{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:18:42Z","timestamp":1788232722214,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.diabres.2005.02.003","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T23:31:07Z","timestamp":1110324667000},"page":"103-109","source":"Crossref","is-referenced-by-count":41,"title":["Protective effect of vanadyl sulfate on the pancreas of streptozotocin-induced diabetic rats"],"prefix":"10.1016","volume":"70","author":[{"given":"Sema","family":"Bolkent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehnaz","family":"Bolkent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevim","family":"Tunali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2005.02.003_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/07315724.1998.10718730","article-title":"Nutritional factors that can favourably influence the glucose\/insulin system: Vanadium","volume":"17","author":"Verma","year":"1998","journal-title":"J. Am. College Nutr."},{"key":"10.1016\/j.diabres.2005.02.003_bib2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.pa.24.040184.002441","article-title":"Mechanisms of action of vanadium","volume":"24","author":"Nechay","year":"1984","journal-title":"Ann. Rev. Pharm. Toxicol."},{"key":"10.1016\/j.diabres.2005.02.003_bib3","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0006-2952(84)90498-2","article-title":"Vanadate and its significance in biochemistry and pharmacology","volume":"33","author":"Erdmann","year":"1984","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.diabres.2005.02.003_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000187913","article-title":"Biochemistry and pathophysiology of vanadium","volume":"67","author":"Dafnis","year":"1994","journal-title":"Nephron"},{"key":"10.1016\/j.diabres.2005.02.003_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/acm.1999.5.273","article-title":"Vanadium: a review of its potential role in the fight against diabetes","volume":"5","author":"Badmaev","year":"1999","journal-title":"J. Altern. Complem. Med."},{"key":"10.1016\/j.diabres.2005.02.003_bib6","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S1387-7003(03)00050-9","article-title":"Biological, medicinal aspects of vanadium","volume":"6","author":"Rehder","year":"2003","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.diabres.2005.02.003_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1043-2760(96)00262-7","article-title":"Vanadium compounds. Biological actions and potential as pharmacological agents","volume":"8","author":"Tsiani","year":"1997","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.diabres.2005.02.003_bib8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1055\/s-2003-41620","article-title":"Effects of some vanadyl coordination compounds on the in vitro insulin release from rat pancreatic islets","volume":"35","author":"Conconi","year":"2003","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.diabres.2005.02.003_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF00400477","article-title":"Vanadate increases cell surface insulin binding and improves insulin sensitivity in both normal and insulin-resistant rat adipocytes","volume":"35","author":"Eriksson","year":"1992","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2005.02.003_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/bj2320273","article-title":"Selectivity of the insulin-like actions of vanadate on glucose and protein metabolism in skeletal muscle","volume":"232","author":"Clark","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/j.diabres.2005.02.003_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1139\/y00-053","article-title":"Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent","volume":"78","author":"Cam","year":"2000","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.diabres.2005.02.003_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/BF00285328","article-title":"Effects of vanadate administration on blood glucose and insulin levels as well as on the exocrine pancreatic function in streptozotocin-diabetic rats","volume":"32","author":"Bendayan","year":"1989","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2005.02.003_bib13","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1016\/S0021-9258(18)48292-0","article-title":"Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats","volume":"262","author":"Meyerovitch","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diabres.2005.02.003_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-5173(99)00071-X","article-title":"Transdermally delivered peroxovanadium can lower blood glucose levels in diabetic rats","volume":"183","author":"Brand","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.diabres.2005.02.003_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-2999(96)00768-6","article-title":"Vanadyl sulphate differently influences insulin response to glucose in isolated pancreas of normal rats after in vivo or in vitro exposure","volume":"318","author":"Cadene","year":"1996","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.diabres.2005.02.003_bib16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0026-0495(00)90418-9","article-title":"Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies","volume":"49","author":"Goldfine","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.diabres.2005.02.003_bib17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1677\/joe.0.1260451","article-title":"Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats","volume":"126","author":"Sakurai","year":"1990","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.diabres.2005.02.003_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0010-8545(02)00302-8","article-title":"Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes","volume":"237","author":"Shechter","year":"2003","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.diabres.2005.02.003_bib19","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2337\/diabetes.40.4.492","article-title":"Antidiabetic action of vanadyl in rats independent of in vivo insulin-receptor kinase activity","volume":"40","author":"Venkatesan","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2005.02.003_bib20","first-page":"70","article-title":"Trophic effects of vanadium on beta-cells of STZ-induced insulin dependent diabetic rats and evidence for long term relief of diabetes mellitus","volume":"110","author":"Dehghani","year":"1999","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.diabres.2005.02.003_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1007075204494","article-title":"Anti-diabetic and toxic effects of vanadium compounds","volume":"206","author":"Srivastava","year":"2000","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.diabres.2005.02.003_bib22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-0773.1990.tb00812.x","article-title":"Toxicological aspects of vanadyl sulphate on diabetic rats: effects on vanadium levels and pancreatic B-cell morphology","volume":"67","author":"Mongold","year":"1990","journal-title":"Pharm. Toxicol."},{"key":"10.1016\/j.diabres.2005.02.003_bib23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0026-0495(97)90121-9","article-title":"Partial preservation of pancreatic \u03b2-cells by vanadium: evidence for long-term amelioration of diabetes","volume":"46","author":"Cam","year":"1997","journal-title":"Metabolism"},{"key":"10.1016\/j.diabres.2005.02.003_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1139\/y97-003","article-title":"Acute and chronic response to vanadium following two methods of streptozotocin-diabetes induction","volume":"75","author":"Yao","year":"1997","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.diabres.2005.02.003_bib25","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI106180","article-title":"Diabetogenic action of streptozotocin. Relationship of dose to metabolic response","volume":"48","author":"Jound","year":"1969","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.diabres.2005.02.003_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/00365516309079736","article-title":"Differences between the enzymatic and toluidine methods of blood glucose determination","volume":"15","author":"Relander","year":"1963","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.diabres.2005.02.003_bib27","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.diabres.2005.02.003_bib28","unstructured":"J.L. Hintze, Copyright C, 865, East 400, North Kaysville, UT, 84 (1986) 037 (801), 546-0445."},{"key":"10.1016\/j.diabres.2005.02.003_bib29","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1073\/pnas.80.20.6162","article-title":"Vanadium ions stimulate DNA synthesis in Swiss mouse 3T3 and 3T6 cells","volume":"80","author":"Smith","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.diabres.2005.02.003_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0773.1994.tb01083.x","article-title":"One-year treatment of streptozotocin-induced diabetic rats with vanadyl sulphate","volume":"74","author":"Dai","year":"1994","journal-title":"Pharm. Toxicol."},{"key":"10.1016\/j.diabres.2005.02.003_bib31","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1530\/eje.0.1410546","article-title":"Distinct glucose lowering and beta cell protective effects of vanadium and food restriction in streptozotocin-diabetes","volume":"141","author":"Cam","year":"1999","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.diabres.2005.02.003_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1006853426679","article-title":"Multifunctional actions of vanadium compounds on insulin signaling pathways: evidence for preferential enhancement of metabolic versus mitogenic effects","volume":"182","author":"Fantus","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.diabres.2005.02.003_bib33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/BF00399953","article-title":"Long-term effectiveness of oral vanadyl sulphate in streptozotocin-diabetic rats","volume":"36","author":"Cam","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2005.02.003_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0300-483X(93)90096-B","article-title":"Vanadium treatment of diabetic Sprague-Dawley rats results in tissue vanadium accumulation and pro-oxidant effects","volume":"83","author":"Oster","year":"1993","journal-title":"Toxicology"},{"key":"10.1016\/j.diabres.2005.02.003_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02580932","article-title":"Antioxidant effect of vanadate on experimental diabetic rats","volume":"27","author":"Sekar","year":"1990","journal-title":"Acta Diabetol. Lat."},{"key":"10.1016\/j.diabres.2005.02.003_bib36","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0891-5849(01)00693-1","article-title":"The effect of glurenom (gliquidone) on lenses and skin in experimental diabetes","volume":"31","author":"Yarat","year":"2001","journal-title":"Free Radic. Biol. Med."}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822705000367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822705000367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T18:49:41Z","timestamp":1625597381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822705000367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0168822705000367"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2005.02.003","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}