{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:48:43Z","timestamp":1781106523691,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.diabres.2025.112358","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:25:26Z","timestamp":1751423126000},"page":"112358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effectiveness of probiotic therapy as an adjunct in the management of periodontal disease in type 2 diabetics: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"226","author":[{"given":"Wang","family":"Yuqi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Hangying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ruyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Xiaolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yajing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2025.112358_b0005","unstructured":"Organization WH. Diabetes, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes\/; 2024 [accessed 14 November, 2024]."},{"key":"10.1016\/j.diabres.2025.112358_b0010","unstructured":"World Health O. Global oral health status report: towards universal health coverage for oral health by 2030. Geneva: World Health Organization; 2022."},{"key":"10.1016\/j.diabres.2025.112358_b0015","doi-asserted-by":"crossref","first-page":"13686","DOI":"10.1038\/s41598-021-93062-6","article-title":"Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"11","author":"St\u00f6hr","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabres.2025.112358_b0020","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12903-020-01180-w","article-title":"Epidemiologic relationship between periodontitis and type 2 diabetes mellitus","volume":"20","author":"Wu","year":"2020","journal-title":"BMC Oral Health"},{"issue":"43","key":"10.1016\/j.diabres.2025.112358_b0025","first-page":"233","article-title":"Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation","volume":"2007","author":"Nassar","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0030","first-page":"16","article-title":"Periodontal disease as part of the insulin resistance syndrome in diabetic patients","volume":"7","author":"Nishimura","year":"2005","journal-title":"J Int Acad Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tripleo.2007.06.027","article-title":"Oral infection, hyperglycemia, and endothelial dysfunction","volume":"105","author":"Janket","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.diabres.2025.112358_b0040","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2337\/db06-0922","article-title":"Genetic variation, C-reactive protein levels, and incidence of diabetes","volume":"56","author":"Dehghan","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2025.112358_b0045","first-page":"806","article-title":"Diabetes and oral health: a case-control study","volume":"3","author":"Bharateesh","year":"2012","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.diabres.2025.112358_b0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.chom.2017.06.014","article-title":"Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity","volume":"22","author":"Xiao","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.diabres.2025.112358_b0055","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.4049\/jimmunol.138.5.1464","article-title":"Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption","volume":"138","author":"Stashenko","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.diabres.2025.112358_b0060","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4049\/jimmunol.1602035","article-title":"IL-1\u03b2 induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity: a possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and talin-1","volume":"200","author":"Shiratori","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.diabres.2025.112358_b0065","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1440-1754.2012.02508.x","article-title":"Probiotics in neonatology","volume":"48","author":"Hickey","year":"2012","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.diabres.2025.112358_b0070","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/jcpe.12155","article-title":"Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study","volume":"40","author":"Teughels","year":"2013","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0075","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/jcpe.12995","article-title":"Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial","volume":"45","author":"Invernici","year":"2018","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0080","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1902\/jop.2015.140612","article-title":"Clinical and biochemical evaluation of lozenges containing lactobacillus reuteri as an adjunct to non-surgical periodontal therapy in chronic periodontitis","volume":"86","author":"\u0130nce","year":"2015","journal-title":"J Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0085","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/jcpe.12387","article-title":"Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1-year follow-up study","volume":"42","author":"Tekce","year":"2015","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0090","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1016\/j.dsx.2018.07.016","article-title":"Probiotic and synbiotic supplementation could improve metabolic syndrome in prediabetic adults: a randomized controlled trial","volume":"13","author":"Kassaian","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.diabres.2025.112358_b0095","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1080\/13813455.2021.1928225","article-title":"Does symbiotic supplementation which contains bacillus Coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial","volume":"129","author":"Velayati","year":"2023","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.diabres.2025.112358_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/foods10071455","article-title":"Influence of lactobacillus paracasei HII01 supplementation on glycemia and inflammatory biomarkers in type 2 diabetes: a randomized clinical trial","volume":"10","author":"Toejing","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.diabres.2025.112358_b0105","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.17582\/journal.pjz\/20210715070747","article-title":"Effect of basic periodontal therapy combined with probiotics on oral microecology and blood sugar control in patients with diabetes and periodontitis","volume":"55","author":"Hu","year":"2023","journal-title":"Pak. J. Zool."},{"key":"10.1016\/j.diabres.2025.112358_b0110","article-title":"Effectiveness of probiotic therapy in the management of periodontaldisease in diabetic patients","volume":"20","author":"de Brito","year":"2024","journal-title":"A Scoping Rev Current Diabetes Rev"},{"key":"10.1016\/j.diabres.2025.112358_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.diabres.2025.112358_b0120","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.diabres.2025.112358_b0125","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.diabres.2025.112358_b0130","doi-asserted-by":"crossref","first-page":"378","DOI":"10.11124\/JBIES-23-00268","article-title":"The revised JBI critical appraisal tool for the assessment of risk of bias for quasi-experimental studies","volume":"22","author":"Barker","year":"2024","journal-title":"JBI Evid Synth"},{"key":"10.1016\/j.diabres.2025.112358_b0135","unstructured":"Cohen J. Statistical power analysis for the behavioral sciences (2nd ed: Statistical power analysis for the behavioral sciences; 1988."},{"key":"10.1016\/j.diabres.2025.112358_b0140","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.diabres.2025.112358_b0145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"Dersimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.diabres.2025.112358_b0150","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"09","key":"10.1016\/j.diabres.2025.112358_b0155","first-page":"139","article-title":"Effects of periodontal base intervention combined with probiotics on adiponectin and inflammatory factors in gingival crevicular fluid in elderly patients with type 2 diabetes mellitus and chronic periodontitis [J]","volume":"17","author":"Hui-qing","year":"2023","journal-title":"Chinese J Modern Drug Application"},{"issue":"07","key":"10.1016\/j.diabres.2025.112358_b0160","first-page":"515","article-title":"Effect of probiotics combined with periodontal therapy on inflammatory factors and bone metabolic factors in gingival crevicular fluid of patients with periodontitis combined type 2 diabetes [J]","volume":"15","author":"Jianbo","year":"2021","journal-title":"Chinese J Clinicians(Electronic Edition)"},{"key":"10.1016\/j.diabres.2025.112358_b0165","first-page":"135","article-title":"Clinical value of periodontal basic intervention combined with probiotics in elderly patients with type 2 diabetes mellitus and chronic periodontitis [J]","volume":"6","author":"Shuyin","year":"2024","journal-title":"Special Health"},{"key":"10.1016\/j.diabres.2025.112358_b0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/DMSO.S230060","article-title":"The impacts of synbiotic supplementation on periodontal indices and biomarkers of oxidative stress in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. A double-blind, placebo-controlled trial","volume":"13","author":"Bazyar","year":"2020","journal-title":"Diabetes, Metabolic Syndrome and Obesity"},{"key":"10.1016\/j.diabres.2025.112358_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2019.101629","article-title":"A comparative clinical, microbiological and glycemic analysis of photodynamic therapy and Lactobacillus reuteri in the treatment of chronic periodontitis in type-2 diabetes mellitus patients","volume":"29","author":"Elsadek","year":"2020","journal-title":"Photodiagn Photodyn Ther"},{"key":"10.1016\/j.diabres.2025.112358_b0180","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00784-023-05441-0","article-title":"Effect of adjuvant probiotic therapy (Lactobacillus reuteri) in the treatment of periodontitis associated with diabetes mellitus: clinical, controlled, and randomized study","volume":"28","author":"Jardini","year":"2024","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.diabres.2025.112358_b0185","first-page":"430","article-title":"The effects of synbiotic supplementation along with non-surgical periodontal therapy in improving the metabolic status and inflammatory markers in type 2 diabetes mellitus patients with periodontal disease: a double-blind randomized clinical trial","volume":"13","author":"Yarahmadi","year":"2024","journal-title":"J Edu Health Promotion"},{"issue":"01","key":"10.1016\/j.diabres.2025.112358_b0190","first-page":"71","article-title":"Advances in research on the mechanism of association between periodontitis and diabetes mellitus [J]","volume":"54","author":"Li-li","year":"2023","journal-title":"J Sichuan Univ (Med Sci)"},{"key":"10.1016\/j.diabres.2025.112358_b0195","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12602-019-9521-4","article-title":"Probiotics as an adjunct therapy for the treatment of halitosis, dental caries and periodontitis","volume":"12","author":"Bustamante","year":"2020","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.diabres.2025.112358_b0200","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4166\/kjg.2019.74.6.314","article-title":"Role of gut microbiota in type 2 diabetes mellitus and its complications: novel insights and potential intervention strategies","volume":"74","author":"Woldeamlak","year":"2019","journal-title":"Korean J Gastroenterol"},{"key":"10.1016\/j.diabres.2025.112358_b0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S095442241700018X","article-title":"Probiotics, prebiotics, synbiotics and insulin sensitivity","volume":"31","author":"Kim","year":"2018","journal-title":"Nutr Res Rev"},{"key":"10.1016\/j.diabres.2025.112358_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031113","article-title":"Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota","volume":"7","author":"Riboulet-Bisson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.diabres.2025.112358_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2021.105196","article-title":"What do we know about the mechanisms of action of probiotics on factors involved in the pathogenesis of periodontitis? A scoping review of in vitro studies","volume":"129","author":"Routier","year":"2021","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.diabres.2025.112358_b0220","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1600-051X.2012.01914.x","article-title":"Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial","volume":"39","author":"Iniesta","year":"2012","journal-title":"J Clin Periodontol"},{"issue":"Suppl 11","key":"10.1016\/j.diabres.2025.112358_b0225","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-051X.2010.01665.x","article-title":"Do probiotics offer opportunities to manipulate the periodontal oral microbiota?","volume":"38","author":"Teughels","year":"2011","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.diabres.2025.112358_b0230","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2024.2307416","article-title":"Manipulating the diseased oral microbiome: the power of probiotics and prebiotics","volume":"16","author":"Yu","year":"2024","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.diabres.2025.112358_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106520","article-title":"The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: a systematic review, meta-analysis, and meta-regression of clinical trials","volume":"185","author":"Paul","year":"2022","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.diabres.2025.112358_b0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0296962","article-title":"Distribution and determinants of glycosylated hemoglobin in adolescents - results from a nationwide population-based survey in Germany","volume":"19","author":"Patelakis","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.diabres.2025.112358_b0245","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s13300-021-01005-1","article-title":"Movement is improvement: the therapeutic effects of exercise and general physical activity on glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Shah","year":"2021","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.diabres.2025.112358_b0250","doi-asserted-by":"crossref","DOI":"10.1007\/s12602-024-10377-2","article-title":"Antidiabetic effect of bifidobacterium animalis TISTR 2591 in a rat model of type 2 diabetes","author":"Hanchang","year":"2024","journal-title":"Probiotics Antimicrob Proteins"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725003729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725003729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T21:04:51Z","timestamp":1753909491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822725003729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"alternative-id":["S0168822725003729"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112358","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of probiotic therapy as an adjunct in the management of periodontal disease in type 2 diabetics: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112358"}}