{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:05:40Z","timestamp":1790535940591,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"FIND"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.diagmicrobio.2019.114937","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T19:46:21Z","timestamp":1573587981000},"page":"114937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Detection of mycobacterial lipoarabinomannan in serum for diagnosis of active tuberculosis"],"prefix":"10.1016","volume":"96","author":[{"given":"Mary","family":"Brock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hanlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira R.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0005","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tube.2018.06.004","article-title":"Detection of lipoarabinomannan in urine and serum of HIV-positive and HIV-negative TB suspects using an improved capture-enzyme linked immuno absorbent assay and gas chromatography\/mass spectrometry","volume":"111","author":"Amin","year":"2018","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(19)30001-5","article-title":"Novel high sensitivity tuberculosis point-of-care test for people living with HIV","author":"Broger","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215443","article-title":"Sensitive electrochemiluminescence (ECL) immunoassays for detecting lipoarabinomannan (LAM) and ESAT-6 in urine and serum from tuberculosis patients","author":"Broger","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0020","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.1701673","article-title":"Characterization of the antigenic heterogeneity of lipoarabinomannan, the major surface glycolipid of Mycobacterium tuberculosis, and complexity of antibody specificities toward this antigen","volume":"200","author":"Choudhary","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1039\/C6AN02110G","article-title":"Detection of the tuberculosis antigenic marker mannose-capped lipoarabinomannan in pretreated serum by surface-enhanced Raman scattering","volume":"142","author":"Crawford","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0030","series-title":"eaal2807","article-title":"Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity. Sci Transl Med 9(420)","author":"Paris","year":"2017"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0035","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0140-6736(15)01092-2","article-title":"Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial","volume":"387","author":"Peter","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0040","unstructured":"https:\/\/portal.quanterix.com\/files\/documentation\/Lower_Limit_of_Quantitation_LLOQ.pdf. Quanterix."},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0045","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nbt.1641","article-title":"Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations","volume":"28","author":"Rissin","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0050","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1128\/jcm.30.9.2415-2418.1992","article-title":"Detection of lipoarabinomannan as a diagnostic test for tuberculosis","volume":"30","author":"Sada","year":"1992","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.tube.2013.02.015","article-title":"Association of lipoarabinomannan with high density lipoprotein in blood: implications for diagnostics","volume":"93","author":"Sakamuri","year":"2013","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032340","article-title":"A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings","volume":"7","author":"Sarkar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/postgradmedj-2013-132053","article-title":"Application of lipoarabinomannan antigen in tuberculosis diagnostics: current evidence","volume":"90","author":"Sarkar","year":"2014","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011420.pub2","article-title":"Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults","author":"Shah","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2019.114937_bb0075","doi-asserted-by":"crossref","first-page":"e01338","DOI":"10.1128\/JCM.01338-18","article-title":"A novel sensitive immunoassay targeting the 5-methylthio-d-xylofuranose-lipoarabinomannan epitope meets the WHO's performance target for tuberculosis diagnosis","volume":"56","author":"Sigal","year":"2018","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0080","series-title":"High-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting","author":"World Health Organization","year":"2014"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0085","series-title":"The use of lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis and screening of active tuberculosis in people living with HIV; policy update","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.diagmicrobio.2019.114937_bb0090","series-title":"2018 Global tuberculosis report","author":"World Health Organization","year":"2018"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889319307710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889319307710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:53:19Z","timestamp":1760003599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889319307710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0732889319307710"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2019.114937","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of mycobacterial lipoarabinomannan in serum for diagnosis of active tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2019.114937","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114937"}}