{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:33:51Z","timestamp":1788870831192,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"crossref","award":["CMRPG380291"],"award-info":[{"award-number":["CMRPG380291"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.diabres.2011.10.034","type":"journal-article","created":{"date-parts":[[2011,11,23]],"date-time":"2011-11-23T20:10:53Z","timestamp":1322079053000},"page":"358-363","source":"Crossref","is-referenced-by-count":108,"title":["Risk factors for lower extremity amputation in diabetic foot disease categorized by Wagner classification"],"prefix":"10.1016","volume":"95","author":[{"given":"Jui-Hung","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jir-Shiong","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Huei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Sheng","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hwu","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brend Ray-Sea","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2011.10.034_bib0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2337\/diacare.6.1.87","article-title":"The epidemiology of lower extremity amputations in diabetic individuals","volume":"6","author":"Most","year":"1983","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0010","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.2337\/diacare.26.12.3351","article-title":"Prevalence and risk factors of diabetic foot problems in Taiwan: a cross-sectional survey of non-type 1 diabetic patients from a nationally representative sample","volume":"26","author":"Tseng","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0015","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2337\/diacare.18.4.509","article-title":"Risk factors for lower extremity amputation in persons with diabetes","volume":"18","author":"Selby","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0020","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2337\/diacare.19.6.607","article-title":"Risk factors predicting lower extremity amputations in patients with NIDDM","volume":"19","author":"Lehto","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0025","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2337\/diacare.19.7.704","article-title":"A foot risk classification system to predict diabetic amputation in Pima Indians","volume":"19","author":"Mayfield","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0030","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/diacare.19.7.710","article-title":"Diabetes and nontraumatic lower extremity amputations","volume":"19","author":"Humphrey","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2337\/diacare.11.1.8","article-title":"Lower-extremity amputations in NIDDM. 12-yr follow-up study in Pima Indians","volume":"11","author":"Nelson","year":"1988","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0040","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2337\/diacare.22.7.1029","article-title":"Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers","volume":"22","author":"Adler","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0045","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.diabres.2006.07.029","article-title":"PAD-SEARCH Study Group. Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis","volume":"76","author":"Rhee","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.diabres.2011.10.034_bib0050","first-page":"388","article-title":"Ten-year clinical analysis of diabetic leg amputees","volume":"93","author":"Tseng","year":"1994","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.diabres.2011.10.034_bib0055","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.2337\/dc06-1343","article-title":"Age and sex may significantly interact with diabetes on the risks of lower-extremity amputation and peripheral revascularization procedures: evidence from a cohort of a half-million diabetic patients","volume":"29","author":"Chen","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0060","first-page":"143","article-title":"A classification and treatment program for diabetic, neuropathic, and dysvascular foot problems","volume":"28","author":"Wagner","year":"1979","journal-title":"Am Acad Orthop Surg Instructional Course Lect"},{"key":"10.1016\/j.diabres.2011.10.034_bib0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2337\/diacare.24.1.84","article-title":"A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems","volume":"24","author":"Oyibo","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/107110078800900301","article-title":"Treatment of diabetic foot infections: Wagner classification, therapy, and outcome","volume":"9","author":"Calhoun","year":"1988","journal-title":"Foot Ankle"},{"key":"10.1016\/j.diabres.2011.10.034_bib0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.diabres.2010.08.002","article-title":"C-reactive protein as an outcome predictor for percutaneous transluminal angioplasty in diabetic patients with peripheral arterial disease and infected foot ulcers","volume":"90","author":"Lin","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.diabres.2011.10.034_bib0080","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1464-5491.1995.tb02055.x","article-title":"Comparing the incidence of lower extremity amputations across the world: the Global Lower Extremity Amputation Study","volume":"12","year":"1995","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabres.2011.10.034_bib0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.diabres.2011.10.034_bib0090","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"The expert committee on the diagnosis and classification of diabetes mellitus: report of the expert committee on the diagnosis and classification of diabetes mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0095","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0100","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2337\/dc07-2145","article-title":"Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers: a 6.5-year follow-up study","volume":"31","author":"Ghanassia","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2796.1999.00523.x","article-title":"Factors predicting lower extremity amputations in patients with type 1 or type 2 diabetes mellitus: a population-based 7-year follow-up study","volume":"246","author":"H\u00e4m\u00e4l\u00e4inen","year":"1999","journal-title":"J Intern Med"},{"key":"10.1016\/j.diabres.2011.10.034_bib0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdiacomp.2007.04.004","article-title":"Epidemiology of diabetic foot problems and predictive factors for limb loss","volume":"22","author":"Nather","year":"2008","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.diabres.2011.10.034_bib0115","first-page":"179","article-title":"Risk factors for amputation in diabetic patients: a case-control study","volume":"29","author":"Flores Rivera","year":"1998","journal-title":"Arch Med Res"},{"key":"10.1016\/j.diabres.2011.10.034_bib0120","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1524-475X.2009.00527.x","article-title":"Preliminary development of a diabetic foot ulcer database from a wound electronic medical record: a tool to decrease limb amputations","volume":"17","author":"Golinko","year":"2009","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.diabres.2011.10.034_bib0125","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/00000658-197506000-00014","article-title":"Wound healing in man: tensile strength of healing wounds in some patient groups","volume":"181","author":"Lindstedt","year":"1975","journal-title":"Ann Surg"},{"key":"10.1016\/j.diabres.2011.10.034_bib0130","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2106\/00004623-198668070-00013","article-title":"Amputations at the middle level of the foot. A retrospective and prospective review","volume":"68","author":"Pinzur","year":"1986","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.diabres.2011.10.034_bib0135","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2337\/dc07-2244","article-title":"Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes","volume":"31","author":"Margolis","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0140","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/107110079701801107","article-title":"Clinical characteristics and outcome in 223 diabetic patients with deep foot infections","volume":"18","author":"Eneroth","year":"1997","journal-title":"Foot Ankle Int"},{"key":"10.1016\/j.diabres.2011.10.034_bib0145","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/01.ATV.0000156877.94472.a5","article-title":"Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?","volume":"25","author":"Coller","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.diabres.2011.10.034_bib0150","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2337\/diacare.27.8.1885","article-title":"Incidence of lower-extremity amputation in American Indians: The strong heart study","volume":"27","author":"Resnick","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2011.10.034_bib0155","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.2337\/diacare.27.11.2636","article-title":"Explanations for the high risk of diabetes-related amputation in a Caribbean population of Black African descent and potential for prevention","volume":"27","author":"Hennis","year":"2004","journal-title":"Diabetes Care"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822711005973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822711005973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T21:13:24Z","timestamp":1588799604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822711005973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0168822711005973"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2011.10.034","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}