channel rhodopsin engineering and exploration of new optogenetic tools","volume":"8","author":"Hegemann","year":"2011","journal-title":"Nature methods"},{"issue":"4","key":"10.1016\/j.diabet.2013.11.002_bib0345","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.diabet.2013.11.002_bib0265","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nn.2739","article-title":"AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training","volume":"14","author":"Aponte","year":"2011","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.diabet.2013.11.002_bib0270","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature11270","article-title":"Deconstruction of a neural circuit for hunger","volume":"488","author":"Atasoy","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2013.11.002_bib0275","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2013.09.009","article-title":"Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP","volume":"18","author":"Krashes","year":"2013","journal-title":"Cell metabolism"},{"key":"10.1016\/j.diabet.2013.11.002_bib0280","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1749-6632.2010.05800.x","article-title":"Hypothalamic control of energy metabolism via the autonomic nervous system","volume":"1212","author":"Kalsbeek","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0285","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nn1226","article-title":"Orexigen-sensitive NPY\/AgRP pacemaker neurons in the hypothalamic arcuate nucleus","volume":"7","author":"van den Top","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0290","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1172\/JCI31743","article-title":"The central melanocortin system directly controls peripheral lipid metabolism","volume":"117","author":"Nogueiras","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.diabet.2013.11.002_bib0295","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1467-789X.2009.00669.x","article-title":"Regulation of lipid metabolism by energy availability: a role for the central nervous system","volume":"11","author":"Nogueiras","year":"2010","journal-title":"Obes Rev"},{"key":"10.1016\/j.diabet.2013.11.002_bib0300","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nn.2569","article-title":"Melanocortin signaling in the CNS directly regulates circulating cholesterol","volume":"13","author":"Perez-Tilve","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0305","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.peptides.2006.08.036","article-title":"NPY\/AgRP neurons are not essential for feeding responses to glucoprivation","volume":"28","author":"Luquet","year":"2007","journal-title":"Peptides"},{"issue":"22","key":"10.1016\/j.diabet.2013.11.002_bib0350","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1038\/emboj.2012.250","article-title":"Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning","volume":"31","author":"Joly-Amado","year":"2012","journal-title":"Embo J"},{"key":"10.1016\/j.diabet.2013.11.002_bib0315","doi-asserted-by":"crossref","first-page":"11815","DOI":"10.1523\/JNEUROSCI.2234-10.2010","article-title":"Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity","volume":"30","author":"Dietrich","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.diabet.2013.11.002_bib0320","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pharmthera.2007.09.006","article-title":"Inter-organ metabolic communication involved in energy homeostasis: potential therapeutic targets for obesity and metabolic syndrome","volume":"117","author":"Yamada","year":"2008","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.diabet.2013.11.002_bib0325","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/jn\/121.8.1146","article-title":"Obesity, a disorder of nutrient partitioning: the MONA LISA hypothesis","volume":"121","author":"Bray","year":"1991","journal-title":"J Nutr [Review]"},{"key":"10.1016\/j.diabet.2013.11.002_bib0330","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nm0603-645","article-title":"Rethinking the central causes of diabetes","volume":"9","author":"Elmquist","year":"2003","journal-title":"Nat Med"}],"container-title":["Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363613002279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363613002279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T20:22:53Z","timestamp":1564950173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363613002279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S1262363613002279"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2013.11.002","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central orchestration of peripheral nutrient partitioning and substrate utilization: Implications for the metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabet.2013.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}