{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:26:12Z","timestamp":1789910772675,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NHMRC-JDRF Special Program","award":["465199"],"award-info":[{"award-number":["465199"]}]}],"content-domain":{"domain":["diabetesresearchclinicalpractice.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.diabres.2015.10.010","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T04:45:20Z","timestamp":1445921120000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells"],"prefix":"10.1016","volume":"110","author":[{"given":"Petra","family":"Augstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Naselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Loudovaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne J.","family":"Hawthorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bandala-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Heinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard C.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2015.10.010_bib0205","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00577838","article-title":"A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide","volume":"7","author":"Hopsu-Havu","year":"1966","journal-title":"Histochemie"},{"key":"10.1016\/j.diabres.2015.10.010_bib0210","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1016\/S0021-9258(17)39973-8","article-title":"Purification and subunit structure of adenosine deaminase from human kidney","volume":"252","author":"Schrader","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1016\/j.diabres.2015.10.010_bib0215","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0305-0491(97)00327-1","article-title":"The CP-I subunit of adenosine deaminase complexing protein from calf kidney is identical to human, mouse, and rat dipeptidyl peptidase IV","volume":"119","author":"Ben-Shooshan","year":"1998","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.diabres.2015.10.010_bib0220","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","article-title":"The physiology of glucagon-like peptide 1","volume":"87","author":"Holst","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.diabres.2015.10.010_bib0225","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/44.5.8627002","article-title":"Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice","volume":"44","author":"Mentzel","year":"1996","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.diabres.2015.10.010_bib0230","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.2174\/092986709788803114","article-title":"Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme","volume":"16","author":"Matteucci","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.diabres.2015.10.010_bib0235","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.8101391","article-title":"Direct association of adenosine deaminase with a T cell activation antigen, CD26","volume":"261","author":"Kameoka","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.diabres.2015.10.010_bib0240","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1742-4658.2009.07526.x","article-title":"The dipeptidyl peptidase IV family in cancer and cell biology","volume":"277","author":"Yu","year":"2010","journal-title":"FEBS J"},{"key":"10.1016\/j.diabres.2015.10.010_bib0245","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1517\/14656566.2013.824966","article-title":"Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety","volume":"14","author":"Deacon","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.diabres.2015.10.010_bib0250","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrendo.2012.140","article-title":"GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus","volume":"8","author":"Meier","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.diabres.2015.10.010_bib0255","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2010.11.002","article-title":"Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications","volume":"124","author":"Nauck","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.diabres.2015.10.010_bib0260","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/33.6.2582028","article-title":"Adenosine deaminase complexing proteins are localized in exocrine glands of the rabbit","volume":"33","author":"Schrader","year":"1985","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.diabres.2015.10.010_bib0265","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.mce.2011.04.008","article-title":"Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers","volume":"339","author":"Dorrell","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.diabres.2015.10.010_bib0270","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/41.1.8093256","article-title":"Dipeptidyl peptidase IV is sorted to the secretory granules in pancreatic islet A-cells","volume":"41","author":"Poulsen","year":"1993","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.diabres.2015.10.010_bib0275","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1177\/37.12.2573631","article-title":"Distribution of adenosine deaminase complexing protein (ADCP) in human tissues","volume":"37","author":"Dinjens","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.diabres.2015.10.010_bib0280","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI66514","article-title":"Epigenomic plasticity enables human pancreatic \u03b1 to \u03b2 cell reprogramming","volume":"123","author":"Bramswig","year":"2013","journal-title":"J Clin Investig"},{"key":"10.1016\/j.diabres.2015.10.010_bib0285","first-page":"S24","article-title":"Direct enhancement of insulin secretion by dipeptidyl peptidase 4 inhibitors in pancreatic islets: studies in incretin receptor deficient mice","volume":"56","author":"Omar","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.10.010_bib0290","series-title":"Annual meeting of the EASD Islet Study Group","article-title":"DPP-4 (CD26) is expressed by ductal and islet cells in human adult pancreas","author":"Augstein","year":"2012"},{"key":"10.1016\/j.diabres.2015.10.010_bib0295","first-page":"S216","article-title":"DPP-4 (CD26) is expressed by ductal and islet cells in human adult pancreas","volume":"56","author":"Augstein","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.10.010_bib0300","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00125-014-3299-4","article-title":"Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes","volume":"57","author":"Omar","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.10.010_bib0305","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3727\/096368911X566262","article-title":"Expression of pro- and antiapoptotic molecules of the Bcl-2 family in human islets postisolation","volume":"21","author":"Campbell","year":"2012","journal-title":"Cell Transpl"},{"key":"10.1016\/j.diabres.2015.10.010_bib0310","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cell.2005.05.027","article-title":"Loss of ARNT\/HIF1\u03b2 mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes","volume":"122","author":"Gunton","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.diabres.2015.10.010_bib0315","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.scr.2008.04.001","article-title":"Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers","volume":"1","author":"Dorrell","year":"2008","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.diabres.2015.10.010_bib0320","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.2337\/diab.33.10.1012","article-title":"Human proinsulin-specific antigenic determinants identified by monoclonal antibodies","volume":"33","author":"Madsen","year":"1984","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2015.10.010_bib0325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00006676-199708000-00005","article-title":"Immunohistochemical differentiation of monoclonal GAD antibodies recognizing linear or conformational epitope regions","volume":"15","author":"Augstein","year":"1997","journal-title":"Pancreas"},{"key":"10.1016\/j.diabres.2015.10.010_bib0330","unstructured":"Collins T. Colocalisation Available from: http:\/\/www.macbiophotonics.ca\/imagej. [accessed 12.11.2012]."},{"key":"10.1016\/j.diabres.2015.10.010_bib0335","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ncpendmet0946","article-title":"Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus?","volume":"4","author":"Meier","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1016\/j.diabres.2015.10.010_bib0340","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00125-010-1896-4","article-title":"Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?","volume":"54","author":"Nauck","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.10.010_bib0345","doi-asserted-by":"crossref","unstructured":"Drucker DJ. Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 Banting Lecture. Diabetes n.d.;64:317\u201326.","DOI":"10.2337\/db14-1514"},{"key":"10.1016\/j.diabres.2015.10.010_bib0350","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1007\/s00125-012-2716-9","article-title":"A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets","volume":"55","author":"Marchetti","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.10.010_bib0355","doi-asserted-by":"crossref","first-page":"678","DOI":"10.2337\/db07-1124","article-title":"Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance","volume":"57","author":"Vollmer","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2015.10.010_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/mpa.0b013e318149f2dc","article-title":"Stem cell marker prominin-1\/AC133 is expressed in duct cells of the adult human pancreas","volume":"36","author":"Lardon","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.diabres.2015.10.010_bib0365","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/CS20040302","article-title":"Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders","volume":"108","author":"Gorrell","year":"2005","journal-title":"Clinical Science"},{"key":"10.1016\/j.diabres.2015.10.010_bib0370","first-page":"1","article-title":"Adult pancreas side population cells expand after \u03b2 cell injury and are a source of insulin-secreting cells","author":"Banakh","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.diabres.2015.10.010_bib0375","first-page":"603","article-title":"A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer","volume":"6","author":"Pang","year":"2010","journal-title":"Stem Cell"},{"key":"10.1016\/j.diabres.2015.10.010_bib0380","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1634\/stemcells.2004-0342","article-title":"Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis","volume":"23","author":"Kucia","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.diabres.2015.10.010_bib0385","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5966\/sctm.2011-0025","article-title":"Concise review: pancreas regeneration: recent advances and perspectives","volume":"1","author":"Lysy","year":"2012","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.diabres.2015.10.010_bib0390","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrgastro.2011.114","article-title":"From tissue turnover to the cell of origin for pancreatic cancer","volume":"8","author":"Kong","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.diabres.2015.10.010_bib0395","first-page":"S180(A425)","article-title":"Pancreatic duct glands \u2014 a stem cell niche in the pancreas?","volume":"55","author":"Gier","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2015.10.010_bib0400","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMp1314078","article-title":"Pancreatic safety of incretin-based drugs \u2014 FDA and EMA assessment","volume":"370","author":"Egan","year":"2015","journal-title":"N Engl J Med"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822715004106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822715004106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T09:18:27Z","timestamp":1653383907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822715004106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0168822715004106"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2015.10.010","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2015.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}