{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:16:11Z","timestamp":1790241371469,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.diagmicrobio.2019.06.005","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T02:29:43Z","timestamp":1560479383000},"page":"114853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Variation in the formation of persister cells against meropenem in Klebsiella pneumoniae bacteremia and analysis of its clinical features"],"prefix":"10.1016","volume":"95","author":[{"given":"Jin Seo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Seon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Ran","family":"Peck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Soo","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10069","article-title":"Metabolite-enabled eradication of bacterial persisters by aminoglycosides","volume":"473","author":"Allison","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.molcel.2013.04.002","article-title":"Metabolic control of persister formation in Escherichia coli","volume":"50","author":"Amato","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084361","article-title":"Heterogeneous persister cells formation in Acinetobacter baumannii","volume":"8","author":"Barth","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003144","article-title":"Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin","volume":"9","author":"Bernier","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro.2016.34","article-title":"Distinguishing between resistance, tolerance and persistence to antibiotic treatment","volume":"14","author":"Brauner","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0030","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1128\/AAC.00952-15","article-title":"Loss of hypermucoviscosity and increased fitness cost in colistin-resistant Klebsiella pneumoniae sequence type 23 strains","volume":"59","author":"Choi","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0035","doi-asserted-by":"crossref","first-page":"578e83","DOI":"10.1016\/j.jinf.2006.11.008","volume":"54","author":"Chung","year":"2007","journal-title":"J Infect"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0040","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/jac\/dkx102","article-title":"Variation in formation of persister cells against colistin in Acinetobacter baumannii isolates and its relationship with treatment failure","volume":"72","author":"Chung","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0045","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing. 24th informational supplement. Document M100-S27. Wayne, Pa, USA. 2017."},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11538-012-9796-z","article-title":"Effect of periodic disinfection on persisters in a one-dimensional biofilm model","volume":"75","author":"Cogan","year":"2013","journal-title":"Bull Math Biol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0055","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00285-008-0243-6","article-title":"Failure of antibiotic treatment in microbial populations","volume":"59","author":"De Leenheer","year":"2009","journal-title":"J Mathe Biol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0060","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","article-title":"Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates","volume":"43","author":"Diancourt","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000317","article-title":"Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli","volume":"8","author":"Dorr","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0070","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1099\/jmm.0.030932-0","article-title":"Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies","volume":"60","author":"Fauvart","year":"2011","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0075","article-title":"Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline","volume":"10","author":"Feng","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0080","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1099\/jmm.0.000542","article-title":"Combination of polymyxin B and meropenem eradicates persister cells from Acinetobacter baumannii strains in exponential growth","volume":"66","author":"Gallo","year":"2017","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tim.2014.03.008","article-title":"Bacterial persisters: formation, eradication, and experimental systems","volume":"22","author":"Helaine","year":"2014","journal-title":"Trend Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0090","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1126\/science.1244705","article-title":"Internalization of Salmonella by macrophages induces formation of nonreplicating persisters","volume":"343","author":"Helaine","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3181\/00379727-50-13773","article-title":"Observations on the mechanism of action of penicillin","volume":"50","author":"Hobby","year":"1942","journal-title":"Proc Exp Biol Med"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003123","article-title":"Pharmacodynamics, population dynamics, and the evolution of persistence in Staphylococcus aureus","volume":"9","author":"Johnson","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0105","doi-asserted-by":"crossref","unstructured":"Keren I, Mulcahy LR, Lewis K. Chapter 19. Persister eradication: lessons from the world of natural products. In: Hopwood DA. Methods in enzymology Vol. 517: Academic Press, 2012; 517:387\u2013406.","DOI":"10.1016\/B978-0-12-404634-4.00019-X"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0110","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1534\/genetics.104.035352","article-title":"Bacterial persistence: a model of survival in changing environments","volume":"169","author":"Kussell","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0115","first-page":"235","article-title":"Staphylococcus aureus persisters tolerant to bactericidal antibiotics","volume":"22","author":"Lechner","year":"2012","journal-title":"J Mol Microbiol Biotechnol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0120","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1086\/502156","article-title":"Role of comorbidity in mortality related to Staphylococcus aureus bacteremia: a prospective study using the Charlson weighted index of comorbidity","volume":"24","author":"Lesens","year":"2003","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0125","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/JB.06707-11","article-title":"A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance","volume":"194","author":"Leung","year":"2012","journal-title":"J Bacteriol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrmicro1557","article-title":"Persister cells, dormancy and infectious disease","volume":"5","author":"Lewis","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1099\/jmm.0.000680","article-title":"Survival of bactericidal antibiotic treatment by tolerant persister cells of Klebsiella pneumoniae","volume":"67","author":"Li","year":"2018","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0140","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cell.2013.07.048","article-title":"(p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity","volume":"154","author":"Maisonneuve","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0145","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1128\/AEM.01576-14","article-title":"The fatty acid signaling molecule cis-2-decenoic acid increases metabolic activity and reverts persister cells to an antimicrobial-susceptible state","volume":"80","author":"Marques","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0150","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/cc5713","article-title":"Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury","volume":"11","author":"Mehta","year":"2007","journal-title":"Crit Care"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0155","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1128\/AAC.00757-16","article-title":"In vitro emergence of high persistence upon periodic aminoglycoside challenge in the ESKAPE pathogens","volume":"60","author":"Michiels","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.drup.2016.10.002","article-title":"Molecular mechanisms and clinical implications of bacterial persistence","volume":"29","author":"Michiels","year":"2016","journal-title":"Drug Resist Updates"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0165","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/JB.01231-09","article-title":"Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules","volume":"192","author":"Moker","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0170","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1128\/JB.01651-09","article-title":"Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis","volume":"192","author":"Mulcahy","year":"2010","journal-title":"J Bact"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0175","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/femsre\/fux013","article-title":"Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance","volume":"41","author":"Navon-Venezia","year":"2017","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0180","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1128\/AAC.00296-11","article-title":"Carbapenems: past, present, and future","volume":"55","author":"Papp-Wallace","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.7326\/0003-4819-140-1-200401060-00008","article-title":"International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial infections","volume":"140","author":"Paterson","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0190","first-page":"3267","article-title":"Gradual increase in antibiotic concentration affects persistence of Klebsiella pneumoniae","volume":"70","author":"Ren","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jinf.2011.05.003","article-title":"Comparison of CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae isolates from patients with bacteremia","volume":"63","author":"Shin","year":"2011","journal-title":"J Infect"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0200","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1128\/JCM.00977-11","article-title":"Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan","volume":"49","author":"Siu","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004321","article-title":"Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity","volume":"10","author":"Starkey","year":"2014","journal-title":"PLoS Patho"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0210","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00630-15","article-title":"Mapping the evolution of hypervirulent Klebsiella pneumoniae","volume":"6","author":"Struve","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0215","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nchembio.915","article-title":"Signaling-mediated bacterial persister formation","volume":"8","author":"Vega","year":"2012","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0220","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/pathogens3030743","article-title":"Antibiotic resistance related to biofilm formation in Klebsiella pneumoniae","volume":"3","author":"Vuotto","year":"2014","journal-title":"Pathogens"},{"key":"10.1016\/j.diagmicrobio.2019.06.005_bb0225","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/bit.25721","article-title":"Combatting bacterial persister cells","volume":"113","author":"Wood","year":"2016","journal-title":"Biotechnol Bioeng"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889319302445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889319302445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:52:44Z","timestamp":1760003564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889319302445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0732889319302445"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2019.06.005","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variation in the formation of persister cells against meropenem in Klebsiella pneumoniae bacteremia and analysis of its clinical features","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2019.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114853"}}