{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:24:57Z","timestamp":1791419097818,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009094","name":"Turun Yliopistollisen Keskussairaalan Koulutus- ja Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.diabres.2020.108456","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T08:25:43Z","timestamp":1600935943000},"page":"108456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes"],"prefix":"10.1016","volume":"170","author":[{"given":"Mikael S.","family":"Huhtala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Tertti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2020.108456_b0005","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.ajog.2004.11.039","article-title":"Gestational diabetes: The consequences of not treating","volume":"192","author":"Langer","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.diabres.2020.108456_b0010","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/1471-0528.13261","article-title":"Maternal lipid levels during pregnancy and gestational diabetes: A systematic review and meta-analysis","volume":"122","author":"Ryckman","year":"2015","journal-title":"BJOG An Int J Obstet Gynaecol"},{"key":"10.1016\/j.diabres.2020.108456_b0015","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jproteome.5b00260","article-title":"Prediction of gestational diabetes through NMR metabolomics of maternal blood","volume":"14","author":"Pinto","year":"2015","journal-title":"J Proteome Res"},{"key":"10.1016\/j.diabres.2020.108456_b0020","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.2337\/dc16-0863","article-title":"An unbiased lipidomics approach identifies early second trimester lipids predictive of maternal glycemic traits and gestational diabetes mellitus","volume":"39","author":"Lu","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2020.108456_b0025","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2337\/diacare.15.11.1605","article-title":"Prediction of infant birth weight by GDM screening tests. Importance of plasma triglyceride","volume":"15","author":"Knopp","year":"1992","journal-title":"Diabet Care"},{"key":"10.1016\/j.diabres.2020.108456_b0030","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2337\/db15-1748","article-title":"Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth","volume":"65","author":"Scholtens","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2020.108456_b0035","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00125-016-4182-2","article-title":"Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes","volume":"60","author":"Sandler","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2020.108456_b0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/dme.13150","article-title":"Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis","volume":"34","author":"Butalia","year":"2017","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabres.2020.108456_b0045","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2017-000456","article-title":"Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7\u20139 years of age","volume":"6","author":"Rowan","year":"2018","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.diabres.2020.108456_b0050","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.2337\/dc15-0658","article-title":"Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes","volume":"38","author":"Xu","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2020.108456_b0055","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/dme.13636","article-title":"Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial","volume":"35","author":"Safai","year":"2018","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabres.2020.108456_b0060","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jpba.2009.01.008","article-title":"Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride","volume":"49","author":"Huo","year":"2009","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.diabres.2020.108456_b0065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2337\/dc12-1097","article-title":"Maternal and Neonatal Circulating Markers of Metabolic and Cardiovascular Risk in the Metformin in Gestational Diabetes (MiG) Trial: Responses to maternal metformin versus insulin treatment","volume":"36","author":"Barrett","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2020.108456_b0070","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.2337\/dc08-0039","article-title":"Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus","volume":"31","author":"Schaefer-Graf","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2020.108456_b0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1464-5491.2004.01336.x","article-title":"Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance","volume":"22","author":"Di Cianni","year":"2005","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabres.2020.108456_b0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/dom.12017","article-title":"Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin","volume":"15","author":"Tertti","year":"2013","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.diabres.2020.108456_b0085","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1039\/b910205a","article-title":"High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism","volume":"134","author":"Soininen","year":"2009","journal-title":"Analyst"},{"key":"10.1016\/j.diabres.2020.108456_b0090","first-page":"1540","article-title":"Characteristic of recent fetal growth curves in Finland","volume":"105","author":"Pihkala","year":"1989","journal-title":"Duodecim"},{"key":"10.1016\/j.diabres.2020.108456_b0095","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","article-title":"Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses","volume":"14","author":"Th\u00e9venot","year":"2015","journal-title":"J Proteome Res"},{"key":"10.1016\/j.diabres.2020.108456_b0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12916-016-0733-0","article-title":"Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence","volume":"14","author":"Wang","year":"2016","journal-title":"BMC Med"},{"key":"10.1016\/j.diabres.2020.108456_b0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12916-018-1248-7","article-title":"The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial","volume":"17","author":"Mills","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.diabres.2020.108456_b0110","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2337\/diab.41.12.1651","article-title":"Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women","volume":"41","author":"Montelongo","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2020.108456_b0115","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0022-2275(20)37617-3","article-title":"Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women","volume":"37","author":"Alvarez","year":"1996","journal-title":"J Lipid Res"},{"key":"10.1016\/j.diabres.2020.108456_b0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0009-9120(94)90013-2","article-title":"Changes in cholesteryl ester transfer protein activity during normal gestation and postpartum","volume":"27","author":"Iglesias","year":"1994","journal-title":"Clin Biochem"},{"key":"10.1016\/j.diabres.2020.108456_b0125","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.116.001564","article-title":"Effect of Metformin on Metabolites and Relation With Myocardial Infarct Size and Left Ventricular Ejection Fraction After Myocardial Infarction","volume":"10","author":"Eppinga","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.diabres.2020.108456_b0130","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S2213-8587(15)00219-3","article-title":"Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): A randomised, double-blind, placebo-controlled trial","volume":"3","author":"Chiswick","year":"2015","journal-title":"Lancet Diabet Endocrinol"},{"key":"10.1016\/j.diabres.2020.108456_b0135","first-page":"227","article-title":"Short-term antidiabetic treatment with insulin or metformin has a similar impact on the components of metabolic syndrome in women with gestational diabetes mellitus requiring antidiabetic agents: results of a prospective, randomised study","volume":"67","author":"Zawiejska","year":"2016","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.diabres.2020.108456_b0140","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.2337\/dc12-2445","article-title":"Maternal lipids are as important as glucose for fetal growth: findings from the Pune Maternal Nutrition Study","volume":"36","author":"Kulkarni","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2020.108456_b0145","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/oby.2011.43","article-title":"Maternal serum lipids during pregnancy and infant birth weight: The influence of prepregnancy","volume":"19","author":"Misra","year":"2011","journal-title":"BMI Obesity"},{"key":"10.1016\/j.diabres.2020.108456_b0150","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1464-5491.2011.03346.x","article-title":"Differences in the implications of maternal lipids on fetal metabolism and growth between gestational diabetes mellitus and control pregnancies","volume":"28","author":"Schaefer-Graf","year":"2011","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabres.2020.108456_b0155","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1001\/jama.2016.1975","article-title":"Genetic evidence for causal relationships between maternal obesity-related traits and birth weight","volume":"315","author":"Tyrrell","year":"2016","journal-title":"JAMA - J Am Med Assoc"},{"key":"10.1016\/j.diabres.2020.108456_b0160","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1210\/jc.2006-2403","article-title":"Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies","volume":"92","author":"Gauster","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabres.2020.108456_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0104826","article-title":"Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)","volume":"9","author":"Barrett","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.diabres.2020.108456_b0170","doi-asserted-by":"crossref","first-page":"209.e1","DOI":"10.1016\/j.ajog.2009.04.019","article-title":"Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus","volume":"201","author":"Radaelli","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.diabres.2020.108456_b0175","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/1753495X17725465","article-title":"Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin","volume":"10","author":"Balani","year":"2017","journal-title":"Obstet Med"},{"key":"10.1016\/j.diabres.2020.108456_b0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.plefa.2011.10.012","article-title":"Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates","volume":"86","author":"Kuipers","year":"2012","journal-title":"Prostaglandins Leukot Essent Fat Acids"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822720307099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822720307099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:15:56Z","timestamp":1759173356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822720307099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":36,"alternative-id":["S0168822720307099"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2020.108456","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2020.108456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108456"}}