{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:37:47Z","timestamp":1793122667345,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","diabetesresearchclinicalpractice.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Research and Clinical Practice"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.diabres.2026.113571","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:53:41Z","timestamp":1790610821000},"page":"113571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Associations of IDL cholesterol and LDL \u03b1-tocopherol with diabetic kidney disease in type 2 diabetes"],"prefix":"10.1016","volume":"241","author":[{"given":"Yuji","family":"Hirowatari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Manita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Hakoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Katsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekatsu","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diabres.2026.113571_b0005","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.diabres.2026.113571_b0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.diabres.2026.113571_b0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00125-003-1111-y","article-title":"Diabetic dyslipidaemia: from basic research to clinical practice","volume":"46","author":"Taskinen","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2026.113571_b0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.35772\/ghm.2019.01007","article-title":"Diabetic dyslipidemia: evaluation and mechanism","volume":"1","author":"Yanai","year":"2019","journal-title":"Glob Health Med"},{"key":"10.1016\/j.diabres.2026.113571_b0025","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.2337\/diacare.27.6.1496","article-title":"Lipids and lipoproteins in patients with type 2 diabetes","volume":"27","author":"Krauss","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2026.113571_b0030","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1161\/01.ATV.17.12.3542","article-title":"Lipoprotein heterogeneity and apolipoprotein B metabolism","volume":"17","author":"Packard","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.diabres.2026.113571_b0035","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00125-015-3525-8","article-title":"Pathophysiology of diabetic dyslipidaemia : where are we?","volume":"58","author":"Verg\u00e8s","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2026.113571_b0040","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0140-6736(14)61177-6","article-title":"Triglycerides and cardiovascular disease","volume":"384","author":"Nordestgaard","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.diabres.2026.113571_b0045","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/01.CIR.0000091339.70120.53","article-title":"Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion","volume":"108","author":"Festa","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2026.113571_b0050","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1001\/jama.287.19.2570","article-title":"Diabetes and atherosclerosis: epidemiology, pathophysiology, and management","volume":"287","author":"Beckman","year":"2002","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.diabres.2026.113571_b0055","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s001250051058","article-title":"Is type II diabetes mellitus a disease of the innate immune system?","volume":"41","author":"Pickup","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.diabres.2026.113571_b0060","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/14728222.2023.2288272","article-title":"Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets","volume":"27","author":"Galindo","year":"2023","journal-title":"Exp Opin Ther Targets"},{"key":"10.1016\/j.diabres.2026.113571_b0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/ars.2009.2733","article-title":"Oxidized LDL: diversity, patterns of recognition, and pathophysiology","volume":"13","author":"Levitan","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.diabres.2026.113571_b0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(01)00238-0","article-title":"Atherosclerosis. The road ahead","volume":"104","author":"Glass","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.diabres.2026.113571_b0075","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1161\/01.CIR.95.4.1062","article-title":"Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis","volume":"95","author":"Steinberg","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2026.113571_b0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0891-5849(92)90181-F","article-title":"The role of lipid peroxidation and antioxidants in oxidative modification of LDL","volume":"13","author":"Esterbauer","year":"1992","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.diabres.2026.113571_b0085","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1161\/01.ATV.17.7.1438","article-title":"Vitamin E\/lipid peroxide ratio and susceptibility of LDL to oxidative modification in non-insulin-dependent diabetes mellitus","volume":"17","author":"Yoshida","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.diabres.2026.113571_b0090","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1161\/01.ATV.15.2.190","article-title":"The effect of alpha-tocopherol supplementation on LDL oxidation. A dose-response study","volume":"15","author":"Jialal","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.diabres.2026.113571_b0095","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.diabres.2026.113571_b0100","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2337\/diacare.26.2.437","article-title":"Pulse wave velocity as an indicator of atherosclerosis in impaired fasting glucose: the Tanno and Sobetsu study","volume":"26","author":"Ohnishi","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.diabres.2026.113571_b0105","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1194\/jlr.D300003-JLR200","article-title":"Measurement of cholesterol of major serum lipoprotein classes by anion-exchange HPLC with perchlorate ion-containing eluent","volume":"44","author":"Hirowatari","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.diabres.2026.113571_b0110","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/0004563215584405","article-title":"A rapid anion-exchange chromatography for measurement of cholesterol concentrations in five lipoprotein classes and estimation of lipoprotein profiles in male volunteers without overt diseases","volume":"52","author":"Manita","year":"2015","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.diabres.2026.113571_b0115","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.5551\/jat.RV17037","article-title":"Innovatively established analysis method for lipoprotein profiles based on high-performance anion-exchange liquid chromatography","volume":"26","author":"Hirowatari","year":"2019","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.diabres.2026.113571_b0120","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1038\/srep04086","article-title":"Automated measurement method for the determination of vitamin E in plasma lipoprotein classes","volume":"4","author":"Hirowatari","year":"2014","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.diabres.2026.113571_b0125","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1194\/jlr.D003624","article-title":"Analysis of cholesterol levels in lipoprotein (a) with anion-exchange chromatography","volume":"51","author":"Hirowatari","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.diabres.2026.113571_b0130","doi-asserted-by":"crossref","first-page":"14705","DOI":"10.1038\/s41598-021-94099-3","article-title":"Rate of decline in kidney function and known age\u2013of\u2013onset or duration of type 2 diabetes","volume":"11","author":"Buyadaa","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.diabres.2026.113571_b0135","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.2169\/internalmedicine.53.2999","article-title":"The combination of the ankle brachial index and brachial ankle pulse wave velocity exhibits a superior association with outcomes in diabetic patients","volume":"53","author":"Chang","year":"2014","journal-title":"Intern Med"},{"key":"10.1016\/j.diabres.2026.113571_b0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0021-9150(00)00673-0","article-title":"Atherogenic lipoprotein changes in diabetic nephropathy","volume":"156","author":"Shoji","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.diabres.2026.113571_b0145","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1681\/ASN.V971277","article-title":"Intermediate-density lipoprotein as an independent risk factor for aortic atherosclerosis in hemodialysis patients","volume":"9","author":"Shoji","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.diabres.2026.113571_b0150","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.diabres.2026.113571_b0155","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","article-title":"The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction","volume":"22","author":"An","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.diabres.2026.113571_b0160","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1161\/01.CIR.0000093660.86242.BB","article-title":"Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS","volume":"108","author":"Griendling","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.diabres.2026.113571_b0165","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10157-016-1283-7","article-title":"Oxidative stress markers in type 2 diabetes patients with diabetic nephropathy","volume":"21","author":"Chou","year":"2017","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.diabres.2026.113571_b0170","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.atherosclerosis.2016.03.003","article-title":"The novel selective PPAR\u03b1 modulator (SPPARM\u03b1) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis","volume":"249","author":"Hennuyer","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.diabres.2026.113571_b0175","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1007\/s00210-023-02595-2","article-title":"Bezafibrate reduces the damage, activation and mechanical properties of lung fibroblast cells induced by hydrogen peroxide","volume":"396","author":"Reghelin","year":"2023","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.diabres.2026.113571_b0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tox.2006.10.016","article-title":"Protective effect of bezafibrate on streptozotocin-induced oxidative stress and toxicity in rats","volume":"229","author":"Anwer","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.diabres.2026.113571_b0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0323749","article-title":"Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: a systematic review and meta-analysis","volume":"20","author":"Sabeel","year":"2025","journal-title":"PLoS One"}],"container-title":["Diabetes Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822726004912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168822726004912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:27:20Z","timestamp":1793122040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168822726004912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":37,"alternative-id":["S0168822726004912"],"URL":"https:\/\/doi.org\/10.1016\/j.diabres.2026.113571","relation":{},"ISSN":["0168-8227"],"issn-type":[{"value":"0168-8227","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of IDL cholesterol and LDL \u03b1-tocopherol with diabetic kidney disease in type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Diabetes Research and Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diabres.2026.113571","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113571"}}