{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:41:49Z","timestamp":1780375309786,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","content-domain":{"domain":["patient-research.elsevier.com","dmidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.diagmicrobio.2014.03.020","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T21:33:19Z","timestamp":1396042399000},"page":"322-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Clinical utility of Aspergillus galactomannan and PCR in bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in patients with haematological malignancies"],"prefix":"10.1016","volume":"79","author":[{"given":"Siow-Chin","family":"Heng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon C.-A.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Orla","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Thursky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee L.","family":"Manser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini D.","family":"De Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona L.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Nation","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.M.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Slavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3324\/haematol.2011.051995","article-title":"Comparative clinical effectiveness of prophylactic voriconazole\/posaconazole to fluconazole\/itraconazole in patients with acute myeloid leukemia\/myelodysplastic syndrome undergoing cytotoxic chemotherapy over a 12-year period","volume":"97","author":"Ananda-Rajah","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0010","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1046\/j.1365-2141.2003.04308.x","article-title":"Galactomannan detection in computerized tomography-based broncho-alveolar lavage fluid and serum in haematological patients at risk for invasive pulmonary aspergillosis","volume":"121","author":"Becker","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0015","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1378\/chest.09-0701","article-title":"Contribution of galactomannan antigen detection in BAL to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies","volume":"137","author":"Bergeron","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0020","doi-asserted-by":"crossref","first-page":"i15","DOI":"10.1093\/jac\/dkq438","article-title":"Detection and investigation of invasive mould disease","volume":"66","author":"Cuenca Estrella","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0030","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0025","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1128\/JCM.06423-11","article-title":"Detection of galactomannan in bronchoalveolar lavage fluid samples of patients at risk for invasive pulmonary aspergillosis: analytical and clinical validity","volume":"50","author":"D'Haese","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0035","series-title":"Aspergillosis: from diagnosis to prevention","first-page":"423","article-title":"Defining invasive aspergillosis: what the revised EORTC\/MSG definitions have in store","author":"Donnelly","year":"2010"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10096-008-0616-1","article-title":"Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance","volume":"28","author":"Frealle","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0045","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1007\/s00259-012-2143-7","article-title":"Use of FDG PET\/CT for investigation of febrile neutropenia: evaluation in high-risk cancer patients","volume":"39","author":"Guy","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0050","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1128\/JCM.43.10.5366-5368.2005","article-title":"Development of a nested qualitative real-time PCR assay to detect Aspergillus species DNA in clinical specimens","volume":"43","author":"Halliday","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0055","doi-asserted-by":"crossref","DOI":"10.3109\/1040841X.2013.804033","article-title":"Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: a systematic review and meta-analysis","author":"Heng","year":"2013","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0060","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1200\/JCO.2002.07.004","article-title":"Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients","volume":"20","author":"Herbrecht","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1086\/510535","article-title":"Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy","volume":"195","author":"Hope","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2334-10-44","article-title":"Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients","volume":"10","author":"Hsu","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2334-8-73","article-title":"Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid","volume":"8","author":"Khot","year":"2008","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0080","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/651263","article-title":"Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001\u20132006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database","volume":"50","author":"Kontoyiannis","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0085","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.diagmicrobio.2010.03.017","article-title":"Clinical utility and prognostic value of bronchoalveolar lavage galactomannan in patients with hematologic malignancies","volume":"68","author":"Luong","year":"2010","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0090","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1086\/647935","article-title":"Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases","volume":"49","author":"Maertens","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0095","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.ejca.2009.05.001","article-title":"Diagnosis and antimicrobial therapy of lung infiltrates in febrile neutropenic patients: Guidelines of the infectious diseases working party of the German Society of Haematology and Oncology","volume":"45","author":"Maschmeyer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1473-3099(04)01045-X","article-title":"Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis","volume":"4","author":"Mennink-Kersten","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0105","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/jac\/dks111","article-title":"Piperacillin\/tazobactam (Tazocin) seems to be no longer responsible for false-positive results of the galactomannan assay","volume":"67","author":"Mikulska","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/10428194.2010.542600","article-title":"Design issues in a randomized controlled trial of a pre-emptive versus empiric antifungal strategy for invasive aspergillosis in patients with high-risk hematologic malignancies","volume":"52","author":"Morrissey","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0115","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1473-3099(13)70076-8","article-title":"Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients: a randomised controlled trial","volume":"13","author":"Morrissey","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0120","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1128\/JCM.42.12.5517-5522.2004","article-title":"Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid","volume":"42","author":"Musher","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0125","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bbmt.2010.11.013","article-title":"Galactomannan testing in bronchoalveolar lavage fluid facilitates the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies and stem cell transplant recipients","volume":"17","author":"Nguyen","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0130","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jinf.2010.08.014","article-title":"Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis","volume":"61","author":"Park","year":"2010","journal-title":"J Infect"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0135","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/annonc\/mdm571","article-title":"Aspergillus galactomannan testing in patients with long-term neutropenia: implications for clinical management","volume":"19","author":"Penack","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0140","doi-asserted-by":"crossref","first-page":"e874","DOI":"10.1016\/j.ijid.2011.09.011","article-title":"Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological diseases\u2014the role of factors affecting assay performance","volume":"15","author":"Racil","year":"2011","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/thorax.56.5.379","article-title":"Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures","volume":"56","author":"Rano","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0150","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1093\/jac\/dks208","article-title":"Therapy with antifungals decreases the diagnostic performance of PCR for diagnosing invasive aspergillosis in bronchoalveolar lavage samples of patients with haematological malignancies","volume":"67","author":"Reinwald","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0609.2012.01806.x","article-title":"Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples","volume":"89","author":"Reinwald","year":"2012","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0160","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1128\/JCM.41.8.3922-3925.2003","article-title":"Comparison of real-time PCR, conventional PCR, and galactomannan antigen detection by enzyme-linked immunosorbent assay using bronchoalveolar lavage fluid samples from hematology patients for diagnosis of invasive pulmonary aspergillosis","volume":"41","author":"Sanguinetti","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0165","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jinf.2012.08.003","article-title":"Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry","volume":"65","author":"Steinbach","year":"2012","journal-title":"J Infect"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0170","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1445-5994.2010.02340.x","article-title":"Use of empiric antimicrobial therapy in neutropenic fever. Australian Consensus Guidelines 2011 Steering Committee","volume":"41","author":"Tam","year":"2011","journal-title":"Intern Med J"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0175","first-page":"89","article-title":"A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples","volume":"24","author":"Tuon","year":"2007","journal-title":"Rev Iberoam Micol"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0180","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000196477","article-title":"Pulmonary aspergillosis: early diagnosis improves survival","volume":"62","author":"von Eiff","year":"1995","journal-title":"Respiration"},{"key":"10.1016\/j.diagmicrobio.2014.03.020_bb0185","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1128\/JCM.01767-09","article-title":"Aspergillus PCR: one step closer to standardization","volume":"48","author":"White","year":"2010","journal-title":"J Clin Microbiol"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073288931400131X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073288931400131X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T04:20:44Z","timestamp":1538713244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073288931400131X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S073288931400131X"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2014.03.020","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical utility of Aspergillus galactomannan and PCR in bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in patients with haematological malignancies","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2014.03.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2014 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}