{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:34:27Z","timestamp":1768253667325,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770819"],"award-info":[{"award-number":["81770819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970704"],"award-info":[{"award-number":["81970704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030026"],"award-info":[{"award-number":["82030026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","award":["2021-LCYJ-DBZ-10"],"award-info":[{"award-number":["2021-LCYJ-DBZ-10"]}],"id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["YY-086"],"award-info":[{"award-number":["YY-086"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["BE2022666"],"award-info":[{"award-number":["BE2022666"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes &amp; Metabolism"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.diabet.2022.101397","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T12:50:42Z","timestamp":1666443042000},"page":"101397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low levels of osteocalcin, but not CTX or P1NP, are associated with nonalcoholic hepatic steatosis and steatohepatitis"],"prefix":"10.1016","volume":"49","author":[{"given":"Da","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-5100","authenticated-orcid":false,"given":"Tianwei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabet.2022.101397_bib0001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.diabet.2022.101397_bib0002","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.diabet.2022.101397_bib0003","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cgh.2014.04.014","article-title":"Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies","volume":"13","author":"Singh","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.diabet.2022.101397_bib0004","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hep.30254","article-title":"burden of illness and economic model for patients with nonalcoholic steatohepatitis in the United States","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2022.101397_bib0005","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrrheum.2012.157","article-title":"The skeleton as an endocrine organ","volume":"8","author":"DiGirolamo","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.diabet.2022.101397_bib0006","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/bs.acc.2019.07.010","article-title":"Myokines: the endocrine coupling of skeletal muscle and bone","volume":"94","author":"Gomarasca","year":"2020","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.diabet.2022.101397_bib0007","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/382448a0","article-title":"Increased bone formation in osteocalcin-deficient mice","volume":"382","author":"Ducy","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.diabet.2022.101397_bib0008","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41401-019-0311-z","article-title":"Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.diabet.2022.101397_bib0009","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1665-2681(19)31587-X","article-title":"Relation of osteocalcin with insulin resistance and histopathological changes of non alcoholic fatty liver disease","volume":"10","author":"Aller","year":"2011","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.diabet.2022.101397_bib0010","first-page":"21435","article-title":"Serum osteocalcin levels are inversely associated with the presence of nonalcoholic fatty liver disease in patients with coronary artery disease","volume":"8","author":"Du","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.diabet.2022.101397_bib0011","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/MEG.0000000000000535","article-title":"Association of nonalcoholic fatty liver disease with bone mineral density and serum osteocalcin levels in Korean men","volume":"28","author":"Yang","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.diabet.2022.101397_bib0012","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/aps.2015.81","article-title":"Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels","volume":"36","author":"Luo","year":"2015","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.diabet.2022.101397_bib0013","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/1440-1681.12063","article-title":"Relationship between serum osteocalcin levels and non-alcoholic fatty liver disease in Chinese men","volume":"40","author":"Dou","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.diabet.2022.101397_bib0014","first-page":"2187","article-title":"Analysis of the correlation between non-alcoholic fatty liver disease and bone metabolism indicators in healthy middle-aged men","volume":"22","author":"Pontillo","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.diabet.2022.101397_bib0015","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1751-2980.2008.00331.x","article-title":"Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases","volume":"9","author":"Zeng","year":"2008","journal-title":"J Dig Dis"},{"key":"10.1016\/j.diabet.2022.101397_bib0016","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2022.101397_bib0017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-021-00142-4","article-title":"Endocrine role of bone in the regulation of energy metabolism","volume":"9","author":"Zhou","year":"2021","journal-title":"Bone Res"},{"key":"10.1016\/j.diabet.2022.101397_bib0018","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3389\/fendo.2019.00926","article-title":"Bone turnover markers and probable advanced nonalcoholic fatty liver disease in middle-aged and elderly men and postmenopausal women with type 2 diabetes","volume":"10","author":"Wang","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.diabet.2022.101397_bib0019","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.diabet.2018.10.001","article-title":"Association between non-alcoholic fatty liver disease and bone turnover biomarkers in post-menopausal women with type 2 diabetes","volume":"45","author":"Mantovani","year":"2019","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.diabet.2022.101397_bib0020","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/jbmr.4227","article-title":"Osteocalcin and non-alcoholic fatty liver disease: lessons from two population-based cohorts and animal models","volume":"36","author":"Xia","year":"2021","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.diabet.2022.101397_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9178616","article-title":"Osteocalcin alleviates nonalcoholic fatty liver disease in mice through GPRC6A","volume":"2021","author":"Zhang","year":"2021","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.diabet.2022.101397_bib0022","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/hep.30538","article-title":"Association between nonalcoholic fatty liver disease and reduced bone mineral density in children: a meta-analysis","volume":"70","author":"Mantovani","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2022.101397_bib0023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/apt.15087","article-title":"Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density","volume":"49","author":"Mantovani","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.diabet.2022.101397_bib0024","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41574-020-00431-8","article-title":"Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver","volume":"17","author":"Goossens","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.diabet.2022.101397_bib0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cgh.2020.04.067","article-title":"Women have a lower risk of nonalcoholic fatty liver disease but a higher risk of progression vs men: a systematic review and meta-analysis","volume":"19","author":"Balakrishnan","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.diabet.2022.101397_bib0026","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12072-021-10265-9","article-title":"Gender differences in the association of body composition and biopsy-proved nonalcoholic steatohepatitis","volume":"16","author":"Fang","year":"2022","journal-title":"Hepatol Int"},{"key":"10.1016\/j.diabet.2022.101397_bib0027","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00774-015-0734-7","article-title":"An overview of osteocalcin progress","volume":"34","author":"Li","year":"2016","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.diabet.2022.101397_bib0028","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1210\/en.2014-1430","article-title":"Osteocalcin protects against nonalcoholic steatohepatitis in a mouse model of metabolic syndrome","volume":"155","author":"Gupte","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.diabet.2022.101397_bib0029","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1210\/en.2012-2144","article-title":"Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-kappaB signaling pathway","volume":"154","author":"Zhou","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.diabet.2022.101397_bib0030","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s12020-016-0926-5","article-title":"Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK","volume":"53","author":"Du","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.diabet.2022.101397_bib0031","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/hep.29085","article-title":"Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta-analysis","volume":"65","author":"Dulai","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.diabet.2022.101397_bib0032","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"}],"container-title":["Diabetes &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363622000799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1262363622000799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:58:50Z","timestamp":1761130730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1262363622000799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1262363622000799"],"URL":"https:\/\/doi.org\/10.1016\/j.diabet.2022.101397","relation":{},"ISSN":["1262-3636"],"issn-type":[{"value":"1262-3636","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low levels of osteocalcin, but not CTX or P1NP, are associated with nonalcoholic hepatic steatosis and steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Diabetes & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabet.2022.101397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101397"}}