{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:09:17Z","timestamp":1789819757272,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.diabres.2014.10.011","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T06:39:45Z","timestamp":1414132785000},"page":"15-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography"],"prefix":"10.1016","volume":"107","author":[{"given":"Christina","family":"Byrne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonny","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik \u00d8der","family":"Hjortkj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.M.","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.T.","family":"Kuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik","family":"Hilsted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.F.","family":"Kofoed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2014.10.011_bib0005","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.2337\/dc06-1161","article-title":"Type 1 diabetes and coronary artery disease","volume":"29","author":"Orchard","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2014.10.011_bib0010","doi-asserted-by":"crossref","DOI":"10.2337\/dc12-2024","article-title":"Effect of Type 1 Diabetes Mellitus on Carotid Structure and Function in Adolescents and Young Adults: The SEARCH CVD Study","author":"Urbina","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2014.10.011_bib0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1475-2840-11-145","article-title":"Early signs of atherosclerosis are associated with insulin resistance in non-obese adolescent and young adults with type 1 diabetes","volume":"11","author":"Rathsman","year":"2012","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0020","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2337\/diab.34.12.1301","article-title":"The effect of metabolic control on hemodynamics in short-term insulin-dependent diabetic patients","volume":"34","author":"Mathiesen","year":"1985","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2014.10.011_bib0025","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00125-002-0819-4","article-title":"The effects of insulin and short-term hyperglycaemia on myocardial blood flow in young men with uncomplicated Type I diabetes","volume":"45","author":"Sundell","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2014.10.011_bib0030","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/hrt.2003.013722","article-title":"Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes","volume":"90","author":"Laine","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.diabres.2014.10.011_bib0035","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/CIRCULATIONAHA.110.992297","article-title":"Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans","volume":"124","author":"Rana","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2014.10.011_bib0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/clc.4960280210","article-title":"Abnormal myocardial perfusion and contractile recruitment during exercise in type 1 diabetic patients","volume":"28","author":"Scognamiglio","year":"2005","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0045","doi-asserted-by":"crossref","first-page":"H2279","DOI":"10.1152\/ajpheart.00615.2011","article-title":"Increased basal coronary blood flow as a cause of reduced coronary flow reserve in diabetic patients","volume":"301","author":"Picchi","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0050","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/RLI.0b013e318124a884","article-title":"Quantification of myocardial perfusion using dynamic 64-detector computed tomography","volume":"42","author":"George","year":"2007","journal-title":"Invest Radiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0055","article-title":"Patterns of myocardial perfusion in humans evaluated with contrast-enhanced 320 multidetector computed tomography","author":"Kuhl","year":"2011","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.diabres.2014.10.011_bib0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0735-1097(87)80083-9","article-title":"Use of ultrafast computed tomography to quantitate regional myocardial perfusion: a preliminary report","volume":"9","author":"Rumberger","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcct.2013.01.010","article-title":"Sex- and age-related differences of myocardial perfusion at rest assessed with multidetector computed tomography","volume":"7","author":"Byrne","year":"2013","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.diabres.2014.10.011_bib0070","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s10554-013-0234-6","article-title":"Value of cardiac 320-multidetector computed tomography and cardiac magnetic resonance imaging for assessment of myocardial perfusion defects in patients with known chronic ischemic heart disease","volume":"29","author":"Qayyum","year":"2013","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.diabres.2014.10.011_bib0075","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2014.10.011_bib0080","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.2337\/db11-1235","article-title":"Cardiovascular autonomic neuropathy and subclinical cardiovascular disease in normoalbuminuric type 1 diabetic patients","volume":"61","author":"Mogensen","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2014.10.011_bib0085","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.298.3.299","article-title":"Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women","volume":"298","author":"Nordestgaard","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.diabres.2014.10.011_bib0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1148\/radiol.10091399","article-title":"Characterization and correction of beam-hardening artifacts during dynamic volume CT assessment of myocardial perfusion","volume":"256","author":"Kitagawa","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.diabres.2014.10.011_bib0095","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jcct.2009.01.001","article-title":"SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography","volume":"3","author":"Raff","year":"2009","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.diabres.2014.10.011_bib0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jacc.2006.04.014","article-title":"Multidetector computed tomography myocardial perfusion imaging during adenosine stress","volume":"48","author":"George","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0110","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/clc.4960221205","article-title":"Coronary artery blood flow: physiologic and pathophysiologic regulation","volume":"22","author":"Feliciano","year":"1999","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0115","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/01.CIR.100.8.813","article-title":"Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus","volume":"100","author":"Di Carli","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2014.10.011_bib0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jacc.2005.03.056","article-title":"The effects of plasma insulin and glucose on myocardial blood flow in patients with type 1 diabetes mellitus","volume":"46","author":"Srinivasan","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0125","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.yjmcc.2011.08.018","article-title":"Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation","volume":"52","author":"Belin de Chantemele","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0130","doi-asserted-by":"crossref","first-page":"H2558","DOI":"10.1152\/ajpheart.01198.2007","article-title":"High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation","volume":"294","author":"Jebelovszki","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.diabres.2014.10.011_bib0135","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1161\/01.RES.0000241051.83067.62","article-title":"Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus","volume":"99","author":"Szerafin","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.diabres.2014.10.011_bib0140","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/01.CIR.101.6.689","article-title":"alpha-adrenergic coronary vasoconstriction and myocardial ischemia in humans","volume":"101","author":"Heusch","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2014.10.011_bib0145","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.atherosclerosis.2010.11.035","article-title":"Ivabradine improves coronary flow reserve in patients with stable coronary artery disease","volume":"215","author":"Skalidis","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.diabres.2014.10.011_bib0150","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/eurheartj\/ehn337","article-title":"Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction","volume":"29","author":"Heusch","year":"2008","journal-title":"Eur Heart J"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822714004719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822714004719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T08:23:22Z","timestamp":1538123002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822714004719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0168822714004719"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2014.10.011","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2014.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}