{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:29:16Z","timestamp":1786987756634,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.diabres.2025.112461","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T14:51:50Z","timestamp":1757170310000},"page":"112461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Beta-hydroxybutyrate ameliorates cardiac fibrosis in diabetic cardiomyopathy rats via regulating macrophage polarization"],"prefix":"10.1016","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3125-9927","authenticated-orcid":false,"given":"Mei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.diabres.2025.112461_b0005","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.3390\/ijms23073587","article-title":"Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart failure in patients with Diabetes Mellitus","volume":"23","author":"Nakamura","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.diabres.2025.112461_b0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","article-title":"Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease","volume":"61","author":"Jia","year":"2018","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.diabres.2025.112461_b0015","article-title":"Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy","volume":"3","author":"Li","year":"2023","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.diabres.2025.112461_b0020","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41467-022-28044-x","article-title":"The mitochondrial \u03b2-oxidation enzyme HADHA restrains hepatic glucagon response by promoting \u03b2-hydroxybutyrate production","volume":"13","author":"Pan","year":"2022","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.diabres.2025.112461_b0025","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.3390\/ijms23073788","article-title":"Exercise Ameliorates Atherosclerosis via Up-Regulating Serum \u03b2-Hydroxybutyrate Levels","volume":"23","author":"Xu","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"22","key":"10.1016\/j.diabres.2025.112461_b0030","doi-asserted-by":"crossref","first-page":"16142","DOI":"10.3390\/ijms242216142","article-title":"Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.diabres.2025.112461_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109161","article-title":"Ketogenic diet modulates cardiac metabolic dysregulation in streptozocin-induced diabetic rats","volume":"111","author":"Trang","year":"2023","journal-title":"J Nutr Biochem"},{"issue":"2","key":"10.1016\/j.diabres.2025.112461_b0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.14336\/AD.2019.0510","article-title":"Ketogenic Diet Ameliorates Cardiac Dysfunction via Balancing Mitochondrial Dynamics and Inhibiting Apoptosis in Type 2 Diabetic mice","volume":"11","author":"Guo","year":"2020","journal-title":"Aging Dis"},{"issue":"19","key":"10.1016\/j.diabres.2025.112461_b0045","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020729","article-title":"Ketone Ester D-\u03b2-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic mice","volume":"10","author":"Thai","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"10.1016\/j.diabres.2025.112461_b0050","article-title":"Macrophages: the good, the bad, and the Gluttony","volume":"12","author":"Ross","year":"2021","journal-title":"Front Immunol"},{"issue":"877","key":"10.1016\/j.diabres.2025.112461_b0055","article-title":"Macrophage M1\/M2 polarization","volume":"15","author":"Yunna","year":"2020","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.diabres.2025.112461_b0060","first-page":"63","article-title":"Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs","volume":"9","author":"Peterson","year":"2022","journal-title":"Regenerative Systems J Cardiovasc Dev Dis"},{"issue":"5","key":"10.1016\/j.diabres.2025.112461_b0065","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.3390\/ijms22052715","article-title":"Macrophage Polarization in Cardiac Tissue Repair following Myocardial Infarction","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"20","key":"10.1016\/j.diabres.2025.112461_b0070","article-title":"Natural Melanin\/Alginate Hydrogels Achieve Cardiac Repair through ROS Scavenging and Macrophage Polarization","volume":"8","author":"Zhou","year":"2021","journal-title":"Adv Sci (Weinh)"},{"issue":"268","key":"10.1016\/j.diabres.2025.112461_b0075","article-title":"The effect of miR-471-3p on macrophage polarization in the development of diabetic cardiomyopathy","volume":"1","author":"Liu","year":"2021","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.diabres.2025.112461_b0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body \u03b2-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med"},{"issue":"16","key":"10.1016\/j.diabres.2025.112461_b0085","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1111\/jcmm.16601","article-title":"Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK\u03b1\/TGF-\u03b2\/Smad signalling in type 2 diabetic rats","volume":"25","author":"Tian","year":"2021","journal-title":"J Cell Mol Med"},{"issue":"11","key":"10.1016\/j.diabres.2025.112461_b0090","article-title":"Left ventricular ejection fraction: clinical, pathophysiological, and technical limitations","volume":"7","author":"Vancheri","year":"2024","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.diabres.2025.112461_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165739","article-title":"Cardiac ketone body metabolism","volume":"1866","author":"Abdul Kadir","year":"2020","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"10.1016\/j.diabres.2025.112461_b0100","doi-asserted-by":"crossref","unstructured":"Yamahara K, Yasuda-Yamahara M, Kuwagata S, Chin-Kanasaki M, Kume S. Ketone Body Metabolism in Diabetic Kidney Disease. Kidney360. 2024 Feb 1;5(2):320-326. doi: 10.34067\/KID.0000000000000359.","DOI":"10.34067\/KID.0000000000000359"},{"key":"10.1016\/j.diabres.2025.112461_b0105","unstructured":"Liu Y, Ma L, Fu P. Ketone Body Metabolism and Renal Diseases. Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 20;54(6):1091-1096. Chinese. doi: 10.12182\/20231160202."},{"issue":"41","key":"10.1016\/j.diabres.2025.112461_b0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-nutr-111120-111518","article-title":"Metabolic and Signaling Roles of Ketone Bodies in Health and Disease","volume":"11","author":"Puchalska","year":"2021","journal-title":"Annu Rev Nutr"},{"issue":"4","key":"10.1016\/j.diabres.2025.112461_b0115","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114753","article-title":"Ketone body oxidation increases cardiac endothelial cell proliferation","volume":"14","author":"Weis","year":"2022","journal-title":"EMBO Mol Med"},{"issue":"2022","key":"10.1016\/j.diabres.2025.112461_b0120","article-title":"Ketone Body\u03b2-Hydroxybutyrate Prevents Myocardial Oxidative stress in Septic Cardiomyopathy","volume":"18","author":"Ji","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"829","key":"10.1016\/j.diabres.2025.112461_b0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2018.04.019","article-title":"Treatment with D-\u03b2-hydroxybutyrate protects heart from ischemia\/reperfusion injury in mice","volume":"15","author":"Yu","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"14","key":"10.1016\/j.diabres.2025.112461_b0130","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.2147\/JIR.S331320","article-title":"\u03b2-Hydroxybutyrate Mitigated Heart failure with Preserved Ejection Fraction by increasing Treg Cells via Nox2\/GSK-3\u03b2","volume":"16","author":"Liao","year":"2021","journal-title":"J Inflamm Res"},{"issue":"6","key":"10.1016\/j.diabres.2025.112461_b0135","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006573","article-title":"Chronically Elevating Circulating Ketones can Reduce Cardiac Inflammation and Blunt the Development of Heart failure","volume":"13","author":"Byrne","year":"2020","journal-title":"Circ Heart Fail"},{"issue":"15","key":"10.1016\/j.diabres.2025.112461_b0140","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.2147\/JIR.S370483","article-title":"The NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibrosis","volume":"7","author":"Fan","year":"2022","journal-title":"J Inflamm Res"},{"issue":"7","key":"10.1016\/j.diabres.2025.112461_b0145","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cardfail.2025.01.028","article-title":"Therapeutic Ketosis for Heart failure: a State-of-the-Art Review","volume":"31","author":"Kodur","year":"2025","journal-title":"J Card Fail"},{"issue":"1","key":"10.1016\/j.diabres.2025.112461_b0150","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s12872-025-04832-3","article-title":"Diabetic ketoacidosis and hyperosmolar hyperglycemic state in diabetes patients with heart failure: insight from the National inpatient sample","volume":"25","author":"Alroobi","year":"2025","journal-title":"BMC Cardiovasc Disord"},{"issue":"49","key":"10.1016\/j.diabres.2025.112461_b0155","doi-asserted-by":"crossref","first-page":"19314","DOI":"10.1523\/JNEUROSCI.3102-13.2013","article-title":"\u03b2-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3","volume":"33","author":"Won","year":"2013","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.diabres.2025.112461_b0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nm.3779","article-title":"Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes","volume":"21","author":"Tang","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.diabres.2025.112461_b0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.metabol.2017.08.005","article-title":"The diabetic heart utilizes ketone bodies as an energy source","volume":"77","author":"Mizuno","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.diabres.2025.112461_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103010","article-title":"Empagliflozin improves mitochondrial dysfunction in diabetic cardiomyopathy by modulating ketone body metabolism and oxidative stress","volume":"69","author":"Cai","year":"2024","journal-title":"Redox Biol"},{"issue":"131","key":"10.1016\/j.diabres.2025.112461_b0175","article-title":"Interleukin-1\u03b2 polarization in M1 macrophage mediates myocardial fibrosis in diabetes","volume":"20","author":"Guo","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"22","key":"10.1016\/j.diabres.2025.112461_b0180","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.1039\/D4FO03543G","article-title":"Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1","volume":"15","author":"Nan","year":"2024","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.diabres.2025.112461_b0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12967-019-1999-8","article-title":"Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy","volume":"17","author":"Jin","year":"2019","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.diabres.2025.112461_b0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1124\/jpet.112.200808","article-title":"The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats","volume":"345","author":"Jadhav","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.diabres.2025.112461_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104279","article-title":"NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats by transcriptionally suppressing CCR5 and inducing M2 polarization of macrophages","volume":"140","author":"Miao","year":"2022","journal-title":"Microvasc Res"},{"issue":"12","key":"10.1016\/j.diabres.2025.112461_b0200","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41419-024-07268-3","article-title":"\u03b2-Hydroxybutyrate suppresses M1 macrophage polarization through \u03b2-hydroxybutyrylation of the STAT1 protein","volume":"15","author":"Bai","year":"2024","journal-title":"Cell Death Dis"},{"issue":"380","key":"10.1016\/j.diabres.2025.112461_b0205","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jconrel.2025.02.005","article-title":"Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1\/M2 balance for osteoarthritis therapy","volume":"10","author":"Chen","year":"2025","journal-title":"J Control Release"},{"issue":"2","key":"10.1016\/j.diabres.2025.112461_b0210","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cmet.2016.07.010","article-title":"Nutritional Ketosis Alters fuel Preference and Thereby Endurance Performance in Athletes","volume":"24","author":"Cox","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.diabres.2025.112461_b0215","doi-asserted-by":"crossref","unstructured":"I S Sobczak A, A Blindauer C, J Stewart A. Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes. Nutrients. 2019 Aug 28;11(9):2022. doi: 10.3390\/nu11092022.","DOI":"10.3390\/nu11092022"},{"issue":"2018","key":"10.1016\/j.diabres.2025.112461_b0220","article-title":"The effect and Mechanism of KLF7 in the TLR4\/NF-\u03baB\/IL-6 Inflammatory Signal Pathway of Adipocytes","volume":"26","author":"Zhang","year":"2018","journal-title":"Mediators Inflamm"},{"issue":"5","key":"10.1016\/j.diabres.2025.112461_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2024.102336","article-title":"White adipose tissue in metabolic associated fatty liver disease","volume":"48","author":"Zhu","year":"2024","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"2","key":"10.1016\/j.diabres.2025.112461_b0230","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1096\/fj.03-0330fje","article-title":"Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice","volume":"18","author":"Erol","year":"2004","journal-title":"FASEB J"},{"issue":"11","key":"10.1016\/j.diabres.2025.112461_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21098","article-title":"\u03b2-Hydroxybutyrate as an epigenetic modifier: underlying mechanisms and implications","volume":"9","author":"He","year":"2023","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.diabres.2025.112461_b0240","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41401-023-01222-3","article-title":"Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF\/CCL2\/CCR2 and phenotype switching","volume":"45","author":"Shen","year":"2024","journal-title":"Acta Pharmacol Sin"},{"issue":"13","key":"10.1016\/j.diabres.2025.112461_b0245","article-title":"The Role of M1\/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis","volume":"19","author":"Cutolo","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.diabres.2025.112461_b0250","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1253\/circj.CJ-19-0959","article-title":"M2b Macrophages Regulate Cardiac Fibroblast Activation and Alleviate Cardiac Fibrosis after Reperfusion Injury","volume":"84","author":"Yue","year":"2020","journal-title":"Circ J"},{"issue":"14","key":"10.1016\/j.diabres.2025.112461_b0255","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1113\/JP276747","article-title":"Cardiomyopathy in obesity, insulin resistance and diabetes","volume":"598","author":"Nakamura","year":"2020","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.diabres.2025.112461_b0260","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1152\/japplphysiol.01155.2002","article-title":"Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats","volume":"94","author":"Enoki","year":"2003","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.diabres.2025.112461_b0265","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12933-025-02646-3","article-title":"BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2","volume":"24","author":"Xu","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.diabres.2025.112461_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctcp.2023.101774","article-title":"Effects of ketone supplements on blood \u03b2-hydroxybutyrate, glucose and insulin: a systematic review and three-level meta-analysis","volume":"52","author":"Yu","year":"2023","journal-title":"Complement Ther Clin Pract"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725004759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725004759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:22:11Z","timestamp":1764080531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822725004759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":54,"alternative-id":["S0168822725004759"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112461","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beta-hydroxybutyrate ameliorates cardiac fibrosis in diabetic cardiomyopathy rats via regulating macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112461"}}