{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:49:32Z","timestamp":1792900172982,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.diabres.2025.112934","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:39:30Z","timestamp":1760071170000},"page":"112934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Consistent efficacy and safety of automated insulin delivery in children aged 2\u20136 years: results from the LENNY trial continuation phase"],"prefix":"10.1016","volume":"230","author":[{"given":"K.","family":"Dovc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-188X","authenticated-orcid":false,"given":"Ak.","family":"Tuomaala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kuusela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-146X","authenticated-orcid":false,"given":"I.","family":"Rabbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-3276","authenticated-orcid":false,"given":"V.","family":"Tiberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-3529","authenticated-orcid":false,"given":"C.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ahom\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-1321","authenticated-orcid":false,"given":"A.","family":"Zanfardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-2353","authenticated-orcid":false,"given":"R.","family":"Schiaffini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Jullian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"di Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Castaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2025.112934_b0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12916-017-0958-6","article-title":"Fluctuations in the incidence of type 1 diabetes in the United States from 2001 to 2015: a longitudinal study","volume":"15","author":"Rogers","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.diabres.2025.112934_b0010","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0140-6736(18)31506-X","article-title":"Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study","volume":"392","author":"Rawshani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.diabres.2025.112934_b0015","doi-asserted-by":"crossref","DOI":"10.1177\/20406223241229855","article-title":"Brain functional and structural changes in diabetic children. how can intellectual development be optimized in type 1 diabetes?","volume":"15","author":"Stanis\u0142awska-Kubiak","year":"2024","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.diabres.2025.112934_b0020","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s11892-014-0520-2","article-title":"Young children with type 1 diabetes: challenges, research, and future directions","volume":"14","author":"Streisand","year":"2014","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.diabres.2025.112934_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2024.1434276","article-title":"Age-based challenges to type 1 diabetes management in the pediatric population","volume":"12","author":"Lan","year":"2024","journal-title":"Front Pediatr"},{"key":"10.1016\/j.diabres.2025.112934_b0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/pedi.12956","article-title":"\u201cI'm essentially his pancreas\u201d: Parent perceptions of diabetes burden and opportunities to reduce burden in the care of children <8\u2009years old with type 1 diabetes","volume":"21","author":"Commissariat","year":"2020","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/pedi.12525","article-title":"Nighttime is the worst time: Parental fear of hypoglycemia in young children with type 1 diabetes","volume":"19","author":"Van Name","year":"2018","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12887-021-02569-4","article-title":"Parents' experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence","volume":"21","author":"Kimbell","year":"2021","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.diabres.2025.112934_b0045","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.2337\/dc18-2625","article-title":"APCam11, AP@Home, and KidsAP Consortia. Young Children have Higher Variability of Insulin Requirements: Observations during Hybrid Closed-Loop Insulin delivery","volume":"42","author":"Dovc","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2025.112934_b0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1089\/dia.2022.0313","article-title":"MiniMed 780G\u2122 in 2- to 6-Year-Old Children: Safety and Clinical Outcomes after the first 12 Weeks","volume":"25","author":"Pulkkinen","year":"2023","journal-title":"Diabetes Technol Ther"},{"key":"10.1016\/j.diabres.2025.112934_b0055","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/dom.15562","article-title":"During an 18-month course of automated insulin delivery treatment, children aged 2 to 6\u2009years achieve and maintain a higher time in tight range","volume":"26","author":"Pulkkinen","year":"2024","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.diabres.2025.112934_b0060","doi-asserted-by":"crossref","unstructured":"Battelino T, Kuusela S, Shetty A, Rabbone I, Cherubini V, Campbell F, et al. LENNY study group. Efficacy and safety of automated insulin delivery in children aged 2-6 years (LENNY): an open-label, multicentre, randomised, crossover trial. Lancet Diabetes Endocrinol; 2025 Jun 18:S2213-8587(25)00091-9. doi: 10.1016\/S2213-8587(25)00091-9.","DOI":"10.1016\/S2213-8587(25)00091-9"},{"key":"10.1016\/j.diabres.2025.112934_b0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"issue":"5","key":"10.1016\/j.diabres.2025.112934_b0070","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2337\/diacare.10.5.617","article-title":"Fear of hypoglycemia: quantification, validation, and utilization","volume":"10","author":"Cox","year":"1987","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2025.112934_b0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1472-6823-15-2","article-title":"Assessing fear of hypoglycemia in a population-based study among parents of children with type 1 diabetes - psychometric properties of the hypoglycemia fear survey - parent version","volume":"15","author":"Haugstvedt","year":"2015","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.diabres.2025.112934_b0080","unstructured":"Food and Drug Administration. Diabetes Mellitus: Efficacy Endpoints for Clinical Trials Investigating Antidiabetic Drugs and Biological Products 2023. Available at: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/diabetes-mellitus-efficacy-endpoints-clinical-trials-investigating-antidiabetic-drugs-and-biological [Last accessed 19 September 2025]."},{"issue":"4","key":"10.1016\/j.diabres.2025.112934_b0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/sim.4067","article-title":"Multiple imputation using chained equations: issues and guidance for practice","volume":"30","author":"White","year":"2011","journal-title":"Stat Med"},{"key":"10.1016\/j.diabres.2025.112934_b0090","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/pedi.13427","article-title":"ISPAD Clinical Practice Consensus guidelines 2022: managing diabetes in preschoolers","volume":"23","author":"Sundberg","year":"2022","journal-title":"Pediatr Diabetes"},{"issue":"8","key":"10.1016\/j.diabres.2025.112934_b0095","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/pedi.13455","article-title":"ISPAD Clinical Practice Consensus guidelines 2022: Glycemic targets and glucose monitoring for children, adolescents, and young people with diabetes","volume":"23","author":"de Bock","year":"2022","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0100","unstructured":"Medtronic press release April 18, 2025. New Simplera Sync\u2122 sensor for the MiniMed\u2122 780G System now FDA approved. Available at: https:\/\/news.medtronic.com\/2025-04-18-New-Simplera-Sync-TM-sensor-for-the-MiniMed-TM-780G-System-now-FDA-approved [Last accessed 01 September, 2025]."},{"key":"10.1016\/j.diabres.2025.112934_b0105","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1111\/dom.14807","article-title":"Predictors of time in target glucose range in real-world users of the MiniMed 780G system","volume":"24","author":"Casta\u00f1eda","year":"2022","journal-title":"Diabetes Obes Metab"},{"issue":"7","key":"10.1016\/j.diabres.2025.112934_b0110","doi-asserted-by":"crossref","DOI":"10.1111\/dme.70048","article-title":"Impact of Simplera Sync\u2122 sensors and Extended\u2122 Wear infusion Sets on glycaemia and system performance of the MiniMed\u2122 780G system in children and young adults with previously high HbA1c","volume":"42","author":"Michaels","year":"2025","journal-title":"Diabet Med"},{"key":"10.1016\/j.diabres.2025.112934_b0115","unstructured":"Medtronic, 2024. SimpleraTM system: getting started with continuous glucose monitoring. Available at: https:\/\/www.medtronicdiabetes.com\/sites\/default\/files\/library\/download-library\/user-guides\/Getting-started-with-the-Simplera-system.pdf [Last accessed 04 September, 2025]."},{"key":"10.1016\/j.diabres.2025.112934_b0120","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/pedi.12980","article-title":"Poor metabolic control in childhood strongly correlates to diabetes-related premature death in persons <30\u2009years of age-a population-based cohort study","volume":"21","author":"Samuelsson","year":"2020","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/pedi.12085","article-title":"A high mean-HbA1c value 3\u201315 months after diagnosis of type 1 diabetes in childhood is related to metabolic control, macroalbuminuria, and retinopathy in early adulthood\u2013a pilot study using two nation-wide population based quality registries","volume":"15","author":"Samuelsson","year":"2014","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0130","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1399-5448.2008.00472.x","article-title":"Good glycemic control remains crucial in prevention of late diabetic complications\u2013the Link\u00f6ping Diabetes Complications Study","volume":"10","author":"Nordwall","year":"2009","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0135","article-title":"HbA1clevel as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes: swedish population based cohort study","volume":"366","author":"Lind","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.diabres.2025.112934_b0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2352-4642(20)30339-4","article-title":"Early versus delayed insulin pump therapy in children with newly diagnosed type 1 diabetes: results from the multicentre, prospective diabetes follow-up DPV registry","volume":"5","author":"Kamrath","year":"2021","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.diabres.2025.112934_b0145","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/pedi.12420","article-title":"Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure","volume":"18","author":"Siller","year":"2017","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.diabres.2025.112934_b0150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2337\/dc13-1388","article-title":"Diabetes Research in Children Network (DirecNet). Alterations in white matter structure in young children with type 1 diabetes","volume":"37","author":"Barnea-Goraly","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2025.112934_b0155","doi-asserted-by":"crossref","unstructured":"Nally LM, Sherr JL, Garg SK, Marks BE, Laffel LM, Pihoker C, et al.; SUCCEED Study Group. Safety and Glycemic Outcomes of the MiniMed 780G System with a Disposable All-in-One Sensor. Diabetes Technol Ther. 2025 Aug 18. doi: 10.1177\/15209156251368928.","DOI":"10.1177\/15209156251368928"},{"key":"10.1016\/j.diabres.2025.112934_b0160","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/dc21-2359","article-title":"Safety and glycemic outcomes with a tubeless automated insulin delivery system in very young children with type 1 diabetes: a single-arm multicenter clinical trial","volume":"45","author":"Sherr","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2025.112934_b0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJMoa2111673","article-title":"KidsAP Consortium. Randomized Trial of Closed-Loop Control in very Young Children with Type 1 Diabetes","volume":"386","author":"Ware","year":"2022","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.diabres.2025.112934_b0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/dom.15992","article-title":"Children and adolescent with suboptimal control of type 1 diabetes improve during the first 2\u2009years on automated insulin delivery system","volume":"27","author":"Kiilavuori","year":"2025","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"10.1016\/j.diabres.2025.112934_b0175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12916-024-03396-x","article-title":"Long-term assessment of the NHS hybrid closed-loop real-world study on glycaemic outcomes, time-in-range, and quality of life in children and young people with type 1 diabetes","volume":"22","author":"Ng","year":"2024","journal-title":"BMC Med"},{"issue":"6","key":"10.1016\/j.diabres.2025.112934_b0180","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1089\/dia.2022.0491","article-title":"MiniMed 780G Six-month Use in Children and Adolescents with Type 1 Diabetes: Clinical Targets and Predictors of Optimal Glucose Control","volume":"25","author":"Lombardo","year":"2023","journal-title":"Diabetes Technol Ther"},{"issue":"S3","key":"10.1016\/j.diabres.2025.112934_b0185","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/dia.2023.0433","article-title":"Celebrating the Data from 100,000 Real-World users of the MiniMed\u2122 780G System in Europe, Middle East, and Africa Collected over 3 Years: from Data to Clinical evidence","volume":"26","author":"Choudhary","year":"2024","journal-title":"Diabetes Technol Ther"},{"issue":"S3","key":"10.1016\/j.diabres.2025.112934_b0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1089\/dia.2023.0453","article-title":"Early Real-World Performance of the MiniMed\u2122 780G Advanced Hybrid Closed-Loop System and Recommended Settings Use in the United States","volume":"26","author":"Thrasher","year":"2024","journal-title":"Diabetes Technol Ther"},{"key":"10.1016\/j.diabres.2025.112934_b0195","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1111\/dom.15023","article-title":"Real-world performance of the MiniMed 780G advanced hybrid closed loop system in Latin America: Substantial improvement in glycaemic control with each technology iteration of the MiniMed automated insulin delivery system","volume":"25","author":"Grassi","year":"2023","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.diabres.2025.112934_b0200","series-title":"Diabetes","article-title":"MiniMed 780G system users achieve similar glycemic outcomes regardless of socioeconomic status","author":"McVean","year":"2025"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725009489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822725009489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:55:18Z","timestamp":1781067318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822725009489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":40,"alternative-id":["S0168822725009489"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112934","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Consistent efficacy and safety of automated insulin delivery in children aged 2\u20136 years: results from the LENNY trial continuation phase","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2025.112934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112934"}}