{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:46:18Z","timestamp":1783478778716,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870606"],"award-info":[{"award-number":["81870606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2017J01365"],"award-info":[{"award-number":["2017J01365"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolism"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.diabet.2020.101221","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T08:27:51Z","timestamp":1608971271000},"page":"101221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dose\u2013response relationship between serum fibroblast growth factor 21 and liver fat content in non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-2704","authenticated-orcid":false,"given":"F.","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2020.101221_bib0005","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1053\/j.gastro.2016.03.005","article-title":"Contribution of alcoholic and nonalcoholic fatty liver disease to the burden of liver-related morbidity and mortality","volume":"150","author":"Younossi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.diabet.2020.101221_bib0010","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2020.101221_bib0015","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2020.101221_bib0020","doi-asserted-by":"crossref","first-page":"14561","DOI":"10.1038\/s41598-017-14706-0","article-title":"Predictors of liver fat and stiffness in non-alcoholic fatty liver disease (NAFLD)\u2014an 11-year prospective study","volume":"7","author":"Lallukka","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabet.2020.101221_bib0025","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.cgh.2015.01.027","article-title":"Association between quantity of liver fat and cardiovascular risk in patients with nonalcoholic fatty liver disease independent of nonalcoholic steatohepatitis","volume":"13","author":"Arulanandan","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.diabet.2020.101221_bib0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jhep.2016.02.023","article-title":"Fatty liver is an independent predictor of early carotid atherosclerosis","volume":"65","author":"Pais","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.diabet.2020.101221_bib0035","doi-asserted-by":"crossref","first-page":"21894","DOI":"10.1038\/srep21894","article-title":"Hepatic fat content is a determinant of metabolic phenotypes and increased carotid intima-media thickness in obese adults","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabet.2020.101221_bib0040","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/hep.26455","article-title":"Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials","volume":"58","author":"Noureddin","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2020.101221_bib0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hep.29797","article-title":"Noninvasive, quantitative assessment of liver fat by MRI-PDFF as an Endpoint in NASH Trials","volume":"68","author":"Caussy","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2020.101221_bib0050","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/db08-0392","article-title":"Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2020.101221_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2010.05.018","article-title":"Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride","volume":"53","author":"Li","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.diabet.2020.101221_bib0060","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2020.101221_bib0065","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.diabet.2020.101221_bib0070","doi-asserted-by":"crossref","first-page":"30484","DOI":"10.1038\/srep30484","article-title":"Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL\/6J mice","volume":"29","author":"Rusli","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabet.2020.101221_bib0075","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1210\/jc.2013-1250","article-title":"Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage","volume":"98","author":"Giannini","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2020.101221_bib0080","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.jhep.2011.12.025","article-title":"Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers","volume":"56","author":"Shen","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.diabet.2020.101221_bib0085","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2362.2010.02338.x","article-title":"Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease","volume":"40","author":"Yilmaz","year":"2010","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.diabet.2020.101221_bib0090","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jhep.2012.10.029","article-title":"High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China","volume":"58","author":"Li","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.diabet.2020.101221_bib0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1210\/jc.2015-3308","article-title":"Endurance exercise reduces hepatic fat content and serum fibroblast growth factor 21 levels in elderly men","volume":"101","author":"Taniguchi","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2020.101221_bib0100","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1210\/jc.2018-02378","article-title":"Contribution of liver fat to weight loss-induced changes in serum hepatokines: a randomized controlled trial","volume":"104","author":"Telgenkamp","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabet.2020.101221_bib0105","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.soard.2017.03.033","article-title":"Reduction in serum fibroblast growth factor-21 after gastric bypass is related to changes in hepatic fat content","volume":"13","author":"Fjeldborg","year":"2017","journal-title":"Surg Obes Relat Dis"},{"key":"10.1016\/j.diabet.2020.101221_bib0110","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1001\/jamainternmed.2016.3202","article-title":"Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: a randomized clinical trial","volume":"176","author":"Zhang","year":"2016","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.diabet.2020.101221_bib0115","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/dom.12809","article-title":"Long-term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults: a 1-year follow-up study","volume":"19","author":"Zhang","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.diabet.2020.101221_bib0120","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat Med"},{"key":"10.1016\/j.diabet.2020.101221_bib0125","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/13543784.2020.1718104","article-title":"Fibroblast growth factor (FGF)-21 based therapies: a magic bullet for nonalcoholic fatty liver disease (NAFLD)?","volume":"29","author":"Ritchie","year":"2020","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.diabet.2020.101221_bib0130","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hep.29721","article-title":"Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis","volume":"68","author":"Younossi","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2020.101221_bib0135","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1038\/s41598-017-05257-5","article-title":"Complementary role of fibroblast growth factor 21 and cytokeratin 18 in monitoring the different stages of nonalcoholic fatty liver disease","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabet.2020.101221_bib0140","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9729107","article-title":"Diagnostic value of CK-18, FGF-21, and related biomarker panel in nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"2017","author":"He","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.diabet.2020.101221_bib0145","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41401-019-0321-x","article-title":"Serum biomarkers combined with ultrasonography for early diagnosis of non-alcoholic fatty liver disease confirmed by magnetic resonance spectroscopy","volume":"41","author":"Qian","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.diabet.2020.101221_bib0150","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jhep.2017.06.003","article-title":"New trends on obesity and NAFLD in Asia","volume":"67","author":"Fan","year":"2017","journal-title":"J Hepatol"}],"container-title":["Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363620302780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363620302780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:57:50Z","timestamp":1761130670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363620302780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1262363620302780"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2020.101221","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose\u2013response relationship between serum fibroblast growth factor 21 and liver fat content in non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabet.2020.101221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101221"}}