{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:14:24Z","timestamp":1789755264748,"version":"4.0.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.diabres.2023.110868","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T03:30:07Z","timestamp":1691119807000},"page":"110868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["MicroRNA biomarkers target genes and pathways associated with type 2 diabetes"],"prefix":"10.1016","volume":"203","author":[{"given":"Dorian","family":"Kariuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley E.","family":"Aouizerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesava","family":"Asam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka M.","family":"Kanaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Florez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-7533","authenticated-orcid":false,"given":"Elena","family":"Flowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2023.110868_b0005","unstructured":"IDF Diabetes Atlas. International Diabetes Federation. Accessed 15 Feb 2023. Available from https:\/\/diabetesatlas.org\/."},{"key":"10.1016\/j.diabres.2023.110868_b0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biochi.2017.05.007","article-title":"Role of MicroRNAs in Type 2 diabetes and associated vascular complications","volume":"139","author":"Banerjee","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.diabres.2023.110868_b0015","article-title":"The type 2 diabetes 'modern preventable pandemic' and replicable lessons from the COVID-19 crisis","volume":"25","author":"Singer","year":"2022","journal-title":"Prev Med Rep"},{"key":"10.1016\/j.diabres.2023.110868_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00095.2014","article-title":"MicroRNAs associated with exercise and diet: a systematic review","volume":"47","author":"Flowers","year":"2015","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.diabres.2023.110868_b0025","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12672","article-title":"Co-expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes","volume":"25","author":"Flowers","year":"2022","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.diabres.2023.110868_b0030","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.diabres.2023.110868_b0035","first-page":"dgac714","article-title":"MicroRNAs associated with incident diabetes in the diabetes prevention program","author":"Flowers","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.diabres.2023.110868_b0040","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2337\/diacare.22.4.623","article-title":"Design and methods for a clinical trial in the prevention of type 2 diabetes","volume":"22","author":"The Diabetes Prevention Program","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2023.110868_b0045","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2337\/diacare.25.12.2165","article-title":"The Diabetes Prevention Program (DPP): description of lifestyle intervention","volume":"25","author":"Diabetes Prevention Program (DPP) Research Group","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2023.110868_b0050","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2337\/diacare.23.11.1619","article-title":"The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group","volume":"23","author":"The Diabetes Prevention Program Research Group","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2023.110868_b0055","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baad014","article-title":"Review of databases for experimentally validated human microRNA-mRNA interactions","author":"Kariuki","year":"2023","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.diabres.2023.110868_b0060","first-page":"D148","article-title":"miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database","volume":"48","author":"Huang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.diabres.2023.110868_b0065","article-title":"Supplementary manuscript files","volume":"V1","author":"Flowers","year":"2023","journal-title":"Harvard Dataverse"},{"key":"10.1016\/j.diabres.2023.110868_b0070","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cmet.2022.03.011","article-title":"Evaluating human genetic support for hypothesized metabolic disease genes","volume":"34","author":"Dornbos","year":"2022","journal-title":"Cell Metab"},{"key":"10.1016\/j.diabres.2023.110868_b0075","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00125-019-4969-z","article-title":"VEGF-A and blood vessels: a beta cell perspective","volume":"62","author":"Staels","year":"2019","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.diabres.2023.110868_b0080","doi-asserted-by":"crossref","DOI":"10.1177\/14791641211055837","article-title":"Circulating microRNAs are associated with variability in fasting blood glucose over 12-months and target pathways related to type 2 diabetes: A pilot study","volume":"18","author":"Flowers","year":"2021","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"10.1016\/j.diabres.2023.110868_b0085","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fendo.2018.00338","article-title":"PTEN: tumor suppressor and metabolic regulator","volume":"9","author":"Chen","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.diabres.2023.110868_b0090","unstructured":"Common Metabolic Diseases Knowledge Portal (cmdkp.org). 2023 Jan 23; https:\/\/hugeamp.org\/phenotype.html?phenotype=T2D (RRID:SCR_020937)."},{"key":"10.1016\/j.diabres.2023.110868_b0095","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.tcb.2011.03.001","article-title":"Bcl-2 proteins in diabetes: mitochondrial pathways of \u03b2-cell death and dysfunction","volume":"21","author":"Gurzov","year":"2011","journal-title":"Trends Cell Biol"},{"issue":"6","key":"10.1016\/j.diabres.2023.110868_b0100","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/CIRCULATIONAHA.121.057789","article-title":"ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis","volume":"145","author":"Cheng","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2023.110868_b0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2020.08.013","article-title":"Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease","volume":"311","author":"Ma","year":"2020","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.diabres.2023.110868_b0110","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/10935266221079569","article-title":"Review of the pathologic characteristics in myhre syndrome: gain-of-function pathogenic variants in SMAD4 cause a Multisystem Fibroproliferative Response","volume":"25","author":"Starr","year":"2022","journal-title":"Pediatr Dev Pathol"},{"issue":"9","key":"10.1016\/j.diabres.2023.110868_b0115","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.3390\/ijms24097900","article-title":"SMAD4 Expression in Monocytes as a Potential Biomarker for Atherosclerosis Risk in Patients with Obstructive Sleep Apnea","volume":"24","author":"D\u00edaz-Garc\u00eda","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.diabres.2023.110868_b0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.biocel.2015.01.009","article-title":"AGE\/RAGE signalling regulation by miRNAs: associations with diabetic complications and therapeutic potential","volume":"60","author":"Piperi","year":"2015","journal-title":"Int J Biochem Cell Biol"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822723006319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822723006319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T03:45:22Z","timestamp":1736394322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822723006319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":24,"alternative-id":["S0168822723006319"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2023.110868","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA biomarkers target genes and pathways associated with type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2023.110868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110868"}}