{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:17:56Z","timestamp":1790410676498,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.diagmicrobio.2018.09.015","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T02:21:02Z","timestamp":1538619662000},"page":"238-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["How safe is doxycycline for young children or for pregnant or breastfeeding women?"],"prefix":"10.1016","volume":"93","author":[{"given":"Gary P.","family":"Wormser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Wormser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc","family":"Strle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burke A.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0005","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jac\/dkl224","article-title":"Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines","volume":"58","author":"Agwuh","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/art.39866","article-title":"Autoimmune arthritides, rheumatoid arthritis, psoriatic arthritis, or peripheral spondyloarthritis following Lyme disease","volume":"69","author":"Arvikar","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1834-7819.2005.tb00373.x","article-title":"Doxycycline-induced staining of permanent adult dentition","volume":"50","author":"Ayaslioglu","year":"2005","journal-title":"Aust Dent J"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0020","first-page":"1","article-title":"Centers for Disease Control and Prevention. Surveillance for Lyme disease\u2014United States, 1992\u20132006","volume":"57","author":"Bacon","year":"2008","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6502a1","article-title":"Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichiosis, and anaplasmosis\u2014United States","volume":"65","author":"Biggs","year":"2016","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0030","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/archdischild-2016-310964","article-title":"QUESTION 1: teething issues: can doxycycline be safely used in young children?","volume":"101","author":"Boast","year":"2016","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0035","doi-asserted-by":"crossref","first-page":"714","DOI":"10.5694\/j.1326-5377.1968.tb83133.x","article-title":"Tetracycline-induced tooth changes: part 2. Prevalence, localization and nature of staining in extracted deciduous teeth","volume":"2","author":"Brearley","year":"1968","journal-title":"Med J Aust"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0040","first-page":"306","article-title":"Tetracyclines and teeth. An experimental investigation into five types in the rat","volume":"126","author":"Bridges","year":"1969","journal-title":"Br Dent J"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.amjmed.2009.05.011","article-title":"Subjective symptoms after treatment of early Lyme disease","volume":"123","author":"Cerar","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1001\/archpedi.1963.02080040455005","article-title":"Growth inhibition of prematures receiving tetracycline","volume":"10","author":"Cohlan","year":"1963","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0055","series-title":"Red Book, 2018-2021: report of the Committee on Infectious Diseases","first-page":"905","author":"Committee on Infectious Diseases","year":"2018"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0060","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1517\/14740338.2016.1133584","article-title":"Revisting doxycycline in pregnancy and early childhood\u2014time to rebuild its reputation?","volume":"15","author":"Cross","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0065","series-title":"Antibiotic essentials","first-page":"541","author":"Cunha","year":"2017"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0070","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/0140-6736(90)93103-V","article-title":"Amoxicillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis","volume":"2","author":"Dattwyler","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0075","series-title":"Kucers' the use of antibiotics","first-page":"851","article-title":"Doxycycline","author":"Eisen","year":"2010"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/02813432.2017.1288812","article-title":"Symptom load and general function among patients with erythema migrans: a prospective study with a one year follow-up after antibiotic treatment in Norwegian general practice","volume":"35","author":"Eliassen","year":"2017","journal-title":"Scand J Prim Health Care"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2018.02.028","article-title":"Comparison of phenoxymethyl penicillin, amoxicillin, and doxycycline for erythema migrans in general practice. A randomized controlled trial with a one year follow-up","author":"Eliassen","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0090","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0140-6736(69)91787-5","article-title":"Doxycycline and the teeth","volume":"1","author":"Forti","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0095","first-page":"271","article-title":"Treatment of infection in premature infants with a new tetracycline: doxycycline","volume":"5","author":"Forti","year":"1967","journal-title":"Antibiotica"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0100","first-page":"147","article-title":"Tetracycline antibiotics and tooth discoloration","volume":"1","author":"Frankel","year":"1964","journal-title":"J Oral Ther Pharmacol"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0105","first-page":"75","article-title":"Effect of administration of tetracycline in pregnancy on the primary dentition of the offspring","volume":"25","author":"Genot","year":"1970","journal-title":"J Oral Med"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0110","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1542\/peds.47.3.567","article-title":"Tetracyclines and permanent teeth: the relation between dose and tooth color","volume":"47","author":"Grossman","year":"1971","journal-title":"Pediatrics"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0115","first-page":"245","article-title":"Tetracyclines and the human dentition","volume":"5","author":"Guggenheimer","year":"1984","journal-title":"Compend Contin Educ Dent"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0120","first-page":"33","article-title":"The tetracyclines and their effect on teeth. A Clinical Study","volume":"75","author":"Hamp","year":"1967","journal-title":"Odontol Tidskr"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2710.2007.00853.x","article-title":"Association between tetracycline or doxycycline and hepatotoxicity: a population-based case\u2013control study","volume":"32","author":"Heaton","year":"2007","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0130","first-page":"484","article-title":"Dental aspects of tetracycline therapy: literature review and results of a prevalence survey","volume":"44","author":"Hennon","year":"1965","journal-title":"J Indiana Dent Assoc"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0135","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/cid\/ciu397","article-title":"Lyme disease testing by large commercial laboratories in the United States","volume":"59","author":"Hinckley","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0140","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/jps.2600630819","article-title":"Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans","volume":"63","author":"Jaffe","year":"1974","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0145","first-page":"190","article-title":"The tetracyclines: a review of the literature\u20141948 through 1963","volume":"1","author":"Johnson","year":"1964","journal-title":"J Oral Ther Pharmacol"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0150","first-page":"129","article-title":"Dental staining and antimicrobial therapy","volume":"93","author":"Keitel","year":"1965","journal-title":"CMAJ"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0155","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(66)92683-3","article-title":"Tetracycline and the teeth","volume":"2","author":"Kowalewska","year":"1966","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0160","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/649920","article-title":"Antibiotic treatment duration and long-term outcomes of patients with early Lyme disease from a Lyme disease-hyperendemic area","volume":"50","author":"Kowalski","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0165","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9378(66)90328-0","article-title":"Discoloration of deciduous teeth induced by administration of tetracycline antepartum","volume":"96","author":"Kutscher","year":"1966","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0170","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00006454-199805000-00019","article-title":"Doxycycline and staining of permanent teeth","volume":"17","author":"Lochary","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0175","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/AAC.39.3.661","article-title":"Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with erythema migrans","volume":"39","author":"Luger","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0180","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0002-9343(92)90270-L","article-title":"Treatment of early Lyme disease","volume":"92","author":"Massarotti","year":"1992","journal-title":"Am J Med"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0185","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5694\/j.1326-5377.1970.tb77755.x","article-title":"Tetracycline-induced tooth changes, part 4. Discoloration and hypoplasia induced by tetracycline analogues","volume":"1","author":"McIntosh","year":"1970","journal-title":"Med J Aust"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0190","first-page":"547","article-title":"Prediction of tetracycline-induced tooth discoloration","volume":"88","author":"Moffitt","year":"1974","journal-title":"JADA"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0195","first-page":"216","article-title":"Comparative concentrations of a tetracycline antibiotic in serum and maternal milk","volume":"6","author":"Morganti","year":"1968","journal-title":"Antibiotica"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0205","doi-asserted-by":"crossref","first-page":"E625","DOI":"10.1503\/cmaj.161020","article-title":"Use of antibiotics during pregnancy and risk of spontaneous abortion","volume":"189","author":"Muanda","year":"2017","journal-title":"CMAJ"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0200","doi-asserted-by":"crossref","DOI":"10.1111\/bcp.13364","article-title":"Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study","author":"Muanda","year":"2017","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0210","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7326\/0003-4819-117-4-273","article-title":"Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease","volume":"117","author":"Nadelman","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0215","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1097\/01.AOG.0000216197.26783.b5","article-title":"Antibiotic use in pregnancy and lactation. What is and is not known about teratogenic and toxic risks","volume":"107","author":"Nahum","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0220","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2011.06354.x","article-title":"The history of the tetracyclines","volume":"1241","author":"Nelson","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0225","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3201\/eid2109.150417","article-title":"Incidence of clinician-diagnosed Lyme disease, United States, 2005-2010","volume":"21","author":"Nelson","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0230","first-page":"18","article-title":"Tetracycline stained vital teeth\u2014review of the literature","volume":"58","author":"Patterson","year":"1979","journal-title":"J Indiana Dent Assoc"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0235","first-page":"549","article-title":"The possibility of tooth discoloration after doxycycline therapy in infants and toddlers","volume":"51","author":"Poloczek","year":"1975","journal-title":"Z Allgemeinmed"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0240","first-page":"668","article-title":"Controlled study of the effect of tetracycline on primary dentition","volume":"5","author":"Porter","year":"1965","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0245","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1093\/jac\/dkx245","article-title":"Dental staining after doxycycline use in children","volume":"72","author":"Poyhonen","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0250","first-page":"630","article-title":"The St. Regis environmental health issue: assessment of dental defects","volume":"106","author":"Rebich","year":"1983","journal-title":"JADA"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0255","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.contraception.2008.09.006","article-title":"Doxycycline serum levels at the time of dilation and evacuation with two dosing regimens","volume":"79","author":"Reeves","year":"2009","journal-title":"Contraception"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0260","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1001\/jama.2016.2884","article-title":"Diagnosis, treatment and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis","volume":"315","author":"Sanchez","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0265","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000220581","article-title":"Some pharmacokinetic aspects of doxycycline metabolism in man","volume":"13","author":"Schach von Wittenau","year":"1968","journal-title":"Chemotherapy"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2018.09.015_bb0270","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1093\/jpids\/pix029","article-title":"Clinical presentation and outcomes of children with human granulocytic anaplasmosis","volume":"7","author":"Schotthoefer","year":"2018","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0275","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0031-3955(16)30364-9","article-title":"The tetracyclines. Applied pharmacology","volume":"3","author":"Schwachman","year":"1956","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/000992280204100402","article-title":"Tetracyclines in pediatrics revisited","volume":"41","author":"Shetty","year":"2002","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0285","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.diagmicrobio.2017.08.003","article-title":"Anaplasmosis in pediatric patients: case report and review","volume":"89","author":"Sigurjonsdottir","year":"2017","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"Supplement 52","key":"10.1016\/j.diagmicrobio.2018.09.015_bb0290","first-page":"S38","article-title":"Tetracycline","volume":"48","author":"Storey","year":"1967","journal-title":"Australas J Pharm"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0295","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.diagmicrobio.2018.01.025","article-title":"Is the risk of early neurologic Lyme borreliosis reduced by preferentially treating patients with erythema migrans with doxycycline?","volume":"91","author":"Strle","year":"2018","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0300","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/adc.42.223.311","article-title":"Side-effects to antibiotics in cystic fibrosis: dental changes in relation to antibiotic administration","volume":"42","author":"Swallow","year":"1967","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0305","series-title":"Drug-induced Diseases","first-page":"117","article-title":"Tooth discolouration due to tetracyclines","volume":"3","author":"Toaff","year":"1963"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0310","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jpeds.2015.02.015","article-title":"No visible dental staining in children treated with doxycycline for suspected Rocky Mountain spotted fever","volume":"166","author":"Todd","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0315","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/cid\/civ636","article-title":"Incidence and patterns of extended-course antibiotic therapy in patients evaluated for Lyme disease","volume":"61","author":"Tseng","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0320","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/0009922806290026","article-title":"Absence of tooth staining with doxycycline treatment in young children","volume":"46","author":"Volovitz","year":"2007","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0325","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0140-6736(62)90534-2","article-title":"Prematurity, tetracycline, and oxytetracycline in tooth development","volume":"2","author":"Wallman","year":"1962","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0330","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(62)91840-8","article-title":"Teeth pigmented by tetracycline","volume":"1","author":"Wallman","year":"1962","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0335","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1749-6632.1988.tb31867.x","article-title":"Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans","volume":"539","author":"Weber","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.diagmicrobio.2018.09.015_bb0340","first-page":"69","article-title":"Discoloration of the teeth associated with oxytetracycline administration to premature birth children","volume":"30","author":"Zegarelli","year":"1963","journal-title":"J Dent Child"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889318304383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889318304383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:51:41Z","timestamp":1760003501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889318304383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0732889318304383"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2018.09.015","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How safe is doxycycline for young children or for pregnant or breastfeeding women?","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2018.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}