{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:01:39Z","timestamp":1793984499905,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005709","name":"Endocrine Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.diabres.2025.112404","type":"journal-article","created":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T18:38:14Z","timestamp":1754246294000},"page":"112404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Low prolactin levels as a marker of gestational diabetes in late pregnancy"],"prefix":"10.1016","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7353-8437","authenticated-orcid":false,"given":"Roberta","family":"Scairati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata S.","family":"Auriemma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Di","family":"Meglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Mastantuoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Graziadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guendalina Del","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Legnante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3682-9403","authenticated-orcid":false,"given":"Fidelma","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio Di","family":"Spiezio Sardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.diabres.2025.112404_b0005","article-title":"Normal pregnancy- a state of insulin resistance","volume":"8","author":"Sonagra","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.diabres.2025.112404_b0010","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.2337\/dc24-S002","article-title":"2. Diagnosis and classification of diabetes: standards of care in diabetes\u20142024","volume":"47","author":"ElSayed","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2025.112404_b0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4093\/dmj.2021.0335","article-title":"Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications","volume":"46","author":"Moon","year":"2022","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.diabres.2025.112404_b0020","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/dc18-1646","article-title":"Hyperglycemia and adverse pregnancy outcome follow-up study (HAPO FUS): maternal gestational diabetes mellitus and childhood glucose metabolism","volume":"42","author":"Lowe","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2025.112404_b0025","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.2023.19869","article-title":"Early metformin in gestational diabetes","volume":"330","author":"Dunne","year":"2023","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.diabres.2025.112404_b0030","article-title":"Postnatal cardiometabolic health after metformin use in gestational diabetes: a secondary analysis of the EMERGE Trial","author":"Dunne","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.diabres.2025.112404_b0035","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1210\/clinem\/dgae289","article-title":"Risk assessment of diabetes mellitus during and after pregnancy in women with prolactinomas","volume":"109","author":"Scairati","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.diabres.2025.112404_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14190","article-title":"Prolactin effects on the pathogenesis of diabetes mellitus","volume":"54","author":"Scairati","year":"2024","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"10.1016\/j.diabres.2025.112404_b0045","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s11154-024-09891-z","article-title":"Cardiometabolic effects of hypoprolactinemia","volume":"25","author":"Auriemma","year":"2024","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.diabres.2025.112404_b0050","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.2337\/db15-1527","article-title":"Gestational diabetes mellitus from inactivation of prolactin receptor and MafB in Islet \u03b2-cells","volume":"65","author":"Banerjee","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2025.112404_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187923","article-title":"Breastfeeding and maternal cardiovascular risk factors and outcomes: a systematic review","volume":"12","author":"Nguyen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.diabres.2025.112404_b0060","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.2337\/db12-0393","article-title":"Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus","volume":"61","author":"Ziegler","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2025.112404_b0065","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.molmet.2014.01.002","article-title":"Beneficial effects of breastfeeding in women with gestational diabetes mellitus","volume":"3","author":"Much","year":"2014","journal-title":"Mol Metab"},{"key":"10.1016\/j.diabres.2025.112404_b0070","unstructured":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. https:\/\/iris.who.int\/handle\/10665\/42330; 2000;[accessed 25 June 2025]."},{"key":"10.1016\/j.diabres.2025.112404_b0075","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1210\/endo.132.2.8425500","article-title":"Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy","volume":"132","author":"Brelje","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.diabres.2025.112404_b0080","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1210\/en.2008-1003","article-title":"Prolactin receptor is required for normal glucose homeostasis and modulation of \u03b2-cell mass during pregnancy","volume":"150","author":"Huang","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.diabres.2025.112404_b0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/JOE-18-0518","article-title":"Pancreatic prolactin receptor signaling regulates maternal glucose homeostasis","volume":"241","author":"Nteeba","year":"2019","journal-title":"J Endocrinol"},{"key":"10.1016\/j.diabres.2025.112404_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114244","article-title":"Targeting PI3K\/AKT signaling pathway in obesity","volume":"159","author":"Savova","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.diabres.2025.112404_b0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-055257","article-title":"Lactogenic hormones in relation to maternal metabolic health in pregnancy and postpartum: protocol for a systematic review","volume":"12","author":"Rassie","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.diabres.2025.112404_b0100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2217\/dmt.10.24","article-title":"Mechanisms in the adaptation of maternal \u03b2-cells during pregnancy","volume":"1","author":"Ernst","year":"2011","journal-title":"Diabetes Management"},{"key":"10.1016\/j.diabres.2025.112404_b0105","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.3390\/jcm13061732","article-title":"Early HbA1c levels as a predictor of adverse obstetric outcomes: a systematic review and meta-analysis","volume":"13","author":"Ma\u00f1\u00e9","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.diabres.2025.112404_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136498","article-title":"Hepatic-derived extracellular vesicles in late pregnancy promote mammary gland development by stimulating prolactin receptor-mediated JAK2\/STAT5\/mTOR signalling","volume":"281","author":"Zhu","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.diabres.2025.112404_b0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10911-008-9069-5","article-title":"Prolactin regulation of mammary gland development","volume":"13","author":"Oakes","year":"2008","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1016\/j.diabres.2025.112404_b0120","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12020-019-02170-x","article-title":"Low prolactin levels are associated with visceral adipocyte hypertrophy and insulin resistance in humans","volume":"67","author":"Ponce","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.diabres.2025.112404_b0125","doi-asserted-by":"crossref","DOI":"10.1210\/en.2016-1444","article-title":"Prolactin promotes adipose tissue fitness and insulin sensitivity in obese males","author":"Ruiz-Herrera","year":"2016","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.diabres.2025.112404_b0130","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1530\/EJE-20-0144","article-title":"Maternal prolactin is associated with glucose status and PCOS in pregnancy: odense Child Cohort","volume":"183","author":"Overgaard","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.diabres.2025.112404_b0135","doi-asserted-by":"crossref","unstructured":"Rassie K, Giri R, Joham AE, Mousa A, Teede H. Prolactin in relation to gestational diabetes and metabolic risk in pregnancy and postpartum: A systematic review and meta-analysis. Front Endocrinol (Lausanne) 2022;13:1069625. Published 2022 Dec 22. doi:10.3389\/fendo.2022.1069625.","DOI":"10.3389\/fendo.2022.1069625"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725004188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725004188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T12:43:35Z","timestamp":1762260215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822725004188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":27,"alternative-id":["S0168822725004188"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112404","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low prolactin levels as a marker of gestational diabetes in late pregnancy","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112404"}}