{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:43:08Z","timestamp":1792806188388,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.diabres.2026.113443","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:12:10Z","timestamp":1784329930000},"page":"113443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Serum vs. exosomal miRNA signatures in South Asian adults with prediabetes: implications for T2DM risk prediction"],"prefix":"10.1016","volume":"239","author":[{"given":"Angel","family":"Mendonca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardanan Subramonia","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-2130","authenticated-orcid":false,"given":"Sujatha","family":"Sundaresan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2026.113443_b0005","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S2213-8587(17)30174-2","article-title":"Prevalence of diabetes and prediabetes in 15 states of India: results from the ICMR-INDIAB population-based cross-sectional study","volume":"5","author":"Anjana","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.diabres.2026.113443_b0010","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1038\/s41598-025-88460-z","article-title":"Assessing type-2 diabetes risk based on the Indian diabetes risk score among adults aged 45 and above in India","volume":"15","author":"Maniyara","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabres.2026.113443_b0015","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2337\/dc23-1514","article-title":"Natural history of type 2 diabetes in Indians: time to progression","volume":"47","author":"Narayan","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2026.113443_b0020","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/endrev\/bnae032","article-title":"Insulin resistance in type 1 diabetes: Pathophysiological, clinical, and therapeutic relevance","volume":"46","author":"Apostolopoulou","year":"2025","journal-title":"Endocr Rev"},{"key":"10.1016\/j.diabres.2026.113443_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2025.05.005","article-title":"Personalized molecular signatures of insulin resistance and type 2 diabetes","volume":"188","author":"Kj\u00e6rgaard","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.diabres.2026.113443_b0030","doi-asserted-by":"crossref","first-page":"11766","DOI":"10.3390\/ijms252111766","article-title":"The impact of gestational diabetes mellitus on minipuberty in girls","volume":"25","author":"Kowalcze","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.diabres.2026.113443_b0035","article-title":"Inositols administration: further insights on their biological role","author":"Coldebella","year":"2022","journal-title":"Ital J Gynaecol Obstet"},{"key":"10.1016\/j.diabres.2026.113443_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines14020394","article-title":"From metabolism to mind: the cardio-metabolic-brain axis and the role of insulin resistance-a review","volume":"14","author":"Cielecka","year":"2026","journal-title":"Biomedicines"},{"key":"10.1016\/j.diabres.2026.113443_b0045","doi-asserted-by":"crossref","DOI":"10.1007\/s12038-022-00295-2","article-title":"Role of microRNAs in regulation of insulin secretion and insulin signaling involved in type 2 diabetes mellitus","volume":"47","author":"Mendonca","year":"2022","journal-title":"J Biosci"},{"key":"10.1016\/j.diabres.2026.113443_b0050","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41388-024-03076-3","article-title":"MicroRNAs: circulating biomarkers for the early detection of imperceptible cancers via biosensor and machine-learning advances","volume":"43","author":"Metcalf","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.diabres.2026.113443_b0055","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1016\/j.bpj.2023.09.019","article-title":"Effects of microRNA-mediated negative feedback on gene expression noise","volume":"122","author":"Adhikary","year":"2023","journal-title":"Biophys J"},{"key":"10.1016\/j.diabres.2026.113443_b0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/00045632221129778","article-title":"Key methodological challenges in detecting circulating miRNAs in different biofluids","volume":"60","author":"Mestry","year":"2023","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.diabres.2026.113443_b0065","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/diagnostics15182346","article-title":"Extracellular RNAs in liquid biopsy: applications in MASLD and MASH diagnosis and monitoring","volume":"15","author":"Raptis","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.diabres.2026.113443_b0070","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1631\/jzus.B1600490","article-title":"Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders","volume":"19","author":"Yao","year":"2018","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.diabres.2026.113443_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128372","article-title":"Circulating MiRNAs of \u201cAsian Indian phenotype\u201d identified in subjects with impaired glucose tolerance and patients with type 2 diabetes","volume":"10","author":"Prabu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.diabres.2026.113443_b0080","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-025-06232-2","article-title":"Comparative analysis of exosomes isolated by ultracentrifugation and total exosome isolation reagent: a biophysical and physicochemical study","volume":"27","author":"Mendonca","year":"2025","journal-title":"J Nanopart Res"},{"key":"10.1016\/j.diabres.2026.113443_b0085","doi-asserted-by":"crossref","DOI":"10.7324\/JABB.2024.111009","article-title":"In silico screening and analysis of candidate microRNA-target interaction involved in progression of prediabetes to Type II Diabetes Mellitus","author":"Mendonca","year":"2023","journal-title":"J Appl Biol Biotechnol"},{"key":"10.1016\/j.diabres.2026.113443_b0090","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1007\/s00125-020-05169-6","article-title":"Age-, sex- and ethnicity-related differences in body weight, blood pressure, HbA1c and lipid levels at the diagnosis of type 2 diabetes relative to people without diabetes","volume":"63","author":"Wright","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2026.113443_b0095","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41440-023-01566-7","article-title":"Indicators of insulin resistance in clinical practice","volume":"47","author":"Sasaki","year":"2024","journal-title":"Hypertens Res"},{"key":"10.1016\/j.diabres.2026.113443_b0100","doi-asserted-by":"crossref","DOI":"10.1007\/s00592-025-02513-3","article-title":"A 14-year prospective cohort study of type 2 diabetes development in Dutch healthy adults of south Asian origin: risk factors and the association with metabolic syndrome and HOMA-IR","author":"Beckmann","year":"2025","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.diabres.2026.113443_b0105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s13105-020-00760-2","article-title":"Role of miRNAs in the pathogenesis of T2DM, insulin secretion, insulin resistance, and \u03b2 cell dysfunction: the story so far","volume":"76","author":"Kaur","year":"2020","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.diabres.2026.113443_b0110","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/jcb.26271","article-title":"Molecular aspects of diabetes mellitus: resistin, microRNA, and exosome","volume":"119","author":"Saeedi Borujeni","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.diabres.2026.113443_b0115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12902-023-01498-w","article-title":"Identification of novel circulating miRNAs biomarkers for healthy obese and lean children","volume":"23","author":"Ma","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.diabres.2026.113443_b0120","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bbrc.2018.07.084","article-title":"Saturated fatty acids-induced miR-424-5p aggravates insulin resistance via targeting insulin receptor in hepatocytes","volume":"503","author":"Min","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.diabres.2026.113443_b0125","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1002\/jcp.27300","article-title":"MiR-128-3p accelerates cardiovascular calcification and insulin resistance through ISL1-dependent Wnt pathway in type 2 diabetes mellitus rats","volume":"234","author":"Wang","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.diabres.2026.113443_b0130","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3390\/antiox10091331","article-title":"Taxifolin and sorghum ethanol extract protect against hepatic insulin resistance via the miR-195\/IRS1\/PI3K\/AKT and AMPK signalling pathways","volume":"10","author":"Lee","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.diabres.2026.113443_b0135","doi-asserted-by":"crossref","first-page":"19805","DOI":"10.18632\/aging.203393","article-title":"MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression","volume":"13","author":"Liu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.diabres.2026.113443_b0140","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/oby.23360","article-title":"MiR-195 promotes pancreatic \u03b2-cell dedifferentiation by targeting Mfn2 and impairing Pi3k\/Akt signaling in type 2 diabetes","volume":"30","author":"Xu","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.diabres.2026.113443_b0145","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00125-014-3197-9","article-title":"miR-195 regulates SIRT1-mediated changes in diabetic retinopathy","volume":"57","author":"Mortuza","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2026.113443_b0150","first-page":"1","article-title":"BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model","volume":"47","author":"Han","year":"2024","journal-title":"Immunopharmacol Immunotoxicol"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822726003633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822726003633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:12:23Z","timestamp":1792804343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822726003633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S0168822726003633"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2026.113443","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum vs. exosomal miRNA signatures in South Asian adults with prediabetes: implications for T2DM risk prediction","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2026.113443","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113443"}}