{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:13:53Z","timestamp":1780496033309,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Achaogen"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","dmidjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.diagmicrobio.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T02:45:22Z","timestamp":1510281922000},"page":"228-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Antimicrobial activity of plazomicin against Enterobacteriaceae -producing carbapenemases from 50 Brazilian medical centers"],"prefix":"10.1016","volume":"90","author":[{"given":"Andreza Francisco","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Bail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Antonia Sanches","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keite","family":"da Silva Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanise Vendruscolo","family":"Dalmolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Silva","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Luis Lopes","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa W.","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Francisco","family":"Tuon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0005","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1128\/AAC.00572-10","article-title":"Synthesis and spectrum of the neoglycoside ACHN-490","volume":"54","author":"Aggen","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ajic.2014.11.003","article-title":"Molecular epidemiology of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae in different facilities in southern Brazil","volume":"43","author":"Arend","year":"2015","journal-title":"Am J Infect Control"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.mib.2010.09.004","article-title":"Combating evolution with intelligent design: the neoglycoside ACHN-490","volume":"13","author":"Armstrong","year":"2010","journal-title":"Curr Opin Microbiol"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0020","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.diagmicrobio.2011.08.016","article-title":"Updated multiplex polymerase chain reaction for detection of 16S rRNA methylases: high prevalence among NDM-1 producers","volume":"71","author":"Bercot","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0025","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1128\/AAC.01458-15","article-title":"Characterization of Tn3000, a transposon responsible for blaNDM-1 dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India","volume":"59","author":"Campos","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2017.11.004_bb0030","series-title":"Performance standard for antimicrobial susceptibility testing; twenty-third informational supplement","author":"Clinical Laboratory Standard Insitute (CLSI)","year":"2017"},{"key":"10.1016\/j.diagmicrobio.2017.11.004_bb9020","series-title":"- M07 - A10 - Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically","author":"Clinical Laboratory Standard Insitute","year":"2015"},{"key":"10.1016\/j.diagmicrobio.2017.11.004_bb0035","series-title":"Plazomicin versus meropenem for the treatment of complicated urinary tract infection and acute pyelonephritis: results of the EPIC study. ECCMID","author":"Cloutier","year":"2017"},{"key":"10.1016\/j.diagmicrobio.2017.11.004_bb0040","series-title":"Plazomicin is associated with improved survival and safety compared with Colistin in the treatment of serious infections due to carbapenem-resistant Enterobacteriaceae: results of the CARE study. ECCMID","author":"Connolly","year":"2017"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-0035-1544208","article-title":"Carbapenemase-producing Enterobacteriaceae","volume":"36","author":"Doi","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.diagmicrobio.2017.11.004_bb0050","series-title":"European Committee on Antimicrobial Susceptibility testing","article-title":"Clinical breakpoint","author":"EUCAST","year":"2017"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0055","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3201\/eid2007.121004","article-title":"Deaths attributable to carbapenem-resistant Enterobacteriaceae infections","volume":"20","author":"Falagas","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0060","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/14787210.2016.1204911","article-title":"The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?","volume":"14","author":"Falagas","year":"2016","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.diagmicrobio.2017.11.004_bb0065","series-title":"Drug safety communication\u2014increased risk of death with Tygacil (tigecycline) compared to other antibiotics used to treat similar infections","author":"FDA","year":"2010"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1179\/1973947812Y.0000000015","article-title":"Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece","volume":"24","author":"Galani","year":"2012","journal-title":"J Chemother"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0075","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1128\/AAC.00873-15","article-title":"Can plazomicin alone or in combination be a therapeutic option against carbapenem-resistant Acinetobacter baumannii?","volume":"59","author":"Garcia-Salguero","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2017.11.004_bb9005","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1128\/AAC.00869-16","article-title":"Association between the Presence of Aminoglycoside-Modifying Enzymes and In Vitro Activity of Gentamicin, Tobramycin, Amikacin, and Plazomicin against Klebsiella pneumoniae Carbapenemase- and Extended-Spectrum-\u03b2-Lactamase-Producing Enterobacter Species","volume":"60","author":"Haidar","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0080","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/jac\/dkt078","article-title":"Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK","volume":"68","author":"Hidalgo","year":"2013","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0085","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1517\/13543784.2015.1095180","article-title":"Plazomicin: an investigational therapy for the treatment of urinary tract infections","volume":"24","author":"Karaiskos","year":"2015","journal-title":"Expert Opin Investig Drugs"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0090","doi-asserted-by":"crossref","first-page":"O117","DOI":"10.1111\/1469-0691.12341","article-title":"Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options","volume":"20","author":"Kontopidou","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0095","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ijantimicag.2015.01.011","article-title":"Colistin treatment in carbapenem-resistant Acinetobacter baumannii pneumonia patients: incidence of nephrotoxicity and outcomes","volume":"45","author":"Kwon","year":"2015","journal-title":"Int J Antimicrob Agents"},{"issue":"20","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0100","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003694","article-title":"Bacteremic urinary tract infection caused by multidrug-resistant Enterobacteriaceae are associated with severe sepsis at admission: implication for empirical therapy","volume":"95","author":"Lee","year":"2016","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0105","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jac\/dkq408","article-title":"Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates","volume":"66","author":"Livermore","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0110","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1128\/AAC.00470-16","article-title":"Frequency of BKC-1-producing Klebsiella species isolates","volume":"60","author":"Martins","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0115","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1089\/mdr.2012.0125","article-title":"Characterization of aminoglycoside-modifying enzymes in enterobacteriaceae clinical strains and characterization of the plasmids implicated in their diffusion","volume":"19","author":"Miro","year":"2013","journal-title":"Microb Drug Resist"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0120","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/jac\/dkr563","article-title":"Rapid detection of carbapenemase genes by multiplex real-time PCR","volume":"67","author":"Monteiro","year":"2012","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0125","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","article-title":"The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria","volume":"9","author":"Nordmann","year":"2009","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0130","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3201\/eid1710.110655","article-title":"Global spread of carbapenemase-producing Enterobacteriaceae","volume":"17","author":"Nordmann","year":"2011","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0135","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3201\/eid1906.121515","article-title":"New Delhi metallo-beta-lactamase-producing Enterobacteriaceae, United States","volume":"19","author":"Rasheed","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0140","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1128\/AAC.02634-15","article-title":"Multicenter prospective cohort study of renal failure in patients treated with colistin versus polymyxin B","volume":"60","author":"Rigatto","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2017.11.004_bb9010","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ijantimicag.2015.07.021","article-title":"In vitro activity of the next-generation aminoglycoside plazomicin alone and in combination with colistin, meropenem, fosfomycin or tigecycline against carbapenemase-producing Enterobacteriaceae strains","volume":"46","author":"Rodr\u00edguez-Avial","year":"2015","journal-title":"Int J Antimicrob Agents"},{"issue":"Suppl. 1","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bjm.2016.10.002","article-title":"Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on beta-lactams and polymyxins","volume":"47","author":"Sampaio","year":"2016","journal-title":"Braz J Microbiol"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0150","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1128\/AAC.02510-13","article-title":"Detection of OXA-370, an OXA-48-related class D beta-lactamase, in Enterobacter hormaechei from Brazil","volume":"58","author":"Sampaio","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0155","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijantimicag.2015.12.021","article-title":"New drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance","volume":"47","author":"Syue","year":"2016","journal-title":"Int J Antimicrob Agents"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jhin.2012.01.010","article-title":"Working Group in Healthcare Associated I. Surveillance programme for multidrug-resistant bacteria in healthcare-associated infections: an urban perspective in South Brazil","volume":"80","author":"Toledo","year":"2012","journal-title":"J Hosp Infect"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0165","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijantimicag.2013.12.002","article-title":"Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium","volume":"43","author":"Tuon","year":"2014","journal-title":"Int J Antimicrob Agents"},{"issue":"11\u201312","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0170","first-page":"3","article-title":"Acute kidney injury in patients using amikacin in an era of carbapenem-resistant bacteria","volume":"48","author":"Tuon","year":"2016","journal-title":"Infect Dis (Lond)"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0175","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/cid\/ciw243","article-title":"Ceftazidime\/avibactam and ceftolozane\/tazobactam: second-generation beta-lactam\/beta-lactamase inhibitor combinations","volume":"63","author":"van Duin","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0180","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1128\/AAC.02636-14","article-title":"Surveillance of carbapenem-resistant Klebsiella pneumoniae: tracking molecular epidemiology and outcomes through a regional network","volume":"58","author":"van Duin","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0185","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/AAC.02744-13","article-title":"In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in Canadian hospitals as part of the CANWARD study, 2011-2012","volume":"58","author":"Walkty","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2017.11.004_bb0190","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/AAC.45.4.1151-1161.2001","article-title":"Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae","volume":"45","author":"Yigit","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2017.11.004_bb9015","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/jac\/dkx261","article-title":"In vitro activity of plazomicin against \u03b2-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE)","volume":"72","author":"Zhang","year":"2017","journal-title":"J Antimicrob Chemother"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889317303553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889317303553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T00:35:25Z","timestamp":1535243725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889317303553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0732889317303553"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2017.11.004","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial activity of plazomicin against Enterobacteriaceae-producing carbapenemases from 50 Brazilian medical centers","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}