{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T06:58:19Z","timestamp":1774162699721,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003646","name":"National Health Insurance Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.diabres.2022.110083","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T11:37:07Z","timestamp":1663328227000},"page":"110083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Severe hypoglycemia and risk of hospitalization for heart failure in adults with diabetes treated with oral medications with or without insulin: A population-based study"],"prefix":"10.1016","volume":"192","author":[{"given":"You-Bin","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Jong","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoseob","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Yoon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyuri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Yeon","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Man","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.diabres.2022.110083_b0005","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S2213-8587(18)30315-2","article-title":"Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management","volume":"7","author":"Amiel","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"10.1016\/j.diabres.2022.110083_b0010","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2337\/dc17-1669","article-title":"The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes","volume":"41","author":"Lee","year":"2018","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.diabres.2022.110083_b0015","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002875","article-title":"Association Between Severe Hypoglycemia and Cardiovascular Disease Risk in Japanese Patients With Type 2 Diabetes","volume":"5","author":"Goto","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"Suppl 2","key":"10.1016\/j.diabres.2022.110083_b0020","doi-asserted-by":"crossref","first-page":"S205","DOI":"10.2337\/dcS15-3014","article-title":"Hypoglycemia and Cardiovascular Risk: Is There a Major Link?","volume":"39","author":"Hanefeld","year":"2016","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.diabres.2022.110083_b0025","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.jacc.2016.06.049","article-title":"Severe Hypoglycemia and Elevated High-Sensitivity Cardiac Troponin T in Older Adults With Diabetes: The ARIC Study","volume":"68","author":"Lee","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"15","key":"10.1016\/j.diabres.2022.110083_b0030","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jacc.2018.07.067","article-title":"Hypoglycemia and Elevated Troponin in Patients With Diabetes and Coronary Artery Disease","volume":"72","author":"Rezende","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.diabres.2022.110083_b0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2337\/dc20-0552","article-title":"Severe Hypoglycemia, Cardiac Structure and Function, and Risk of Cardiovascular Events Among Older Adults With Diabetes","volume":"44","author":"Echouffo-Tcheugui","year":"2021","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.diabres.2022.110083_b0040","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4093\/dmj.2020.0282","article-title":"Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes","volume":"45","author":"Park","year":"2021","journal-title":"Diabetes Metab J"},{"issue":"3","key":"10.1016\/j.diabres.2022.110083_b0045","doi-asserted-by":"crossref","first-page":"e955","DOI":"10.1210\/clinem\/dgab794","article-title":"Severe Hypoglycemia and Incident Heart Failure among Adults With Type 2 Diabetes","volume":"107","author":"Echouffo-Tcheugui","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabres.2022.110083_b0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12933-019-0909-y","article-title":"Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study","volume":"18","author":"Yun","year":"2019","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.diabres.2022.110083_b0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4093\/dmj.2016.40.1.79","article-title":"Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service","volume":"40","author":"Lee","year":"2016","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.diabres.2022.110083_b0060","first-page":"799","article-title":"Data Resource Profile: The National Health Information Database of the National Health Insurance Service in South Korea","volume":"46","author":"Seong","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"1","key":"10.1016\/j.diabres.2022.110083_b0065","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-020-01051-2","article-title":"Hospitalization for heart failure incidence according to the transition in metabolic health and obesity status: a nationwide population-based study","volume":"19","author":"Lee","year":"2020","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.diabres.2022.110083_b0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-019-0953-7","article-title":"Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study","volume":"18","author":"Lee","year":"2019","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.diabres.2022.110083_b0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/cncr.32485","article-title":"Long-term risk of congestive heart failure in younger breast cancer survivors: A nationwide study by the SMARTSHIP group","volume":"126","author":"Lee","year":"2020","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.diabres.2022.110083_b0080","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.2337\/dc14-0908","article-title":"Association between severe hypoglycemia, adverse macrovascular events, and inflammation in the Edinburgh Type 2 Diabetes Study","volume":"37","author":"Bedenis","year":"2014","journal-title":"Diabetes Care"},{"issue":"15","key":"10.1016\/j.diabres.2022.110083_b0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1056\/NEJMoa1003795","article-title":"Severe hypoglycemia and risks of vascular events and death","volume":"363","author":"Zoungas","year":"2010","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.diabres.2022.110083_b0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJMoa1812389","article-title":"Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes","volume":"380","author":"Wiviott","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.diabres.2022.110083_b0095","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2337\/diacare.26.5.1485","article-title":"Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring","volume":"26","author":"Desouza","year":"2003","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.diabres.2022.110083_b0100","doi-asserted-by":"crossref","first-page":"E388","DOI":"10.1152\/ajpendo.00051.2019","article-title":"Repetitive hypoglycemia reduces activation of glucose-responsive neurons in C1 and C3 medullary brain regions to subsequent hypoglycemia","volume":"317","author":"Kakall","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.diabres.2022.110083_b0105","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2337\/dc15-0533","article-title":"Seminal Contributions to the Understanding of Hypoglycemia and Glucose Counterregulation and the Discovery of HAAF (Cryer Syndrome)","volume":"38","author":"Dagogo-Jack","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2022.110083_b0110","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.2337\/diabetes.54.12.3592","article-title":"Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes","volume":"54","author":"Cryer","year":"2005","journal-title":"Diabetes"},{"issue":"Suppl 2","key":"10.1016\/j.diabres.2022.110083_b0115","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.2337\/dc11-s220","article-title":"Hypoglycemia and cardiovascular risks","volume":"34","author":"Frier","year":"2011","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.diabres.2022.110083_b0120","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.2337\/db13-0468","article-title":"Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk","volume":"63","author":"Chow","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2022.110083_b0125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.diabres.2016.11.021","article-title":"QT prolongation caused by insulin-induced hypoglycaemia - An interventional study in 119 individuals","volume":"123","author":"Kacheva","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"5","key":"10.1016\/j.diabres.2022.110083_b0130","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2337\/dc16-1972","article-title":"Cardiac Effects of Sulfonylurea-Related Hypoglycemia","volume":"40","author":"Middleton","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2022.110083_b0135","first-page":"2035","article-title":"Diabetes and cardiovascular disease","volume":"241","author":"Kannel","year":"1979","journal-title":"The Framingham study Jama"},{"issue":"6","key":"10.1016\/j.diabres.2022.110083_b0140","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.semnephrol.2018.08.005","article-title":"Heart Failure in End-Stage Kidney Disease: Pathophysiology, Diagnosis, and Therapeutic Strategies","volume":"38","author":"Rangaswami","year":"2018","journal-title":"Semin Nephrol"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882272200897X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882272200897X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:21:36Z","timestamp":1759173696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882272200897X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":28,"alternative-id":["S016882272200897X"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2022.110083","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severe hypoglycemia and risk of hospitalization for heart failure in adults with diabetes treated with oral medications with or without insulin: A population-based study","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2022.110083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110083"}}