{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:46:01Z","timestamp":1784119561580,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.diabres.2023.110686","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:55:14Z","timestamp":1682369714000},"page":"110686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Impact of gliflozins on cardiac remodeling in patients with type 2 diabetes mellitus &amp; reduced ejection fraction heart failure: A pilot prospective study. GLISCAR study"],"prefix":"10.1016","volume":"200","author":[{"given":"Giuseppe","family":"Palmiero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-1235","authenticated-orcid":false,"given":"Arturo","family":"Cesaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-3430","authenticated-orcid":false,"given":"Raffaele","family":"Galiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Loffredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-7533","authenticated-orcid":false,"given":"Alfredo","family":"Caturano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Vetrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-3821","authenticated-orcid":false,"given":"Luca","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rosaria Di Palo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestino","family":"Sardu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Marfella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Limongelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Carlo Sasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.diabres.2023.110686_b0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/ejhf.1170","article-title":"Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology","volume":"20","author":"Seferovi\u0107","year":"2018","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.diabres.2023.110686_b0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2459\/JCM.0b013e32834058d1","article-title":"Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure","volume":"12","author":"Metra","year":"2011","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"9","key":"10.1016\/j.diabres.2023.110686_b0015","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/CIRCULATIONAHA.117.028136","article-title":"Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Pep-tide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors","volume":"136","author":"Nauck","year":"2017","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.diabres.2023.110686_b0020","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/CIRCULATIONAHA.118.037778","article-title":"Empagliflozin reduced mortality and hospitalization for Heart Failure across the spectrum of cardiovascular risk in the EMPA-REG OUTCOME Trial","volume":"139","author":"Fitchett","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.diabres.2023.110686_b0025","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/CIRCULATIONAHA.117.032038","article-title":"Canagliflozin for Primary and Secondary Prevention of Cardiovascular Events: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)","volume":"137","author":"Mahaffey","year":"2018","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.diabres.2023.110686_b0030","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"for the DAPA-HF Trial Committees and Investigators. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.diabres.2023.110686_b0035","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"2019 ESC Guidelines on Diabetes, Pre-Diabetes, and Cardiovascular dis-eases developed in collaboration with the EASD","volume":"41","author":"Cosentino","year":"2020","journal-title":"Eur Heart J"},{"issue":"23","key":"10.1016\/j.diabres.2023.110686_b0040","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1414266","article-title":"Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes","volume":"372","author":"Hayward","year":"2015","journal-title":"N Engl J Med"},{"issue":"27","key":"10.1016\/j.diabres.2023.110686_b0045","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.diabres.2023.110686_b0050","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/CIRCULATIONAHA.116.025795","article-title":"Ejection fraction. Misunderstood and overrated (Changing the paradigm in categorizing heart failure)","volume":"135","author":"Konstam","year":"2017","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.diabres.2023.110686_b0055","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.hlc.2019.03.012","article-title":"Echocardiographic strain in clinical practice","volume":"28","author":"Trivedi","year":"2019","journal-title":"Heart Lung Circ"},{"issue":"6","key":"10.1016\/j.diabres.2023.110686_b0060","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","article-title":"A novel clinical method for quantification of regional left ventricular pres-sure-strain loop area: a non-invasive index of myocardial work","volume":"33","author":"Russell","year":"2012","journal-title":"Eur Heart J"},{"issue":"12","key":"10.1016\/j.diabres.2023.110686_b0065","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/ehjci\/jey024","article-title":"Estimation of myocardial work from pressure-strain loops analysis: an experimental evaluation","volume":"19","author":"Hubert","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"9","key":"10.1016\/j.diabres.2023.110686_b0070","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.diabres.2023.110686_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.diabres.2023.110686_b0080","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1182\/blood.V126.23.1774.1774","article-title":"In patients with light-chain (AL) amyloidosis myocardial contraction frac-tion (MCF) is a simple, but powerful prognostic measure that can be calculated from a standard echocardiogram","volume":"126","author":"Milani","year":"2015","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.diabres.2023.110686_b0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.echo.2014.11.003","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardise deformation imaging","volume":"28","author":"Voigt","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"7","key":"10.1016\/j.diabres.2023.110686_b0090","doi-asserted-by":"crossref","first-page":"H996","DOI":"10.1152\/ajpheart.00191.2013","article-title":"Assessment of wasted myocardial work: A novel method to quantify energy loss due to uncoordinated left ventricular contractions","volume":"305","author":"Russell","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.diabres.2023.110686_b0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.echo.2017.08.016","article-title":"Association between global longitudinal strain and cardiovascular events in patients with left bundle branch block assessed using two-dimensional speckle-tracking echocardiography","volume":"31","author":"Hwang","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.diabres.2023.110686_b0100","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ehjci\/jey188","article-title":"Echocardiographic reference ranges for average non-invasive myocardial work indices: Results from the EACVI NORRE study","volume":"20","author":"Manganaro","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"9","key":"10.1016\/j.diabres.2023.110686_b0105","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/ehjci\/jez036","article-title":"Significant functional mitral regurgitation affects left atrial function in heart failure patients: haemodynamic correlations and prognostic implications","volume":"20","author":"Palmiero","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"9","key":"10.1016\/j.diabres.2023.110686_b0110","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009047","article-title":"Validation of the Tricuspid Annular Plane Systolic Excursion\/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hyperten-sion","volume":"12","author":"Tello","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.diabres.2023.110686_b0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/antiox11020208","article-title":"Unraveling and Targeting Myocardial Regeneration Deficit in Diabetes","volume":"11","author":"Molinaro","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.diabres.2023.110686_b0120","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3390\/ijms24021132","article-title":"Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy","volume":"24","author":"Marino","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.diabres.2023.110686_b0125","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2337\/db21-0536","article-title":"Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age","volume":"71","author":"Marino","year":"2022","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.diabres.2023.110686_b0130","doi-asserted-by":"crossref","first-page":"e12931","DOI":"10.1111\/acel.12931","article-title":"Aged-senescent cells contribute to impaired heart regeneration","volume":"18","author":"Lewis-McDougall","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.diabres.2023.110686_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111740","article-title":"Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice","volume":"208","author":"Salerno","year":"2022","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"10.1016\/j.diabres.2023.110686_b0140","doi-asserted-by":"crossref","first-page":"854","DOI":"10.4239\/wjd.v5.i6.854","article-title":"Place of sodium-glucose co-transporter type 2 inhibitors for the treatment of type 2 diabetes","volume":"5","author":"Mikhail","year":"2014","journal-title":"World J Di-abetes"},{"issue":"6","key":"10.1016\/j.diabres.2023.110686_b0145","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1111\/dom.13670","article-title":"Uric acid and the cardio-renal effects of SGLT2 inhibitors","volume":"21","author":"Bailey","year":"2019","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"10.1016\/j.diabres.2023.110686_b0150","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-020-01209-y","article-title":"Effect of sodium-glucose cotransporter 2 inhibitors on cardiac structure and function in type 2 diabetes mellitus patients with or without chronic heart failure: a meta-analysis","volume":"20","author":"Yu","year":"2021","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"10.1016\/j.diabres.2023.110686_b0155","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1002\/ehf2.13645","article-title":"SGLT2 inhibitors and cardiac remodelling: a systematic review and me-ta-analysis of randomized cardiac magnetic resonance imaging trials","volume":"8","author":"Dhingra","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"1","key":"10.1016\/j.diabres.2023.110686_b0160","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-021-02250-9","article-title":"Effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on left ventricular remodelling and longitudinal strain: a prospective observational study","volume":"21","author":"Gamaza-Chuli\u00e1n","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.diabres.2023.110686_b0165","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2018.01.053","article-title":"Relevance of the TAPSE\/PASP ratio in pulmonary arterial hypertension","volume":"266","author":"Tello","year":"2018","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.diabres.2023.110686_b0170","doi-asserted-by":"crossref","DOI":"10.4081\/monaldi.2020.1269","article-title":"Echocardiography of right ventricular-arterial coupling predicts survival of elderly patients with heart failure and reduced to mid-range ejec-tion fraction","volume":"90","author":"Rosa","year":"2020","journal-title":"Monaldi Arch Chest Dis"},{"issue":"7","key":"10.1016\/j.diabres.2023.110686_b0175","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.3390\/ijms23073651","article-title":"An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors","volume":"23","author":"Salvatore","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"20","key":"10.1016\/j.diabres.2023.110686_b0180","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.3390\/ijms232012325","article-title":"Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular Mechanisms","volume":"23","author":"La Grotta","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.diabres.2023.110686_b0185","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.2147\/DDDT.S269514","article-title":"SGLT2 Inhibitors: A Novel Player in the Treatment and Prevention of Diabetic Cardiomyopathy","volume":"14","author":"Li","year":"2020","journal-title":"Drug Des Devel Ther"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822723004473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822723004473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:25:05Z","timestamp":1759173905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822723004473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":37,"alternative-id":["S0168822723004473"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2023.110686","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of gliflozins on cardiac remodeling in patients with type 2 diabetes mellitus & reduced ejection fraction heart failure: A pilot prospective study. GLISCAR study","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2023.110686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110686"}}