{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:55:28Z","timestamp":1761177328184,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007476","name":"Canadian Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolism"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.diabet.2018.01.003","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T08:33:56Z","timestamp":1515659636000},"page":"197-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of short-term intensive insulin therapy on the incretin response in early type 2 diabetes"],"prefix":"10.1016","volume":"45","author":[{"given":"H.","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.K.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Zinman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.W.","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Retnakaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2018.01.003_bib0080","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.2337\/dc16-0954","article-title":"Reconciliation of type 2 diabetes remission rates in studies of Roux-en-Y gastric bypass","volume":"39","author":"Isaman","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.01.003_bib0085","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/ijo.2009.254","article-title":"Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes","volume":"34","author":"Kashyap","year":"2010","journal-title":"Int J Obes"},{"key":"10.1016\/j.diabet.2018.01.003_bib0090","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.2337\/db13-0022","article-title":"Exaggerated glucagon-like peptide 1 response is important for improved \u03b2-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes","volume":"62","author":"J\u00f8rgensen","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2018.01.003_bib0095","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.2337\/dc12-1535","article-title":"GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery","volume":"36","author":"Jim\u00e9nez","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.01.003_bib0100","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/db14-0558","article-title":"GLP-1 plays a limited role in improved glycemia shortly after Roux-en-Y gastric bypass: a comparison with intensive lifestyle modification","volume":"64","author":"Vetter","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2018.01.003_bib0105","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/S0140-6736(08)60762-X","article-title":"Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial","volume":"371","author":"Weng","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.diabet.2018.01.003_bib0110","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S2213-8587(13)70006-8","article-title":"Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"1","author":"Kramer","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.diabet.2018.01.003_bib0115","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1210\/jc.2015-1947","article-title":"Effect of short-term intensive insulin therapy on post-challenge hyperglucagonemia in early type 2 diabetes","volume":"100","author":"Kramer","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2018.01.003_bib0120","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/j.1464-5491.2008.02579.x","article-title":"Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes","volume":"25","author":"H\u00f8jberg","year":"2008","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabet.2018.01.003_bib0125","first-page":"734","article-title":"Effects of short-term intensive glycemic control on insulin, glucagon, and glucagon-like peptide-1 secretion in patients with Type 2 diabetes","volume":"36","author":"Shimodaira","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.diabet.2018.01.003_bib0130","doi-asserted-by":"crossref","first-page":"e000270","DOI":"10.1136\/bmjdrc-2016-000270","article-title":"Predictors of sustained drug-free diabetes remission over 48 weeks following short-term intensive insulin therapy in early type 2 diabetes","volume":"4","author":"Kramer","year":"2016","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.diabet.2018.01.003_bib0135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/dc15-0575","article-title":"Determinants of diabetes remission and glycemic control after bariatric surgery","volume":"39","author":"Panunzi","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.01.003_bib0140","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2337\/dc06-1549","article-title":"Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes","volume":"30","author":"Laferr\u00e8re","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.01.003_bib0145","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/oby.2007.83","article-title":"Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release","volume":"16","author":"Rodieux","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.diabet.2018.01.003_bib0150","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00125-008-0943-x","article-title":"Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes","volume":"51","author":"H\u00f8jberg","year":"2008","journal-title":"Diabetologia"}],"container-title":["Diabetes & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363618300053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363618300053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:56:00Z","timestamp":1761130560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363618300053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1262363618300053"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2018.01.003","relation":{},"ISSN":["1262-3636"],"issn-type":[{"type":"print","value":"1262-3636"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of short-term intensive insulin therapy on the incretin response in early type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabet.2018.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}