{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:37:23Z","timestamp":1792301843243,"version":"4.4.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.diabres.2007.01.043","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T16:07:33Z","timestamp":1177085253000},"page":"S110-S115","source":"Crossref","is-referenced-by-count":13,"special_numbering":"S","title":["Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes"],"prefix":"10.1016","volume":"77","author":[{"given":"Yongsoo","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2007.01.043_bib1","series-title":"Diabetes Mellitus: A Fundamantal and Clinical Text","first-page":"347","article-title":"Natural history of type 1 diabetes","author":"Park","year":"2000"},{"key":"10.1016\/j.diabres.2007.01.043_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/1520-7560(2000)9999:9999<::AID-DMRR164>3.0.CO;2-M","article-title":"Genetic susceptibility factors of type 1 diabetes in Asians and their functional evaluation","volume":"17","author":"Park","year":"2001","journal-title":"Diab. Metab. Res. Rev."},{"issue":"Suppl.","key":"10.1016\/j.diabres.2007.01.043_bib3","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.diabres.2003.10.026","article-title":"Prediction of the risk of type 1 diabetes from polymorphisms in candidate genes","volume":"66","author":"Park","year":"2004","journal-title":"Diab. Res. Clin. Pract."},{"key":"10.1016\/j.diabres.2007.01.043_bib4","unstructured":"Y. Park, Why is type 1 diabetes so uncommon in Asia? Ann. N. Y. Acad. Sci., in press."},{"key":"10.1016\/j.diabres.2007.01.043_bib5","series-title":"Perspectives of Diabetes in the New Millennium. Proceedings of the 11th Korea\u2013Japan Symposium on Diabetes Mellitus","first-page":"64","article-title":"Development of a new type 1 diabetes-related autoantibody detection method using GAD65\/IA-2 fusion protein","author":"Choi","year":"2003"},{"key":"10.1016\/j.diabres.2007.01.043_bib6","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0198-8859(98)00076-7","article-title":"Combinations of HLA DR and DQ molecules determine the susceptibility to insulin-dependent diabetes mellitus in Koreans","volume":"59","author":"Park","year":"1998","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.diabres.2007.01.043_bib7","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1210\/jc.85.12.4538","article-title":"Common susceptibility and transmission pattern of HLA DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes","volume":"85","author":"Park","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.diabres.2007.01.043_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-065X.1999.tb01377.x","article-title":"HLA class II transgenic mice: models of the human CD4+ T cell immune response","volume":"172","author":"Sonderstrup","year":"1999","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.diabres.2007.01.043_bib9","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/hmg\/6.8.1275","article-title":"Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups","volume":"8","author":"Marron","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.diabres.2007.01.043_bib10","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2337\/diabetes.49.3.492","article-title":"Genetic and physical fine-mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33","volume":"49","author":"Marron","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2007.01.043_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.gene.6364211","article-title":"Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3\u2032 +6230 G>A polymorphism","volume":"6","author":"Anjos","year":"2005","journal-title":"Genes Immun."},{"key":"10.1016\/j.diabres.2007.01.043_bib12","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ng1391","article-title":"A new IkBa modifier, SUMO-L, is associated with type 1 diabetes","volume":"36","author":"Guo","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.diabres.2007.01.043_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/ng0205-112a","article-title":"Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes","volume":"37","author":"Park","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.diabres.2007.01.043_bib14","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.2337\/diabetes.54.12.3582","article-title":"Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes","volume":"54","author":"Noso","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2007.01.043_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/ng0397-293","article-title":"The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes","volume":"15","author":"Pugliese","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.diabres.2007.01.043_bib16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2337\/diabetes.50.4.895","article-title":"Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen","volume":"50","author":"Diez","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2007.01.043_bib17","series-title":"Perspectives of Diabetes in the New Millennium. Proceedings of the 11th Korea\u2013Japan Symposium on Diabetes Mellitus","first-page":"79","author":"Park","year":"2003"},{"key":"10.1016\/j.diabres.2007.01.043_bib18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00125-006-0185-8","article-title":"Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas","volume":"49","author":"Dogra","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2007.01.043_bib19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1196\/annals.1288.073","article-title":"AIRE-1 (autoimmune regulator type 1) as a regulator of the thymic induction of negative selection","volume":"1005","author":"Park","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882270700174X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882270700174X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T03:28:07Z","timestamp":1546918087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882270700174X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S016882270700174X"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2007.01.043","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}