{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:15:02Z","timestamp":1791317702341,"version":"4.3.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolism"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.diabet.2018.09.004","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T17:40:44Z","timestamp":1537897244000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":164,"title":["A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes"],"prefix":"10.1016","volume":"45","author":[{"given":"I.","family":"Medina-Vera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanchez-Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Noriega-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Granados-Portillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guevara-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Flores-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Avila-Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Tovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2018.09.004_bib0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.09.004_bib0010","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.2337\/dc13-0800","article-title":"Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men","volume":"36","author":"Mahendran","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.09.004_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.52.1.1","article-title":"Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?","volume":"52","author":"Evans","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2018.09.004_bib0020","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem J"},{"key":"10.1016\/j.diabet.2018.09.004_bib0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/gmic.19897","article-title":"Microbial degradation of complex carbohydrates in the gut","volume":"3","author":"Flint","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.diabet.2018.09.004_bib0030","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2018.09.004_bib0035","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1530\/EJE-14-0874","article-title":"Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus","volume":"172","author":"Allin","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.diabet.2018.09.004_bib0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1373\/clinchem.2016.263640","article-title":"Increased trimethylamine n-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus","volume":"63","author":"Tang","year":"2017","journal-title":"Clin Chem"},{"issue":"7612","key":"10.1016\/j.diabet.2018.09.004_bib0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"issue":"Suppl. 2","key":"10.1016\/j.diabet.2018.09.004_bib0050","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults\u2009\u2013\u2009The evidence report. National Institutes of Health","volume":"6","year":"1998","journal-title":"Obes Res"},{"key":"10.1016\/j.diabet.2018.09.004_bib0055","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature15766","article-title":"Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota","volume":"528","author":"Forslund","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2018.09.004_bib0060","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/0140-6736(93)90939-E","article-title":"Glutamine and the preservation of gut integrity","volume":"341","author":"van der Hulst","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.diabet.2018.09.004_bib0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/MCO.0000000000000339","article-title":"Glutamine and the regulation of intestinal permeability: from bench to bedside","volume":"20","author":"Achamrah","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.diabet.2018.09.004_bib0070","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2337\/dc12-0413","article-title":"Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"35","author":"Inzucchi","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabet.2018.09.004_bib0075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1475-2891-13-60","article-title":"Gut microbiota, probiotics and diabetes","volume":"13","author":"Gomes","year":"2014","journal-title":"Nutr J"},{"key":"10.1016\/j.diabet.2018.09.004_bib0080","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/CMR.00008-07","article-title":"Bacteroides: the good, the bad, and the nitty-gritty","volume":"20","author":"Wexler","year":"2007","journal-title":"Clin Microbiol Rev"},{"issue":"94","key":"10.1016\/j.diabet.2018.09.004_bib0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030","author":"Whiting","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.diabet.2018.09.004_bib0090","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00125-002-0878-6","article-title":"Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients","volume":"45","author":"Vilsboll","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabet.2018.09.004_bib0095","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ijo.2017.305","article-title":"Pro-inflammatory gene expression profile in obese adults with high plasma GIP levels","volume":"42","author":"Goralska","year":"2018","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.diabet.2018.09.004_bib0100","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/oby.2006.129","article-title":"Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification","volume":"14","author":"Getty-Kaushik","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.diabet.2018.09.004_bib0105","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.00100.2012","article-title":"Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes","volume":"304","author":"Timper","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.diabet.2018.09.004_bib0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1365-2362.32.s3.3.x","article-title":"Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction","volume":"323","author":"Boden","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.diabet.2018.09.004_bib0115","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ymgme.2010.08.007","article-title":"Increase in HDL-C concentration by a dietary portfolio with soy protein and soluble fiber is associated with the presence of the ABCA1R230C variant in hyperlipidemic Mexican subjects","volume":"101","author":"Guevara-Cruz","year":"2010","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.diabet.2018.09.004_bib0120","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1001\/archinte.167.10.1068","article-title":"Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study","volume":"167","author":"Wilson","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.diabet.2018.09.004_bib0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biochi.2015.06.020","article-title":"Metabolic endotoxemia with obesity: Is it real and is it relevant?","volume":"124","author":"Boutagy","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.diabet.2018.09.004_bib0130","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1016\/j.ajpath.2017.08.005","article-title":"Lipopolysaccharide-induced increase in intestinal epithelial tight permeability is mediated by toll-like receptor 4\/myeloid differentiation primary response 88 (MyD88) activation of myosin light chain kinase expression","volume":"187","author":"Nighot","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.diabet.2018.09.004_bib0135","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1007\/s00125-015-3712-7","article-title":"Gut microorganisms as promising targets for the management of type 2 diabetes","volume":"58","author":"Delzenne","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabet.2018.09.004_bib0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12263-014-0431-5","article-title":"Omental adipose tissue gene expression, gene variants, branched-chain amino acids, and their relationship with metabolic syndrome and insulin resistance in humans","volume":"9","author":"Serralde-Zuniga","year":"2014","journal-title":"Genes Nutr"},{"key":"10.1016\/j.diabet.2018.09.004_bib0145","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3945\/jn.108.101485","article-title":"Glutamine deprivation alters intestinal tight junctions via a PI3-K\/Akt mediated pathway in Caco-2 cells","volume":"139","author":"Li","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.diabet.2018.09.004_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chom.2015.12.012","article-title":"Metformin joins forces with microbes","volume":"19","author":"Cabreiro","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.diabet.2018.09.004_bib0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2018.09.004_bib0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2018.09.004_bib0165","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3945\/ajcn.117.157107","article-title":"Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes","volume":"106","author":"Shan","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.diabet.2018.09.004_bib0170","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.diabet.2018.09.004_bib0175","doi-asserted-by":"crossref","first-page":"62","DOI":"10.7812\/TPP\/14-036","article-title":"A plant-based diet, atherogenesis, and coronary artery disease prevention","volume":"19","author":"Tuso","year":"2015","journal-title":"Perm J"},{"key":"10.1016\/j.diabet.2018.09.004_bib0180","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2337\/ds16-0003","article-title":"Nutrition considerations for microbiota health in diabetes.","volume":"29","author":"Jardine","year":"2016","journal-title":"Diabetes Spectr"},{"key":"10.1016\/j.diabet.2018.09.004_bib0185","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnut.2017.00034","article-title":"The role of supplemental complex dietary carbohydrates and gut microbiota in promoting cardiometabolic and immunological health in obesity: lessons from healthy non-obese individuals","volume":"4","author":"Vinke","year":"2017","journal-title":"Front Nutr"},{"key":"10.1016\/j.diabet.2018.09.004_bib0190","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1017\/jns.2014.68","article-title":"A randomised, double-blind, cross-over study investigating the prebiotic effect of agave fructans in healthy human subjects","volume":"4","author":"Ramnani","year":"2015","journal-title":"J Nutr Sci"},{"key":"10.1016\/j.diabet.2018.09.004_bib0195","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11130-016-0573-2","article-title":"Rheological flow behavior of structural polysaccharides from edible tender cladodes of wild, semidomesticated and cultivated \u2018Nopal\u2019 (Opuntia) of Mexican highlands","volume":"71","author":"Lopez-Palacios","year":"2016","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1016\/j.diabet.2018.09.004_bib0200","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1038\/s41598-017-05096-4","article-title":"Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat\/sucrose diet","volume":"7","author":"Sanchez-Tapia","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabet.2018.09.004_bib0205","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jand.2014.06.352","article-title":"The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts","volume":"114","author":"Lopez-Romero","year":"2014","journal-title":"J Acad Nutr Diet"}],"container-title":["Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363618301757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363618301757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T07:28:23Z","timestamp":1693898903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363618301757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1262363618301757"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2018.09.004","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabet.2018.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}