{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:28:07Z","timestamp":1786987687574,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["WSN-165"],"award-info":[{"award-number":["WSN-165"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["SWYY-091"],"award-info":[{"award-number":["SWYY-091"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570736"],"award-info":[{"award-number":["81570736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600632"],"award-info":[{"award-number":["81600632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500612"],"award-info":[{"award-number":["81500612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770819"],"award-info":[{"award-number":["81770819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703294"],"award-info":[{"award-number":["81703294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400832"],"award-info":[{"award-number":["81400832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570737"],"award-info":[{"award-number":["81570737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370947"],"award-info":[{"award-number":["81370947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600637"],"award-info":[{"award-number":["81600637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380092"],"award-info":[{"award-number":["021414380092"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380208"],"award-info":[{"award-number":["021414380208"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380317"],"award-info":[{"award-number":["021414380317"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380160"],"award-info":[{"award-number":["021414380160"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380142"],"award-info":[{"award-number":["021414380142"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380296"],"award-info":[{"award-number":["021414380296"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380279"],"award-info":[{"award-number":["021414380279"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309605"],"award-info":[{"award-number":["2017YFC1309605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1304804"],"award-info":[{"award-number":["2016YFC1304804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170125"],"award-info":[{"award-number":["BK20170125"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["QNRC2016018"],"award-info":[{"award-number":["QNRC2016018"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["QNRC2016019"],"award-info":[{"award-number":["QNRC2016019"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["QNRC2016020"],"award-info":[{"award-number":["QNRC2016020"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["ZDRCA2016062"],"award-info":[{"award-number":["ZDRCA2016062"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes & Metabolism"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.diabet.2018.08.005","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T08:29:18Z","timestamp":1535963358000},"page":"341-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Type 1 innate lymphoid cells are associated with type 2 diabetes"],"prefix":"10.1016","volume":"45","author":[{"given":"F.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2018.08.005_bib0005","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","article-title":"Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants","volume":"387","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.diabet.2018.08.005_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cellimm.2017.03.001","article-title":"Role of immune cells in obesity induced low grade inflammation and insulin resistance","volume":"315","author":"Asghar","year":"2017","journal-title":"Cell Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0020","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2018.08.005_bib0025","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1002\/jcp.26250","article-title":"The role of innate lymphoid cells in health and disease","volume":"233","author":"Mohammadi","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0035","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1177\/1352458516662726","article-title":"Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets","volume":"23","author":"Gross","year":"2017","journal-title":"Mult Scler"},{"key":"10.1016\/j.diabet.2018.08.005_bib0040","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jid.2016.07.017","article-title":"In Situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin","volume":"136","author":"Bruggen","year":"2016","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0045","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.immuni.2016.06.016","article-title":"Adipose-resident Group 1 innate lymphoid cells promote obesity-associated insulin resistance","volume":"45","author":"O Sullivan","year":"2016","journal-title":"Immunity"},{"issue":"Supplement 1","key":"10.1016\/j.diabet.2018.08.005_bib0050","first-page":"S13","article-title":"Classification and diagnosis of diabetes: standards of medical care in diabetes\u2009\u2013\u20092018","volume":"41","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.08.005_bib0055","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1210\/jc.2014-2583","article-title":"Positive association between serum levels of bone resorption marker CTX and HbA1c in women with normal glucose tolerance","volume":"100","author":"Xuan","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2018.08.005_bib0060","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/dmrr.2443","article-title":"The beneficial effect of metformin on \u03b2-cell function in non-obese Chinese subjects with newly diagnosed type 2 diabetes","volume":"29","author":"Bi","year":"2013","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.diabet.2018.08.005_bib0065","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2337\/db16-1167","article-title":"Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio metabolism study","volume":"66","author":"Gastaldelli","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2018.08.005_bib0070","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00281-017-0668-3","article-title":"Regulation of immunometabolism in adipose tissue","volume":"40","author":"Kumari","year":"2018","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fimmu.2016.00426","article-title":"Type 1 innate lymphoid cell biology: lessons learnt from natural killer cells","volume":"7","author":"Jiao","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0080","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/oby.21003","article-title":"Adipose tissue as an immunological organ","volume":"23","author":"Grant","year":"2015","journal-title":"Obesity"},{"key":"10.1016\/j.diabet.2018.08.005_bib0085","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.cmet.2013.05.008","article-title":"Immunological goings-on in visceral adipose tissue","volume":"17","author":"Mathis","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.diabet.2018.08.005_bib0090","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni.3489","article-title":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis","volume":"17","author":"Klose","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0095","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ni.3482","article-title":"NK cells and type 1 innate lymphoid cells: partners in host defense","volume":"17","author":"Spits","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells\u2009\u2013\u2009a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nri3349","article-title":"Innate lymphoid cells\u2009\u2013\u2009how did we miss them?","volume":"13","author":"Walker","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.diabet.2018.08.005_bib0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.immuni.2015.06.019","article-title":"Interleukin-12 and -23 control plasticity of CD127+ group 1 and group 3 innate lymphoid cells in the intestinal lamina propria","volume":"43","author":"Bernink","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.diabet.2018.08.005_bib0115","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2013.02.010","article-title":"Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-\u03b3-producing cells","volume":"38","author":"Fuchs","year":"2013","journal-title":"Immunity"}],"container-title":["Diabetes & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363618301629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363618301629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:57:42Z","timestamp":1778799462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363618301629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1262363618301629"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2018.08.005","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type 1 innate lymphoid cells are associated with type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabet.2018.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}