{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:45:10Z","timestamp":1790027110503,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.diabres.2015.04.008","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T21:22:24Z","timestamp":1429564944000},"page":"199-205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes"],"prefix":"10.1016","volume":"109","author":[{"given":"Hiroyuki","family":"Kato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Tenjin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Tsukiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Ohshige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Terashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyoshi","family":"Sada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyasu","family":"Sasaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.diabres.2015.04.008_bib0155","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-012-2534-0","article-title":"Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"55","author":"Inzucchi","year":"2012","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.diabres.2015.04.008_bib0160","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2337\/dc12-0413","article-title":"Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"35","author":"Inzucchi","year":"2012","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.diabres.2015.04.008_bib0165","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s00125-012-2827-3","article-title":"Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis","volume":"56","author":"Kim","year":"2013","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.diabres.2015.04.008_bib0170","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.298.2.194","article-title":"Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis","volume":"298","author":"Amori","year":"2007","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.diabres.2015.04.008_bib0175","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1592\/phco.30.5.463","article-title":"Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus","volume":"30","author":"Neumiller","year":"2010","journal-title":"Pharmacotherapy"},{"issue":"5","key":"10.1016\/j.diabres.2015.04.008_bib0180","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/hep.23569","article-title":"Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway","volume":"51","author":"Gupta","year":"2010","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.diabres.2015.04.008_bib0185","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1478-3231.2011.02462.x","article-title":"Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signaling alteration induced by a high-fat diet in nonalcoholic steatohepatitis","volume":"31","author":"Svegliati-Baroni","year":"2011","journal-title":"Liver Int"},{"issue":"12","key":"10.1016\/j.diabres.2015.04.008_bib0190","doi-asserted-by":"crossref","first-page":"e50117","DOI":"10.1371\/journal.pone.0050117","article-title":"Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists","volume":"7","author":"Cuthbertson","year":"2012","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.diabres.2015.04.008_bib0195","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00592-011-0322-9","article-title":"Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin","volume":"49","author":"Aoki","year":"2012","journal-title":"Acta Diabetol"},{"issue":"2","key":"10.1016\/j.diabres.2015.04.008_bib0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00125-001-0719-z","article-title":"The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men","volume":"45","author":"Agers\u00f8","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.04.008_bib0205","doi-asserted-by":"crossref","first-page":"e38744","DOI":"10.1371\/journal.pone.0038744","article-title":"Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity","volume":"7","author":"Kern","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.diabres.2015.04.008_bib0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.diabres.2014.04.028","article-title":"Sitagliptin attenuates methionine\/choline-deficient diet-induced steatohepatitis","volume":"105","author":"Jung","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.diabres.2015.04.008_bib0215","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1097-0096(199601)24:1<25::AID-JCU4>3.0.CO;2-N","article-title":"Sonographic diagnosis of fatty liver using a histogram technique that compares liver and renal cortical echo amplitudes","volume":"24","author":"Osawa","year":"1996","journal-title":"J Clin Ultrasound"},{"issue":"5","key":"10.1016\/j.diabres.2015.04.008_bib0220","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1507\/endocrj.K09E-272","article-title":"Dose-ranging efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus","volume":"57","author":"Iwamoto","year":"2010","journal-title":"Endocr J"},{"issue":"Suppl","key":"10.1016\/j.diabres.2015.04.008_bib0225","first-page":"S33","article-title":"Clinical profile of the novel sulphonylurea glimepiride","volume":"31","author":"Rosskamp","year":"1996","journal-title":"Diabetes Res Clin Pract"},{"issue":"6","key":"10.1016\/j.diabres.2015.04.008_bib0230","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1210\/jc.2004-1959","article-title":"Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients","volume":"90","author":"Tamura","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.diabres.2015.04.008_bib0235","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1210\/jc.2006-2384","article-title":"Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects","volume":"92","author":"Sato","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.diabres.2015.04.008_bib0240","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1053\/j.gastro.2009.01.048","article-title":"Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction","volume":"136","author":"Kirk","year":"2009","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.diabres.2015.04.008_bib0245","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1016\/j.orcp.2010.12.007","article-title":"Intrahepatic lipid content is linked to insulin resistance in obese subjects","volume":"5","author":"Sada","year":"2011","journal-title":"Obes Res Clin Pract"},{"issue":"9","key":"10.1016\/j.diabres.2015.04.008_bib0250","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1463-1326.2007.00801.x","article-title":"Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects","volume":"10","author":"Tamura","year":"2008","journal-title":"Diabetes Obes Metab"},{"issue":"12","key":"10.1016\/j.diabres.2015.04.008_bib0255","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1007\/s00125-011-2311-5","article-title":"Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status","volume":"54","author":"Stephenne","year":"2011","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.diabres.2015.04.008_bib0260","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/CS20110386","article-title":"Cellular and molecular mechanisms of metformin: an overview","volume":"122","author":"Viollet","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"10.1016\/j.diabres.2015.04.008_bib0265","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1748-1716.2009.01970.x","article-title":"AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives","volume":"196","author":"Viollet","year":"2009","journal-title":"Acta Physiol (Oxf)"},{"issue":"6","key":"10.1016\/j.diabres.2015.04.008_bib0270","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jhep.2010.09.032","article-title":"Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase","volume":"54","author":"Ben-Shlomo","year":"2011","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.diabres.2015.04.008_bib0275","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1478-3231.2011.02462.x","article-title":"Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis","volume":"31","author":"Svegliati-Baroni","year":"2011","journal-title":"Liver Int"},{"issue":"7","key":"10.1016\/j.diabres.2015.04.008_bib0280","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/oby.2006.129","article-title":"Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification","volume":"14","author":"Getty-Kaushik","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"10.1016\/j.diabres.2015.04.008_bib0285","first-page":"1133","article-title":"Effect of GLP-1 on d-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects","volume":"17","author":"Sancho","year":"2006","journal-title":"Int J Mol Med"},{"issue":"11","key":"10.1016\/j.diabres.2015.04.008_bib0290","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1210\/en.2011-1070","article-title":"Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance","volume":"152","author":"Vendrell","year":"2011","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.diabres.2015.04.008_bib0295","doi-asserted-by":"crossref","first-page":"E908","DOI":"10.1210\/jc.2013-3350","article-title":"Disruption of GIP\/GIPR axis in human adipose tissue is linked to obesity and insulin resistance","volume":"99","author":"Ceperuelo-Mallafr\u00e9","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.diabres.2015.04.008_bib0300","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.trsl.2011.09.005","article-title":"Serum level of soluble CD26\/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and\/or sulfonylurea","volume":"159","author":"Aso","year":"2012","journal-title":"Transl Res"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822715001904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822715001904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T21:02:26Z","timestamp":1566594146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822715001904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0168822715001904"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2015.04.008","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2015.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}